AR094548A1 - Dispersión sólida físicamente estable - Google Patents
Dispersión sólida físicamente estableInfo
- Publication number
- AR094548A1 AR094548A1 ARP140100191A ARP140100191A AR094548A1 AR 094548 A1 AR094548 A1 AR 094548A1 AR P140100191 A ARP140100191 A AR P140100191A AR P140100191 A ARP140100191 A AR P140100191A AR 094548 A1 AR094548 A1 AR 094548A1
- Authority
- AR
- Argentina
- Prior art keywords
- solid dispersion
- approximately
- compound
- polymer
- dispersion according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Dispersión sólida físicamente estable que comprende un compuesto que presenta una solubilidad acuosa inferior a 1 mg/ml y un punto de fusión >270ºC conjuntamente con un polímero estabilizador. Reivindicación 2: Dispersión sólida según la reivindicación 1, en la que el compuesto que presenta una solubilidad acuosa inferior a 1 mg/ml es el ácido 4-{[(2R,3S,4R,5S)-4-(4-cloro-2-fluorofenil)-3-(3-cloro-2-fluorofenil)-4-ciano-5-(2,2-dimetilpropil)-pirrolidín-2-carbonil]-amino}-3-metoxibenzoico, de fórmula (1). Reivindicación 3: Dispersión sólida según la reivindicación 1 ó 2, en la que el polímero estabilizador es acetato-succinato de hipromelosa (HPMCAS). Reivindicación 4: Dispersión sólida según la reivindicación 1 ó 2, en la que el polímero estabilizador es EUDRAGITR L-100 ó Eudragit L100-55. Reivindicación 5: Dispersión sólida según la reivindicación 1 ó 2, en la que el polímero estabilizador es copovidona (PVP VA 64). Reivindicación 6: Dispersión sólida según cualquiera de las reivindicaciones 2 a 5, en la que la proporción entre la cantidad en peso de Compuesto de fórmula (1) según la reivindicación 2 en la dispersión sólida y la cantidad en peso del polímero estabilizador en la misma es de entre 5:95 y 70:30. Reivindicación 11: Formulación sólida de dosis unitaria según la reivindicación 10, que comprende aproximadamente 80% de la dispersión sólida según cualquiera de las reivindicaciones 6 a 9 en forma de una dispersión sólida amorfa, conjuntamente con aproximadamente 7% de croscarmelosa sódica. aproximadamente 6,8% de manitol, aproximadamente 4% de crospovidona, aproximadamente 1,5% de dióxido de silicio coloidal y aproximadamente 0,7% de estearato de magnesio, que seguidamente se encapsula o se comprime y se recubre en forma de tableta. Reivindicación 12: Método para preparar una dispersión sólida de un compuesto que presenta una solubilidad acuosa inferior a 1 mg/ml y un polímero iónico que comprende formar una solución del compuesto y el polímero en dimetilacetamida, o cualquier otro solvente adecuado, y coprecipitar el fármaco con el polímero utilizando antisolvente. Reivindicación 14: Dispersión sólida según cualquiera de las reivindicaciones 1 a 8 para la utilización como medicamento para el tratamiento del cáncer, en particular de la LMA o el cáncer de próstata.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361755074P | 2013-01-22 | 2013-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR094548A1 true AR094548A1 (es) | 2015-08-12 |
Family
ID=50023547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140100191A AR094548A1 (es) | 2013-01-22 | 2014-01-22 | Dispersión sólida físicamente estable |
Country Status (24)
Country | Link |
---|---|
US (2) | US9427427B2 (es) |
EP (1) | EP2948141A1 (es) |
JP (1) | JP6192244B2 (es) |
KR (1) | KR101737250B1 (es) |
CN (3) | CN104936589A (es) |
AR (1) | AR094548A1 (es) |
AU (1) | AU2014210103B2 (es) |
BR (1) | BR112015015758B1 (es) |
CA (1) | CA2892025C (es) |
CL (1) | CL2015001649A1 (es) |
CR (1) | CR20150287A (es) |
EA (1) | EA028009B1 (es) |
HK (1) | HK1211217A1 (es) |
IL (1) | IL239657B (es) |
MA (1) | MA38289A1 (es) |
MX (1) | MX2015008911A (es) |
MY (1) | MY192032A (es) |
NZ (1) | NZ708272A (es) |
PE (1) | PE20151335A1 (es) |
PH (1) | PH12015501620A1 (es) |
SG (1) | SG11201504499VA (es) |
UA (1) | UA116004C2 (es) |
WO (1) | WO2014114575A1 (es) |
ZA (1) | ZA201504187B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6621761B2 (ja) * | 2014-04-15 | 2019-12-18 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 薬学的に活性な化合物の固体形態 |
PT107846B (pt) * | 2014-08-01 | 2019-03-22 | Hovione Farm S A | Produção de nano- partículas de dispersões sólidas amorfas por co-precipitação controlada |
CN106999432A (zh) | 2014-12-05 | 2017-08-01 | 阿拉贡药品公司 | 抗癌组合物 |
SI3226842T1 (sl) * | 2014-12-05 | 2021-04-30 | Aragon Pharmaceuticals, Inc. | Protirakavi sestavki |
JP6796083B2 (ja) * | 2015-06-09 | 2020-12-02 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップCapsugel Belgium NV | カプセル中の薬剤の噴霧乾燥ディスパーションからの迅速な溶解を達成するための製剤 |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
AU2018255063A1 (en) * | 2017-04-21 | 2018-11-22 | Bio-Synectics Inc. | Method for preparing active material nanoparticles using lipid as lubricant for milling |
BR112019027473A2 (pt) * | 2017-07-04 | 2020-07-07 | Jiangsu Hengrui Medicine Co., Ltd. | composição farmacêutica e método para preparar a mesma |
WO2019193488A1 (en) | 2018-04-06 | 2019-10-10 | Capsugel Belgium Nv | Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)] |
WO2019213106A1 (en) | 2018-04-30 | 2019-11-07 | Teva Pharmaceuticals International Gmbh | Solid state forms of idasanutlin |
TW202043225A (zh) * | 2019-01-25 | 2020-12-01 | 英屬開曼群島商百濟神州有限公司 | B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途 |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
US20220233449A1 (en) * | 2019-05-31 | 2022-07-28 | Jiangsu Hengrui Medicine Co., Ltd. | Solid dispersion and preparation method therefor |
CN114585362B (zh) * | 2019-09-23 | 2024-05-07 | 生态有限公司 | 治疗制剂及其用途 |
AU2020395495B2 (en) * | 2019-12-02 | 2024-05-09 | Astrazeneca Ab | Solid pharmaceutical formulations of 6-(2-chloro-6-methylpyridin-4-yl)-5-(-4-fluorophenyl)-1,2,4-triazin-3-amine |
KR20220119023A (ko) * | 2019-12-20 | 2022-08-26 | 인터벳 인터내셔널 비.브이. | 중합체 매트릭스에 분산된 피라졸 화합물의 제약 조성물 |
TW202211911A (zh) * | 2020-06-05 | 2022-04-01 | 美商應用材料股份有限公司 | 經塗佈的藥物組成物及製備彼之方法 |
CN112022812B (zh) * | 2020-11-03 | 2021-01-29 | 上海亚盛医药科技有限公司 | 一种包含杂环类化合物的组合物、其制备方法和应用 |
EP4119128A1 (en) * | 2021-07-13 | 2023-01-18 | Dr. Falk Pharma Gmbh | Pharmaceutical composition for the oral administration of poorly soluble drugs comprising an amorphous solid dispersion |
WO2024025609A1 (en) * | 2022-07-26 | 2024-02-01 | Wellstat Therapeutics Corporation | Uridine triacetate amorphous formulation and uses thereof |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
GB9511220D0 (en) | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
EP0904060B1 (en) | 1996-05-20 | 2003-12-10 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
SE9700655L (sv) | 1997-02-25 | 1998-05-11 | Neste Oy | Förfarande för framställning av ftalsyraanhydrid |
US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
IL143580A0 (en) | 1998-12-11 | 2002-04-21 | Pharmasolutions Inc | Pharmaceutical compositions containing lipophilic drugs and methods for the preparation thereof |
EP1027885B1 (en) | 1999-02-09 | 2008-07-09 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
US6057289A (en) | 1999-04-30 | 2000-05-02 | Pharmasolutions, Inc. | Pharmaceutical composition comprising cyclosporin in association with a carrier in a self-emulsifying drug delivery system |
HUP0303700A3 (en) | 2000-07-17 | 2006-07-28 | Astellas Pharma Inc Chuo Ku | Pharmaceutical composition improved in peroral absorbability |
CN1240437C (zh) | 2000-10-31 | 2006-02-08 | 贝林格尔·英格海姆药物公司 | 口服的自乳化的吡喃酮蛋白酶抑制剂制剂 |
CN100518831C (zh) | 2002-08-15 | 2009-07-29 | 刘云清 | 固体纳米药物及其制备方法 |
US7438261B2 (en) | 2004-09-09 | 2008-10-21 | David R. Porter | Stratospheric balloon utilizing electrostatic inflation of walls |
CN103272234A (zh) | 2006-03-20 | 2013-09-04 | 沃泰克斯药物股份有限公司 | 药物组合物 |
US8354444B2 (en) * | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
AR078033A1 (es) * | 2009-04-03 | 2011-10-12 | Plexxikon Inc | Una dispersion solida, que contiene al compuesto {3-[5-(4-(cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico, composiciones y formulaciones que comprenden a dicha dispersion solida; metodos para fabricar dicha dispersion solida, formas 1 y 2 de |
CN102871950B (zh) * | 2011-07-15 | 2016-04-20 | 上海睿智化学研究有限公司 | 一种熊果酸固体分散体及其制备方法 |
US20130245089A1 (en) * | 2012-03-19 | 2013-09-19 | Hoffmann-La Roche Inc. | Method for administration |
US20140128431A1 (en) * | 2012-04-03 | 2014-05-08 | Hoffmann-Laroche Inc. | Pharmaceutical composition with improved bioavailability, safety and tolerability |
-
2014
- 2014-01-20 NZ NZ708272A patent/NZ708272A/en not_active IP Right Cessation
- 2014-01-20 AU AU2014210103A patent/AU2014210103B2/en active Active
- 2014-01-20 PE PE2015001370A patent/PE20151335A1/es unknown
- 2014-01-20 UA UAA201507997A patent/UA116004C2/uk unknown
- 2014-01-20 CN CN201480005646.7A patent/CN104936589A/zh active Pending
- 2014-01-20 JP JP2015553108A patent/JP6192244B2/ja active Active
- 2014-01-20 SG SG11201504499VA patent/SG11201504499VA/en unknown
- 2014-01-20 MY MYPI2015702350A patent/MY192032A/en unknown
- 2014-01-20 EA EA201591276A patent/EA028009B1/ru not_active IP Right Cessation
- 2014-01-20 BR BR112015015758-0A patent/BR112015015758B1/pt active IP Right Grant
- 2014-01-20 CN CN202011052449.4A patent/CN112353762A/zh active Pending
- 2014-01-20 EP EP14701504.4A patent/EP2948141A1/en active Pending
- 2014-01-20 MX MX2015008911A patent/MX2015008911A/es active IP Right Grant
- 2014-01-20 CA CA2892025A patent/CA2892025C/en active Active
- 2014-01-20 KR KR1020157019822A patent/KR101737250B1/ko active IP Right Grant
- 2014-01-20 WO PCT/EP2014/050974 patent/WO2014114575A1/en active Application Filing
- 2014-01-20 CN CN202011052471.9A patent/CN112370427A/zh active Pending
- 2014-01-21 US US14/159,679 patent/US9427427B2/en active Active
- 2014-01-22 AR ARP140100191A patent/AR094548A1/es unknown
-
2015
- 2015-05-28 CR CR20150287A patent/CR20150287A/es unknown
- 2015-06-10 ZA ZA2015/04187A patent/ZA201504187B/en unknown
- 2015-06-12 CL CL2015001649A patent/CL2015001649A1/es unknown
- 2015-06-25 IL IL239657A patent/IL239657B/en active IP Right Grant
- 2015-07-22 PH PH12015501620A patent/PH12015501620A1/en unknown
- 2015-07-23 MA MA38289A patent/MA38289A1/fr unknown
- 2015-12-08 HK HK15112066.7A patent/HK1211217A1/xx unknown
-
2016
- 2016-07-01 US US15/200,419 patent/US10034854B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR094548A1 (es) | Dispersión sólida físicamente estable | |
AR073792A1 (es) | Formulacion farmaceutica. metodo. uso | |
PE20151592A1 (es) | Formulacion de liberacion sostenida de mosapride que proporciona efectos farmacologicos y clinicos con administracion una vez al dia | |
AR082024A1 (es) | Formulacion de anticuerpo contra ox40l humano | |
EA201591003A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
MX2016001971A (es) | Composiciones farmaceuticas parenterales acuosas estables de peptidos insulinotropicos. | |
PH12014502778B1 (en) | Antibody formulation | |
CU24350B1 (es) | DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET | |
MX2015016344A (es) | Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades. | |
UA117103C2 (uk) | Сполука, яка має активність агоніста глюкагону | |
AR067309A1 (es) | Formulaciones farmaceuticas que contienen derivados de acido lipoico | |
PE20161373A1 (es) | Composiciones de liberacion retardada de linaclotida | |
BR112015011179A2 (pt) | composições aquosas estáveis compreendendo insulina humana ou um análogo ou derivado das mesmas | |
NZ630335A (en) | Injectable preparation for a poorly soluble drug in a dispersion medium | |
MX2016005395A (es) | Formulacion estable de insulina glulisina. | |
CU24619B1 (es) | Letermovir amorfo y formulaciones farmacéuticas sólidas del mismo para administración por via oral | |
UA112352C2 (uk) | Фармацевтична композиція для профілактики і лікування психічних, поведінкових, когнітивних розладів | |
MX2022003376A (es) | Composiciones de proteinas estables. | |
EA201590797A1 (ru) | Препараты с модифицированным высвобождением опрозомиба | |
PH12017502252B1 (en) | Stable pharmaceutical composition for oral administration | |
CL2015002721A1 (es) | Formulaciones oftálmicas | |
BR112016002342A2 (pt) | Microesfera entecavir, método para preparação de uma microesfera entecavir, e, composição farmacêutica | |
MX2017005163A (es) | Composiciones de liberación prolongada de onapristona y métodos. | |
BR112015009504A2 (pt) | inibidores de rock | |
MX2019015927A (es) | Composiciones para administración de fármacos y métodos de uso de las mismas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |