MA27885A1 - Derives de n-pyrrolidine-3-ylamide servant d'inhibiteurs de reabsorption de serotonine et de noradrenaline - Google Patents

Derives de n-pyrrolidine-3-ylamide servant d'inhibiteurs de reabsorption de serotonine et de noradrenaline

Info

Publication number
MA27885A1
MA27885A1 MA28674A MA28674A MA27885A1 MA 27885 A1 MA27885 A1 MA 27885A1 MA 28674 A MA28674 A MA 28674A MA 28674 A MA28674 A MA 28674A MA 27885 A1 MA27885 A1 MA 27885A1
Authority
MA
Morocco
Prior art keywords
alkyl
aryl
het
alkoxy
serotonin
Prior art date
Application number
MA28674A
Other languages
English (en)
Inventor
Paul Vincent Fish
Michael Jonathan Fray
Deborah Jane Lovering
Alan Stobie
Florian Wakenhut
Gavin Alistair Whitlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0314048.0A external-priority patent/GB0314048D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of MA27885A1 publication Critical patent/MA27885A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

DEPOSANT Société dite : PFIZER INC. REVENDICATION DE PRIORITES GB 17 Juin 2003 GB 0314048.0 US 6 Août 2003 60/493,126 Dérivés de N-pyrrolidine-3-ylamide servant d'inhibiteurs de réabsorption de sérotonine et de noradrénaline Un composé de formule (I) et ses dérivés acceptables du point de vue pharmaceutique et/ou vétérinaire, formule dans laquelle R1 représente H, un groupe alkyle en C1 à C6, -C(X)Y, cycloalkyle en C3 à C8, aryle, het, aryl (alkyle en C1 à C4) ou het (alkyle en C1 à C4) , dans lequel les groupes cycloalkyle, aryle ou het sont facultativement substitués avec au moins un substituant choisi indépendamment entre des substituants alkyle en C1 à C8, alkoxy en C1 à C8, OH, halogéno, CF3, OCF3, SCF3, hydroxyalkyle en C1 à C6, (alkoxy en C1 à C4) (alkyle en C1 à C6) et (alkyle en C1 à C4) S (alkyle en C1 à C4) , R2 représente un groupe aryle ou hétéroaryle, chacun facultativement substitué avec au moins un substituant choisi indépendamment entre des substituants alkyle en C1 à C8, alkoxy en C1 à C8, OH, halogéno, CF3, OCF3, SCF3, hydroxyalkyle en C1 à C6, (alkoxy en C1 à C4) (alkyle en C1 à C6) et (alkyle en C1 à C4) S (alkyle en C1 à C4) ; R3 représente un groupe alkyle en C1 à C6, cycloalkyle en C3 à C8, (cycloalkyle en C3 à C8) (alkyle en C1 à C6) , aryle, het, aryl (alkyle en C8 à C4) ou het (alkyle en C1 à C4) , dans lequel les groupes cycloalkyle, aryle ou het sont facultativement substitués avec au moins un substituant choisi indépendamment entre des substituants alkyle en C1 à C6, alkoxy en C1 à C6, OH, halogéno, CF3, OCF3, SCF3, hydroxyalkyle en C1 à C6, (alkoxy en C1 à C6) (alkyle en C1 à C6) et (alkyle en C1 à C4) S (alkyle en C1 à C4) ; X représente S ou O ; Y représente H, un groupe alkyle en C1 à C6, aryle, het, aryl (alkyle en C1 à C4) ou het (alkyle en C1 à C4) ; et n est égal à 1 ou 2 ; sous réserve que, lorsque n est égal à 1, m est égal à 0 ou 1 et, lorsque n est égal à 2, m est égal à 0, oé, si m est égal à 0, alors * représente un centre chiral. Les composés de la présente invention ont une activité comme inhibiteurs de réabsorption de sérotonine et de noradrénaline et, en conséquence, sont utiles dans divers domaines thérapeutiques, par exemple l'incontinence urinaire.
MA28674A 2003-06-17 2005-12-16 Derives de n-pyrrolidine-3-ylamide servant d'inhibiteurs de reabsorption de serotonine et de noradrenaline MA27885A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0314048.0A GB0314048D0 (en) 2003-06-17 2003-06-17 Novel compounds
US49312603P 2003-08-06 2003-08-06

Publications (1)

Publication Number Publication Date
MA27885A1 true MA27885A1 (fr) 2006-05-02

Family

ID=33554153

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28674A MA27885A1 (fr) 2003-06-17 2005-12-16 Derives de n-pyrrolidine-3-ylamide servant d'inhibiteurs de reabsorption de serotonine et de noradrenaline

Country Status (31)

Country Link
US (2) US7378436B2 (fr)
EP (1) EP1638933B1 (fr)
JP (1) JP4137159B2 (fr)
KR (1) KR100803796B1 (fr)
AP (1) AP2005003467A0 (fr)
AR (1) AR044715A1 (fr)
AT (1) ATE398107T1 (fr)
AU (1) AU2004247487B2 (fr)
BR (1) BRPI0411594A (fr)
CA (1) CA2530159C (fr)
CY (1) CY1110434T1 (fr)
DE (1) DE602004014372D1 (fr)
DK (1) DK1638933T3 (fr)
EA (1) EA009881B1 (fr)
EC (1) ECSP056232A (fr)
ES (1) ES2305776T3 (fr)
HR (2) HRP20050993A2 (fr)
IL (1) IL172063A0 (fr)
IS (1) IS8136A (fr)
MA (1) MA27885A1 (fr)
MX (1) MXPA05013960A (fr)
NL (1) NL1026438C2 (fr)
NZ (1) NZ544046A (fr)
PA (1) PA8605301A1 (fr)
PE (1) PE20050631A1 (fr)
PL (1) PL1638933T3 (fr)
PT (1) PT1638933E (fr)
SI (1) SI1638933T1 (fr)
TW (1) TW200505852A (fr)
UY (1) UY28360A1 (fr)
WO (1) WO2004110995A1 (fr)

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Also Published As

Publication number Publication date
NZ544046A (en) 2009-08-28
IS8136A (is) 2005-11-21
ECSP056232A (es) 2006-04-19
SI1638933T1 (sl) 2008-10-31
IL172063A0 (en) 2009-02-11
JP2006527758A (ja) 2006-12-07
NL1026438C2 (nl) 2005-09-20
ES2305776T3 (es) 2008-11-01
US20050137229A1 (en) 2005-06-23
US7378436B2 (en) 2008-05-27
AP2005003467A0 (en) 2006-12-31
CA2530159A1 (fr) 2004-12-23
EA200501730A1 (ru) 2006-08-25
NL1026438A1 (nl) 2004-12-20
KR20060036927A (ko) 2006-05-02
PA8605301A1 (es) 2005-02-04
ATE398107T1 (de) 2008-07-15
EA009881B1 (ru) 2008-04-28
WO2004110995A8 (fr) 2005-04-21
HRP20050993A2 (en) 2006-03-31
KR100803796B1 (ko) 2008-02-14
DK1638933T3 (da) 2008-07-28
JP4137159B2 (ja) 2008-08-20
EP1638933B1 (fr) 2008-06-11
AR044715A1 (es) 2005-09-21
UY28360A1 (es) 2005-01-31
EP1638933A1 (fr) 2006-03-29
PT1638933E (pt) 2008-07-22
PL1638933T3 (pl) 2008-10-31
PE20050631A1 (es) 2005-09-14
HRP20080339T3 (en) 2008-08-31
AU2004247487A1 (en) 2004-12-23
CA2530159C (fr) 2010-02-02
DE602004014372D1 (de) 2008-07-24
CY1110434T1 (el) 2015-04-29
TW200505852A (en) 2005-02-16
AU2004247487B2 (en) 2010-05-20
US20080306123A1 (en) 2008-12-11
MXPA05013960A (es) 2006-02-24
WO2004110995A1 (fr) 2004-12-23
BRPI0411594A (pt) 2006-08-29

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