EA021284B1 - Антитела и их производные - Google Patents
Антитела и их производные Download PDFInfo
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- EA021284B1 EA021284B1 EA201070888A EA201070888A EA021284B1 EA 021284 B1 EA021284 B1 EA 021284B1 EA 201070888 A EA201070888 A EA 201070888A EA 201070888 A EA201070888 A EA 201070888A EA 021284 B1 EA021284 B1 EA 021284B1
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- antibody
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- pain
- antibodies
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| IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| EA021284B1 (ru) | 2008-02-04 | 2015-05-29 | Лей Лайн Дженомикс С.П.А. | Антитела и их производные |
| WO2010029497A1 (en) * | 2008-09-12 | 2010-03-18 | Pfizer Limited | Treatment of endometriosis |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| NZ611076A (en) | 2010-12-01 | 2015-09-25 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
| EA201492163A1 (ru) * | 2012-06-08 | 2015-08-31 | Гленмарк Фармасьютикалс С.А. | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА К TrkA, СОДЕРЖАЩИЕ АМИНОКИСЛОТНЫЕ ЗАМЕНЫ |
| US20150183885A1 (en) * | 2012-06-08 | 2015-07-02 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
| EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
| MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
| US10793634B2 (en) | 2017-06-09 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Anti-TrkB antibodies |
| AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
| CN109628425A (zh) * | 2019-01-02 | 2019-04-16 | 周越 | 一种人原肌球蛋白受体激酶a突变体及应用 |
| AU2020281378B2 (en) * | 2019-05-30 | 2025-09-11 | Sunshine Lake Pharma Co., Ltd. | Anti-TrkA antibodies and uses thereof |
| US20220411527A1 (en) * | 2019-11-06 | 2022-12-29 | The Regents Of The University Of California | Compositions and methods for transferrin receptor 1 targeting |
| CN114516917B (zh) * | 2020-11-20 | 2022-11-18 | 广东东阳光药业有限公司 | 人源化抗TrkA的抗体及其应用 |
| CN117264068A (zh) | 2021-02-28 | 2023-12-22 | 熙源安健医药（上海）有限公司 | 抗TrkA抗体或其抗原结合片段、其制备方法和应用 |
| EP4457246A4 (en) | 2021-12-28 | 2025-11-19 | 4B Tech Suzhou Limited | TRKA ANTIBODIES AND THEIR APPLICATION |
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| WO2000073344A2 (en) * | 1999-05-26 | 2000-12-07 | Lay Line Genomics Spa | Monoclonal antibodies, synthetic and biotechnological derivatives thereof acting as ngf-antagonist molecules |
| WO2005061540A2 (en) * | 2003-12-24 | 2005-07-07 | Lay Line Genomics S.P.A. | Method for the humanization of antibodies and humanized antibodies thereby obtained |
| WO2006131951A2 (en) * | 2005-06-07 | 2006-12-14 | Pangenetics B.V. | MOLECULES THAT ARE ABLE TO INHIBIT THE BINDING BETWEEN NGF AND THE TrkA RECEPTOR AS ANALGESICS WITH PROLONGED EFFECT |
| WO2006137106A2 (en) * | 2005-06-24 | 2006-12-28 | Lay Line Genomics S.P.A | Method for the potentiation of opioid analgesics effects on pain |
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| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| WO1998045435A2 (en) | 1997-04-10 | 1998-10-15 | Genetics Institute, Inc. | SECRETED EXPRESSED SEQUENCE TAGS (sESTs) |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| GB2340334B (en) * | 1998-07-29 | 2003-06-25 | Ericsson Telefon Ab L M | Telephone apparatus |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| PT1556083E (pt) | 2002-10-08 | 2011-03-17 | Rinat Neuroscience Corp | Métodos para tratar a dor pós-cirúrgica pela administração de um anticorpo contra o factor de crescimento nervoso e composições que contêm o mesmo |
| US7255860B2 (en) | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| PT2206728T (pt) | 2004-04-07 | 2018-04-17 | Rinat Neuroscience Corp | Métodos de tratamento da dor associada ao cancro ósseo através da administração de um anticorpo antagonista do fator de crescimento nervoso |
| EA021284B1 (ru) | 2008-02-04 | 2015-05-29 | Лей Лайн Дженомикс С.П.А. | Антитела и их производные |
| WO2009155932A2 (en) | 2008-06-25 | 2009-12-30 | H. Lundbeck A/S | Modulation of the trpv : vps10p-domain receptor system for the treatment of pain |
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| WO2000073344A2 (en) * | 1999-05-26 | 2000-12-07 | Lay Line Genomics Spa | Monoclonal antibodies, synthetic and biotechnological derivatives thereof acting as ngf-antagonist molecules |
| WO2005061540A2 (en) * | 2003-12-24 | 2005-07-07 | Lay Line Genomics S.P.A. | Method for the humanization of antibodies and humanized antibodies thereby obtained |
| WO2006131951A2 (en) * | 2005-06-07 | 2006-12-14 | Pangenetics B.V. | MOLECULES THAT ARE ABLE TO INHIBIT THE BINDING BETWEEN NGF AND THE TrkA RECEPTOR AS ANALGESICS WITH PROLONGED EFFECT |
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| UGOLINI GABRIELE ET AL.: "The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain". PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 20 FEB 2007, vol. 104, no. 8, 20 February 2007 (2007-02-20), pages 2985-2990, XP002523974, ISSN: 0027-8424, page 2986, right-hand column - page 2989, right-hand column, paragraph 3 * |
Also Published As
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| PT2252633E (pt) | 2013-11-19 |
| WO2009098238A1 (en) | 2009-08-13 |
| CN101939337A (zh) | 2011-01-05 |
| AP2929A (en) | 2014-06-30 |
| JP2011514314A (ja) | 2011-05-06 |
| BRPI0905955A2 (pt) | 2015-08-04 |
| ZA201006218B (en) | 2011-08-31 |
| PL2252633T3 (pl) | 2014-02-28 |
| AU2009211340A1 (en) | 2009-08-13 |
| KR20100114536A (ko) | 2010-10-25 |
| CA2713786A1 (en) | 2009-08-13 |
| CN101939337B (zh) | 2016-03-09 |
| AU2009211340B2 (en) | 2013-09-12 |
| IL207390A (en) | 2015-06-30 |
| ES2435917T9 (es) | 2014-04-02 |
| AP2010005379A0 (en) | 2010-08-31 |
| NZ587701A (en) | 2013-03-28 |
| US9751947B2 (en) | 2017-09-05 |
| IL207390A0 (en) | 2010-12-30 |
| HK1150314A1 (en) | 2011-11-25 |
| EP2252633B1 (en) | 2013-08-14 |
| EA201070888A1 (ru) | 2011-04-29 |
| EP2252633B9 (en) | 2014-02-19 |
| MY191348A (en) | 2022-06-17 |
| US20110145941A1 (en) | 2011-06-16 |
| BRPI0905955A8 (pt) | 2018-05-08 |
| EP2252633A1 (en) | 2010-11-24 |
| JP5719596B2 (ja) | 2015-05-20 |
| ES2435917T3 (es) | 2013-12-26 |
| DK2252633T3 (da) | 2013-11-11 |
| KR101782857B1 (ko) | 2017-09-28 |
| MX2010008571A (es) | 2010-12-02 |
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