EA033220B1 - Фталазиноны и изохинолиноны в качестве ингибиторов rock - Google Patents

Фталазиноны и изохинолиноны в качестве ингибиторов rock

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Publication number
EA033220B1
EA033220B1 EA201790202A EA201790202A EA033220B1 EA 033220 B1 EA033220 B1 EA 033220B1 EA 201790202 A EA201790202 A EA 201790202A EA 201790202 A EA201790202 A EA 201790202A EA 033220 B1 EA033220 B1 EA 033220B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
rock inhibitors
isoquinolinones
phthalazinones
relates
Prior art date
Application number
EA201790202A
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English (en)
Other versions
EA201790202A1 (ru
Inventor
Питер В. Гланц
Янь Цзоу
Мими Л. Кван
Владимир Ладзиата
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201790202A1 publication Critical patent/EA201790202A1/ru
Publication of EA033220B1 publication Critical patent/EA033220B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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Abstract

Изобретение относится к соединениям формулы (I)или их стереоизомерам, таутомерам или фармацевтически приемлемым солям, где все переменные являются таковыми, как определено в данном описании. Эти соединения представляют собой селективные ROCK ингибиторы. Изобретение также относится к фармацевтическим композициям, содержащим эти соединения, и способам лечения сердечно-сосудистых, гладкой мускулатуры, онкологических, невропатологических, аутоиммунных, фиброзных и/или воспалительных заболеваний с их применением.
EA201790202A 2013-01-18 2014-01-17 Фталазиноны и изохинолиноны в качестве ингибиторов rock EA033220B1 (ru)

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