HUE038064T2 - Pirrolidin karboxilsav származékok, mint G-protein kapcsolat receptor 43 (GPR43) agonistái, gyógyszerészeti készítmény és felhasználási eljárások metabolikus rendellenességek kezelésében - Google Patents
Pirrolidin karboxilsav származékok, mint G-protein kapcsolat receptor 43 (GPR43) agonistái, gyógyszerészeti készítmény és felhasználási eljárások metabolikus rendellenességek kezelésébenInfo
- Publication number
- HUE038064T2 HUE038064T2 HUE10792934A HUE10792934A HUE038064T2 HU E038064 T2 HUE038064 T2 HU E038064T2 HU E10792934 A HUE10792934 A HU E10792934A HU E10792934 A HUE10792934 A HU E10792934A HU E038064 T2 HUE038064 T2 HU E038064T2
- Authority
- HU
- Hungary
- Prior art keywords
- gpr43
- agonists
- methods
- carboxylic acid
- pharmaceutical composition
- Prior art date
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP09306270 | 2009-12-18 | ||
US37337010P | 2010-08-13 | 2010-08-13 | |
US37601310P | 2010-08-23 | 2010-08-23 |
Publications (1)
Publication Number | Publication Date |
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HUE038064T2 true HUE038064T2 (hu) | 2018-10-29 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HUE10792934A HUE038064T2 (hu) | 2009-12-18 | 2010-12-17 | Pirrolidin karboxilsav származékok, mint G-protein kapcsolat receptor 43 (GPR43) agonistái, gyógyszerészeti készítmény és felhasználási eljárások metabolikus rendellenességek kezelésében |
Country Status (22)
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US (6) | US9695120B2 (hu) |
EP (2) | EP2513053B1 (hu) |
JP (1) | JP6144913B2 (hu) |
KR (1) | KR101827529B1 (hu) |
CN (1) | CN102812003B (hu) |
AU (1) | AU2010332765C1 (hu) |
BR (1) | BR112012018374B1 (hu) |
CA (1) | CA2784528C (hu) |
CY (1) | CY1119730T1 (hu) |
DK (1) | DK2513053T3 (hu) |
EA (1) | EA023861B3 (hu) |
ES (1) | ES2655091T3 (hu) |
HR (1) | HRP20171991T1 (hu) |
HU (1) | HUE038064T2 (hu) |
LT (1) | LT2513053T (hu) |
MX (1) | MX339252B (hu) |
NO (1) | NO2513053T3 (hu) |
PL (1) | PL2513053T3 (hu) |
PT (1) | PT2513053T (hu) |
RS (1) | RS56751B1 (hu) |
SI (1) | SI2513053T1 (hu) |
WO (1) | WO2011073376A1 (hu) |
Families Citing this family (18)
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ES2655091T3 (es) * | 2009-12-18 | 2018-02-16 | Ogeda Sa | Derivados del ácido pirrolidíncarboxílico como agonistas del receptor 43 acoplado a proteína G (GPR43), composición farmacéutica y métodos para su uso en el tratamiento de trastornos metabólicos |
AU2013202982C1 (en) * | 2012-01-06 | 2017-01-05 | Novartis Ag | Heterocyclic compounds and methods for their use |
AU2013290100A1 (en) | 2012-07-11 | 2015-01-29 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
CA2929436C (en) * | 2013-11-27 | 2021-06-15 | Euroscreen Sa | Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases |
CN107108581B (zh) * | 2014-08-21 | 2020-06-23 | 百时美施贵宝公司 | 作为强效rock抑制剂的回接苯甲酰胺衍生物 |
KR101656662B1 (ko) | 2014-11-18 | 2016-09-12 | 한국생명공학연구원 | 2-옥소-1,2,3,4-테트라하이드로피리미딘-5-카르복사미드 유도체를 유효성분으로 함유하는 대사성 질환 예방 또는 치료용 약학적 조성물 |
CN107033015B (zh) * | 2017-06-02 | 2019-04-30 | 南京欧信医药技术有限公司 | 一种药物中间体的合成方法 |
PL3752501T3 (pl) | 2018-02-13 | 2023-08-21 | Gilead Sciences, Inc. | Inhibitory pd-1/pd-l1 |
JP7242702B2 (ja) | 2018-04-19 | 2023-03-20 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
SG11202110742TA (en) | 2019-04-02 | 2021-10-28 | Aligos Therapeutics Inc | Compounds targeting prmt5 |
WO2021018786A1 (en) | 2019-07-26 | 2021-02-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of ffar2 agonists for the treatment of bacterial superinfections post-viral infection |
CN110981779B (zh) * | 2019-11-23 | 2021-02-26 | 武汉理工大学 | R-2-(2,5-二氟苯基)吡咯烷的合成方法 |
EP4165021A1 (en) | 2020-06-10 | 2023-04-19 | Epics Therapeutics | Synthesis of (2s,5r)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid |
US12054457B2 (en) | 2022-10-11 | 2024-08-06 | Epics Therapeutics | Polymorphs of (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid and preparation processes thereof |
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