EA019354B1 - Применение димирацетама для лечения хронической боли - Google Patents

Применение димирацетама для лечения хронической боли Download PDF

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Publication number
EA019354B1
EA019354B1 EA200901237A EA200901237A EA019354B1 EA 019354 B1 EA019354 B1 EA 019354B1 EA 200901237 A EA200901237 A EA 200901237A EA 200901237 A EA200901237 A EA 200901237A EA 019354 B1 EA019354 B1 EA 019354B1
Authority
EA
Eurasian Patent Office
Prior art keywords
dimiracetam
pain
treatment
rats
administration
Prior art date
Application number
EA200901237A
Other languages
English (en)
Russian (ru)
Other versions
EA200901237A1 (ru
Inventor
Карло Фарина
Карла Гелардини
Паола Петрилло
Original Assignee
Нойротуне Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нойротуне Аг filed Critical Нойротуне Аг
Publication of EA200901237A1 publication Critical patent/EA200901237A1/ru
Publication of EA019354B1 publication Critical patent/EA019354B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA200901237A 2007-04-16 2008-04-15 Применение димирацетама для лечения хронической боли EA019354B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000770A ITMI20070770A1 (it) 2007-04-16 2007-04-16 Impiego di dimiracetam nel trattamento del dolore cronico
PCT/EP2008/054553 WO2008125674A1 (en) 2007-04-16 2008-04-15 Use of dimiracetam in the treatment of chronic pain

Publications (2)

Publication Number Publication Date
EA200901237A1 EA200901237A1 (ru) 2010-04-30
EA019354B1 true EA019354B1 (ru) 2014-03-31

Family

ID=39628738

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200901237A EA019354B1 (ru) 2007-04-16 2008-04-15 Применение димирацетама для лечения хронической боли
EA201300826A EA022867B1 (ru) 2007-04-16 2008-04-15 Применение димирацетама для лечения остеоартрита и связанных с ним заболеваний

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201300826A EA022867B1 (ru) 2007-04-16 2008-04-15 Применение димирацетама для лечения остеоартрита и связанных с ним заболеваний

Country Status (15)

Country Link
US (2) US7989421B2 (enExample)
EP (3) EP2146706B1 (enExample)
JP (1) JP5409602B2 (enExample)
CN (2) CN103284997B (enExample)
AU (1) AU2008237901B2 (enExample)
BR (1) BRPI0810475A2 (enExample)
CA (1) CA2684363C (enExample)
EA (2) EA019354B1 (enExample)
ES (2) ES2584161T3 (enExample)
IL (2) IL201498A (enExample)
IT (1) ITMI20070770A1 (enExample)
MX (1) MX2009011380A (enExample)
PL (2) PL2857017T3 (enExample)
WO (1) WO2008125674A1 (enExample)
ZA (1) ZA200906991B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125898B2 (en) 2008-11-14 2015-09-08 Neurotune Ag Acetam derivatives for pain relief
PL2598504T3 (pl) 2010-07-26 2014-10-31 Neurotune Ag Sposób otrzymywania dimiracetamu
EP2658540A1 (en) * 2010-10-29 2013-11-06 Neurotune AG Therapeutic use of dimiracetam to prevent the hand&foot syndrome caused by sorafenib
JPWO2012137645A1 (ja) * 2011-04-07 2014-07-28 旭化成ファーマ株式会社 抗癌剤に起因する異痛症の予防及び／又は治療剤
CN102743372B (zh) * 2012-06-30 2015-09-09 江苏省中医药研究院 一种化疗致血痹动物模型建立方法
JOP20190251A1 (ar) * 2017-05-31 2019-10-21 Metys Pharmaceuticals AG تركيبات تآزرية تشتمل على (r)-ديميراسيتام (1) و(s)-ديميراسيتام (2) بنسبة غير راسيمية
MX2020005310A (es) * 2017-11-21 2020-10-08 Medoncare Pharmaceutical Co Ltd Producto de combinacion que comprende dicicloplatino y metodo de preparacion y uso del mismo.
DE102019107619A1 (de) 2019-03-25 2020-10-01 Mondi Ag Verpackungsbeutel aus einem Kunststoffgewebeverbund
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001039779A1 (en) * 1999-12-01 2001-06-07 Ucb, S.A. A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
EP1356812A1 (en) * 2000-12-28 2003-10-29 Daiichi Pharmaceutical Co., Ltd. Medicines for treatment and prevention of neurogenic pain
WO2004085438A2 (en) * 2003-03-24 2004-10-07 Nikem Research S.R.L. Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3324219A1 (de) * 1983-07-05 1985-01-17 Hoechst Ag, 6230 Frankfurt Mehrlagige elektroisolierfolie
US5028595A (en) * 1987-09-18 1991-07-02 Hoffmann-La Roche Inc. Method for preventing AIDS in a subject or treating a subject infected with the AIDS virus
IT1233860B (it) 1988-02-08 1992-04-21 Isf Spa Derivati del peridroazacicloalca (1,2-a) imidazolo ad attivita' nootropa
GB9123641D0 (en) 1991-11-07 1992-01-02 Isf Spa Process

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001039779A1 (en) * 1999-12-01 2001-06-07 Ucb, S.A. A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders
EP1356812A1 (en) * 2000-12-28 2003-10-29 Daiichi Pharmaceutical Co., Ltd. Medicines for treatment and prevention of neurogenic pain
WO2004085438A2 (en) * 2003-03-24 2004-10-07 Nikem Research S.R.L. Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PINZA M. ET AL.: "Synthesis and Pharmacological Activity of a Series of Dihydro-1H-pyrrolo[l,2a]imidazole-2,5(3H,6H)-diones, a Novel Class of Potent Cognition Enhancers", JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 36, no. 26, 24 December 1993 (1993-12-24), pages 4214-4220, XP002295812, ISSN: 0022-2623, page 4214, left-hand column, paragraph 3, page 4216, right-hand column, paragraph 4 - page 4217, paragraph 4 *
REN J. ET AL.: "Effect of Levetiracetam on Fibromyalgia Pain and Tenderness: Comparison with PHN", JOURNAL OF PAIN, ANNUAL MEETING OF THE AMERICAN PAIN SOCIETY, vol. 4, no. 2, suppll, March 2003 (2003-03), page 72, POSTER 883, XP008095978, the whole document *

Also Published As

Publication number Publication date
CA2684363A1 (en) 2008-10-23
PL2146706T3 (pl) 2015-07-31
US7989421B2 (en) 2011-08-02
PL2857017T3 (pl) 2016-11-30
EP2857017A2 (en) 2015-04-08
IL218851A (en) 2013-09-30
IL201498A (en) 2013-10-31
EP2857017A3 (en) 2015-05-06
ES2536631T3 (es) 2015-05-27
EP2146706B1 (en) 2015-02-25
IL218851A0 (en) 2012-05-31
US20110251250A1 (en) 2011-10-13
EA022867B1 (ru) 2016-03-31
JP5409602B2 (ja) 2014-02-05
AU2008237901A1 (en) 2008-10-23
ZA200906991B (en) 2011-03-30
ES2584161T3 (es) 2016-09-26
AU2008237901B2 (en) 2013-06-27
CN101677984A (zh) 2010-03-24
EP2620149A2 (en) 2013-07-31
ITMI20070770A1 (it) 2008-10-17
EA200901237A1 (ru) 2010-04-30
EP2146706A1 (en) 2010-01-27
CN103284997B (zh) 2015-06-03
EP2620149A3 (en) 2013-08-07
US8222241B2 (en) 2012-07-17
HK1209053A1 (en) 2016-03-24
WO2008125674A1 (en) 2008-10-23
MX2009011380A (es) 2010-07-06
EA201300826A1 (ru) 2013-11-29
IL201498A0 (en) 2010-05-31
CA2684363C (en) 2016-02-09
BRPI0810475A2 (pt) 2015-10-20
US20100129469A1 (en) 2010-05-27
JP2010524882A (ja) 2010-07-22
CN103284997A (zh) 2013-09-11
EP2857017B1 (en) 2016-05-25

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM