DK2331687T3 - Antimikrobielle midler - Google Patents

Antimikrobielle midler

Info

Publication number
DK2331687T3
DK2331687T3 DK09782176.3T DK09782176T DK2331687T3 DK 2331687 T3 DK2331687 T3 DK 2331687T3 DK 09782176 T DK09782176 T DK 09782176T DK 2331687 T3 DK2331687 T3 DK 2331687T3
Authority
DK
Denmark
Prior art keywords
antimicrobial agents
antimicrobial
agents
Prior art date
Application number
DK09782176.3T
Other languages
English (en)
Inventor
Yves Briers
Guido Volckaert
Rob Lavigne
Original Assignee
Univ Leuven Kath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leuven Kath filed Critical Univ Leuven Kath
Application granted granted Critical
Publication of DK2331687T3 publication Critical patent/DK2331687T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462Lysozyme (3.2.1.17)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02Local antiseptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
DK09782176.3T 2008-08-26 2009-08-25 Antimikrobielle midler DK2331687T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0815484.1A GB0815484D0 (en) 2008-08-26 2008-08-26 Antibacterial agents
PCT/EP2009/060947 WO2010023207A2 (en) 2008-08-26 2009-08-25 Antimicrobial agents

Publications (1)

Publication Number Publication Date
DK2331687T3 true DK2331687T3 (da) 2013-01-07

Family

ID=39846783

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09782176.3T DK2331687T3 (da) 2008-08-26 2009-08-25 Antimikrobielle midler

Country Status (17)

Country Link
US (1) US9809808B2 (da)
EP (1) EP2331687B1 (da)
JP (2) JP5153943B2 (da)
KR (1) KR101473271B1 (da)
CN (1) CN102197132B (da)
AU (1) AU2009286760B2 (da)
BR (1) BRPI0917508A2 (da)
CA (1) CA2735077C (da)
DK (1) DK2331687T3 (da)
EA (1) EA024794B1 (da)
ES (1) ES2395357T3 (da)
GB (1) GB0815484D0 (da)
HK (1) HK1157818A1 (da)
IL (1) IL211441A (da)
MX (1) MX2011001957A (da)
PL (1) PL2331687T3 (da)
WO (1) WO2010023207A2 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
KR20170024129A (ko) 2009-06-26 2017-03-06 카톨리에케 유니버시테이트 루벤 항균제
KR101701890B1 (ko) * 2009-06-26 2017-02-02 뤼산도 아게 항균제
MX2012002216A (es) 2009-08-24 2012-04-10 Univ Leuven Kath Nueva endolisina obpgplys.
MX340520B (es) * 2010-04-27 2016-07-12 Lysando Ag * Metodo de reduccion de biopeliculas.
JP6058540B2 (ja) 2010-09-17 2017-01-11 テクニファー−インダストリア テクニカ ファーマシューティカ,エス.エー. 抗菌性ファージ、ファージペプチド、及びそれらの使用方法
GB201018518D0 (en) 2010-11-03 2010-12-15 Univ Leuven Kath Novel endolysin
EP2468856A1 (en) * 2010-12-23 2012-06-27 Lysando Aktiengesellschaft Antimicrobial Agents
AU2012245357B2 (en) * 2011-04-21 2017-06-08 The Rockefeller University Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
EP2702070B1 (en) * 2011-04-27 2015-09-30 Lysando AG New antimicrobial agents
US9068204B2 (en) 2013-03-15 2015-06-30 The United States Of America, As Represented By The Secretary Of Agriculture Peptidoglycan hydrolase antimicrobials for eradicating lactobacilli that contaminate and reduce ethanol yields in biofuel fermentation
WO2015070912A1 (en) 2013-11-14 2015-05-21 Lysando Ag Modified el188 endolysin sequence
WO2015070911A1 (en) * 2013-11-14 2015-05-21 Lysando Ag Modified kz144 endolysin sequence
US10329550B2 (en) 2014-02-14 2019-06-25 Lysando Ag Antimicrobial agents
EA201692031A1 (ru) * 2014-04-08 2017-07-31 Лисандо Аг Фармацевтическая композиция с активным действием в отношении хронических бактериальных инфекций
BR112016030580B1 (pt) * 2014-06-26 2023-12-19 The Rockefeller University Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas
CN104762285B (zh) * 2015-04-23 2017-10-27 武汉菲吉乐科生物科技有限公司 一种自内裂解大肠杆菌的裂解酶及其应用
WO2018109229A1 (en) * 2016-12-16 2018-06-21 Universidade Do Minho Novel endolysin
WO2018185634A1 (en) * 2017-04-03 2018-10-11 Sasinapas Co., Ltd. Engineered gram-negative endolysins
AU2018384790A1 (en) * 2017-12-12 2020-07-30 Contrafect Corporation Identification of lysins and derivatives thereof with bacterial activity against pseudomonas aeruginosa
US20210198645A1 (en) 2018-05-30 2021-07-01 Lysando Ag Novel antimicrobial fusion proteins
AU2019276253A1 (en) 2018-05-30 2020-11-26 Lysando Ag Novel antimicrobial proteins
KR20220007123A (ko) * 2019-05-08 2022-01-18 파고메드 바이오파르마 게엠베하 신규 가드네렐라 엔도리신 및 이의 용도
WO2023225518A2 (en) * 2022-05-16 2023-11-23 The Broad Institute, Inc. Engineered pnma proteins and delivery systems thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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AU2132088A (en) 1987-07-06 1989-01-30 Louisiana State University Agricultural And Mechanical College Inhibition of eucaryotic pathogens and neoplasms and stimulation of fibroblasts and lymphocytes with lytic peptides
GB2255561B (en) * 1991-04-20 1995-06-21 Agricultural & Food Res Lysins from bacteriophages
DE69332740T2 (de) 1992-08-21 2004-02-05 The University Of British Columbia, Vancouver Kationische peptide und verfahren zu deren herstellung
PT778733E (pt) 1994-09-01 2001-06-29 Novozymes As Composicao proteica basica para matar ou inibir celulas microbianas
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US5997862A (en) * 1997-10-31 1999-12-07 New Horizons Diagnostics Corporation Therapeutic treatment of group A streptococcal infections
US6428784B1 (en) 1997-10-31 2002-08-06 New Horizons Diagnostics Corp Vaginal suppository for treating group B Streptococcus infection
US6288212B1 (en) 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
US5993809A (en) 1998-11-18 1999-11-30 Children's Hospital Medical Center Lysozyme fusion proteins in infections
WO2001000855A1 (en) 1999-06-23 2001-01-04 Ppl Therapeutics (Scotland) Ltd. Fusion proteins incorporating lysozyme
EP1501935B1 (en) 2002-04-22 2009-09-23 Dow Global Technologies Inc. Low-cost production of peptides
US7566447B2 (en) 2003-05-15 2009-07-28 Iogenetics, Llc Biocides
EP1680503B1 (en) 2003-09-11 2011-06-22 Novozymes Adenium Biotech A/S Recombinant production of antimicrobial agents
WO2005108563A2 (en) 2004-04-19 2005-11-17 University Of Chicago Peptidoglycan-hydrolyzing protein encoded by bacteriophage n4
US7572602B1 (en) 2004-12-03 2009-08-11 The United States Of America As Represented By The Secretary Of Agriculture Nucleic acid encoding endolysin fusion protein
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ES2346808T3 (es) 2006-03-31 2010-10-20 The University Court Of The University Of St. Andrews Composiciones antimicrobianas que comprenden un peptido cationico y una endopeptidasa de glicilglicina.
DE102006061002A1 (de) 2006-12-22 2008-06-26 Profos Ag Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien
US9296789B2 (en) 2007-09-25 2016-03-29 Pastoral Greenhouse Gas Research Ltd. Vaccines and vaccine components for inhibition of microbial cells
US20100310522A1 (en) 2007-11-26 2010-12-09 Plant Bioscience Limited Novel Polypeptides Having Endolysin Activity and Uses Thereof
US8481289B2 (en) 2008-07-24 2013-07-09 The United States Of America, As Represented By The Secretary Of Agriculture Triple acting antimicrobials that are refractory to resistance development
EP2157100A1 (en) 2008-08-19 2010-02-24 Profos AG Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
US8389679B2 (en) 2009-02-05 2013-03-05 The Regents Of The University Of California Targeted antimicrobial moieties
KR20170024129A (ko) 2009-06-26 2017-03-06 카톨리에케 유니버시테이트 루벤 항균제
MX2012002216A (es) 2009-08-24 2012-04-10 Univ Leuven Kath Nueva endolisina obpgplys.
MX340520B (es) 2010-04-27 2016-07-12 Lysando Ag * Metodo de reduccion de biopeliculas.

Also Published As

Publication number Publication date
CA2735077C (en) 2019-04-09
ES2395357T3 (es) 2013-02-12
EP2331687B1 (en) 2012-09-19
US9809808B2 (en) 2017-11-07
US20110243915A1 (en) 2011-10-06
IL211441A (en) 2015-04-30
EA201100312A1 (ru) 2011-10-31
BRPI0917508A2 (pt) 2015-08-04
AU2009286760A1 (en) 2010-03-04
WO2010023207A3 (en) 2010-07-15
WO2010023207A2 (en) 2010-03-04
EA024794B1 (ru) 2016-10-31
AU2009286760B2 (en) 2015-08-27
GB0815484D0 (en) 2008-10-01
CN102197132B (zh) 2016-01-13
JP2012500642A (ja) 2012-01-12
HK1157818A1 (en) 2012-07-06
JP5571757B2 (ja) 2014-08-13
JP2013081465A (ja) 2013-05-09
KR101473271B1 (ko) 2014-12-16
JP5153943B2 (ja) 2013-02-27
CA2735077A1 (en) 2010-03-04
EP2331687A2 (en) 2011-06-15
CN102197132A (zh) 2011-09-21
KR20110049883A (ko) 2011-05-12
PL2331687T3 (pl) 2013-02-28
MX2011001957A (es) 2011-06-20

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