EA024794B1 - Вариант эндолизина со встроенным катионным пептидом с активностью, разрушающей липополисахарид - Google Patents
Вариант эндолизина со встроенным катионным пептидом с активностью, разрушающей липополисахарид Download PDFInfo
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- EA024794B1 EA024794B1 EA201100312A EA201100312A EA024794B1 EA 024794 B1 EA024794 B1 EA 024794B1 EA 201100312 A EA201100312 A EA 201100312A EA 201100312 A EA201100312 A EA 201100312A EA 024794 B1 EA024794 B1 EA 024794B1
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- endolysin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| EP3714895A3 (en) | 2009-06-26 | 2020-11-25 | Lysando AG | Antimicrobial agents |
| WO2010149795A1 (en) * | 2009-06-26 | 2010-12-29 | Lysando Holding Establishment | Antimicrobial agents |
| EA024253B1 (ru) * | 2009-08-24 | 2016-08-31 | Катхолике Университейт Лёвен, К.У. Лёвен Р Энд Д | Литический полипептид с пептидогликангидролазной активностью и его применение против инфекций, вызванных грамотрицательными бактериями |
| DK2563916T3 (en) * | 2010-04-27 | 2015-10-05 | Lysando Ag | METHOD FOR REDUCING biofilms |
| PT3443970T (pt) * | 2010-09-17 | 2020-10-09 | Technophage Investig E Desenvolvimento Em Biotecnologia Sa | Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos |
| GB201018518D0 (en) | 2010-11-03 | 2010-12-15 | Univ Leuven Kath | Novel endolysin |
| EP2468856A1 (en) * | 2010-12-23 | 2012-06-27 | Lysando Aktiengesellschaft | Antimicrobial Agents |
| CN108578685A (zh) * | 2011-04-21 | 2018-09-28 | 洛克菲勒大学 | 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素 |
| WO2012146738A1 (en) * | 2011-04-27 | 2012-11-01 | Lysando Holding Ag | New antimicrobial agents |
| US9068204B2 (en) | 2013-03-15 | 2015-06-30 | The United States Of America, As Represented By The Secretary Of Agriculture | Peptidoglycan hydrolase antimicrobials for eradicating lactobacilli that contaminate and reduce ethanol yields in biofuel fermentation |
| WO2015070912A1 (en) | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified el188 endolysin sequence |
| WO2015070911A1 (en) * | 2013-11-14 | 2015-05-21 | Lysando Ag | Modified kz144 endolysin sequence |
| EP3105322B1 (en) | 2014-02-14 | 2018-12-12 | Lysando AG | Antimicrobial agents |
| AU2015243359B2 (en) * | 2014-04-08 | 2020-03-12 | Lysando Ag | Pharmaceutical composition against chronic bacterial infections |
| GB2543453A (en) | 2014-06-26 | 2017-04-19 | Univ Rockefeller | Acinetobacter lysins |
| CN104762285B (zh) * | 2015-04-23 | 2017-10-27 | 武汉菲吉乐科生物科技有限公司 | 一种自内裂解大肠杆菌的裂解酶及其应用 |
| JP7033596B2 (ja) * | 2016-12-16 | 2022-03-10 | ウニベルシダージ ド ミーニョ | 新規エンドリシン |
| US11208643B2 (en) * | 2017-04-03 | 2021-12-28 | Sasinapas Co., Ltd. | Engineered gram-negative endolysins |
| BR112020011433A2 (pt) * | 2017-12-12 | 2020-12-01 | Contrafect Corporation | identificação de lisinas e seus derivados com atividade bacteriana contra pseudomonas aeruginosa |
| JP7515409B2 (ja) | 2018-05-30 | 2024-07-12 | ライサンド アーゲー | 新規抗微生物融合タンパク質 |
| AU2019276253A1 (en) | 2018-05-30 | 2020-11-26 | Lysando Ag | Novel antimicrobial proteins |
| AU2020268752B2 (en) * | 2019-05-08 | 2025-12-18 | BioNTech SE | Novel gardnerella endolysins and uses thereof |
| WO2023225518A2 (en) * | 2022-05-16 | 2023-11-23 | The Broad Institute, Inc. | Engineered pnma proteins and delivery systems thereof |
| CN117737001B (zh) * | 2022-12-27 | 2024-08-09 | 菲吉乐科(南京)生物科技有限公司 | 一种防治犬细菌性腹泻的大肠杆菌噬菌体及其应用 |
| CN118620800B (zh) * | 2024-08-08 | 2024-11-12 | 中国兽医药品监察所 | 一株鼻疽伯克霍尔德氏菌及其应用 |
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| DE3854476T2 (de) | 1987-07-06 | 1996-04-04 | Univ Louisiana State | Inhibierung von eukaryotischen pathogenen und neoplasmen mit lytischen peptiden. |
| EP0656952B1 (en) * | 1992-08-21 | 2003-03-05 | The University Of British Columbia | Cationic peptides and method for production |
| PT778733E (pt) | 1994-09-01 | 2001-06-29 | Novozymes As | Composicao proteica basica para matar ou inibir celulas microbianas |
| US6503881B2 (en) | 1996-08-21 | 2003-01-07 | Micrologix Biotech Inc. | Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics |
| US6288212B1 (en) | 1998-08-28 | 2001-09-11 | The University Of British Columbia | Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor |
| US5993809A (en) | 1998-11-18 | 1999-11-30 | Children's Hospital Medical Center | Lysozyme fusion proteins in infections |
| AU5553600A (en) | 1999-06-23 | 2001-01-31 | Ppl Therapeutics (Scotland) Ltd | Fusion proteins incorporating lysozyme |
| KR20050016362A (ko) | 2002-04-22 | 2005-02-21 | 다우 글로벌 테크놀로지스 인크. | 펩티드의 저비용 생산 |
| US7566447B2 (en) | 2003-05-15 | 2009-07-28 | Iogenetics, Llc | Biocides |
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| WO2005108563A2 (en) | 2004-04-19 | 2005-11-17 | University Of Chicago | Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4 |
| US7572602B1 (en) | 2004-12-03 | 2009-08-11 | The United States Of America As Represented By The Secretary Of Agriculture | Nucleic acid encoding endolysin fusion protein |
| DE102005040347A1 (de) | 2005-08-25 | 2007-03-01 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von Listerien |
| EP2004215B1 (en) | 2006-03-31 | 2010-06-09 | The University Court of the University of St. Andrews | Anti-microbial compositions comprising a cationic peptide and a glycylglycine endopeptidase |
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| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| WO2010091294A2 (en) | 2009-02-05 | 2010-08-12 | The Regents Of The University Of California | New targeted antimicrobial moieties |
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| DK2563916T3 (en) | 2010-04-27 | 2015-10-05 | Lysando Ag | METHOD FOR REDUCING biofilms |
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| US5985271A (en) * | 1997-10-31 | 1999-11-16 | New Horizons Diagnostics Corp. | Prophylactic and theraputic treatment of group A streptococcal infection |
| US20020127220A1 (en) * | 1997-10-31 | 2002-09-12 | Vincent Fiochetti | Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract- |
| DE102006061002A1 (de) * | 2006-12-22 | 2008-06-26 | Profos Ag | Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien |
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| CA2735077A1 (en) | 2010-03-04 |
| HK1157818A1 (en) | 2012-07-06 |
| ES2395357T3 (es) | 2013-02-12 |
| US20110243915A1 (en) | 2011-10-06 |
| AU2009286760B2 (en) | 2015-08-27 |
| CN102197132B (zh) | 2016-01-13 |
| CN102197132A (zh) | 2011-09-21 |
| JP2013081465A (ja) | 2013-05-09 |
| MX2011001957A (es) | 2011-06-20 |
| JP2012500642A (ja) | 2012-01-12 |
| BRPI0917508A2 (pt) | 2015-08-04 |
| JP5153943B2 (ja) | 2013-02-27 |
| DK2331687T3 (da) | 2013-01-07 |
| EP2331687A2 (en) | 2011-06-15 |
| KR20110049883A (ko) | 2011-05-12 |
| GB0815484D0 (en) | 2008-10-01 |
| JP5571757B2 (ja) | 2014-08-13 |
| PL2331687T3 (pl) | 2013-02-28 |
| US9809808B2 (en) | 2017-11-07 |
| WO2010023207A3 (en) | 2010-07-15 |
| AU2009286760A1 (en) | 2010-03-04 |
| WO2010023207A2 (en) | 2010-03-04 |
| EP2331687B1 (en) | 2012-09-19 |
| EA201100312A1 (ru) | 2011-10-31 |
| IL211441A (en) | 2015-04-30 |
| KR101473271B1 (ko) | 2014-12-16 |
| CA2735077C (en) | 2019-04-09 |
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