EA031801B1 - Способ получения промежуточного соединения иопромида - Google Patents

Способ получения промежуточного соединения иопромида Download PDF

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Publication number
EA031801B1
EA031801B1 EA201690757A EA201690757A EA031801B1 EA 031801 B1 EA031801 B1 EA 031801B1 EA 201690757 A EA201690757 A EA 201690757A EA 201690757 A EA201690757 A EA 201690757A EA 031801 B1 EA031801 B1 EA 031801B1
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EA
Eurasian Patent Office
Prior art keywords
chemical formula
reaction
stage
compound represented
solvent
Prior art date
Application number
EA201690757A
Other languages
English (en)
Russian (ru)
Other versions
EA201690757A1 (ru
Inventor
Ёнг Сук Джин
Вол Юнг Ким
Джун Хван Ли
Сынг Тэ Ким
Санг Хьюн Ким
Хи Кьюн Юн
Original Assignee
Дэвунг Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Дэвунг Фармасьютикал Ко., Лтд. filed Critical Дэвунг Фармасьютикал Ко., Лтд.
Publication of EA201690757A1 publication Critical patent/EA201690757A1/ru
Publication of EA031801B1 publication Critical patent/EA031801B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EA201690757A 2013-10-25 2014-10-23 Способ получения промежуточного соединения иопромида EA031801B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130128154A KR101520187B1 (ko) 2013-10-25 2013-10-25 이오프로마이드의 중간체의 제조방법
PCT/KR2014/009991 WO2015060657A1 (en) 2013-10-25 2014-10-23 A method for preparing an intermediate of iopromide

Publications (2)

Publication Number Publication Date
EA201690757A1 EA201690757A1 (ru) 2016-10-31
EA031801B1 true EA031801B1 (ru) 2019-02-28

Family

ID=52993179

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690757A EA031801B1 (ru) 2013-10-25 2014-10-23 Способ получения промежуточного соединения иопромида

Country Status (7)

Country Link
KR (1) KR101520187B1 (ko)
CN (1) CN105636933B (ko)
EA (1) EA031801B1 (ko)
PH (1) PH12016500749A1 (ko)
SA (1) SA516370977B1 (ko)
UA (1) UA114158C2 (ko)
WO (1) WO2015060657A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110078636B (zh) * 2019-05-23 2022-05-17 浙江海洲制药有限公司 一种制备碘普罗胺中间体的方法
CN114436880B (zh) * 2020-11-03 2023-04-28 成都倍特药业股份有限公司 碘普罗胺中间体的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364921A (en) * 1979-03-08 1982-12-21 Schering, Aktiengesellschaft Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
WO1998024757A1 (en) * 1996-12-04 1998-06-11 Dibra S.P.A. A process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid derivatives
WO1998054124A1 (en) * 1997-05-30 1998-12-03 Bracco S.P.A. A process for the preparation of 5-[acetyl (2,3-dihydroxypropyl)amino]-n,n'-bis (2,3-dihydroxypropyl)-2,4,6- triiodo-1,3-benzenedicarboxamide
KR20000061780A (ko) * 1999-03-31 2000-10-25 강재헌 이오프로마이드의 제조방법
KR20090114729A (ko) * 2008-04-30 2009-11-04 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3429949A1 (de) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel
AU5093993A (en) * 1992-09-02 1994-03-29 Mallinckrodt Medical, Inc. Nonionic X-ray contrast agents compositions and methods
JP2011506286A (ja) * 2007-12-05 2011-03-03 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364921A (en) * 1979-03-08 1982-12-21 Schering, Aktiengesellschaft Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
WO1998024757A1 (en) * 1996-12-04 1998-06-11 Dibra S.P.A. A process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid derivatives
WO1998054124A1 (en) * 1997-05-30 1998-12-03 Bracco S.P.A. A process for the preparation of 5-[acetyl (2,3-dihydroxypropyl)amino]-n,n'-bis (2,3-dihydroxypropyl)-2,4,6- triiodo-1,3-benzenedicarboxamide
KR20000061780A (ko) * 1999-03-31 2000-10-25 강재헌 이오프로마이드의 제조방법
KR20090114729A (ko) * 2008-04-30 2009-11-04 주식회사 엘지생명과학 이오프로마이드의 신규한 제조방법

Also Published As

Publication number Publication date
CN105636933A (zh) 2016-06-01
PH12016500749B1 (en) 2016-06-13
KR101520187B1 (ko) 2015-05-13
EA201690757A1 (ru) 2016-10-31
SA516370977B1 (ar) 2017-08-21
WO2015060657A1 (en) 2015-04-30
CN105636933B (zh) 2017-12-15
KR20150047997A (ko) 2015-05-06
UA114158C2 (uk) 2017-04-25
PH12016500749A1 (en) 2016-06-13

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ RU