EA032028B1 - СТИМУЛЯТОРЫ рГЦ - Google Patents

СТИМУЛЯТОРЫ рГЦ Download PDF

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Publication number
EA032028B1
EA032028B1 EA201691194A EA201691194A EA032028B1 EA 032028 B1 EA032028 B1 EA 032028B1 EA 201691194 A EA201691194 A EA 201691194A EA 201691194 A EA201691194 A EA 201691194A EA 032028 B1 EA032028 B1 EA 032028B1
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EA
Eurasian Patent Office
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ring
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group
independently selected
optionally
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EA201691194A
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English (en)
Russian (ru)
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EA201691194A1 (ru
Inventor
Пол Аллан Ренхауэ
Джеймс Эдвард Шеппек
Такаси Накаи
Картик Айер
Николас Роберт Перл
Глен Роберт Ренни
Марк Дж. Карри
Кимберли Кафадар Лонг
Джордж Тодд Милн
Раджеш Р. Ийенгар
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Айронвуд Фармасьютикалз, Инк.
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Application filed by Айронвуд Фармасьютикалз, Инк. filed Critical Айронвуд Фармасьютикалз, Инк.
Publication of EA201691194A1 publication Critical patent/EA201691194A1/ru
Publication of EA032028B1 publication Critical patent/EA032028B1/ru

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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
EA201691194A 2013-12-11 2014-12-10 СТИМУЛЯТОРЫ рГЦ EA032028B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361914908P 2013-12-11 2013-12-11
US201462051539P 2014-09-17 2014-09-17
PCT/US2014/069537 WO2015089182A1 (en) 2013-12-11 2014-12-10 Sgc stimulators

Publications (2)

Publication Number Publication Date
EA201691194A1 EA201691194A1 (ru) 2016-12-30
EA032028B1 true EA032028B1 (ru) 2019-03-29

Family

ID=52293206

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691194A EA032028B1 (ru) 2013-12-11 2014-12-10 СТИМУЛЯТОРЫ рГЦ

Country Status (8)

Country Link
US (2) US20160311826A1 (enExample)
EP (1) EP3092231B1 (enExample)
JP (1) JP2016540017A (enExample)
CN (1) CN106304835A (enExample)
CA (1) CA2933250A1 (enExample)
EA (1) EA032028B1 (enExample)
MX (1) MX2016007522A (enExample)
WO (1) WO2015089182A1 (enExample)

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Publication number Priority date Publication date Assignee Title
CN103313976B (zh) 2010-06-30 2016-11-23 铁木医药有限公司 sGC刺激物
WO2014047325A1 (en) 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EP2970243B1 (en) 2013-03-15 2019-11-27 Cyclerion Therapeutics, Inc. Sgc stimulators
EP3194386A2 (en) * 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2016044447A1 (en) * 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
WO2016044445A2 (en) * 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
CA3006764A1 (en) 2015-12-14 2017-06-22 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of gastrointestinal sphincter dysfunction
EA201990237A1 (ru) * 2016-07-07 2019-08-30 Сайклерион Терапьютикс, Инк. Новые способы получения стимуляторов растворимой гуанилатциклазы
CR20220309A (es) 2016-09-02 2022-09-16 Cyclerion Therapeutics Inc Estimuladores de sgc
EP3525778A1 (de) 2016-10-11 2019-08-21 Bayer Pharma Aktiengesellschaft Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten
EP3525779B1 (de) 2016-10-11 2024-06-05 Bayer Pharma Aktiengesellschaft Kombination enthaltend den sgc stimulator vericuguat und den mineralcorticoid-rezeptor-antagonist finerenone
US20190381039A1 (en) 2016-12-13 2019-12-19 Cyclerion Therapeutics, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS
CN108203396B (zh) * 2016-12-19 2020-12-08 江西东邦药业有限公司 一种脑啡肽酶抑制剂的合成
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
US11897887B2 (en) * 2017-12-19 2024-02-13 Tisento Therapeutics Inc. sGC stimulators
JP7314173B2 (ja) 2018-04-30 2023-07-25 バイエル アクチェンゲゼルシャフト 認知障害の治療のためのｓＧＣ活性化薬及びｓＧＣ刺激薬の使用
MX2020012230A (es) 2018-05-15 2021-01-29 Bayer Ag Uso de benzamidas sustituidas con 1,3-tiazol-2-ilo para el tratamiento de enfermedades asociadas con la sensibilizacion de las fibras nerviosas.
EP3574905A1 (en) 2018-05-30 2019-12-04 Adverio Pharma GmbH Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group
KR20210031931A (ko) 2018-07-11 2021-03-23 사이클리온 테라퓨틱스, 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
EP3911675A1 (en) 2019-01-17 2021-11-24 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
JP7411875B2 (ja) * 2020-10-08 2024-01-12 株式会社 キュロム・バイオサイエンス ベータ－ラパコンを有効成分として含む胆汁うっ滞性肝疾患予防又は治療用薬学組成物

Citations (5)

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WO2012003405A1 (en) * 2010-06-30 2012-01-05 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2012064559A1 (en) * 2010-11-09 2012-05-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2013092512A1 (en) * 2011-12-21 2013-06-27 Bayer Intellectual Property Gmbh Substituted benzylpyrazoles
WO2013101830A1 (en) * 2011-12-27 2013-07-04 Ironwood Pharmaceuticals, Inc. 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators
WO2014202588A1 (en) * 2013-06-21 2014-12-24 Bayer Pharma Aktiengesellschaft Heteroaryl substituted pyrazoles

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