EA033806B9 - Полимерный комплекс лекарственное средство-устройство, содержащий хинаголид, способ его изготовления, его применение и содержащий его набор - Google Patents

Полимерный комплекс лекарственное средство-устройство, содержащий хинаголид, способ его изготовления, его применение и содержащий его набор

Info

Publication number
EA033806B9
EA033806B9 EA201790898A EA201790898A EA033806B9 EA 033806 B9 EA033806 B9 EA 033806B9 EA 201790898 A EA201790898 A EA 201790898A EA 201790898 A EA201790898 A EA 201790898A EA 033806 B9 EA033806 B9 EA 033806B9
Authority
EA
Eurasian Patent Office
Prior art keywords
same
quinagolide
drug
polymeric drug
device unit
Prior art date
Application number
EA201790898A
Other languages
English (en)
Other versions
EA201790898A1 (ru
EA201790898A8 (ru
EA033806B1 (ru
Inventor
Джанет Холлидей
Денис Карр
Алистер Росс
Клэр Янг
Пол Макдоналд
Мохаммад Кадир
Роберт Кокрейн
Гоуэр Рабани
Джоан Карлес Арсе Саес
Аксель Никлас Петри
Original Assignee
Ферринг Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51951583&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA033806(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ферринг Б.В. filed Critical Ферринг Б.В.
Publication of EA201790898A1 publication Critical patent/EA201790898A1/ru
Publication of EA201790898A8 publication Critical patent/EA201790898A8/ru
Publication of EA033806B1 publication Critical patent/EA033806B1/ru
Publication of EA033806B9 publication Critical patent/EA033806B9/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/001—Combinations of extrusion moulding with other shaping operations
    • B29C48/0021—Combinations of extrusion moulding with other shaping operations combined with joining, lining or laminating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2033/00—Use of polymers of unsaturated acids or derivatives thereof as moulding material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/754—Pessaries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Изобретение основано на идентификации группы полиуретановых блок-сополимеров, которые особенно подходят для использования в фармацевтических полимерных комплексах лекарственное средство-устройство и которые обеспечивают улучшенный контроль высвобождения лекарственного средства. В частности, предложен полимерный комплекс лекарственное средство-устройство, содержащий полиуретановый блок-сополимер, получаемый путем совместного взаимодействия поли(алкиленоксида); дифункционального соединения; дифункционального изоцианата и, возможно, блок-сополимера, содержащего поли(алкиленоксидные) блоки; и хинаголид в качестве фармацевтически активного агента. Комплексы лекарственное средство-устройство могут применяться в лечении и/или предупреждении эндометриоза.
EA201790898A 2014-11-07 2015-11-05 Полимерный комплекс лекарственное средство-устройство, содержащий хинаголид, способ его изготовления, его применение и содержащий его набор EA033806B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14192372.2A EP3017809A1 (en) 2014-11-07 2014-11-07 Drug-device unit containing quinagolide
PCT/EP2015/075849 WO2016071466A1 (en) 2014-11-07 2015-11-05 Drug-device unit containing quinagolide

Publications (4)

Publication Number Publication Date
EA201790898A1 EA201790898A1 (ru) 2017-11-30
EA201790898A8 EA201790898A8 (ru) 2018-01-31
EA033806B1 EA033806B1 (ru) 2019-11-27
EA033806B9 true EA033806B9 (ru) 2019-12-19

Family

ID=51951583

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201991882A EA201991882A2 (ru) 2014-11-07 2015-11-05 Комплекс лекарственное средство-устройство, содержащее хинаголид
EA201790898A EA033806B9 (ru) 2014-11-07 2015-11-05 Полимерный комплекс лекарственное средство-устройство, содержащий хинаголид, способ его изготовления, его применение и содержащий его набор

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201991882A EA201991882A2 (ru) 2014-11-07 2015-11-05 Комплекс лекарственное средство-устройство, содержащее хинаголид

Country Status (34)

Country Link
US (2) US20180008535A1 (ru)
EP (3) EP3017809A1 (ru)
JP (2) JP6907120B2 (ru)
KR (1) KR102612852B1 (ru)
CN (2) CN116212032A (ru)
AR (1) AR102571A1 (ru)
AU (2) AU2015341734C1 (ru)
CA (1) CA2966473A1 (ru)
CL (1) CL2017001119A1 (ru)
CO (1) CO2017005578A2 (ru)
DK (1) DK3215118T3 (ru)
EA (2) EA201991882A2 (ru)
ES (1) ES2877973T3 (ru)
HR (1) HRP20210961T1 (ru)
HU (1) HUE054951T2 (ru)
IL (1) IL252088B (ru)
JO (1) JO3561B1 (ru)
LT (1) LT3215118T (ru)
MA (2) MA40897B1 (ru)
MD (1) MD3215118T2 (ru)
MX (1) MX2017005828A (ru)
MY (1) MY193638A (ru)
NZ (1) NZ731763A (ru)
PH (1) PH12017550005A1 (ru)
PL (1) PL3215118T3 (ru)
PT (1) PT3215118T (ru)
RS (1) RS62018B1 (ru)
SA (1) SA517381471B1 (ru)
SG (1) SG11201703596SA (ru)
SI (1) SI3215118T1 (ru)
TN (1) TN2017000175A1 (ru)
TW (1) TWI685339B (ru)
UA (1) UA122329C2 (ru)
WO (1) WO2016071466A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11896685B2 (en) 2018-10-31 2024-02-13 Amorepacific Corporation Core-shell network structure comprising biopolymer and composition comprising same
KR20210069344A (ko) 2019-12-03 2021-06-11 (주)아모레퍼시픽 바이오 폴리머를 포함하는 효능물질 전달체
EP4395751A1 (en) 2021-08-31 2024-07-10 Ferring B.V. Diagnosis and treatment of ectopic endometriosis
WO2024153752A1 (en) 2023-01-20 2024-07-25 Ferring B.V. Stereoselective synthesis of intermediates and synthesis of quinagolids

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WO2008007046A1 (en) * 2006-07-08 2008-01-17 Controlled Therapeutics (Scotland) Limited Polyurethane elastomers
WO2010150098A2 (en) * 2009-06-26 2010-12-29 Ferring International Center Sa Treatment of endometriosis
WO2013013172A1 (en) * 2011-07-20 2013-01-24 The University Of Utah Research Foundation Intravaginal devices for drug delivery

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EP1620060B1 (en) 2003-04-29 2010-03-24 The General Hospital Corporation Methods and devices for the sustained release of multiple drugs
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WO2005025549A2 (en) * 2003-09-10 2005-03-24 Noven Pharmaceuticals, Inc. Multi-layer transdermal drug delivery device
CA2605972C (en) 2005-04-29 2011-08-02 Ferring International Center S.A. Treatment or prevention of ovarian hyperstimulation syndrome (ohss) using a dopamine agonist
SA08290041B1 (ar) 2007-02-01 2012-06-05 فيرينج انترناشونال سنتر اس آيه أدوية من أجل معالجة بطانة الرحم
BRPI0906467C1 (pt) * 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
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US20100210600A1 (en) * 2009-02-19 2010-08-19 Prelief Inc. Methods and Compositions for Treating Urogenital Disorders
JP2013525285A (ja) * 2010-04-08 2013-06-20 サンフォード−バーナム メディカル リサーチ インスティテュート 化合物の送達を増強するための方法および組成物
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WO2008007046A1 (en) * 2006-07-08 2008-01-17 Controlled Therapeutics (Scotland) Limited Polyurethane elastomers
WO2010150098A2 (en) * 2009-06-26 2010-12-29 Ferring International Center Sa Treatment of endometriosis
WO2013013172A1 (en) * 2011-07-20 2013-01-24 The University Of Utah Research Foundation Intravaginal devices for drug delivery

Also Published As

Publication number Publication date
AU2015341734C1 (en) 2020-12-17
SA517381471B1 (ar) 2022-03-06
EA201991882A2 (ru) 2020-01-31
EP3215118B1 (en) 2021-03-17
CN116212032A (zh) 2023-06-06
PL3215118T3 (pl) 2021-07-26
MA40897B1 (fr) 2021-04-30
HUE054951T2 (hu) 2021-10-28
RS62018B1 (sr) 2021-07-30
IL252088A0 (en) 2017-07-31
US20180008535A1 (en) 2018-01-11
MY193638A (en) 2022-10-21
MD3215118T2 (ro) 2021-08-31
US20220040094A1 (en) 2022-02-10
WO2016071466A1 (en) 2016-05-12
NZ731763A (en) 2024-04-26
EP3017809A1 (en) 2016-05-11
DK3215118T3 (da) 2021-06-21
EP3215118A1 (en) 2017-09-13
BR112017009476A2 (pt) 2018-01-02
LT3215118T (lt) 2021-06-10
JP2021155444A (ja) 2021-10-07
JP6907120B2 (ja) 2021-07-21
PT3215118T (pt) 2021-05-31
AU2020270480A1 (en) 2020-12-17
MX2017005828A (es) 2017-11-13
SG11201703596SA (en) 2017-06-29
EA201790898A1 (ru) 2017-11-30
EA201790898A8 (ru) 2018-01-31
MA40897A (fr) 2017-09-13
TW201625245A (zh) 2016-07-16
CN106999422A (zh) 2017-08-01
CO2017005578A2 (es) 2017-08-31
IL252088B (en) 2022-04-01
PH12017550005A1 (en) 2017-10-18
TWI685339B (zh) 2020-02-21
EP3892261A1 (en) 2021-10-13
CL2017001119A1 (es) 2018-01-05
UA122329C2 (uk) 2020-10-26
JO3561B1 (ar) 2020-07-05
SI3215118T1 (sl) 2021-08-31
KR102612852B1 (ko) 2023-12-11
ES2877973T3 (es) 2021-11-17
AR102571A1 (es) 2017-03-08
EA033806B1 (ru) 2019-11-27
TN2017000175A1 (en) 2018-10-19
HRP20210961T1 (hr) 2021-09-17
AU2015341734A1 (en) 2017-06-01
JP2017533272A (ja) 2017-11-09
AU2015341734B2 (en) 2020-08-20
CA2966473A1 (en) 2016-05-12
KR20170080671A (ko) 2017-07-10
MA56414A (fr) 2022-05-04

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