EA011217B1 - N-[(3s)пирролидин-3-ил]бензамидные производные в качестве ингибиторов обратного захвата моноаминов - Google Patents

N-[(3s)пирролидин-3-ил]бензамидные производные в качестве ингибиторов обратного захвата моноаминов Download PDF

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Publication number
EA011217B1
EA011217B1 EA200700920A EA200700920A EA011217B1 EA 011217 B1 EA011217 B1 EA 011217B1 EA 200700920 A EA200700920 A EA 200700920A EA 200700920 A EA200700920 A EA 200700920A EA 011217 B1 EA011217 B1 EA 011217B1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolidin
benzamide
compound according
compound
pain
Prior art date
Application number
EA200700920A
Other languages
English (en)
Russian (ru)
Other versions
EA200700920A1 (ru
Inventor
Пол Винсент Фиш
Томас Райкманс
Алан Стоби
Флориан Уэйкенхат
Гэвин Алистер Уитлок
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200700920A1 publication Critical patent/EA200700920A1/ru
Publication of EA011217B1 publication Critical patent/EA011217B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA200700920A 2004-11-23 2005-11-18 N-[(3s)пирролидин-3-ил]бензамидные производные в качестве ингибиторов обратного захвата моноаминов EA011217B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0425766.3A GB0425766D0 (en) 2004-11-23 2004-11-23 Novel compounds
PCT/IB2005/003643 WO2006056884A1 (en) 2004-11-23 2005-11-18 N- [ (3s)- pyrrolidin-3-yl]- benzamide derivatives as monoamine re-uptake inhibitors

Publications (2)

Publication Number Publication Date
EA200700920A1 EA200700920A1 (ru) 2007-12-28
EA011217B1 true EA011217B1 (ru) 2009-02-27

Family

ID=33548739

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700920A EA011217B1 (ru) 2004-11-23 2005-11-18 N-[(3s)пирролидин-3-ил]бензамидные производные в качестве ингибиторов обратного захвата моноаминов

Country Status (26)

Country Link
EP (1) EP1817281A1 (ko)
JP (1) JP4233596B2 (ko)
KR (1) KR100886294B1 (ko)
CN (1) CN101065355A (ko)
AP (1) AP2007004003A0 (ko)
AR (1) AR052243A1 (ko)
AU (1) AU2005308534A1 (ko)
BR (1) BRPI0518486A2 (ko)
CA (1) CA2589258A1 (ko)
CR (1) CR9171A (ko)
EA (1) EA011217B1 (ko)
GB (1) GB0425766D0 (ko)
GT (1) GT200500337A (ko)
IL (1) IL183191A0 (ko)
MA (1) MA29038B1 (ko)
MX (1) MX2007006138A (ko)
NL (2) NL1030485C2 (ko)
NO (1) NO20072486L (ko)
PA (1) PA8653501A1 (ko)
PE (1) PE20061056A1 (ko)
SV (1) SV2006002311A (ko)
TN (1) TNSN07201A1 (ko)
TW (1) TWI300776B (ko)
UY (1) UY29224A1 (ko)
WO (1) WO2006056884A1 (ko)
ZA (1) ZA200703910B (ko)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628885A5 (en) * 1978-01-01 1982-03-31 Anphar Sa Piperidine derivative
WO2004110995A1 (en) * 2003-06-17 2004-12-23 Pfizer Limited N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
WO2004111003A1 (en) * 2003-06-17 2004-12-23 Pfizer Limited Amide derivatives as selective serotonin re-uptake inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628885A5 (en) * 1978-01-01 1982-03-31 Anphar Sa Piperidine derivative
WO2004110995A1 (en) * 2003-06-17 2004-12-23 Pfizer Limited N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors
WO2004111003A1 (en) * 2003-06-17 2004-12-23 Pfizer Limited Amide derivatives as selective serotonin re-uptake inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NORMAN T. R. ET AL.: "NEW PHARMACOLOGICAL APPROACHES TO THE MANAGEMENT OF DEPRESSION; FROM THEORY TO CLINICAL PRACTICE", AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, MELBOURNE, AU, vol. 26, 1992, pages 73-81, XP002066745, ISSN: 0004-8674 abstract *

Also Published As

Publication number Publication date
KR20070086599A (ko) 2007-08-27
NL1032760A1 (nl) 2006-12-13
SV2006002311A (es) 2006-09-14
NL1030485A1 (nl) 2006-05-24
GT200500337A (es) 2006-06-13
AU2005308534A1 (en) 2006-06-01
UY29224A1 (es) 2006-06-30
CN101065355A (zh) 2007-10-31
GB0425766D0 (en) 2004-12-22
KR100886294B1 (ko) 2009-03-04
PA8653501A1 (es) 2006-06-02
CA2589258A1 (en) 2006-06-01
MX2007006138A (es) 2007-07-19
PE20061056A1 (es) 2006-11-08
NO20072486L (no) 2007-06-20
EA200700920A1 (ru) 2007-12-28
IL183191A0 (en) 2007-08-19
NL1030485C2 (nl) 2006-11-07
AP2007004003A0 (en) 2007-06-30
JP4233596B2 (ja) 2009-03-04
ZA200703910B (en) 2008-09-25
WO2006056884A1 (en) 2006-06-01
AR052243A1 (es) 2007-03-07
NL1032760C2 (nl) 2007-04-17
MA29038B1 (fr) 2007-11-01
TWI300776B (en) 2008-09-11
JP2008520646A (ja) 2008-06-19
TW200626543A (en) 2006-08-01
TNSN07201A1 (fr) 2008-11-21
EP1817281A1 (en) 2007-08-15
CR9171A (es) 2007-07-04
BRPI0518486A2 (pt) 2008-11-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU