EA018615B1 - Кристаллическая калиевая соль аналогов липоксина а - Google Patents

Кристаллическая калиевая соль аналогов липоксина а Download PDF

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Publication number
EA018615B1
EA018615B1 EA200900732A EA200900732A EA018615B1 EA 018615 B1 EA018615 B1 EA 018615B1 EA 200900732 A EA200900732 A EA 200900732A EA 200900732 A EA200900732 A EA 200900732A EA 018615 B1 EA018615 B1 EA 018615B1
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EA
Eurasian Patent Office
Prior art keywords
potassium salt
crystalline
crystalline potassium
formula
disease
Prior art date
Application number
EA200900732A
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English (en)
Russian (ru)
Other versions
EA200900732A1 (ru
Inventor
Тило Хааг
Даня Гроссбах
Габриела Винтер
Михаэль Зандер
Вольфганг Беккманн
Клаус Бартель
Кристиан Динтер
Original Assignee
Байер Интеллекчуал Проперти Гмбх
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Application filed by Байер Интеллекчуал Проперти Гмбх filed Critical Байер Интеллекчуал Проперти Гмбх
Publication of EA200900732A1 publication Critical patent/EA200900732A1/ru
Publication of EA018615B1 publication Critical patent/EA018615B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
EA200900732A 2006-12-04 2007-12-04 Кристаллическая калиевая соль аналогов липоксина а EA018615B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87283006P 2006-12-04 2006-12-04
PCT/EP2007/010785 WO2008068041A1 (en) 2006-12-04 2007-12-04 Crystalline potassium salt of lipoxin a4 analogs

Publications (2)

Publication Number Publication Date
EA200900732A1 EA200900732A1 (ru) 2009-12-30
EA018615B1 true EA018615B1 (ru) 2013-09-30

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EA200900732A EA018615B1 (ru) 2006-12-04 2007-12-04 Кристаллическая калиевая соль аналогов липоксина а

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US (2) US7906678B2 (OSRAM)
EP (2) EP3489214A1 (OSRAM)
JP (1) JP5410984B2 (OSRAM)
KR (3) KR20090101169A (OSRAM)
CN (1) CN101553456B (OSRAM)
AR (1) AR064116A1 (OSRAM)
AU (1) AU2007327765B2 (OSRAM)
BR (1) BRPI0719679A2 (OSRAM)
CA (1) CA2670791C (OSRAM)
CL (1) CL2007003468A1 (OSRAM)
CO (1) CO6190608A2 (OSRAM)
CR (1) CR10837A (OSRAM)
DO (1) DOP2009000130A (OSRAM)
EA (1) EA018615B1 (OSRAM)
EC (1) ECSP099380A (OSRAM)
IL (1) IL198434A (OSRAM)
MA (1) MA31079B1 (OSRAM)
MX (1) MX2009005911A (OSRAM)
MY (1) MY147951A (OSRAM)
NO (1) NO20092528L (OSRAM)
NZ (1) NZ577338A (OSRAM)
PE (2) PE20120395A1 (OSRAM)
SV (1) SV2009003286A (OSRAM)
TN (1) TN2009000167A1 (OSRAM)
TW (1) TWI415833B (OSRAM)
UY (1) UY30755A1 (OSRAM)
WO (1) WO2008068041A1 (OSRAM)
ZA (1) ZA200904689B (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906678B2 (en) * 2006-12-04 2011-03-15 Bayer Schering Pharma Aktiengesellschaft Crystalline potassium salt of lipoxin A4 analogs
US20090036530A1 (en) * 2006-12-04 2009-02-05 Bayer Schering Pharma Aktiengesellschaft Crystalline acid of lipoxin A4 analogs and method of making
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
CN102470158A (zh) * 2009-08-27 2012-05-23 默沙东公司 制备丙型肝炎病毒的蛋白酶抑制剂的工艺方法
CA3149053A1 (en) 2013-02-21 2014-08-28 Forsyth Dental Infirmary For Children Methods for increasing oral osteogenesis using lipoxin a4 (lxa4) and its analogs
WO2016149582A1 (en) * 2015-03-18 2016-09-22 The Forsyth Institute Methods for stabilizing atherosclerotic plaques using lipoxins, resolvins, and analogs thereof
WO2017210604A1 (en) * 2016-06-03 2017-12-07 Thetis Pharmaceuticals Llc Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation
EP3576843A4 (en) 2017-01-31 2020-11-11 The Brigham and Women's Hospital, Inc. ALX RECEIVER LIGANDS DEFINING A BIOCHEMICAL ENDOTYPE FOR INFLAMMATION-BASED DISEASES
CN111875530A (zh) * 2020-08-17 2020-11-03 浙江朗华制药有限公司 一种普拉西坦水合物晶体及其制备方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2003040080A2 (en) * 2001-11-06 2003-05-15 Schering Aktiengesellschaft Lipoxin a4 analogs

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WO1995001179A1 (en) 1993-06-29 1995-01-12 Brigham & Women's Hospital Modulation of inflammation related to columnar epithelia
US6008205A (en) 1997-04-04 1999-12-28 The Brigham & Women's Hospital, Inc. Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses
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ATE303355T1 (de) 1999-03-18 2005-09-15 Brigham & Womens Hospital Lipoxinverbindungen und ihre anwendung
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EP1237549B1 (en) 1999-11-09 2004-02-04 Alcon, Inc Lipoxin a4 and analogues for the treatment of dry eye
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AU2002347539A1 (en) 2001-12-13 2003-06-23 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
ES2373446T3 (es) 2002-03-15 2012-02-03 Dr. Reddy's Laboratories Limited Forma polimórfica i de sal de potasio 5-[4-[[3-metil-4-oxo-3,4,dihidroquinazolina-2-il]metoxi]bencil]tiazolidina-2,4-diona.
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IL198434A (en) 2012-09-24
CN101553456A (zh) 2009-10-07
EP3489214A1 (en) 2019-05-29
HK1135961A1 (en) 2010-06-18
MY147951A (en) 2013-02-15
ZA200904689B (en) 2011-10-26
US8049035B2 (en) 2011-11-01
EP2089350A1 (en) 2009-08-19
UY30755A1 (es) 2008-07-31
AU2007327765A1 (en) 2008-06-12
KR20090101169A (ko) 2009-09-24
JP2010511649A (ja) 2010-04-15
IL198434A0 (en) 2010-02-17
CL2007003468A1 (es) 2008-07-04
WO2008068041A1 (en) 2008-06-12
NZ577338A (en) 2011-02-25
US20110124910A1 (en) 2011-05-26
AR064116A1 (es) 2009-03-11
SV2009003286A (es) 2009-10-02
CO6190608A2 (es) 2010-08-19
TWI415833B (zh) 2013-11-21
PE20120395A1 (es) 2012-05-23
EA200900732A1 (ru) 2009-12-30
DOP2009000130A (es) 2009-08-15
TN2009000167A1 (en) 2010-10-18
MX2009005911A (es) 2009-09-07
CN101553456B (zh) 2013-08-28
NO20092528L (no) 2009-08-26
PE20081200A1 (es) 2008-11-06
AU2007327765B2 (en) 2012-04-12
BRPI0719679A2 (pt) 2014-01-14
CR10837A (es) 2009-07-23
JP5410984B2 (ja) 2014-02-05
KR20160054030A (ko) 2016-05-13
CA2670791A1 (en) 2008-06-12
US20080182897A1 (en) 2008-07-31
ECSP099380A (es) 2009-11-30
TW200838847A (en) 2008-10-01
EP2089350B1 (en) 2018-08-22
MA31079B1 (fr) 2010-01-04
KR20140135847A (ko) 2014-11-26
US7906678B2 (en) 2011-03-15
CA2670791C (en) 2017-01-03

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