CA2713786A1 - Anti-trka antibodies and antigen-binding derivatives thereof - Google Patents
Anti-trka antibodies and antigen-binding derivatives thereof Download PDFInfo
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- CA2713786A1 CA2713786A1 CA2713786A CA2713786A CA2713786A1 CA 2713786 A1 CA2713786 A1 CA 2713786A1 CA 2713786 A CA2713786 A CA 2713786A CA 2713786 A CA2713786 A CA 2713786A CA 2713786 A1 CA2713786 A1 CA 2713786A1
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
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Applications Claiming Priority (3)
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| US61/025,995 | 2008-02-04 | ||
| PCT/EP2009/051285 WO2009098238A1 (en) | 2008-02-04 | 2009-02-04 | Anti-trka antibodies and derivatives thereof |
Publications (1)
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| CA2713786A1 true CA2713786A1 (en) | 2009-08-13 |
Family
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Family Applications (1)
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| CA2713786A Abandoned CA2713786A1 (en) | 2008-02-04 | 2009-02-04 | Anti-trka antibodies and antigen-binding derivatives thereof |
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| PT (1) | PT2252633E (enExample) |
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Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| PL2252633T3 (pl) | 2008-02-04 | 2014-02-28 | Lay Line Genomics Spa | Przeciwciała anty-TrkA i ich pochodne |
| WO2010029497A1 (en) * | 2008-09-12 | 2010-03-18 | Pfizer Limited | Treatment of endometriosis |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| MX359070B (es) | 2010-12-01 | 2018-09-13 | Alderbio Holdings Llc | Composiciones anti-ngf y uso de las mismas. |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US20130344064A1 (en) * | 2012-06-08 | 2013-12-26 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
| US20150183885A1 (en) * | 2012-06-08 | 2015-07-02 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
| EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
| MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
| US10793634B2 (en) | 2017-06-09 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Anti-TrkB antibodies |
| AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
| CN109628425A (zh) * | 2019-01-02 | 2019-04-16 | 周越 | 一种人原肌球蛋白受体激酶a突变体及应用 |
| CN114230663B (zh) * | 2019-05-30 | 2022-09-27 | 广东东阳光药业有限公司 | TrkA的抗体及其应用 |
| US20220411527A1 (en) * | 2019-11-06 | 2022-12-29 | The Regents Of The University Of California | Compositions and methods for transferrin receptor 1 targeting |
| AU2021382828A1 (en) * | 2020-11-20 | 2022-10-06 | Sunshine Lake Pharma Co., Ltd. | Humanized anti-TrkA antibodies and uses thereof |
| CN112961244B (zh) | 2021-02-28 | 2023-08-29 | 熙源安健医药（上海）有限公司 | 抗TrkA抗体或其抗原结合片段、其制备方法和应用 |
| KR20240126872A (ko) * | 2021-12-28 | 2024-08-21 | 4비 테크놀로지스 (수저우) 리미티드 | TrkA 항체 및 이의 응용 |
Family Cites Families (18)
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| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| AU6956698A (en) | 1997-04-10 | 1998-10-30 | Genetics Institute Inc. | Secreted expressed sequence tags (sests) |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| GB2340334B (en) * | 1998-07-29 | 2003-06-25 | Ericsson Telefon Ab L M | Telephone apparatus |
| IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| ES2357948T3 (es) | 2002-10-08 | 2011-05-04 | Rinat Neuroscience Corp. | Procedimientos para tratar dolor postquirúrgico mediante la administración de un anticuerpo frente al factor de crecimiento nervioso y composiciones que contienen el mismo. |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| AU2003304238A1 (en) | 2002-10-08 | 2005-01-13 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| JP5301152B2 (ja) | 2004-04-07 | 2013-09-25 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって骨癌の疼痛を処置するための方法 |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) * | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| PL2252633T3 (pl) | 2008-02-04 | 2014-02-28 | Lay Line Genomics Spa | Przeciwciała anty-TrkA i ich pochodne |
| EP2307042B1 (en) | 2008-06-25 | 2014-03-26 | H. Lundbeck A/S | Modulation of the trpv : vps10p-domain receptor system for the treatment of pain |
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| US9751947B2 (en) | 2017-09-05 |
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| AP2010005379A0 (en) | 2010-08-31 |
| DK2252633T3 (da) | 2013-11-11 |
| PT2252633E (pt) | 2013-11-19 |
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| IL207390A0 (en) | 2010-12-30 |
| CN101939337B (zh) | 2016-03-09 |
| EP2252633B1 (en) | 2013-08-14 |
| BRPI0905955A2 (pt) | 2015-08-04 |
| ES2435917T3 (es) | 2013-12-26 |
| AU2009211340B2 (en) | 2013-09-12 |
| ES2435917T9 (es) | 2014-04-02 |
| ZA201006218B (en) | 2011-08-31 |
| EP2252633A1 (en) | 2010-11-24 |
| AU2009211340A1 (en) | 2009-08-13 |
| BRPI0905955A8 (pt) | 2018-05-08 |
| KR20100114536A (ko) | 2010-10-25 |
| NZ587701A (en) | 2013-03-28 |
| US20110145941A1 (en) | 2011-06-16 |
| EA021284B1 (ru) | 2015-05-29 |
| WO2009098238A1 (en) | 2009-08-13 |
| MX2010008571A (es) | 2010-12-02 |
| PL2252633T3 (pl) | 2014-02-28 |
| JP2011514314A (ja) | 2011-05-06 |
| EP2252633B9 (en) | 2014-02-19 |
| KR101782857B1 (ko) | 2017-09-28 |
| IL207390A (en) | 2015-06-30 |
| CN101939337A (zh) | 2011-01-05 |
| EA201070888A1 (ru) | 2011-04-29 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20140117 |
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| FZDE | Discontinued |
Effective date: 20171116 |