EA011423B1 - Метадоновые композиции местного действия и способы их применения - Google Patents
Метадоновые композиции местного действия и способы их применения Download PDFInfo
- Publication number
- EA011423B1 EA011423B1 EA200601776A EA200601776A EA011423B1 EA 011423 B1 EA011423 B1 EA 011423B1 EA 200601776 A EA200601776 A EA 200601776A EA 200601776 A EA200601776 A EA 200601776A EA 011423 B1 EA011423 B1 EA 011423B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methadone
- matrix
- styrene
- subject
- pain
- Prior art date
Links
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
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- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (2)
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| US56668604P | 2004-04-29 | 2004-04-29 | |
| PCT/US2005/014240 WO2005110381A1 (en) | 2004-04-29 | 2005-04-26 | Topical methadone compositions and methods for using the same |
Publications (2)
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| EA200601776A1 EA200601776A1 (ru) | 2007-04-27 |
| EA011423B1 true EA011423B1 (ru) | 2009-02-27 |
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| EA200601776A EA011423B1 (ru) | 2004-04-29 | 2005-04-26 | Метадоновые композиции местного действия и способы их применения |
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| WO2013168000A1 (en) * | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562363B1 (en) * | 1997-09-26 | 2003-05-13 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US6638528B1 (en) * | 2000-01-20 | 2003-10-28 | Noven Pharmaceuticals, Inc. | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| US6660300B1 (en) * | 1998-03-19 | 2003-12-09 | Bristol-Myers Squibb Co. | Method of use of a biphasic controlled release delivery system for high solubility pharmaceuticals and method |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5316759A (en) * | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| EP0399432B1 (en) * | 1989-05-25 | 1994-06-22 | Takeda Chemical Industries, Ltd. | Transdermal therapeutic composition |
| US5580876A (en) * | 1992-09-21 | 1996-12-03 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
| WO1994010987A1 (en) * | 1992-11-09 | 1994-05-26 | Pharmetrix Corporation | Combined analgesic delivery methods for pain management |
| US5883115A (en) * | 1992-11-09 | 1999-03-16 | Pharmetrix Division Technical Chemicals & Products, Inc. | Transdermal delivery of the eutomer of a chiral drug |
| US5589480A (en) * | 1994-08-17 | 1996-12-31 | Elkhoury; George F. | Topical application of opioid analgesic drugs such as morphine |
| US5948389A (en) * | 1995-06-07 | 1999-09-07 | El Khoury & Stein, Ltd. | Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics |
| US5947921A (en) * | 1995-12-18 | 1999-09-07 | Massachusetts Institute Of Technology | Chemical and physical enhancers and ultrasound for transdermal drug delivery |
| US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| DE19642043A1 (de) * | 1995-10-23 | 1997-04-24 | Hexal Ag | Transdermales therapeutisches System (TTS) für die Verabreichung von Wirkstoffen zur Behandlung von Drogenabhängigkeit oder Drogensucht |
| US6787149B1 (en) * | 1996-12-12 | 2004-09-07 | El Khoury And Stein Ltd. | Topical application of opioid analgesic drugs such as morphine |
| US6143278A (en) * | 1998-02-23 | 2000-11-07 | Elkhoury; George F. | Topical application of opioid analgesic drugs such as morphine |
| GB9804885D0 (en) * | 1998-03-06 | 1998-04-29 | Merck Sharp & Dohme | Therapeutic combination |
| DE19850517B4 (de) * | 1998-11-03 | 2004-02-12 | Lts Lohmann Therapie-Systeme Ag | Verwendung eines wirkstoffhaltigen transdermalen therapeutischen Systems in einer Kombinationsbehandlung mit und ohne Ultraschall |
| GB9828480D0 (en) * | 1998-12-24 | 1999-02-17 | Dermatech Limited | Transdermal drug delivery system |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| US6716449B2 (en) * | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
| AU2001235284A1 (en) * | 2000-02-22 | 2001-09-03 | Cellegy Canada Inc. | Methods and compositions for improving sleep |
| US6638981B2 (en) * | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
| US6796429B2 (en) * | 2001-10-22 | 2004-09-28 | 3M Innovative Properties Company | Transdermal/transmucosal patch packaging |
| US6713470B2 (en) * | 2002-01-22 | 2004-03-30 | Ml Laboratories Plc | Method of treatment |
-
2005
- 2005-04-26 NZ NZ550963A patent/NZ550963A/en not_active IP Right Cessation
- 2005-04-26 US US11/115,968 patent/US20050244486A1/en not_active Abandoned
- 2005-04-26 ME MEP-250/08A patent/MEP25008A/xx unknown
- 2005-04-26 WO PCT/US2005/014240 patent/WO2005110381A1/en not_active Ceased
- 2005-04-26 BR BRPI0510428-9A patent/BRPI0510428A/pt not_active IP Right Cessation
- 2005-04-26 CN CNA2005800219605A patent/CN1976689A/zh active Pending
- 2005-04-26 UA UAA200611217A patent/UA88464C2/ru unknown
- 2005-04-26 RS RSP-2006/0605A patent/RS20060605A/sr unknown
- 2005-04-26 EP EP05757678A patent/EP1740162A4/en not_active Ceased
- 2005-04-26 JP JP2007510880A patent/JP5250257B2/ja not_active Expired - Fee Related
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- 2006-11-27 NO NO20065455A patent/NO20065455L/no not_active Application Discontinuation
-
2010
- 2010-04-29 AU AU2010201707A patent/AU2010201707A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562363B1 (en) * | 1997-09-26 | 2003-05-13 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| US6660300B1 (en) * | 1998-03-19 | 2003-12-09 | Bristol-Myers Squibb Co. | Method of use of a biphasic controlled release delivery system for high solubility pharmaceuticals and method |
| US6638528B1 (en) * | 2000-01-20 | 2003-10-28 | Noven Pharmaceuticals, Inc. | Compositions and methods to effect the release profile in the transdermal administration of active agents |
Also Published As
| Publication number | Publication date |
|---|---|
| EA200601776A1 (ru) | 2007-04-27 |
| MEP25008A (en) | 2010-10-10 |
| CA2563489C (en) | 2013-06-18 |
| JP2007538008A (ja) | 2007-12-27 |
| IL178661A0 (en) | 2007-02-11 |
| JP5250257B2 (ja) | 2013-07-31 |
| ZA200608923B (en) | 2008-05-28 |
| WO2005110381A1 (en) | 2005-11-24 |
| KR20070007850A (ko) | 2007-01-16 |
| UA88464C2 (ru) | 2009-10-26 |
| AU2005244214A1 (en) | 2005-11-24 |
| CR8722A (es) | 2007-05-30 |
| AU2010201707A1 (en) | 2010-05-20 |
| NO20065455L (no) | 2007-01-19 |
| CA2563489A1 (en) | 2005-11-24 |
| US20050244486A1 (en) | 2005-11-03 |
| RS20060605A (sr) | 2008-09-29 |
| EP1740162A1 (en) | 2007-01-10 |
| BRPI0510428A (pt) | 2007-10-30 |
| NZ550963A (en) | 2008-11-28 |
| MXPA06012563A (es) | 2007-03-21 |
| AR048878A1 (es) | 2006-06-07 |
| AU2005244214B2 (en) | 2010-02-18 |
| CN1976689A (zh) | 2007-06-06 |
| EP1740162A4 (en) | 2009-11-18 |
| TW200605870A (en) | 2006-02-16 |
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