IL198434A - Crystalline potassium salts of lipoxin a4 , methods for synthesizing them, pharmaceutical compositions comprising them and uses thereof - Google Patents
Crystalline potassium salts of lipoxin a4 , methods for synthesizing them, pharmaceutical compositions comprising them and uses thereofInfo
- Publication number
- IL198434A IL198434A IL198434A IL19843409A IL198434A IL 198434 A IL198434 A IL 198434A IL 198434 A IL198434 A IL 198434A IL 19843409 A IL19843409 A IL 19843409A IL 198434 A IL198434 A IL 198434A
- Authority
- IL
- Israel
- Prior art keywords
- potassium salt
- crystalline
- crystalline potassium
- trien
- ynyloxy
- Prior art date
Links
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- 229930184725 Lipoxin Natural products 0.000 title description 12
- 150000002639 lipoxins Chemical class 0.000 title description 12
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- SSNGRCVTRMPEKF-GFLDRWOPSA-M potassium;2-[(2r,3r,4e,6e,10e,12s)-13-(4-fluorophenoxy)-2,3,12-trihydroxytrideca-4,6,10-trien-8-ynoxy]acetate Chemical compound [K+].[O-]C(=O)COC[C@@H](O)[C@H](O)/C=C/C=C/C#C/C=C/[C@H](O)COC1=CC=C(F)C=C1 SSNGRCVTRMPEKF-GFLDRWOPSA-M 0.000 claims 1
- SSNGRCVTRMPEKF-JFACVCFFSA-M potassium;2-[(2r,3s,4e,6e,10e,12s)-13-(4-fluorophenoxy)-2,3,12-trihydroxytrideca-4,6,10-trien-8-ynoxy]acetate Chemical compound [K+].[O-]C(=O)COC[C@@H](O)[C@@H](O)/C=C/C=C/C#C/C=C/[C@H](O)COC1=CC=C(F)C=C1 SSNGRCVTRMPEKF-JFACVCFFSA-M 0.000 claims 1
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- C07C51/41—Preparation of salts of carboxylic acids
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| US87283006P | 2006-12-04 | 2006-12-04 | |
| PCT/EP2007/010785 WO2008068041A1 (en) | 2006-12-04 | 2007-12-04 | Crystalline potassium salt of lipoxin a4 analogs |
Publications (2)
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| IL198434A0 IL198434A0 (en) | 2010-02-17 |
| IL198434A true IL198434A (en) | 2012-09-24 |
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| IL198434A IL198434A (en) | 2006-12-04 | 2009-04-28 | Crystalline potassium salts of lipoxin a4 , methods for synthesizing them, pharmaceutical compositions comprising them and uses thereof |
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| US20090036530A1 (en) * | 2006-12-04 | 2009-02-05 | Bayer Schering Pharma Aktiengesellschaft | Crystalline acid of lipoxin A4 analogs and method of making |
| UY30755A1 (es) * | 2006-12-04 | 2008-07-31 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4 |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| US8637449B2 (en) * | 2009-08-27 | 2014-01-28 | Merck Sharp & Dohme Corp. | Processes for preparing protease inhibitors of hepatitis C virus |
| CA3149053A1 (en) | 2013-02-21 | 2014-08-28 | Forsyth Dental Infirmary For Children | Methods for increasing oral osteogenesis using lipoxin a4 (lxa4) and its analogs |
| CN114377138A (zh) * | 2015-03-18 | 2022-04-22 | 福塞斯儿童牙科医院 | 使用脂氧素、消退素及其类似物稳定动脉粥状硬化斑块的方法 |
| ES2827796T3 (es) | 2016-06-03 | 2021-05-24 | Thetis Pharmaceuticals Llc | Composiciones y procedimientos relativos a sales de mediadores pro-resolutivos especializados de inflamación |
| US11519911B2 (en) | 2017-01-31 | 2022-12-06 | The Brigham And Women's Hospital, Inc. | ALX receptor ligands define a biochemical endotype for inflammation-based diseases |
| CN111875530A (zh) * | 2020-08-17 | 2020-11-03 | 浙江朗华制药有限公司 | 一种普拉西坦水合物晶体及其制备方法 |
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| US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| EP0703897B1 (en) | 1993-06-15 | 2008-08-20 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds with prolonged half-life |
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
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| US6008205A (en) | 1997-04-04 | 1999-12-28 | The Brigham & Women's Hospital, Inc. | Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses |
| US6236978B1 (en) * | 1997-11-14 | 2001-05-22 | New York University | System and method for dynamic profiling of users in one-to-one applications |
| US6006466A (en) * | 1998-08-20 | 1999-12-28 | Washecka; John | Concealed linear payout holder for fishing leader |
| SE9900274D0 (sv) | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
| CA2365240C (en) | 1999-03-18 | 2009-01-20 | Charles N. Serhan | Regulation of phospholipase d activity |
| DE60022327T2 (de) | 1999-03-18 | 2006-06-29 | The Brigham And Women's Hospital Inc., Boston | Lipoxinverbindungen und ihre anwendung |
| CA2747376A1 (en) | 1999-03-18 | 2000-09-21 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response |
| ATE258791T1 (de) | 1999-11-09 | 2004-02-15 | Alcon Inc | Lipoxin-a4 und deren analoge zur behandlung von trockenen augen |
| US7700650B2 (en) | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| EP1458728A1 (en) | 2001-12-13 | 2004-09-22 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
| EP1487830A1 (en) | 2002-03-15 | 2004-12-22 | Dr. Reddy's Laboratories Ltd. | Novel crystalline form of 5-(4-((3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)methoxy)benzyl)thiazolidine-2,4-dione potassium salt |
| DE602004029982D1 (de) | 2003-01-30 | 2010-12-23 | Lek Pharmaceuticals | Herstellung eines neuen pharmazeutisch geeigneten losartan-salzes und von seinen formen mittels neuer reinigungs- und isolationsverfahren |
| WO2006035291A1 (en) | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir potassium |
| US7223718B2 (en) * | 2005-03-07 | 2007-05-29 | Falcon Lab Llc | Enhanced glyphosate herbicidal concentrates |
| KR20070088764A (ko) | 2005-10-31 | 2007-08-29 | 테바 파마슈티컬 인더스트리즈 리미티드 | 세프디니어 칼륨염의 결정형 |
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