EA013117B1 - Ингибиторы циклинзависимых киназ, относящиеся к ним композиции и применения - Google Patents

Ингибиторы циклинзависимых киназ, относящиеся к ним композиции и применения Download PDF

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Publication number
EA013117B1
EA013117B1 EA200601216A EA200601216A EA013117B1 EA 013117 B1 EA013117 B1 EA 013117B1 EA 200601216 A EA200601216 A EA 200601216A EA 200601216 A EA200601216 A EA 200601216A EA 013117 B1 EA013117 B1 EA 013117B1
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EA
Eurasian Patent Office
Prior art keywords
compound
cells
cyclin
compounds
compound according
Prior art date
Application number
EA200601216A
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English (en)
Russian (ru)
Other versions
EA200601216A1 (ru
Inventor
Николас Бокович
Артур Ф. Клуге
Крис Оулманн
Кришна К. Мартхи
Сия Рам
Чжуньго Ван
Цзяньсин Хуан
Original Assignee
ДжиПиСи БАЙОТЕК, ИНК.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by ДжиПиСи БАЙОТЕК, ИНК. filed Critical ДжиПиСи БАЙОТЕК, ИНК.
Publication of EA200601216A1 publication Critical patent/EA200601216A1/ru
Publication of EA013117B1 publication Critical patent/EA013117B1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA200601216A 2003-12-23 2004-12-21 Ингибиторы циклинзависимых киназ, относящиеся к ним композиции и применения EA013117B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53187203P 2003-12-23 2003-12-23
US56013804P 2004-04-06 2004-04-06
US61648004P 2004-10-06 2004-10-06
PCT/US2004/043492 WO2005063765A1 (en) 2003-12-23 2004-12-21 Inhibitors of cyclin-dependent kinases, compositions and uses related thereto

Publications (2)

Publication Number Publication Date
EA200601216A1 EA200601216A1 (ru) 2006-12-29
EA013117B1 true EA013117B1 (ru) 2010-02-26

Family

ID=34743691

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601216A EA013117B1 (ru) 2003-12-23 2004-12-21 Ингибиторы циклинзависимых киназ, относящиеся к ним композиции и применения

Country Status (12)

Country Link
US (1) US8097619B2 (enExample)
EP (1) EP1709051A1 (enExample)
JP (1) JP4791975B2 (enExample)
KR (1) KR101155883B1 (enExample)
AU (1) AU2004309415B2 (enExample)
BR (1) BRPI0418095A (enExample)
CA (1) CA2551640C (enExample)
EA (1) EA013117B1 (enExample)
IL (1) IL176543A0 (enExample)
MX (1) MXPA06007399A (enExample)
NO (1) NO20063186L (enExample)
WO (1) WO2005063765A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298292A3 (en) * 2004-06-18 2011-08-10 Agennix USA Inc. Kinase inhibitors for treating cancers
EP2019101A1 (en) 2007-07-26 2009-01-28 GPC Biotech AG Pyrazol[3,4-d]pyrimidin-4-one useful as Kinase Inhibitor
JP2013525370A (ja) 2010-04-22 2013-06-20 ヤンセン ファーマシューティカ エヌ.ベー. ケトヘキソキナーゼ阻害剤として有用なインダゾール化合物
BRPI1107312B1 (pt) 2011-11-25 2021-09-08 Universidade Federal De Santa Catarina Composto de acil-hidrazona
JP7166252B2 (ja) 2016-11-30 2022-11-07 メディツィーニシェ・ウニヴェルジテート・インスブルック サイクリン依存性キナーゼ阻害剤としての3-アミノ-1,5-ジヒドロピラゾロ[3,4-d]ピリミジン-4-オン

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054308A1 (en) * 1998-04-21 1999-10-28 Du Pont Pharmaceuticals Company 5-aminoindeno(1,2-c)pyrazol-4-ones as anti-cancer and anti-proliferative agents
US20010027195A1 (en) * 1998-04-21 2001-10-04 Nugiel David A. Indeno [1,2-c]pyrazol-4-ones and their uses
WO2003033499A2 (en) * 2001-10-15 2003-04-24 Gpc Biotech Inc. Inhibitors of cyclin-dependent kinases, compositions and uses related thereto

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3211732A (en) 1965-10-12 Pyrazolob:x-d]pyrlil/hdines
CH398626A (de) 1960-05-11 1966-03-15 Ciba Geigy Verfahren zur Herstellung neuer Pyrazolopyrimidine
JPS60130521A (ja) 1983-12-19 1985-07-12 Morishita Seiyaku Kk 抗癌剤
US4678499A (en) 1985-03-11 1987-07-07 E. I. Du Pont De Nemours And Company Herbicidal sulfonamides
JPS6299361A (ja) 1985-10-25 1987-05-08 Morishita Seiyaku Kk インデノ〔1,2−c〕ピラゾ−ル誘導体
TW370529B (en) 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US6559152B2 (en) 1998-10-13 2003-05-06 Dupont Pharmaceuticals Company 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
US6531477B1 (en) 1998-10-13 2003-03-11 Dupont Pharmaceuticals Company 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
EP1414804A1 (en) 2000-10-20 2004-05-06 Bristol-Myers Squibb Pharma Company Acylsemicarbazides and their use as cyclin dependent kinase (cdk) inhibitors
US6491971B2 (en) 2000-11-15 2002-12-10 G.T. Equipment Technologies, Inc Release coating system for crucibles
US6706718B2 (en) 2000-12-01 2004-03-16 Bristol-Myers Squibb Company 3-(2,4-dimethylthiazol-5-yl)indeno[1,2-c]pyrazol-4-one derivatives and their uses
US7605175B2 (en) * 2001-03-02 2009-10-20 Gpc Biotech Ag Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
JP4343534B2 (ja) 2001-03-02 2009-10-14 ゲーペーツェー バイオテック アクチェンゲゼルシャフト 3ハイブリッド・アッセイ・システム
WO2003004491A1 (en) 2001-07-06 2003-01-16 Bristol-Myers Squibb Pharma Company Semicarbazides and their uses
US20040248905A1 (en) 2001-07-10 2004-12-09 Markwalder Jay A 6-Substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
US6753329B2 (en) 2001-12-03 2004-06-22 Gpc Biotech Inc. Inhibitors of cyclin-dependent kinases, compositions and uses related thereto

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054308A1 (en) * 1998-04-21 1999-10-28 Du Pont Pharmaceuticals Company 5-aminoindeno(1,2-c)pyrazol-4-ones as anti-cancer and anti-proliferative agents
US20010027195A1 (en) * 1998-04-21 2001-10-04 Nugiel David A. Indeno [1,2-c]pyrazol-4-ones and their uses
WO2003033499A2 (en) * 2001-10-15 2003-04-24 Gpc Biotech Inc. Inhibitors of cyclin-dependent kinases, compositions and uses related thereto

Also Published As

Publication number Publication date
CA2551640A1 (en) 2005-07-14
AU2004309415B2 (en) 2010-08-26
CA2551640C (en) 2012-09-11
BRPI0418095A (pt) 2007-04-17
IL176543A0 (en) 2006-10-05
US20090209530A1 (en) 2009-08-20
EA200601216A1 (ru) 2006-12-29
MXPA06007399A (es) 2007-01-26
JP4791975B2 (ja) 2011-10-12
WO2005063765A1 (en) 2005-07-14
HK1101399A1 (zh) 2007-10-18
US8097619B2 (en) 2012-01-17
KR101155883B1 (ko) 2012-06-20
KR20060130624A (ko) 2006-12-19
EP1709051A1 (en) 2006-10-11
JP2007516296A (ja) 2007-06-21
AU2004309415A1 (en) 2005-07-14
NO20063186L (no) 2006-09-20

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU