EA020467B1 - Соединения, обладающие противовоспалительной активностью, и фармацевтическая композиция на их основе - Google Patents

Соединения, обладающие противовоспалительной активностью, и фармацевтическая композиция на их основе Download PDF

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Publication number
EA020467B1
EA020467B1 EA201001556A EA201001556A EA020467B1 EA 020467 B1 EA020467 B1 EA 020467B1 EA 201001556 A EA201001556 A EA 201001556A EA 201001556 A EA201001556 A EA 201001556A EA 020467 B1 EA020467 B1 EA 020467B1
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Eurasian Patent Office
Prior art keywords
compound
group
mmol
disease
inflammatory
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EA201001556A
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English (en)
Russian (ru)
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EA201001556A1 (ru
Inventor
Эрик Андерсон
Гэри Л. Бэултэн
Дебэрэ А. Фергусон
Зин Джайэнг
Роберт М. мл. Крэл
Патрик М. Обрайэн
Мелеэн Висник
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Ритэ Фамэсутикл, Инк.
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Publication of EA201001556A1 publication Critical patent/EA201001556A1/ru
Publication of EA020467B1 publication Critical patent/EA020467B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
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    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
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    • C07J53/001—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class spiro-linked
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
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    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
EA201001556A 2008-04-18 2009-04-20 Соединения, обладающие противовоспалительной активностью, и фармацевтическая композиция на их основе EA020467B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4636308P 2008-04-18 2008-04-18
PCT/US2009/041177 WO2009146218A2 (en) 2008-04-18 2009-04-20 Compounds including an anti-inflammatory pharmacore and methods of use

Publications (2)

Publication Number Publication Date
EA201001556A1 EA201001556A1 (ru) 2011-06-30
EA020467B1 true EA020467B1 (ru) 2014-11-28

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EA201001556A EA020467B1 (ru) 2008-04-18 2009-04-20 Соединения, обладающие противовоспалительной активностью, и фармацевтическая композиция на их основе

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US (4) US8258329B2 (cg-RX-API-DMAC10.html)
EP (1) EP2279196B1 (cg-RX-API-DMAC10.html)
JP (1) JP5564490B2 (cg-RX-API-DMAC10.html)
KR (1) KR101665042B1 (cg-RX-API-DMAC10.html)
CN (2) CN102066397B (cg-RX-API-DMAC10.html)
AU (1) AU2009251437B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0911105B1 (cg-RX-API-DMAC10.html)
CA (1) CA2721665C (cg-RX-API-DMAC10.html)
CO (1) CO6311105A2 (cg-RX-API-DMAC10.html)
EA (1) EA020467B1 (cg-RX-API-DMAC10.html)
IL (1) IL208760A0 (cg-RX-API-DMAC10.html)
MX (2) MX2010011435A (cg-RX-API-DMAC10.html)
NZ (1) NZ588708A (cg-RX-API-DMAC10.html)
SG (1) SG190564A1 (cg-RX-API-DMAC10.html)
TW (1) TW201006474A (cg-RX-API-DMAC10.html)
WO (1) WO2009146218A2 (cg-RX-API-DMAC10.html)

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