AR064116A1 - Sal de potasio cristalina de analogos de lipoxina a4 - Google Patents
Sal de potasio cristalina de analogos de lipoxina a4Info
- Publication number
- AR064116A1 AR064116A1 ARP070105403A ARP070105403A AR064116A1 AR 064116 A1 AR064116 A1 AR 064116A1 AR P070105403 A ARP070105403 A AR P070105403A AR P070105403 A ARP070105403 A AR P070105403A AR 064116 A1 AR064116 A1 AR 064116A1
- Authority
- AR
- Argentina
- Prior art keywords
- potassium salt
- lipoxine
- crystalline potassium
- haloalkoxy
- haloalkyl
- Prior art date
Links
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 title abstract 2
- 239000013078 crystal Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 159000000001 potassium salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87283006P | 2006-12-04 | 2006-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064116A1 true AR064116A1 (es) | 2009-03-11 |
Family
ID=39076610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105403A AR064116A1 (es) | 2006-12-04 | 2007-12-04 | Sal de potasio cristalina de analogos de lipoxina a4 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US7906678B2 (OSRAM) |
| EP (2) | EP3489214A1 (OSRAM) |
| JP (1) | JP5410984B2 (OSRAM) |
| KR (3) | KR20090101169A (OSRAM) |
| CN (1) | CN101553456B (OSRAM) |
| AR (1) | AR064116A1 (OSRAM) |
| AU (1) | AU2007327765B2 (OSRAM) |
| BR (1) | BRPI0719679A2 (OSRAM) |
| CA (1) | CA2670791C (OSRAM) |
| CL (1) | CL2007003468A1 (OSRAM) |
| CO (1) | CO6190608A2 (OSRAM) |
| CR (1) | CR10837A (OSRAM) |
| DO (1) | DOP2009000130A (OSRAM) |
| EA (1) | EA018615B1 (OSRAM) |
| EC (1) | ECSP099380A (OSRAM) |
| IL (1) | IL198434A (OSRAM) |
| MA (1) | MA31079B1 (OSRAM) |
| MX (1) | MX2009005911A (OSRAM) |
| MY (1) | MY147951A (OSRAM) |
| NO (1) | NO20092528L (OSRAM) |
| NZ (1) | NZ577338A (OSRAM) |
| PE (2) | PE20120395A1 (OSRAM) |
| SV (1) | SV2009003286A (OSRAM) |
| TN (1) | TN2009000167A1 (OSRAM) |
| TW (1) | TWI415833B (OSRAM) |
| UY (1) | UY30755A1 (OSRAM) |
| WO (1) | WO2008068041A1 (OSRAM) |
| ZA (1) | ZA200904689B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7906678B2 (en) * | 2006-12-04 | 2011-03-15 | Bayer Schering Pharma Aktiengesellschaft | Crystalline potassium salt of lipoxin A4 analogs |
| US20090036530A1 (en) * | 2006-12-04 | 2009-02-05 | Bayer Schering Pharma Aktiengesellschaft | Crystalline acid of lipoxin A4 analogs and method of making |
| EP2135610A1 (en) | 2008-06-20 | 2009-12-23 | Laboratorios Almirall, S.A. | Combination comprising DHODH inhibitors and methotrexate |
| CN102470158A (zh) * | 2009-08-27 | 2012-05-23 | 默沙东公司 | 制备丙型肝炎病毒的蛋白酶抑制剂的工艺方法 |
| CA3149053A1 (en) | 2013-02-21 | 2014-08-28 | Forsyth Dental Infirmary For Children | Methods for increasing oral osteogenesis using lipoxin a4 (lxa4) and its analogs |
| WO2016149582A1 (en) * | 2015-03-18 | 2016-09-22 | The Forsyth Institute | Methods for stabilizing atherosclerotic plaques using lipoxins, resolvins, and analogs thereof |
| WO2017210604A1 (en) * | 2016-06-03 | 2017-12-07 | Thetis Pharmaceuticals Llc | Compositions and methods relating to salts of specialized pro-resolving mediators of inflammation |
| EP3576843A4 (en) | 2017-01-31 | 2020-11-11 | The Brigham and Women's Hospital, Inc. | ALX RECEIVER LIGANDS DEFINING A BIOCHEMICAL ENDOTYPE FOR INFLAMMATION-BASED DISEASES |
| CN111875530A (zh) * | 2020-08-17 | 2020-11-03 | 浙江朗华制药有限公司 | 一种普拉西坦水合物晶体及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| CA2164951C (en) | 1993-06-15 | 2004-02-10 | Charles N. Serhan | Lipoxin compounds |
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| US6048897A (en) | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| WO1995001179A1 (en) | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US6008205A (en) | 1997-04-04 | 1999-12-28 | The Brigham & Women's Hospital, Inc. | Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses |
| US6236978B1 (en) * | 1997-11-14 | 2001-05-22 | New York University | System and method for dynamic profiling of users in one-to-one applications |
| US6006466A (en) * | 1998-08-20 | 1999-12-28 | Washecka; John | Concealed linear payout holder for fishing leader |
| SE9900274D0 (sv) | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
| ES2344138T3 (es) | 1999-03-18 | 2010-08-19 | The Brigham And Women's Hospital, Inc. | Analogos de 16-fenoxi-lipoxina para utilizacion medica. |
| ATE303355T1 (de) | 1999-03-18 | 2005-09-15 | Brigham & Womens Hospital | Lipoxinverbindungen und ihre anwendung |
| US6387953B1 (en) | 1999-03-18 | 2002-05-14 | Brigham And Women's Hopsital | Inhibition of TNF-(α)-initiated neutrophil response |
| EP1237549B1 (en) | 1999-11-09 | 2004-02-04 | Alcon, Inc | Lipoxin a4 and analogues for the treatment of dry eye |
| WO2001070664A2 (en) | 2000-03-20 | 2001-09-27 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
| US6831186B2 (en) | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| AU2002347539A1 (en) | 2001-12-13 | 2003-06-23 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
| ES2373446T3 (es) | 2002-03-15 | 2012-02-03 | Dr. Reddy's Laboratories Limited | Forma polimórfica i de sal de potasio 5-[4-[[3-metil-4-oxo-3,4,dihidroquinazolina-2-il]metoxi]bencil]tiazolidina-2,4-diona. |
| EP1589966B1 (en) | 2003-01-30 | 2010-11-10 | LEK Pharmaceuticals d.d. | Preparation of new pharmaceutically suitable salt of losartan and forms thereof with new purification and isolation methods |
| WO2006035291A1 (en) | 2004-09-27 | 2006-04-06 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir potassium |
| US7223718B2 (en) * | 2005-03-07 | 2007-05-29 | Falcon Lab Llc | Enhanced glyphosate herbicidal concentrates |
| JP2008525531A (ja) | 2005-10-31 | 2008-07-17 | テバ ファーマシューティカル インダストリーズ リミティド | セフジニルカリウム塩の結晶形 |
| US7906678B2 (en) * | 2006-12-04 | 2011-03-15 | Bayer Schering Pharma Aktiengesellschaft | Crystalline potassium salt of lipoxin A4 analogs |
-
2007
- 2007-12-03 US US11/999,000 patent/US7906678B2/en active Active
- 2007-12-03 UY UY30755A patent/UY30755A1/es not_active Application Discontinuation
- 2007-12-03 CL CL200703468A patent/CL2007003468A1/es unknown
- 2007-12-03 PE PE2012000006A patent/PE20120395A1/es not_active Application Discontinuation
- 2007-12-03 PE PE2007001704A patent/PE20081200A1/es not_active Application Discontinuation
- 2007-12-04 KR KR1020097011427A patent/KR20090101169A/ko not_active Ceased
- 2007-12-04 EA EA200900732A patent/EA018615B1/ru not_active IP Right Cessation
- 2007-12-04 KR KR1020167011173A patent/KR20160054030A/ko not_active Ceased
- 2007-12-04 JP JP2009539669A patent/JP5410984B2/ja not_active Expired - Fee Related
- 2007-12-04 AU AU2007327765A patent/AU2007327765B2/en not_active Ceased
- 2007-12-04 EP EP18190069.7A patent/EP3489214A1/en not_active Withdrawn
- 2007-12-04 NZ NZ577338A patent/NZ577338A/en not_active IP Right Cessation
- 2007-12-04 MX MX2009005911A patent/MX2009005911A/es active IP Right Grant
- 2007-12-04 WO PCT/EP2007/010785 patent/WO2008068041A1/en not_active Ceased
- 2007-12-04 CA CA2670791A patent/CA2670791C/en not_active Expired - Fee Related
- 2007-12-04 CN CN2007800448571A patent/CN101553456B/zh not_active Expired - Fee Related
- 2007-12-04 KR KR1020147030409A patent/KR20140135847A/ko not_active Ceased
- 2007-12-04 TW TW096146154A patent/TWI415833B/zh not_active IP Right Cessation
- 2007-12-04 BR BRPI0719679-2A2A patent/BRPI0719679A2/pt not_active IP Right Cessation
- 2007-12-04 AR ARP070105403A patent/AR064116A1/es unknown
- 2007-12-04 MY MYPI20092224A patent/MY147951A/en unknown
- 2007-12-04 EP EP07847057.2A patent/EP2089350B1/en active Active
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2009
- 2009-04-28 IL IL198434A patent/IL198434A/en not_active IP Right Cessation
- 2009-04-29 TN TNP2009000167A patent/TN2009000167A1/fr unknown
- 2009-06-03 EC EC2009009380A patent/ECSP099380A/es unknown
- 2009-06-04 DO DO2009000130A patent/DOP2009000130A/es unknown
- 2009-06-04 CR CR10837A patent/CR10837A/es unknown
- 2009-06-04 CO CO09057912A patent/CO6190608A2/es not_active Application Discontinuation
- 2009-06-04 SV SV2009003286A patent/SV2009003286A/es unknown
- 2009-06-29 MA MA32056A patent/MA31079B1/fr unknown
- 2009-07-03 ZA ZA2009/04689A patent/ZA200904689B/en unknown
- 2009-07-03 NO NO20092528A patent/NO20092528L/no not_active Application Discontinuation
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2011
- 2011-02-07 US US13/022,139 patent/US8049035B2/en active Active
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