TNSN07201A1 - Derives de n- [(3s)] pyrrolidine -3-yl]benzamide servant d'inhibiteurs de reabsorption de monoamines - Google Patents

Derives de n- [(3s)] pyrrolidine -3-yl]benzamide servant d'inhibiteurs de reabsorption de monoamines

Info

Publication number
TNSN07201A1
TNSN07201A1 TNP2007000201A TNSN07201A TNSN07201A1 TN SN07201 A1 TNSN07201 A1 TN SN07201A1 TN P2007000201 A TNP2007000201 A TN P2007000201A TN SN07201 A TNSN07201 A TN SN07201A TN SN07201 A1 TNSN07201 A1 TN SN07201A1
Authority
TN
Tunisia
Prior art keywords
alkyl
ocf3
alkoxy
het
scf3
Prior art date
Application number
TNP2007000201A
Other languages
English (en)
Inventor
Paul Vincent Fish
Thomas Ryckmans
Alan Stobie
Florian Wakenhut
Gavin Alistair Whitlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN07201A1 publication Critical patent/TNSN07201A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un composé de formule (I) et ses dérivés acceptables du point de vue pharmaceutique et/ou vétérinaire, formule dans laquelle : R1, R2, R3 et R20 représentent chacun indépendamment H, un groupe Cl, Br, F, I, CF3, OCF3, Me ou Et ; R4 représente un groupe het ou cycloalkyle en C3 à C7 facultativement substitué avec un substituant alkyle en C1 à C4, alkoxy en C1 à C4, alkoxyalkyle contenant 2 à 4 atomes de carbone ou –S- (alkyle en C1 à C4 ; a est égal à 0 ou 1 ; et het représente un hétérocycle non aromatique tétra-, penta- ou hexagonal qui contient au moins un hétéroatome de N, O ou S, facultativement condensé avec un groupe carbocyclique penta- ou hexagonal ou un second hétérocycle tétra-, penta- ou hexagonal qui contient au moins un hétéroatome de N, O ou S, le groupe het étant facultativement substitué avec au moins un substituant choisi indépendamment entre des substituants alkyle en C1 à C8, alkoxy en C1 à C8, OH, halogéno, CF3, OCF3, SCF3, hydroxyalkyle en C1 à C8, OH, halogéno, CF3, OCF3, SCF3, hydroxyalkyle en C1à C6, (alkoxy en C1 à C4) (alkyle en C1 à C6) et (alkyle en C1 à C4) –S- (alkyle en C1 à C4) ; sous réserve qu'au moins un des groupes R1, R2 et R3 soit autre que H. Les composés de la présente invention ont une activité comme inhibiteurs de réabsorption de sérotonine et de noradrénaline et sont donc utiles dans divers domaines thérapeutiques, par exemple pour l'incontinence urinaire.
TNP2007000201A 2004-11-23 2007-05-22 Derives de n- [(3s)] pyrrolidine -3-yl]benzamide servant d'inhibiteurs de reabsorption de monoamines TNSN07201A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0425766.3A GB0425766D0 (en) 2004-11-23 2004-11-23 Novel compounds
PCT/IB2005/003643 WO2006056884A1 (fr) 2004-11-23 2005-11-18 Derives de n-[(3s)-pyrrolidin-3-yl]-benzamide utiles comme inhibiteurs de recaptage de monoamine

Publications (1)

Publication Number Publication Date
TNSN07201A1 true TNSN07201A1 (fr) 2008-11-21

Family

ID=33548739

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2007000201A TNSN07201A1 (fr) 2004-11-23 2007-05-22 Derives de n- [(3s)] pyrrolidine -3-yl]benzamide servant d'inhibiteurs de reabsorption de monoamines

Country Status (26)

Country Link
EP (1) EP1817281A1 (fr)
JP (1) JP4233596B2 (fr)
KR (1) KR100886294B1 (fr)
CN (1) CN101065355A (fr)
AP (1) AP2007004003A0 (fr)
AR (1) AR052243A1 (fr)
AU (1) AU2005308534A1 (fr)
BR (1) BRPI0518486A2 (fr)
CA (1) CA2589258A1 (fr)
CR (1) CR9171A (fr)
EA (1) EA011217B1 (fr)
GB (1) GB0425766D0 (fr)
GT (1) GT200500337A (fr)
IL (1) IL183191A0 (fr)
MA (1) MA29038B1 (fr)
MX (1) MX2007006138A (fr)
NL (2) NL1030485C2 (fr)
NO (1) NO20072486L (fr)
PA (1) PA8653501A1 (fr)
PE (1) PE20061056A1 (fr)
SV (1) SV2006002311A (fr)
TN (1) TNSN07201A1 (fr)
TW (1) TWI300776B (fr)
UY (1) UY29224A1 (fr)
WO (1) WO2006056884A1 (fr)
ZA (1) ZA200703910B (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628885A5 (en) * 1978-01-01 1982-03-31 Anphar Sa Piperidine derivative
GB0314054D0 (en) * 2003-06-17 2003-07-23 Pfizer Ltd Amide derivatives as selective serotonin re-uptake inhibitors
PT1638933E (pt) * 2003-06-17 2008-07-22 Pfizer Derivados de n-pirrolidin-3-il-amida como inibidores de recaptação de serotonina e noradrenalina

Also Published As

Publication number Publication date
PE20061056A1 (es) 2006-11-08
MA29038B1 (fr) 2007-11-01
TWI300776B (en) 2008-09-11
UY29224A1 (es) 2006-06-30
CR9171A (es) 2007-07-04
IL183191A0 (en) 2007-08-19
AR052243A1 (es) 2007-03-07
WO2006056884A1 (fr) 2006-06-01
JP4233596B2 (ja) 2009-03-04
TW200626543A (en) 2006-08-01
NO20072486L (no) 2007-06-20
NL1030485C2 (nl) 2006-11-07
CA2589258A1 (fr) 2006-06-01
SV2006002311A (es) 2006-09-14
JP2008520646A (ja) 2008-06-19
AP2007004003A0 (en) 2007-06-30
EP1817281A1 (fr) 2007-08-15
GT200500337A (es) 2006-06-13
NL1032760C2 (nl) 2007-04-17
CN101065355A (zh) 2007-10-31
EA200700920A1 (ru) 2007-12-28
BRPI0518486A2 (pt) 2008-11-18
MX2007006138A (es) 2007-07-19
NL1030485A1 (nl) 2006-05-24
EA011217B1 (ru) 2009-02-27
NL1032760A1 (nl) 2006-12-13
KR20070086599A (ko) 2007-08-27
ZA200703910B (en) 2008-09-25
PA8653501A1 (es) 2006-06-02
KR100886294B1 (ko) 2009-03-04
GB0425766D0 (en) 2004-12-22
AU2005308534A1 (en) 2006-06-01

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TNSN07201A1 (fr) Derives de n- [(3s)] pyrrolidine -3-yl]benzamide servant d'inhibiteurs de reabsorption de monoamines