TW200626543A - Novel compounds - Google Patents
Novel compoundsInfo
- Publication number
- TW200626543A TW200626543A TW094140922A TW94140922A TW200626543A TW 200626543 A TW200626543 A TW 200626543A TW 094140922 A TW094140922 A TW 094140922A TW 94140922 A TW94140922 A TW 94140922A TW 200626543 A TW200626543 A TW 200626543A
- Authority
- TW
- Taiwan
- Prior art keywords
- 4alkyl
- het
- 6alkyl
- ocf3
- heteroatom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
A compound of Formula (I), and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R1, R2, R3 and R20 are each independently H, Cl, Br, F, I, CF3, OCF3, Me or Et; R4 is het or C3-7 cycloalkyl optionally substituted by C1-4alkyl, C1-4 alkoxy, alkoxyalkyl containing 2 to 4 carbon atoms or -S-(C1-4 alkyl); a is 0 or 1; and het is a non-aromatic 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, optionally fused to a 5- or 6- membered carbocyclic group or a second 4-, 5- or 6- membered heterocycle which contains at least one N, O or S heteroatom, wherein the het group is optionally substituted by at least one substituent independently selected from C1-8alkyl, C1-8alkoxy, OH, halo, CF3, OCF3, SCF3, hydroxy-C1-6alkyl, C1-4alkoxy-C1-6alkyl and C1-4alkyl-S-C1-4alkyl; provided that at least one of R1, R2 and R3 are other than H. The compounds of the invention exhibit activity as both serotonin and noradrenaline re-uptake inhibitors and therefore have utility in a variety of therapeutic areas, for example urinary incontinence.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0425766.3A GB0425766D0 (en) | 2004-11-23 | 2004-11-23 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200626543A true TW200626543A (en) | 2006-08-01 |
| TWI300776B TWI300776B (en) | 2008-09-11 |
Family
ID=33548739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094140922A TWI300776B (en) | 2004-11-23 | 2005-11-22 | Novel compounds |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1817281A1 (en) |
| JP (1) | JP4233596B2 (en) |
| KR (1) | KR100886294B1 (en) |
| CN (1) | CN101065355A (en) |
| AP (1) | AP2007004003A0 (en) |
| AR (1) | AR052243A1 (en) |
| AU (1) | AU2005308534A1 (en) |
| BR (1) | BRPI0518486A2 (en) |
| CA (1) | CA2589258A1 (en) |
| CR (1) | CR9171A (en) |
| EA (1) | EA011217B1 (en) |
| GB (1) | GB0425766D0 (en) |
| GT (1) | GT200500337A (en) |
| IL (1) | IL183191A0 (en) |
| MA (1) | MA29038B1 (en) |
| MX (1) | MX2007006138A (en) |
| NL (2) | NL1030485C2 (en) |
| NO (1) | NO20072486L (en) |
| PA (1) | PA8653501A1 (en) |
| PE (1) | PE20061056A1 (en) |
| SV (1) | SV2006002311A (en) |
| TN (1) | TNSN07201A1 (en) |
| TW (1) | TWI300776B (en) |
| UY (1) | UY29224A1 (en) |
| WO (1) | WO2006056884A1 (en) |
| ZA (1) | ZA200703910B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH628885A5 (en) * | 1978-01-01 | 1982-03-31 | Anphar Sa | Piperidine derivative |
| GB0314054D0 (en) * | 2003-06-17 | 2003-07-23 | Pfizer Ltd | Amide derivatives as selective serotonin re-uptake inhibitors |
| PT1638933E (en) * | 2003-06-17 | 2008-07-22 | Pfizer | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors |
-
2004
- 2004-11-23 GB GBGB0425766.3A patent/GB0425766D0/en not_active Ceased
-
2005
- 2005-11-18 EA EA200700920A patent/EA011217B1/en not_active IP Right Cessation
- 2005-11-18 AP AP2007004003A patent/AP2007004003A0/en unknown
- 2005-11-18 CN CNA2005800401025A patent/CN101065355A/en active Pending
- 2005-11-18 CA CA002589258A patent/CA2589258A1/en not_active Abandoned
- 2005-11-18 KR KR1020077014351A patent/KR100886294B1/en not_active IP Right Cessation
- 2005-11-18 AU AU2005308534A patent/AU2005308534A1/en not_active Abandoned
- 2005-11-18 WO PCT/IB2005/003643 patent/WO2006056884A1/en active Application Filing
- 2005-11-18 EP EP05808510A patent/EP1817281A1/en not_active Withdrawn
- 2005-11-18 MX MX2007006138A patent/MX2007006138A/en active IP Right Grant
- 2005-11-18 JP JP2007542360A patent/JP4233596B2/en not_active Expired - Fee Related
- 2005-11-18 BR BRPI0518486-0A patent/BRPI0518486A2/en not_active IP Right Cessation
- 2005-11-21 PE PE2005001362A patent/PE20061056A1/en not_active Application Discontinuation
- 2005-11-21 AR ARP050104866A patent/AR052243A1/en not_active Application Discontinuation
- 2005-11-22 UY UY29224A patent/UY29224A1/en not_active Application Discontinuation
- 2005-11-22 NL NL1030485A patent/NL1030485C2/en not_active IP Right Cessation
- 2005-11-22 GT GT200500337A patent/GT200500337A/en unknown
- 2005-11-22 TW TW094140922A patent/TWI300776B/en active
- 2005-11-23 PA PA20058653501A patent/PA8653501A1/en unknown
- 2005-11-23 SV SV2005002311A patent/SV2006002311A/en unknown
-
2006
- 2006-10-27 NL NL1032760A patent/NL1032760C2/en not_active IP Right Cessation
-
2007
- 2007-05-14 IL IL183191A patent/IL183191A0/en unknown
- 2007-05-15 ZA ZA200703910A patent/ZA200703910B/en unknown
- 2007-05-15 NO NO20072486A patent/NO20072486L/en not_active Application Discontinuation
- 2007-05-22 TN TNP2007000201A patent/TNSN07201A1/en unknown
- 2007-05-23 MA MA29935A patent/MA29038B1/en unknown
- 2007-06-07 CR CR9171A patent/CR9171A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20061056A1 (en) | 2006-11-08 |
| MA29038B1 (en) | 2007-11-01 |
| TWI300776B (en) | 2008-09-11 |
| UY29224A1 (en) | 2006-06-30 |
| CR9171A (en) | 2007-07-04 |
| IL183191A0 (en) | 2007-08-19 |
| AR052243A1 (en) | 2007-03-07 |
| WO2006056884A1 (en) | 2006-06-01 |
| JP4233596B2 (en) | 2009-03-04 |
| NO20072486L (en) | 2007-06-20 |
| NL1030485C2 (en) | 2006-11-07 |
| CA2589258A1 (en) | 2006-06-01 |
| SV2006002311A (en) | 2006-09-14 |
| JP2008520646A (en) | 2008-06-19 |
| AP2007004003A0 (en) | 2007-06-30 |
| EP1817281A1 (en) | 2007-08-15 |
| GT200500337A (en) | 2006-06-13 |
| NL1032760C2 (en) | 2007-04-17 |
| CN101065355A (en) | 2007-10-31 |
| EA200700920A1 (en) | 2007-12-28 |
| BRPI0518486A2 (en) | 2008-11-18 |
| TNSN07201A1 (en) | 2008-11-21 |
| MX2007006138A (en) | 2007-07-19 |
| NL1030485A1 (en) | 2006-05-24 |
| EA011217B1 (en) | 2009-02-27 |
| NL1032760A1 (en) | 2006-12-13 |
| KR20070086599A (en) | 2007-08-27 |
| ZA200703910B (en) | 2008-09-25 |
| PA8653501A1 (en) | 2006-06-02 |
| KR100886294B1 (en) | 2009-03-04 |
| GB0425766D0 (en) | 2004-12-22 |
| AU2005308534A1 (en) | 2006-06-01 |
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