EA023861B3 - Производные пирролидин карбоновой кислоты как агонисты сопряженного с g-белком рецептора 43 (gpr43), фармацевтическая композиция и методы их использования при лечении метаболических нарушений - Google Patents

Производные пирролидин карбоновой кислоты как агонисты сопряженного с g-белком рецептора 43 (gpr43), фармацевтическая композиция и методы их использования при лечении метаболических нарушений

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Publication number
EA023861B3
EA023861B3 EA201200918A EA201200918A EA023861B3 EA 023861 B3 EA023861 B3 EA 023861B3 EA 201200918 A EA201200918 A EA 201200918A EA 201200918 A EA201200918 A EA 201200918A EA 023861 B3 EA023861 B3 EA 023861B3
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EA
Eurasian Patent Office
Prior art keywords
gpr43
agonists
methods
carboxylic acid
pharmaceutical composition
Prior art date
Application number
EA201200918A
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English (en)
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EA023861B1 (ru
EA201200918A1 (ru
Inventor
Хамид Ховейда
Дидье Шилс
Людивин Зут
Жюльен Парк
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Эроскрин С.А.
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Application filed by Эроскрин С.А. filed Critical Эроскрин С.А.
Publication of EA201200918A1 publication Critical patent/EA201200918A1/ru
Publication of EA023861B1 publication Critical patent/EA023861B1/ru
Publication of EA023861B3 publication Critical patent/EA023861B3/ru

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Данное изобретение касается новых соединений формулы I, а также их использования в лечении и/или предотвращении метаболических заболеваний.
EA201200918A 2009-12-18 2010-12-17 Производные пирролидин карбоновой кислоты как агонисты сопряженного с g-белком рецептора 43 (gpr43), фармацевтическая композиция и методы их использования при лечении метаболических нарушений EA023861B3 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09306270 2009-12-18
US37337010P 2010-08-13 2010-08-13
US37601310P 2010-08-23 2010-08-23
PCT/EP2010/070040 WO2011073376A1 (en) 2009-12-18 2010-12-17 Pyrrolidine or thiazolidine carboxylic acid derivatives, pharmaceutical composition and methods for use in treating metabolic disordersas as agonists of g- protein coupled receptor 43 (gpr43)

Publications (3)

Publication Number Publication Date
EA201200918A1 EA201200918A1 (ru) 2012-12-28
EA023861B1 EA023861B1 (ru) 2016-07-29
EA023861B3 true EA023861B3 (ru) 2016-09-30

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EA201200918A EA023861B3 (ru) 2009-12-18 2010-12-17 Производные пирролидин карбоновой кислоты как агонисты сопряженного с g-белком рецептора 43 (gpr43), фармацевтическая композиция и методы их использования при лечении метаболических нарушений

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US (6) US9695120B2 (ru)
EP (2) EP2513053B1 (ru)
JP (1) JP6144913B2 (ru)
KR (1) KR101827529B1 (ru)
CN (1) CN102812003B (ru)
AU (1) AU2010332765C1 (ru)
BR (1) BR112012018374B1 (ru)
CA (1) CA2784528C (ru)
CY (1) CY1119730T1 (ru)
DK (1) DK2513053T3 (ru)
EA (1) EA023861B3 (ru)
ES (1) ES2655091T3 (ru)
HR (1) HRP20171991T1 (ru)
HU (1) HUE038064T2 (ru)
LT (1) LT2513053T (ru)
MX (1) MX339252B (ru)
NO (1) NO2513053T3 (ru)
PL (1) PL2513053T3 (ru)
PT (1) PT2513053T (ru)
RS (1) RS56751B1 (ru)
SI (1) SI2513053T1 (ru)
WO (1) WO2011073376A1 (ru)

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KR101656662B1 (ko) 2014-11-18 2016-09-12 한국생명공학연구원 2-옥소-1,2,3,4-테트라하이드로피리미딘-5-카르복사미드 유도체를 유효성분으로 함유하는 대사성 질환 예방 또는 치료용 약학적 조성물
CN107033015B (zh) * 2017-06-02 2019-04-30 南京欧信医药技术有限公司 一种药物中间体的合成方法
PL3752501T3 (pl) 2018-02-13 2023-08-21 Gilead Sciences, Inc. Inhibitory pd-1/pd-l1
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
KR20230159715A (ko) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
KR102635333B1 (ko) 2018-10-24 2024-02-15 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
SG11202110742TA (en) 2019-04-02 2021-10-28 Aligos Therapeutics Inc Compounds targeting prmt5
WO2021018786A1 (en) 2019-07-26 2021-02-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of ffar2 agonists for the treatment of bacterial superinfections post-viral infection
CN110981779B (zh) * 2019-11-23 2021-02-26 武汉理工大学 R-2-(2,5-二氟苯基)吡咯烷的合成方法
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US12054457B2 (en) 2022-10-11 2024-08-06 Epics Therapeutics Polymorphs of (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid and preparation processes thereof

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