EA023781B1 - Гликозидные производные и их применение - Google Patents

Гликозидные производные и их применение Download PDF

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Publication number
EA023781B1
EA023781B1 EA201200600A EA201200600A EA023781B1 EA 023781 B1 EA023781 B1 EA 023781B1 EA 201200600 A EA201200600 A EA 201200600A EA 201200600 A EA201200600 A EA 201200600A EA 023781 B1 EA023781 B1 EA 023781B1
Authority
EA
Eurasian Patent Office
Prior art keywords
ylmethyl
triol
hydroxymethyltetrahydropyran
phenyl
chloro
Prior art date
Application number
EA201200600A
Other languages
English (en)
Russian (ru)
Other versions
EA201200600A1 (ru
Inventor
Грегори Раймонд Бебернитц
Марк Г. Бок
Думбала Сринивас Редди
Атул Кашинат Хаджаре
Винод Вявахаре
Сандип Бхаусахеб Бхосейл
Суреш Экнат Курхаде
Видеш Салункхе
Надим С. Шаикх
Дебнат Бхуния
П. Венката Палле
Лили Фэн
Джессика Лян
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201200600A1 publication Critical patent/EA201200600A1/ru
Publication of EA023781B1 publication Critical patent/EA023781B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
EA201200600A 2009-10-20 2010-10-19 Гликозидные производные и их применение EA023781B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2173DE2009 2009-10-20
IN2689DE2009 2009-12-23
PCT/EP2010/065747 WO2011048112A1 (en) 2009-10-20 2010-10-19 Glycoside derivatives and uses thereof

Publications (2)

Publication Number Publication Date
EA201200600A1 EA201200600A1 (ru) 2012-12-28
EA023781B1 true EA023781B1 (ru) 2016-07-29

Family

ID=43216622

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200600A EA023781B1 (ru) 2009-10-20 2010-10-19 Гликозидные производные и их применение

Country Status (39)

Country Link
US (7) US8163704B2 (enExample)
EP (1) EP2491029B1 (enExample)
JP (2) JP5384744B2 (enExample)
KR (2) KR101465308B1 (enExample)
CN (1) CN102656165B (enExample)
AR (1) AR078685A1 (enExample)
AU (1) AU2010309833B2 (enExample)
BR (1) BR112012009053B1 (enExample)
CA (1) CA2777812C (enExample)
CL (1) CL2012000991A1 (enExample)
CO (1) CO6531486A2 (enExample)
CR (1) CR20120176A (enExample)
CU (1) CU24079B1 (enExample)
CY (1) CY1117409T1 (enExample)
DK (1) DK2491029T3 (enExample)
EA (1) EA023781B1 (enExample)
EC (1) ECSP12011909A (enExample)
ES (1) ES2564191T3 (enExample)
GT (1) GT201200117A (enExample)
HN (1) HN2012000798A (enExample)
HR (1) HRP20160436T1 (enExample)
HU (1) HUE027531T2 (enExample)
IL (1) IL219309A (enExample)
JO (1) JO3152B1 (enExample)
MA (1) MA33737B1 (enExample)
MX (1) MX2012004700A (enExample)
MY (1) MY158326A (enExample)
NZ (1) NZ598717A (enExample)
PE (1) PE20121281A1 (enExample)
PH (1) PH12012500518A1 (enExample)
PL (1) PL2491029T3 (enExample)
RS (1) RS54563B1 (enExample)
SG (1) SG179562A1 (enExample)
SI (1) SI2491029T1 (enExample)
TN (1) TN2012000109A1 (enExample)
TW (2) TWI558723B (enExample)
UY (1) UY32958A (enExample)
WO (1) WO2011048112A1 (enExample)
ZA (1) ZA201201680B (enExample)

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US8163704B2 (en) * 2009-10-20 2012-04-24 Novartis Ag Glycoside derivatives and uses thereof
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US8614195B2 (en) * 2011-04-14 2013-12-24 Novartis Ag Glycoside derivatives and uses thereof
JP2014510782A (ja) 2011-04-14 2014-05-01 ノバルティス アーゲー グリコシド誘導体およびその使用
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ES2719656T3 (es) * 2011-06-01 2019-07-11 Green Cross Corp Derivados de difenilmetano novedosos como inhibidores del SGLT2
CN102827122B (zh) * 2011-06-17 2015-01-14 山东轩竹医药科技有限公司 糖苷衍生物
CN102863417B (zh) * 2011-07-09 2015-01-14 山东轩竹医药科技有限公司 C-糖苷衍生物
WO2013010679A1 (en) 2011-07-15 2013-01-24 Novartis Ag Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors
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CN104031098A (zh) * 2014-06-21 2014-09-10 李友香 降糖药物
CN105294624B (zh) * 2015-11-16 2018-01-12 山东罗欣药业集团股份有限公司 一种达格列净的制备方法
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CN108203432B (zh) * 2016-12-20 2021-03-02 宜昌东阳光长江药业股份有限公司 吡喃葡萄糖基衍生物及其在医药上的应用
AR111161A1 (es) 2017-03-03 2019-06-12 Novartis Ag Régimen de dosificación para el inhibidor sglt1/2 (licogliflozin)
JP2019517459A (ja) * 2017-04-12 2019-06-24 ノバルティス アーゲー 心不全患者におけるｌｉｋ０６６の使用
JP2020524684A (ja) * 2017-06-21 2020-08-20 ノバルティス アーゲー 非アルコール性脂肪性肝炎の治療のためのリコフリゴジン
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GB201721960D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
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GB201721964D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
GB201721957D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
GB201721967D0 (en) 2017-12-27 2018-02-07 Bp Oil Int Methods for preparing fuel additives
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CN108863736A (zh) * 2018-07-27 2018-11-23 福州大学 一种羰基功能化的芳香羧酸的制备方法
WO2020039394A1 (en) 2018-08-24 2020-02-27 Novartis Ag New drug combinations
WO2020151623A1 (zh) * 2019-01-24 2020-07-30 北京盈科瑞创新药物研究有限公司 化合物、其制备方法及其作为药物中间体的应用
WO2020151620A1 (zh) * 2019-01-24 2020-07-30 北京盈科瑞创新药物研究有限公司 化合物、其制备方法及其作为药物中间体的应用
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
JP2022541503A (ja) 2019-07-23 2022-09-26 ノバルティス アーゲー Ｆｘｒアゴニストを使用した肝疾患の組み合わせ処置
CN111099975A (zh) * 2019-12-23 2020-05-05 河北合佳医药科技集团股份有限公司 一种5-溴-2-氯-4’-乙氧基二苯甲酮的制备方法
JP2023551441A (ja) * 2020-11-19 2023-12-08 ベイジン・インクリーズ・イノベーティブ・ドラッグ・カンパニー，リミテッド グリコシド系誘導体及びその製造方法と応用
KR20220080880A (ko) * 2020-12-08 2022-06-15 주식회사 종근당 엠파글리플로진 공결정을 함유하는 약제학적 조성물
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3

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