EA012204B1 - Три(цикло)замещённые амидные соединения - Google Patents
Три(цикло)замещённые амидные соединения Download PDFInfo
- Publication number
- EA012204B1 EA012204B1 EA200601747A EA200601747A EA012204B1 EA 012204 B1 EA012204 B1 EA 012204B1 EA 200601747 A EA200601747 A EA 200601747A EA 200601747 A EA200601747 A EA 200601747A EA 012204 B1 EA012204 B1 EA 012204B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutically acceptable
- fluorothiazol
- compound
- acceptable salt
- propionamide
- Prior art date
Links
- -1 amide compounds Chemical class 0.000 title claims description 129
- 150000001875 compounds Chemical class 0.000 claims abstract description 120
- 150000003839 salts Chemical class 0.000 claims abstract description 62
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- 201000001421 hyperglycemia Diseases 0.000 claims abstract description 15
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- 230000001225 therapeutic effect Effects 0.000 claims abstract description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 38
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- 229940080818 propionamide Drugs 0.000 claims description 15
- 239000000460 chlorine Substances 0.000 claims description 14
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims description 14
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56417104P | 2004-04-21 | 2004-04-21 | |
| US60107704P | 2004-08-12 | 2004-08-12 | |
| PCT/GB2005/050053 WO2005103021A1 (en) | 2004-04-21 | 2005-04-19 | Tri(cyclo) substituted amide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200601747A1 EA200601747A1 (ru) | 2007-04-27 |
| EA012204B1 true EA012204B1 (ru) | 2009-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200601747A EA012204B1 (ru) | 2004-04-21 | 2005-04-19 | Три(цикло)замещённые амидные соединения |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080242869A1 (enExample) |
| EP (1) | EP1740560A1 (enExample) |
| JP (1) | JP2007533722A (enExample) |
| KR (1) | KR20060134179A (enExample) |
| AU (1) | AU2005235798A1 (enExample) |
| BR (1) | BRPI0510163A (enExample) |
| CA (1) | CA2563192A1 (enExample) |
| EA (1) | EA012204B1 (enExample) |
| IL (1) | IL178473A0 (enExample) |
| MA (1) | MA28545B1 (enExample) |
| MX (1) | MXPA06012008A (enExample) |
| NO (1) | NO20065260L (enExample) |
| NZ (1) | NZ550567A (enExample) |
| WO (1) | WO2005103021A1 (enExample) |
| ZA (1) | ZA200608489B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| RU2005113713A (ru) | 2002-10-03 | 2006-01-20 | Новартис АГ (CH) | Замещенные (тиазол-2-ил)амиды или сульфонамиды в качестве активаторов глюкокиназы, которые могут применяться при лечении диабета типа 2 |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| WO2005095417A1 (en) | 2004-04-02 | 2005-10-13 | Novartis Ag | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
| ATE524479T1 (de) | 2004-04-02 | 2011-09-15 | Novartis Ag | Sulfonamidthiazolpyridinderivate als zur behandlung von typ-2-diabetes geeignete glucokinaseaktivatoren |
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| BRPI0622261A2 (pt) | 2005-07-09 | 2011-08-09 | Astrazeneca Ab | composto, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto |
| RU2008112198A (ru) | 2005-09-29 | 2009-10-10 | Санофи-Авентис (Fr) | Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
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| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
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| BRPI0715531A2 (pt) | 2006-07-24 | 2014-06-24 | Hoffmann La Roche | Composto, composição farmacêutica, método para o tratamento de uma enfermidade e/ou distúrbio metabólico, processo para a preparação de compostos e uso do composto |
| US7902248B2 (en) | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
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| WO2008111473A1 (ja) * | 2007-03-07 | 2008-09-18 | Kyorin Pharmaceutical Co., Ltd. | グルコキナーゼ活性化物質 |
| CL2009000004A1 (es) * | 2008-01-15 | 2010-02-19 | Lilly Co Eli | Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia. |
| KR20100113518A (ko) | 2008-01-18 | 2010-10-21 | 아스텔라스세이야쿠 가부시키가이샤 | 페닐아세트아미드 유도체 |
| US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| SI2275414T1 (sl) | 2008-04-28 | 2015-10-30 | Kyorin Pharmaceutical Co., Ltd., | Ciklopentilakrilamidni derivat |
| WO2009140624A2 (en) | 2008-05-16 | 2009-11-19 | Takeda San Diego, Inc. | Glucokinase activators |
| CN102245574A (zh) * | 2008-12-08 | 2011-11-16 | 欧洲筛选有限公司 | 用于治疗代谢疾病的化合物、药物组合物以及方法 |
| UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
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| WO2000058293A2 (en) * | 1999-03-29 | 2000-10-05 | F. Hoffmann-La Roche Ag | Glucokinase activators |
| WO2001044216A1 (en) * | 1999-12-15 | 2001-06-21 | F. Hoffmann-La Roche Ag | Trans olefinic glucokinase activators |
| WO2001085706A1 (en) * | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
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| WO2002046173A1 (en) * | 2000-12-06 | 2002-06-13 | F. Hoffmann-La Roche Ag | Fused heteroaromatic glucokinase activators |
| US6610846B1 (en) * | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| WO2003095438A1 (en) * | 2002-04-26 | 2003-11-20 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
| WO2004072031A2 (en) * | 2003-02-11 | 2004-08-26 | Prosidion Limited | Phenylacetamides and their use as glucokinase modulators |
-
2005
- 2005-04-19 NZ NZ550567A patent/NZ550567A/en not_active IP Right Cessation
- 2005-04-19 WO PCT/GB2005/050053 patent/WO2005103021A1/en not_active Ceased
- 2005-04-19 AU AU2005235798A patent/AU2005235798A1/en not_active Abandoned
- 2005-04-19 KR KR1020067022240A patent/KR20060134179A/ko not_active Ceased
- 2005-04-19 JP JP2007508982A patent/JP2007533722A/ja not_active Withdrawn
- 2005-04-19 MX MXPA06012008A patent/MXPA06012008A/es unknown
- 2005-04-19 EP EP05732317A patent/EP1740560A1/en not_active Withdrawn
- 2005-04-19 CA CA002563192A patent/CA2563192A1/en not_active Abandoned
- 2005-04-19 US US11/578,752 patent/US20080242869A1/en not_active Abandoned
- 2005-04-19 EA EA200601747A patent/EA012204B1/ru not_active IP Right Cessation
- 2005-04-19 BR BRPI0510163-8A patent/BRPI0510163A/pt not_active IP Right Cessation
-
2006
- 2006-10-05 IL IL178473A patent/IL178473A0/en unknown
- 2006-10-11 ZA ZA2006/08489A patent/ZA200608489B/en unknown
- 2006-10-20 MA MA29401A patent/MA28545B1/fr unknown
- 2006-11-15 NO NO20065260A patent/NO20065260L/no not_active Application Discontinuation
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000058293A2 (en) * | 1999-03-29 | 2000-10-05 | F. Hoffmann-La Roche Ag | Glucokinase activators |
| US6610846B1 (en) * | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| WO2001044216A1 (en) * | 1999-12-15 | 2001-06-21 | F. Hoffmann-La Roche Ag | Trans olefinic glucokinase activators |
| WO2001085706A1 (en) * | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
| WO2002008209A1 (en) * | 2000-07-20 | 2002-01-31 | F. Hoffmann-La Roche Ag | Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators |
| WO2002046173A1 (en) * | 2000-12-06 | 2002-06-13 | F. Hoffmann-La Roche Ag | Fused heteroaromatic glucokinase activators |
| WO2003095438A1 (en) * | 2002-04-26 | 2003-11-20 | F. Hoffmann-La Roche Ag | Substituted phenylacetamides and their use as glucokinase activators |
| WO2004072031A2 (en) * | 2003-02-11 | 2004-08-26 | Prosidion Limited | Phenylacetamides and their use as glucokinase modulators |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20065260L (no) | 2006-11-21 |
| NZ550567A (en) | 2010-07-30 |
| MA28545B1 (fr) | 2007-04-03 |
| WO2005103021A1 (en) | 2005-11-03 |
| BRPI0510163A (pt) | 2007-10-02 |
| US20080242869A1 (en) | 2008-10-02 |
| EA200601747A1 (ru) | 2007-04-27 |
| AU2005235798A1 (en) | 2005-11-03 |
| CA2563192A1 (en) | 2005-11-03 |
| MXPA06012008A (es) | 2007-01-25 |
| JP2007533722A (ja) | 2007-11-22 |
| ZA200608489B (en) | 2008-06-25 |
| IL178473A0 (en) | 2007-02-11 |
| EP1740560A1 (en) | 2007-01-10 |
| KR20060134179A (ko) | 2006-12-27 |
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