EA009242B1 - Enhanced formulations for neutralization of chemical, biological and industrial toxants - Google Patents

Abstract

An enhanced formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The enhanced formulation according to the present invention is non-toxic and non-corrosive and can be delivered by a variety of means and in different phases. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a bleaching activator and water.

Description

This invention is devoted to means and methods for neutralizing toxic chemical, biological and industrial compounds or agents, in particular components of chemical and biological weapons, and methods for their preparation. In particular, this invention is directed to agents containing solubilizing compounds, reactive compounds and bleaching activators, which can be supplied in the form of foaming compositions, sprayable compositions, liquids, fogging compositions and aerosols to increase the rate of neutralization of chemical compounds, and other additives that are intended for destruction or reduction of the influence of certain biological compounds or toxic substances (OM).

Threats from terrorists potentially using weapons of mass destruction are increasing both in the United States and abroad. Issues of application and the threat of using chemical and biological agents as weapons of mass destruction are of paramount importance for both national defense as a whole and municipal authorities.

Some active components of chemical weapons (CW), used by terrorists as a threat, have chemical characteristics that provide an opportunity for the development of countermeasures. The chemicals zorin, soman, and herd (C-agents) are examples of phosphorus-containing compounds that, if chemically altered, may lose their toxicity. Mustard gas, as an example of H-agents, and UX, as an example of Y-agents, can also change chemically and become safe. In addition, some known active components of biological weapons (BW), including botulinum toxin, anthrax bacilli and other spore-forming bacteria, vegetative bacteria, including plague bacteria and various viruses, can also be chemically deactivated.

The use of CW and BO may be accompanied by local or wide dispersal of OM threatening the population. Due to the flexibility of the deployment of substances CW and BO (CBW), attackers can be exposed to them in the whole variety of their physical conditions, in most cases in the form of aerosols and vapors.

An effective, fast and safe (non-toxic and non-corrosive) disinfecting technology is required to restore civilian facilities in the event of an internal terrorist attack. Ideally, this technology should be used in various situations, such as disinfection of open, half-open or closed objects, as well as sensitive equipment. Examples of such facilities for the decontamination of which disinfecting compositions can be used are a stadium (open), an underground metro station (half-open) and a major airport or office building (closed). The foaming option is suitable for increasing the contact time of the composition on a vertical surface.

Disinfection of chemical compounds is primarily focused on chemical warfare agents, in particular on nerve agents (such as C- and Y-agents), and skin

- 1,009242 in bulk (such as mustard gas or just mustard). Reactions involved in the detoxification of chemicals can be divided into substitution reactions and oxidation reactions. The disinfection of biological agents is primarily focused on bacterial spores (for example, anthrax spores), which are considered the most difficult to destroy of all microorganisms. Additional data is discussed in US patent applications with serial numbers 09/607586 and 09/952940.

There is also a need for the quick, safe and effective neutralization of toxic industrial chemicals such as malathion, hydrogen cyanide, sodium cyanide, butyl isocyanate, carbon disulfide and gaseous phosgene.

U.S. Patent Application Serial Number 09/607586 mainly relates to water-based disinfecting technology (ΌΡ-100), which quickly neutralizes the chemical weapons and biological weapons (CBW) chemical agents.

This composition is effective in neutralizing both chemical and biological poisons; safe for the environment (i.e. non-toxic and non-corrosive);

acts on the surface of a number of used products

can be included in a wide variety of carriers (such as foams, liquids, mists), which together satisfy a wide variety of operational goals.

The main interest in the application of this technology by the civilian first-response services (i.e., the fire service, police and chemical safety services, which should be the first to arrive at the site of the attack using CB CB) is followed by the secondary interest associated with the restoration of equipment using the composition . There are technical flaws with the ΌΡ-100 that make it less suitable for use by civilian first responder services. These technical issues include:

1) pH ΌΡ-100 should be adjusted for optimal disinfection of each specific chemical and biological agents. In other words, a specific composition is required to neutralize each specific chemical agent. Despite the fact that adjusting the pH of the composition in the laboratory is relatively simple, doing it in the field is quite difficult and, as a rule, is not acceptable for primary users of this technology (i.e., civilian first-response services);

2) the reaction rate for one chemical agent, mustard gas, is significantly lower compared to the reaction rate for other chemical poisonous substances.

These technical problems limit the effectiveness of the ΌΡ-100 in actual use. The modified ΌΡ-100 композиция composition disclosed in US Patent Application Serial Number 09/952940 aims at the need to adjust the pH for each particular OM (i.e., the first technical problem described previously). However, although ΌΡ-100Ά is improved by funcioning the composition at one particular pH, this does not completely solve the problem and does not even touch upon the second technical problem (i.e., the relatively low reaction rate in the case of mustard gas). In addition, in some ΌΡ-100/100 вариантах variants, short chain alcohols (i.e., isobutanol, isopropanol) can be used, which can cause ignition if the composition is packaged in concentrated form. In addition, some versions of ΌΡ-100 / 100Ά use diethylene glycol monobutyl ether, which can cause false alarms of sensors and detectors for certain chemical agents (especially older sensors that are used in some military installations).

For comparison, we give an example of a preferred composition for ΌΡ-100.

ΌΡ-100.

2.6% Waps. | IA1 80MS (cationic surfactant);

3.3% Abodep 477 (cationic hydrotropic substance);

0.8% 1-dodecanol (fatty alcohol);

0.5% isobutanol (short chain alcohol);

1.6% isopropanol (short chain alcohol);

0.1% 1diag 8000 ™ (cationic polymer);

1.6% diethylene glycol monobutyl ether (solvent);

4% sodium bicarbonate (buffer and peroxide activator);

4% hydrogen peroxide (liquid oxidizing agent);

75% water.

For optimal decontamination of mustard gas and anthrax spores, the pH of this composition should be adjusted to a value of 8; for optimal UX disinfection, the pH of this composition should be adjusted to 10.5. Effective disinfection of chemical poisons is mainly observed at pH in the range of 8-10. For further comparison, we give an example of a preferred composition for ΌΡ-100 A.

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ΌΡ-100Α.

5.3% Waps. | IA1 80MS (cationic surfactant);

2.8% Abodep 477 (cationic hydrotropic substance);

0.65% 1-dodecanol (fatty alcohol);

0.6% isobutanol (short chain alcohol);

0.1% 1diag 8000 ™ (cationic polymer);

1.35% diethylene glycol monobutyl ether (solvent);

4% sodium bicarbonate (buffer and peroxide activator);

4% hydrogen peroxide (oxidizing agent);

81% water.

For optimal decontamination of mustard gas and anthrax spores, the pH of this composition should be adjusted to a value of 8; for optimal disinfection, UX, the pH should be adjusted to a value of 10. Effective disinfection of chemical poisons is mainly observed at pH in the range of 8-10. Also, less than the optimal disinfection of all toxic substances, the pH of this composition should be adjusted to a value of 9.2.

In both examples shown above for ΌΡ-100 and ΌΡ-100Α, hydrogen peroxide interacts with a bicarbonate salt, resulting in the formation of a highly reactive negatively charged nucleophilic compound, hydroperoxycarbonate (HCO ^- ₄ ), which is a strong oxidizing agent. Other negatively charged nucleophiles are formed by the use of hydrogen peroxide, including hydroxyl ions (OH ^- ) and hydroperoxide ions (UN ^- ). The functions of other components in these compositions are discussed in more detail in US patent applications with serial numbers 09/607586 and 09/952940.

The present invention provides improved disinfecting compositions (generally referred to as ΌΡ-200) containing whitening activators that result in faster reaction kinetics, improve the effects of the compositions, and eliminate the need for pH adjustment. Although whitening activators are typically used in (anionic) washing detergents, this invention can be used with cationic surfactants, where the good solubility of the activator in water favors a high reaction rate. The desired whitening activator for the present invention is preferably an activator that is soluble in water, non-toxic, non-flammable and inexpensive.

Glucose pentaacetate is an O-acetyl peroxide activator that is used as an activating agent in a sterilizing composition that contains a cationic surfactant and inorganic peroxide (see Japanese Open Patent Publication No. 62-155203 for Sterilizing Indoor Cattle Composition (1987)) . Glucose pentaacetate is solid at room temperature (i.e., melting point 110 ° C) and insoluble in water. In an aqueous solution containing peroxide, it dissolves very slowly, since it interacts with peroxide. At a glucose pentaacetate concentration of approximately 2%, the dissolution process takes several hours. This circumstance makes it less acceptable for rapidly deploying configurations.

SUMMARY OF THE INVENTION (DISCLOSURE OF THE INVENTION)

This invention is a composition for neutralizing at least one toxic substance, which contains at least two solubilizing compounds, where at least one solubilizing compound is a cationic surfactant and at least one solubilizing compound is a cationic hydrotropic substance;

at least one reactive compound, where at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium perborate, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate;

at least one whitening activator, which is selected from the group consisting of O-acetyl, ила-acetyl and whitening activators of the nitrile group, where at least two solubilizing compounds, at least one reacting compound, and at least one bleaching activator when mixed with water and exposure with at least one toxic substance, neutralizes at least one toxic substance.

In a preferred embodiment, the cationic surfactant contains a quaternary ammonium salt, more preferably cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, alkyl dimethylbenzylammonium salt, tetrabutylammonium bromide, or \ νΐΤί. The composition may further comprise a water-soluble polymer, preferably polyvinyl alcohol, guar gum (cationic or nonionic), polydialldimethylammonium chloride, polyacrylamide, polyethylene oxide, glycerol, polyethylene glycol 8000 (PEC 8000) or. 8000 ™ gadiate (2-hydroxypropyl resin)

- 3 009242 or a combination thereof. The composition may also further comprise a fatty alcohol with 8-20 carbon atoms per molecule, a solvent (preferably dipropylene glycol methyl ether, or diethylene glycol monobutyl ether, or a combination thereof) and / or a carbonate salt (preferably potassium bicarbonate, sodium bicarbonate, ammonium bicarbonate, ammonium bicarbonate lithium bicarbonate, ammonium carbonate or potassium carbonate, or a combination thereof).

Preferably, the whitening activator is soluble in water, preferably acetylcholine chloride, monoacetin (glycerol monoacetate), diacetin (glycerol diacetate), 4-cyanobenzoic acid, ethylene glycol diacetate, propylene glycol monoethyl acetate, methyl acetate, methyl acetate, methyl acetate, methyl acetate, methyl acetate diethylene glycol, glycerol triacetate or propylene glycol diacetate, or a combination thereof. Alternatively, the whitening activator may be insoluble in water, preferably tetraacetylethylenediamine (ΤΑΕΌ), η-nonanoyloxybenzene sulfonate (ΝΟΒ8), or Ν-acetylglucosamine, or a combination thereof. When mixing the composition with water, it is preferred that the pH of the composition is in the range of about 9.6 to about 9.8. In one embodiment of the invention, the composition comprises substantially

1-10% benzalkonium chloride;

1-8% propylene glycol diacetate;

1-16% hydrogen peroxide;

2-8% potassium bicarbonate.

The invention also provides a composition for neutralizing at least one toxic substance, which contains at least one cationic surfactant;

at least one reactive compound, wherein at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium perborate, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate;

at least one whitening activator selected from the group consisting of O-acetyl, Ν-acetyl and whitening activators of the nitrile group;

at least one carbonate salt of at least not one reacting compound; where at least one surfactant, at least one reactive compound, at least one bleaching activator, and at least one carbonate salt, when mixed with water and exposure to at least one toxic substance, neutralizes at least one toxic substance .

In a preferred embodiment, when mixed with water, the pH of the composition is about 9.6 and about 9.8; and the cationic surfactant contains a quaternary ammonium salt, more preferably benzalkonium chloride. At least one carbonate salt is preferably potassium bicarbonate, sodium bicarbonate, ammonium bicarbonate, ammonium hydrogen carbonate, lithium bicarbonate, ammonium carbonate or potassium carbonate, or a combination thereof. One of the implementations contains at least one cationic surfactant, at least one reactive compound, at least one whitening activator and at least one carbonate salt. Preferably, the whitening activator is soluble in water, more preferably it is acetylcholine chloride, monoacetin (glycerol monoacetate), diacetin (glycerol diacetate), 4-cyanobenzoic acid, ethylene glycol diacetate, propylene glycol monomethyl ether acetate, methylene acetate monomethyl ether, methyl acetate, diethylene glycol ether, glycerol triacetate or propylene glycol diacetate, or a combination thereof.

The invention also provides a composition for neutralizing at least one toxic substance, which contains at least one cationic surfactant;

at least one reactive compound, wherein at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium perborate, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate;

at least one water-soluble whitening activator selected from the group consisting of O-acetyl, Ν-acetyl and whitening activators of the nitrile group;

where at least one surfactant, at least one reactive compound and at least one water-soluble whitening activator, when mixed with water and exposure to at least one toxic substance, detoxifies the at least one toxic substance.

In a preferred embodiment, the at least one water-soluble whitening activator is acetylcholine chloride, monoacetin (glycerol monoacetate), diacetin (glycerol diacetate), 4-cyanobenzoic acid, ethylene glycol diacetate monomethyl ether, glycol monoacetate, methylene acetate, glycol monoacetate, methylene acetate , three

- 4 009242 glycerol acetate or propylene glycol diacetate or a combination thereof. The cationic surfactant preferably contains a quaternary ammonium salt, more preferably benzalkonium chloride. In addition, the composition preferably contains at least one carbonate salt, more preferably potassium bicarbonate, sodium bicarbonate, ammonium bicarbonate, ammonium bicarbonate, lithium bicarbonate, ammonium carbonate or potassium carbonate, or a combination thereof. When mixed with water, the pH of the composition is from about 9.6 to about 9.8. One embodiment comprises at least one cationic surfactant, at least one reactive compound, and at least one water-soluble whitening activator.

The invention also provides a composition for neutralizing at least one toxic substance. The composition contains at least one solubilizing compound selected from the group consisting of a cationic hydrotropic substance and a fatty alcohol containing 8-20 carbon atoms per molecule;

at least one reactive compound, where at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea-hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium perborate, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate;

at least one whitening activator selected from the group consisting of O-acetyl, Ν-acetyl and whitening activators of the nitrile group;

where at least one solubilizing compound, at least one reacting compound and at least one whitening activator, when mixed with water and exposure to at least one toxic substance, neutralizes at least one toxic substance.

The invention also represents the above compositions, packaged in kits.

In a first embodiment, the kit includes a pre-mixed component comprising at least two solubilizing compounds;

a first component comprising at least one whitening activator; a second component containing at least one reactive compound.

The first embodiment may also contain water and a base, the pre-mixed component may additionally contain a water-soluble polymer, at least one whitening activator, preferably propylene glycol diacetate, glycerol diacetate and / or ΤΑΕΌ, the pre-mixed component may further contain 8- fatty alcohol 20 carbon atoms per molecule; the at least one reactive compound may be hydrogen urea peroxide with a second component comprising at least one reactive compound that further comprises sodium percarbonate, and the pre-mixed component may further comprise a short chain alcohol.

The second embodiment includes a first pre-mixed component containing at least two solubilizing compounds and water;

a second pre-mixed component containing at least one bleaching activator and at least one reactive compound, where at least one bleaching activator is in solid form.

In a second embodiment, the first pre-mixed component preferably further comprises an acid, at least one bleaching activator preferably contains acetylcholine chloride, at least one reacting compound contains urea hydrogen peroxide, and at least one bleaching activator contains ΤΑΕΌ at least one bleaching activator per capsule to prevent premature reaction with at least one reacting compound.

The third embodiment includes a pre-mixed component containing at least two solubilizing compounds and at least one whitening activator;

a component containing at least one reactive compound.

In a third embodiment, the pre-mixed component may further comprise water and an acid, the component comprising at least one reactive compound may comprise sodium percarbonate and additionally acid, and the at least one reactive compound may comprise urea hydrogen peroxide with the component, containing at least one reactive compound, further comprising a mixture of potassium carbonate and potassium bicarbonate.

The objectives, advantages, new properties and, in addition, the boundaries of the application of this invention, which will be set forth in this description together with the accompanying drawings, will become apparent.

- 5 009242 for a specialist after examination of the above, or can be studied by practical implementation of the invention. The objectives and advantages of the invention can be realized and achieved using the methods and combinations specified in the application for the invention.

Brief Description of the Drawings

The accompanying drawings, which are included and form part of the description, illustrate one or more implementations of the present invention and together with the description help to explain the principles of the invention. The drawings are only illustrative of one or more preferred embodiments of the invention and cannot be construed as limiting the invention.

FIG. 1 is a graph of the effect of ΌΡ-200 components on the elimination of BaeShik d1oYdp spores (anthrax simulator).

FIG. 2 is a schematic diagram of a preferred mixing procedure for the first fast-paced configuration of the present invention (ΌΕ-200 ΗΕ quick deployment).

FIG. 3 is a schematic diagram of a preferred mixing procedure for the second fast-paced configuration of the present invention (ΌΕ-200 быстрого quick-deployment suspension).

DESCRIPTION OF PREFERRED EMBODIMENTS (BEST MODES FOR CARRYING OUT THE INVENTION)

The purpose of this invention is the creation of a single composition that neutralizes the adverse effects of chemical and biological toxic substances, where the toxic substance is any chemical or biological substance, component, species or agent that, while remaining untreated, by chemical or biological effects on life processes can, if leave without treatment, cause death, temporary disability or have a permanent harmful effect on people and animals. Such toxic substances include all chemical or biological poisonous substances, regardless of their origin or method of preparation and where they are produced, whether they are contained in ammunition or elsewhere. Neutralization is defined as mitigation, detoxification, disinfection or other types of destruction of toxic substances in such a way that they become unable to exert acute adverse effects on humans or animals. The composition and the described variants of the present invention can neutralize the infection, however, they themselves do not cause significant negative effects on the health of people and animals.

This invention is directed to an important subset of chemical and biological compounds that encompasses chemical warfare (CW) and biological (BO) weapons of mass destruction. The present invention is also directed to toxic substances that are potentially capable of adversely affecting human and animal health. Such harmful effects include infections, acute and chronic diseases, and fatal outcomes. Such toxic substances can be found in agricultural premises, on livestock and dairy farms, in the process of food production or in packaging equipment. In addition, this invention is directed to meeting the need for such a composition, which itself is not toxic and corrosive and which can be delivered using a variety of means and in various forms. Some implementations are discussed in US patent applications, serial numbers 09/607586 and 09/952940. This invention provides an additional implementation, which has significant differences from the previously described embodiments, and which will be described below.

As used herein, the term composition is defined as an activated product or solution (eg, an aqueous solution) that is used by applying it to a surface or body to neutralize, together or without adding gas (eg, air) to form a foam. Unless specifically indicated, the concentrations listed, constituents or components are relative to the percentage of weight of the total activated solution.

The term water here is defined as pure water, tap water, deionized water, demineralized water, sea water or any other liquid, especially containing H ₂ O.

An example of a minimum list of components for the ΌΡ-200 composition, with which you can achieve a significant rate of destruction of spores, includes four components:

1) a solubilizing compound selected from the group that contains a cationic surfactant (for example, Waps. | Ia1 80MS), a cationic hydrotropic substance (for example, Abodsp 477) and a fatty alcohol (for example, 1-dodecanol);

2) a whitening activator selected from the group that contains O-acetyl, Ν-acetyl and peroxide activators of the nitrile group (for example, propylene glycol diacetate);

3) a reactive component (for example, hydrogen peroxide, peracetic acid);

4) water.

The solubilizing component is used to effectively modify the toxic substance so that it becomes sensitive to the effects, while the reacting component is used to destroy and neutralize the toxic substance, and the whitening activator enhances this process.

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Examples of suitable cationic surfactants are quaternary ammonium salts and polymeric quaternary salts. Examples of suitable quaternary ammonium salts are cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, alkyl dimethylbenzylammonium salt and tetrabutylammonium bromide. A preferred cationic surfactant is ^ νίΐοο Waps. | Ia1 80MS ™, which is a mixture of benzyl (C12-C1b) alkyl dimethylammonium chlorides. The concentration of the quaternary ammonium salt, which is used in the ΌΕ-200 compositions, should preferably be no more than 10%, since at high concentrations the quaternary ammonium salt becomes very toxic to humans and the environment.

Examples of suitable cationic hydrotropic substances are tetrapentylammonium bromide, triacetylmethylammonium bromide and tetrabutylammonium bromide. A preferred cationic hydrotropic substance is νίΐοο Lbodei 477 ™, which is pentamethyltalic alkyltrimethylenediammonium dichloride.

Examples of suitable fatty alcohols are alcohols having 8-20 carbon atoms per molecule, such as 1-dodecanol, pure dodecanol, hexadecanol and 1-tetradecanol.

Examples of suitable whitening activators are discussed later.

Examples of suitable reacting compounds are: peroxide compounds;

hydrogen peroxide;

urea-hydrogen peroxide complex;

sodium perborate;

sodium percarbonate;

sodium perhydrate carbonate; sodium peroxypyrophosphate; sodium hydroperoxysilicate; pyrophosphate peroxide adducts; citrates;

sodium sulfate;

urea and sodium silicate;

activated peroxide compounds (e.g. hydrogen peroxide + bicarbonate);

peracetic acid;

oximes (e.g., butane-2,3-dione, mono-oximet ion and benzohydroxamate);

alkoxides (e.g. methoxide and ethoxide);

aryl oxides (e.g., aryl substituted benzensulfonates);

aldehydes (e.g. glutaraldehyde);

peroxymonosulfate;

Fenton's reagent (a mixture of iron and peroxide);

sodium hypochlorite.

Using these reacting components in the ΌΕ-200 composition, various negatively charged nucleophiles can be obtained, for example, hydroxyl ions (OH ^- ) and hydroperoxide ions (UN ^- ), which are formed using hydrogen peroxide; and / or hydroperoxycarbonate ions (HCO ₄ ^- ), which are formed by combining hydrogen peroxide with a carbonate salt. Hydroperoxycarbonate ions (HCO4 ^- ) are a stronger oxidizing agent than hydroxyl ions (OH ^- ) or hydroperoxide ions (UN ^- ), and are especially effective in reaction with biological toxic substances. When using hydrogen peroxide in ΌΕ-200 compositions, it is preferable that its concentration be less than about 10%, since high concentrations are very corrosive, especially when the concentration of hydrogen peroxide is 30-50%.

In order to achieve very high spore killing rates, it is preferable to add a carbonate salt (e.g. sodium bicarbonate or potassium bicarbonate) to the above minimum list of constituents for the above-described 200-200 compositions. When a peroxide compound (e.g., hydrogen peroxide) is used as a reactive compound of the ΌΕ-200 composition, the added carbonate salt is combined, for example, with hydrogen peroxide to form highly active hydroperoxycarbonate (HCO ₄ ^- ) compounds. The addition of carbonate salts may also cause the composition to be buffered to optimize the pH.

Thus, the minimum list of components for ΌΕ-200 compositions, with which you can achieve very high rates of destruction of spores, may contain five components:

1) a solubilizing agent selected from the group that contains a cationic surfactant (for example, Waps. | Ia1 80MS), a cationic hydrotropic substance (for example, Abodep 477) and a fatty alcohol (for example, 1-dodecanol);

2) a whitening activator selected from the group that contains O-acetyl, Ν-acetyl and peroxide activators of the nitrile group (for example, propylene glycol diacetate);

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3) a reactive component (for example, hydrogen peroxide, peracetic acid, etc.);

4) a carbonate salt (e.g. sodium bicarbonate);

5) water.

Examples of suitable carbonate salts are potassium bicarbonate, sodium bicarbonate, ammonium bicarbonate, ammonium bicarbonate, lithium bicarbonate, ammonium carbonate and potassium carbonate.

FIG. Figure 1 shows the results of a disinfection test for Bacillus spores (initial concentration 10 ⁷ spores / ml). Spores for 1 h (composition pH was 9.8) were exposed with four different subcombinations of different components of the EE-200 compositions. The degree of destruction of spores was determined by culturing surviving organisms. As shown in FIG. 3, significant dispute destruction was achieved by applying two different combinations:

1) an aqueous solution of 2% Waps. | Ia1 (cationic surfactant), 2% propylene glycol diacetate (whitening activator) and 2% hydrogen peroxide (oxidizing agent);

2) an aqueous solution of 2% Waps. | Ia1 (cationic surfactant), 5% potassium bicarbonate (buffer and peroxide activator) and 2% hydrogen peroxide (oxidizing agent).

Very significant spore killing was achieved by using a third combination containing (3) an aqueous solution of 2% Waps. | Ia1 (cationic surfactant), 2% propylene glycol diacetate (whitening activator), 5% potassium bicarbonate (buffer and peroxide activator) and 2% hydrogen peroxide (oxidizing agent).

Next, various alternative embodiments and configurations of the EE-200 compositions will be presented.

EE-200NE (high foam).

This invention is an improved disinfecting composition for high foam applications ('ΌΕ-200ΗΕ). Example EE-200HE composition contains

1-4% (preferably 2%) Waps. | IA1 80MS (cationic surfactant);

0.5-3% (preferably 1%) Lbodei 477 (cationic hydrotropic substance);

0.2-0.8% (preferably 0.4%) 1-dodecanol (fatty alcohol);

0.05-0.1% 1diag 8000 ™ (water soluble cationic polymer);

0.5% dipropylene glycol methyl ether (solvent);

0.1-10% (preferably 1-4%) hydrogen peroxide (oxidizing agent);

0.1-10% (preferably 2-8%) bicarbonate salt (buffer and peroxide activator);

1-4% propylene glycol diacetate (whitening activator);

67-97% water.

This composition is effective at a pH in the range of 7.5-10.5. For optimal disinfection of all toxic substances, the pH of this composition can be adjusted to a value of 9.6-9.8. This high-foam composition includes a water-soluble cationic polymer (e.g., 1diag 8000 ™), which increases the bulk viscosity of the solution and forms a more stable foam.

Examples of suitable water-soluble non-anionic polymers are polyvinyl alcohol, guar gum, (cationic or non-ionic) ammonium polydialldimethyl chloride, polyacrylamide, polyethylene glycol 8000 (PEC 8000) and 1diag 8000 ™ (guar gum 2-hydroxypropyl ether). A cationic polymer is more preferred than a nonionic polymer; the anionic polymer does not work well. Fatty alcohol 1-dodecanol is used to increase the surface viscosity of the lamella foam, as well as to increase the stability of the foam with respect to drainage and destruction of the bubbles.

EE-200EE (low foam).

The present invention is an improved disinfecting composition for low foam applications ('UE-200E). An example of an EE-200EE composition contains

4%! 80MS (cationic surfactant);

0.4% Eaigash1be EEL | N.H-bis- (2-hydroxyethyl) dodecanamide | (foam booster);

1-4% propylene glycol diacetate (whitening activator);

0.5% dipropylene glycol methyl ether (solvent);

0.05-0.1% 1diag 8000 ™ (water soluble cationic polymer);

0.1-10% (preferably 1-4%) hydrogen peroxide (oxidizing agent);

0.1-10% (preferably 2-8%) bicarbonate salt (buffer and peroxide activator);

71-94% water.

This composition is generally effective at a pH of 7.5-10.5. For optimal disinfection of all toxic substances, the pH of this composition can be adjusted to a value of 9.6-9.8.

The term high foam refers to a composition that is capable of forming a highly stable and stable foam, while low foam refers to a composition that forms a less stable foam. The following tables show the improved effects of the EE-200HE and EE-200EE compositions compared to the EE-100L composition. The designation ΝΏ refers to concentrations below the detectable limits, and RSE refers to propylene glycol diacetate (the preferred whitening activator).

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Table 1

Summary of reaction rates for a mustard gas simulator (2-chloroethylphenyl sulfide)

Composition mustard gas simulator (% disinfection) 1 minute 15 minutes 60 min ΏΡ-100Α (pH 8) eighteen 42 81 ΌΡ-100Α (pH 9.2) sixteen 38 83 ΌΡ-200ΗΡ (2% ΡΟΌ / 3% H ₂ O ₂ / 4.5% bicarb) 42 62 Νϋ ΌΡ-200ΗΡ (2% SSR / 3.5% H ₂ O ₂ /4% bicarb) 94 98 Νϋ OR-200BR (2.5% ΡΟϋ / 3% H ₂ O ₂ / 4.5% bicarb) 55 91 ΝΌ

table 2

Generalization of reaction rates for a UC simulator (O-ethyl 8-ethylphenylphosphonothioate)

Composition UX simulator (% disinfection) 1 minute 15 minutes 60 min ΌΡ-100Α (pH 10) 45 99 ΝΌ ΌΡ-100Α (ρΗ 9.2) 33 71 93 ΌΡ-200ΗΡ '(2% ΡΟΌ / 3% H ₂ O ₂ / 4.5% bicarb) 63 98 ΝΌ ΌΡ-200ΗΕ (2% ΡΟΌ / 3.5% H ₂ O ₂ /4% bicarb) 66 99 ΝΟ ΌΓ-200ΙΓ (2.5% Ρ6Ό / 3% H ₂ O ₂ / 4.5% bicarb) 79 98 ΝΌ

Table 3

Generalization of reaction rates for a 0-agent simulator (diphenylchlorophosphate)

Composition 6-agent simulator (% disinfection) 1 minute 15 minutes 60 min ΌΡ-100Α (pH 8) 53 ΝΌ ΝΌ ΌΡ-100Α (pH 9.2) ΝΌ ΝΌ ΝΌ ΌΡ-200ΗΡ (2% Ρ6Ό / 3% H ₂ O ₂ / 4.5% bicarb) ΝΌ ΝΌ ΝΌ ΌΡ-200ΗΡ (2% ΡΟΌ / 3.5% H ₂ O ₂ /4% bicarb) ΝΌ ΝΌ ΝΌ ΌΡ-200ΕΡ (2.5% Ρ6Ό / 3% H ₂ O ₂ / 4.5% bicarb) ΝΌ ΝΌ ΝΌ

Table 4

Generalization of reaction rates for anthrax simulator (Vasya1i§ §1ο6ί§ίί disputes)

Composition anthrax simulator anthrax simulator % destroyed after 30 min % destroyed after 60 min OR-SOA (pH 8) 99.99 99.99999 ϋΡ-ΙΟΟΑ (pH 9.2) 90 99.9 ϋΡ-200ΗΡ (2% ΡΟϋ / 3% H ₂ O ₂ / 4.5% bicarb) 99.99999 99.99999 ОГ-200ЬР (2.5% ΡΟϋ / 3% Н ₂ О ₂ / 4.5% bicarb) 99.99999 99.99999

The differences between the ΌΤ-200 and ΌΤ-100 / 100Α compositions are as follows:

ΌΤ-200 is active against all toxic substances at a single pH value. The composition is effective at pH values in the range of about 7.5 and 10.5; more effective at a pH in the range of about 9.2 and 9.8; and most effective at a pH in the range of about 9.6 and 9.8;

ΌΤ-200 works better against mustard gas;

ΌΤ-200 acts better against bacterial spores;

ΌΤ-200 has lower concentrations of cationic surfactant and / or cationic hydrotropic substance, which further reduces (already low) toxicity and corrosion

- 9 009242 compositions;

ΌΡ-200 has a lower concentration of the component that ensures the stability of the foam, 1 dodecanol;

ΌΡ-200 does not use short-chain alcohol (for example, isobutanol, isopropanol), which causes ignition problems when packaging the composition in concentrated form;

ΌΡ-200 does not use diethylene glycol monobutyl ether (ΌΕΘΜΒΕ), which can cause a false alarm of some sensors and detectors for certain chemical ΟΒ (especially old sensors that are used in some military circuits);

ΌΡ-200 may contain a lower concentration of hydrogen peroxide, which also reduces the (already low) toxicity and corrosion of the composition.

Additional differences between the ΌΡ-200 and ΌΡ-100Ά are as follows:

ΌΡ-200 works optimally at a higher pH value (about 9.6–9.8) compared to ΌΡ-100ΌΡ. However, it should be noted that this is a typical pH value for common household products, such as laundry detergents, shampoos, and dishwashing detergents;

ΌΡ-200 has more individual components that must be stored separately (for example, hydrogen peroxide and a bleaching activator) from the main composition before use, compared to ΌΡ-100Ά (where only one component is hydrogen peroxide should be stored separately). This issue will be considered in more detail below.

One of the reasons for the better effect of ΌΡ-200 compositions (for example, ΌΡ-200ΗΡ and ΌΡ-200ΕΡ) compared to ΌΡ-100 or ΌΡ-100Ά is the addition of a bleaching activator (for example, propylene glycol diacetate). Bleaching activators can be compounds with Ο- or Ν-linked acetyl groups that interact with the strongly nucleophilic hydroperoxide anion (ΟΟΗ ^- ), to produce peroxygenated compounds that are more effective oxidizing agents than hydrogen peroxide alone

Oh Oh

II II

COP — 1_ + UN '“> COP — UN + L

Since 1950, a number of different whitening activators have been used in commercial washing detergents, as well as in other commercial products. The most common activators are tetraacetylethylenediamine (ΤΑΕΌ), which is mainly used in Europe and Asia, and η-nonanoyloxybenzene sulfonate (ΝΟΒ8), which is mainly used in the United States. ΝΟΒ8 is a proprietary chemical of Proctor & Gamble (Rgoe! Og & SachYe). Β The washing detergent contains hydrogen peroxide in solid form (usually in the form of sodium perborate, which reacts in water to form a hydroperoxide anion). The addition of a bleach activator significantly improves the ability of the washing detergent to remove stains from clothes.

It should be noted that ΤΑΕΌ and ΝΟΒ8 whitening activators are highly insoluble in water (for example, the solubility of ΤΑΕΌ at 25 ° C is only 0.1%). In order to get around this problem in the washing detergent, solid ΤΑΕΌ or ΝΟΒ8 particles are converted into suspension form by stirring in the washing machine, where they slowly interact with hydrogen peroxide in the detergent. However, mixing with ΌΡ-200 compositions creates practical problems; therefore, a water soluble whitening activator is preferred.

Suitable water-soluble whitening activators are short-chain organic compounds containing an ether linkage, for example ethylene glycol diacetate, propylene glycol monomethyl ether acetate, methyl acetate, dimethyl glutarate, diethylene glycol monoethyl ether, glycerol diacetate, glycerol diacetate, glycerol diacetate, glycerol diacetate, glycerol diacetate, glycerol diacetate. A preferred water-soluble whitening activator is propylene glycol diacetate (ΡΘΌ), which is presented below

Oh SNs o and ι ί)

CH3 — C — OCH ₂ CHO — C — CH3

This molecule interacts with hydroperoxide anions (ΟΟΗ ^- ) and, through the loss of ether bonds, forms two peroxygenated molecules.

Propylene glycol diacetate also acts as an organic solvent, which is highly effective for solubilizing insoluble organic molecules (for example, toxic components of chemical weapons, as well as foam stabilizers / enhancers such as 1-dodecanol and Eaigash1be ΌΕΑ). Therefore, an additional function of this compound is that it can be used to supplement the solvent - diethylene glycol monobutyl ether (ΌΕΘΜΒΕ), which is used in the compositions ΌΡ-100 and ΌΡ-100 компози, or to supplement the solvent - dipropylene glycol methyl ester, which is used in some ΌΡ -200 compositions. Thus diacetate

- 10 009242 propylene glycol becomes suitable for dual use (i.e., as a solvent and as a whitening activator).

Bleaching activators are generally not stable in water over a long period of time. This is especially true when aqueous solutions have a high pH> 10. Therefore, to increase the shelf life, it is preferable that propylene glycol diacetate (or another bleaching activator) be stored separately from the aqueous solution before use. This is not much different from other products that use bleaching activators (for example, washing detergents), where prior to use all components of the composition are kept dry and separate (in the case of washing detergent, the bleaching activator is placed in a capsule to prevent its reaction with the peroxide component before until both components mix with water).

Another example of a water-soluble whitening activator is ethylene glycol diacetate, which works well in ΌΡ-200 formulations. However, when ethylene glycol diacetate interacts with hydrogen peroxide, ethylene glycol (i.e. antifreeze) is formed, which is a relatively toxic by-product. Propylene glycol diacetate, on the other hand, does not form this relatively toxic by-product.

ΌΡ-200ΝΡ (non-foaming).

The present invention also relates to a non-foaming composition (ΌΡ-200ΝΡ), which can be used for specific applications, for example for the destruction of biological organisms, for batch processing (for example, in the processes of neutralizing a chemical warfare agent by disinfection, for example in a solution bath) or for spraying. A preferred example of this composition contains (amounts are illustrative)

1-10% (preferably 2.5%) benzalkonium chloride (cationic surfactant);

1-8% propylene glycol diacetate (whitening activator);

1-16% hydrogen peroxide (oxidizing agent);

2-8% potassium bicarbonate (buffer and peroxide activator);

65.5-93.5% water.

For optimal action, the pH of the composition can be adjusted to between about 9.6 and 9.8; the composition is effective for disinfecting all toxic substances.

ΌΡ-100Ε.

This invention is also an improved version of ΌΡ-100Α, which uses a whitening activator - propylene glycol diacetate. The preferred implementation of this improved composition (ΌΡ-100Ε) contains (quantities are illustrative)

5.3% Wapdia! 80MS;

2.8% Abodep 477;

0.65% 1-dodecanol;

0.5% isobutanol;

0.1% 1diag 8000 ™;

1.35% diethylene glycol monobutyl ether;

2-8% bicarbonate salt;

1-4% hydrogen peroxide;

1-4% propylene glycol diacetate;

73-85% water.

For optimal action against all toxic substances, the pH of this composition can be adjusted to between about 9.6 and 9.8. The effect of ΌΡ-100Ρ (2% ΡΘΌ / 3% H ₂ O ₂ / 3.75% bicarbonate salt) against chemical imitators is shown in table. 5.

Table 5

Generalization of reaction rates in a kinetic test

ΌΡ-100Ε songs

Simulator % disinfection 1 minute 15 minutes 60 min Mustard gas 83 92 Νϋ C agents Νϋ Νϋ Νϋ UX 66 96 Νϋ

After a 30-minute exposure with ΌΡ-100Ρ, experiments against an anthrax spore simulator (Baehiz dlOdnp) showed spore elimination of 99.9999% (7-bcd).

Instead of propylene glycol diacetate, other whitening activators (for example, water insoluble ΝΟΒ8 or ΤΑΕΌ) can be used in the ΌΡ-100Ε composition. However, as indicated above, instead of the present liquid solution, a suspension is obtained.

In the table. 6, some differences between the ΌΡ-100, ΌΡ-100Α, ΌΡ-100Ρ, ΌΡ-200ΗΡ, ΌΡ-200ΕΡ, ΌΡ-200ΝΡ and ^ Ρ-200ΗΡ-suspension are summarized.

- 11 009242

Table 6

Comparison of various disinfecting compositions

composition adjustments required. pH improved kinetics reduction of flammable constituents forms highly stable foam can use sea water ϋΡ-100 Yes not not Yes not ϋΡ-ΙΟΟΑ not not not Yes not ER-100E not Yes not Yes Yes EE-200NE not Yes Yes Yes Yes OG-200IE not Yes Yes not Yes ϋΡ-200ΝΡ not Yes Yes not Yes ϋΡ-200ΗΡsuspension not Yes Yes Yes Yes

Kit configurations.

The following sections present various examples of configurations of kits (whales) consisting of 2-, 3- and 4-part, for various implementations of the ΏΕ-200 compositions. Basically, kits consisting of 2- and 3-parts have a certain amount of water already pre-packaged in one of two (or three) containers (usually a foaming component). This allows you to quickly alert the disinfectant solution, use small devices (for example, a satchel); in addition, no additional field water is required.

In contrast, for 4-piece kits, it is generally necessary that additional water be added to the field, at or near the site of infection. This allows the packaging containing the remaining three parts to be lighter, which makes it convenient for transportation and storage. However, it is necessary that the source of water (which may be sea water) be in the field.

In general, the ΏΕ-200 composition can be packaged with or without a pre-packaged volume of water, depending on the application.

ΏΕ-200ΗΕ (kit configuration).

For use in the field, the ΏΕ-200ΗΕ composition can be arranged in the form of a set of 4 parts, as shown below (quantities are illustrative).

ΏΕ-200ΗΕ (set of 4 parts).

Part A (foaming concentrate):

Mr. Uagshna! 80MS;

Mr. Abodep 477;

g 1-dodecanol;

g polymer 1adiag 8000 ™;

g dipropylene glycol methyl ester;

7.5 g of potassium bicarbonate;

141 g of water.

Part B (solid component):

g sodium percarbonate;

g urea is hydrogen peroxide.

Part C (whitening activator):

g propylene glycol diacetate.

Part I) (additional water):

800 g water.

In this 4-part configuration example, the volume of water is not included in the package (i.e., in parts A, B and C), thereby minimizing the weight of the package for transportation and storage. In this example, additional water (part □) should be added in the field, near or at the site of infection. For optimal action, the pH of the composition can be adjusted to between approximately 9.6 and 9.8. The composition, as described above, will produce 1 liter of highly foaming solution. In this example, sodium percarbonate delivers a portion of hydrogen peroxide, a portion of bicarbonate, and a base for buffering the solution. The remainder of the hydrogen peroxide is delivered by the urea hydrogen peroxide complex. In this example, the total concentration of hydrogen peroxide is approximately 3%. The viscosity of the composition can be adjusted to about 4-9 mm ² / s.

For mixing the composition ΏΕ-200ΗΕ, arranged in the form of a set of 4 parts, in the field, many different methods can be used, for example.

Method 1. Take additional water (part I)). Then part B is mixed with part I), then parts C and A are added to part BT). Use should preferably be within 8 hours.

- 12 009242

Method 2. Part C is mixed with part A. Take additional water (part Ό), then part B is mixed with part Ό. Store separately until use. If necessary, part A + C is mixed with part Β + Ό. It should preferably be used within 8 hours after mixing part A + C with part Β + Ό.

In general, activated ΌΡ-200 compositions are used preferably within 8 hours after mixing. However, they remain effective for 24 hours or longer. ΌΡ-200ΗΡ (high foam) may be present on the surface for a long period of time and then washed off. Unlike the compositions ΌΡ-100 / 100Α and ΌΡ-200ΗΡ, the composition ΌΡ-200ΡΡ (low foam) can be used according to another method. Namely, instead of leaving the surface for a long period of time, ΌΡ-200ΡΡ should be applied to the surface, left there for a relatively short time (for example, 15-60 minutes), and then rinsed off with a stream of fresh or sea water, under high pressure . This minimizes the corrosion of the material on which it is applied and makes it particularly suitable for the disinfection of aircraft and other equipment where corrosion is unacceptable. In addition, the time required for disinfection is reduced to a minimum, which is especially important when used for military purposes (on the battlefield or on fixed objects).

For ΌΡ-200 compositions, the use of sea water will also be effective as additional water (part Ό). In the table. 7 summarizes the kinetic tests of ΌΡ-200ΗΡ (2% ΡΟΌ / 3.5% Η ₂ Ο ₂ /4% bicarbonate salt) with sea water (“35,000 ppm total dissolved substance).

Table 7

Generalization of reaction rates for ΌΡ-200ΗΡ composition (2% ΡΟΌ / 3.5% Η ₂ Ο ₂ /4% bicarbonate salt) with sea water used as additional water (part Ό)

Simulator % disinfection 1 minute 15 minutes 60 min Mustard gas 24 42 89 C agents Νϋ Νϋ Νϋ UX 62 96 > 99

After a 1-hour exposure with ΌΡ-200ΗΡ with sea water, as an additional water, tests against an anthrax spore simulator (VasShiz βίοδίβίί) showed spore elimination of 99.9999% (7-Sod).

A surface test of the ΌΡ-200ΗΡ composition was performed against mustard gas and UX simulators. For this test, 8 mg of the simulator was applied to a test coupon with a diameter of 2 manufactured by SAKS (Срет1еа1 Adep! 1 \ ez181ap1 S'oaIpd). SAX is a material that is commonly used to paint military vehicles to protect them from the effects of chemical warfare agents. After 1 h, the test coupon was placed in a horizontal position and 1 g of ΌΡ -200ΗΡ (2% ΡΟΠ / 3.5% Η ₂ Ο ₂ /4% bicarbonate salt) was applied. After 60 minutes, to extract the unreacted simulator from the surface, the test coupon was immersed for 15 minutes in 25 ml of acetonitrile. The results presented in table. 8 show a more effective disinfection of the test coupon compared to ^ ^-100Α.

Table 8

ΌΡ-200ΗΡ surface test for SAKS

Disinfecting composition mg UX simulator (unreacted surface simulator after 60 min) mg mustard gas simulator (unreacted surface simulator after 60 min) the control 8.0 ± 0.3 8.0 ± 0.3 ϋΡ-ΙΟΟΑ (pH 9.2) 2.9 4.5 ϋΡ-200ΗΡ (2% ΡΟϋ / 3.5% Η ₂ Ο ₂ / 4.0% bicarbonate salt) 1.4 2.5

ΌΡ-200ΗΡ suspension (kit configuration).

In the ΌΡ-200 compositions, instead of the (water-soluble) propylene glycol diacetate, insoluble whitening activators (such as TABO, ΝΟΒ8 and Ν-acetylglucosamine) can be used. However, in this case, when the composition is mixed with water, a suspension is obtained instead of the real aqueous solution.

The present invention also provides a method of using a water-insoluble solid bleaching activator (eg, TABE) to prepare a chemically active suspension (where Suspension is defined as an aqueous mixture that contains an insoluble, insoluble substance). This exercise, designated as ΌΓ-200ΗΕ suspension, is a modification of the ΌΓ-200ΗΓ preparation. Below is an example of a 4-piece kit.

ΌΓ-200ΗΓ suspension (set of 4 parts).

Part A (foam concentrate):

Mr. Wapcia! 80MS;

Mr. Abodep 477;

g 1-dodecanol;

g polymer Badiag 8000 ™;

g dipropylene glycol methyl ester;

7.5 g of potassium bicarbonate;

161 g of water.

Part B (solid component):

g sodium percarbonate;

g urea is hydrogen peroxide.

Part C (whitening activator):

g TAEN (preferably, encapsulated TAEN, for example, \ Eag \\ '1sk B637).

Part Ό (additional water):

800 g of water (fresh or sea water can be added at the place of use).

The composition, as presented above, will produce 1 L of a foaming solution. For optimal action, the pH of the final composition can be adjusted to a value between approximately 9.6 and 9.8. The following mixing procedures can be used: part B is mixed with part Ό, then parts C and A are added to part B + Ό. Use preferably for 8 hours.

The action of ΌΓ-200ΗΓ suspension (1% TAEE / 3% H ₂ O / 4% bicarbonate salt) against each simulator of chemical poisonous substances is presented in table. nine.

Table 9 Generalization of the reaction rates in the kinetic test of the composition ΌΓ-200ΗΓ in the form of a suspension

Simulator % disinfection 1 minute 15 minutes 60 min Mustard gas 67 96 Νϋ C agents Νϋ Νϋ Νϋ UX 33 95 Νϋ

It should be noted that an improvement in action can be achieved by using higher concentrations of TAEN (for example, 2% TAEN instead of 1% TAEN)

The above examples of various ΌΓ-200 implementations can be typically used in large-scale operations where deployment of the intended equipment and a source of additional water are readily available (for example, for use by the military to disinfect fixed objects such as air bases and seaports), or used to minimize the volume of preliminarily packaged water to minimize the weight of the composition to be transported and stored.

ΌΓ-200 quick deployment configurations.

The present invention also provides configurations oriented to the quick deployment of the ΌΓ-200 compositions and / or their deployment using small deployment devices (for example, hand objects, satchels or objects that fit on small carts). For these applications, all water is pre-packaged in the composition so that no additional field water is required. The first example of the configuration of a 3-piece kit for quick deployment of the ΌΓ-200ΗΓ-ΌΓ-200ΗΕ quick deployment option # 1 (quantities are illustrative) is given below.

ΌΓ-200ΗΓ rapid deployment # 1 (set of 3 parts).

Part A (liquid foaming component):

Mr. Wapcia! 80MS;

Mr. Abodep 477;

g 1-dodecanol;

g polyethylene oxide;

g diethylene glycol monobutyl ether;

g isobutanol;

g potassium bicarbonate;

- 14 009242 approximately 19 g of potassium hydroxide (the pH of part A should be approximately 10.2);

933 g of water.

Part B (solid oxidizing component):

g urea is hydrogen peroxide.

Part C (liquid whitening activator):

g propylene glycol diacetate.

This configuration will produce 1 liter of foaming solution. For optimal action, the pH of the final composition can be adjusted to between approximately 9.6 and 9.8. The following mixing procedure can be used: part B is mixed with part A. After dissolution of the urea hydrogen peroxide, part C is added to part A + B. The use is preferably within 8 hours. The action of PG-200NG quick deployment against chemical poison simulators is presented in table. 10.

Table 10

The reaction rate of the kinetic test configuration IG-200NG quick deployment # 1

Simulator % disinfection 1 minute 15 minutes 60 min Mustard gas 48 82 Νϋ 6 agents Νϋ Νϋ Νϋ UX 71 97 > 99

After a 30-minute exposure with PG-200NG, the rapid deployment of trials against an anthrax spore simulator (Vaschiz d1oYdp) showed the destruction of spores by 99.9999% (7-od).

A schematic example of a preferred mixing procedure for this first quick deployment PG-200NG configuration example is shown in FIG. 2. Urea-hydrogen peroxide dissolves rapidly in water. Therefore, in the event of an attack using chemical or biological military weapons, the composition can be prepared and deployed in a very short time, which makes it ideal for use by the civilian first responder services (fire department, chemical safety units, police and others who should be the first to arrive CBW attacks) and / or military.

However, the particular whitening activator (propylene glycol diacetate) used in this composition is not stable in an aqueous solution whose pH is greater than about 9.9. Therefore, it is very important to properly mix the right components. For example, if part C is mixed with part A before part B is added, then there may be some decrease in PG-200NG activity, since propylene glycol diacetate is exposed to a solution whose pH is greater than 9.9. This, however, will not happen if part B is added to part A before part C is added, since adding part B to part A reduces the pH of the mixture A + B to a value lower than about 9.9.

The solvent, diethylene glycol monobutyl ether used in Part A (foaming solution) of the first example for PG-200NG quick deployment # 1, differs from the solvent (dipropylene glycol methyl ester) used in the previously described PG-200NG composition in that dipropylene glycol methyl ester not stable in a high pH environment, which is necessary for the foaming component (part A) of the rapid deployment configuration. It should also be remembered that short-chain alcohol (e.g. isobutanol) must be added to the foaming component (part A) of the quick deployment configuration # 1 of PG-200NG. This low molecular weight alcohol can cause problems associated with ignition in highly concentrated PG-200NG configurations, but in the less concentrated configurations discussed in this description, this problem is absent. The use of isobutanol also promotes the dissolution of 1-dodecanol in Part A and improves the kinetics (chemical activity) of the composition. In addition, the compositions preferably use a polyethylene oxide polymer that has not been used in other previously presented ΌΓ-200 compositions (i.e., 8000 ™ Badiag). This alternative polymer is used because 8000 ™ badiag is also unstable in the high pH environment of the liquid foaming portion (Part A) of the quick deployment composition. Therefore, the preferred composition for PG-200NG quick deployment # 1 contains the following.

□ E-200NG quick deployment # 1:

1-4% (preferably 2%)! 80MS (cationic surfactant);

0.5-3% (preferably 1%) Abodep 477 (cationic hydrotropic substance); 0.2-0.8% (preferably 0.4%) 1-dodecanol (fatty alcohol);

0.5-8% (preferably 0.5%) polyethylene glycol (polymer);

- 15 009242

0.6-1.2% (preferably 0.8%) diethylene glycol monobutyl ether (solvent);

0-1% (preferably 0.5%) isobutanol (short chain alcohol);

0.1-10% (preferably 2-8%) bicarbonate salt (buffer and peroxide activator);

0.1-10% (preferably 1-4%) hydrogen peroxide (oxidizing agent);

0.1-10% (preferably 1-4%) propylene glycol diacetate (whitening activator);

52-97% water.

For optimal action, the pH of the composition should be adjusted to a value in the range of approximately 9.6-9.8 and then the composition will be effective for disinfecting all infectious substances.

The second example of the configuration of a 3-part kit for the fast-deploying version of the ΌΡ-200ΗΡ, ΌΡ-200ΗΡ quick deployment # 2, contains (the numbers are illustrative) the following.

ΌΡ-200ΗΡ quick deployment # 2 (set of 3 parts).

Part A (liquid foaming component):

Mr. Wag. | IA1 80MS;

Mr. Abodep 477;

g 1-dodecanol;

g polymer polyethylene glycol 8000;

g diethylene glycol monobutyl ether;

g isobutanol;

g potassium bicarbonate;

approximately 25 g of potassium hydroxide (the pH of part A should be adjusted to a value of approximately 10.2);

933 g of water.

Part B (solid oxidizing component):

g urea is hydrogen peroxide.

Part C (liquid whitening activator):

g propylene glycol diacetate.

In the second example, the polyethylene glycol polymer 8000 replaces the polyethylene oxide polymer, which is used in ΗΡ-200ΗΡ rapid deployment # 1.

The third example of the configuration of a 3-piece kit for the fast deployment version of the ΌΡ-200ΗΡ, ΌΡ-200ΗΡ quick deployment # 3 contains (the numbers are illustrative) the following.

ΌΡ-200ΗΡ quick deployment # 3 (set of 3 parts).

Part A (liquid foaming component):

Mr. Wag. | IA1 80MS;

Mr. Abodep 477;

g 1-dodecanol;

g polymer polyethylene glycol 8000;

g hexylene glycol;

g potassium carbonate;

g potassium bicarbonate;

700 g of water.

Part B (solid oxidizing component):

g urea is hydrogen peroxide.

Part C (liquid whitening activator):

g glycol diacetate (i.e. diacetin).

In the third example, the polyethylene ethylene oxide polymer, which is used in the # 200 quick deployment # 1 as a water-soluble polymer, is replaced by 8000 polyethylene glycol. In addition, diethylene glycol monobutyl ether and isobutanol used as solvents are replaced by hexylene glycol. And finally, propylene glycol diacetate, which is used as a whitening activator, is replaced by glycol diacetate (i.e. diacetin). These substitutions in the third example were made to reduce or eliminate the use of short chain alcohol and / or solvents with high vapor pressure in order to prevent possible problems associated with the evaporation of the most volatile components during a very long (from several months to several years) shelf life of liquid a foaming component (part A), especially when stored at high ambient temperatures. It should be noted that a combination of 45 g of potassium carbonate and 5 g of potassium bicarbonate was chosen both to supply the proper amount of carbonate / bicarbonate and to appropriately control the ρΗ value. Alternatively, to increase ρΗ to the desired value, 50 g of potassium bicarbonate (without potassium carbonate) was used and then an appropriate amount of potassium hydroxide (base) was added.

ΌΡ-200ΗΡ quick deployment suspension.

This invention also represents a configuration of a 2-piece kit for a ΌΡ-200 разверты quick deployment suspension (ΌΡ-200ΗΡ quick deployment suspension), in which

- 16 009242 rum ΤΑΕΏ (or other solid peroxide activator) is used as a whitening activator. This example is a quick deployment configuration and also does not require the addition of additional water in the field (quantities are illustrative).

EG-200NG quick deployment suspension (set of 2 parts).

Part Α (liquid foaming component):

Mr. Walzia! 80MS:

Mr. Ayodep 477;

g 1-dodecanol;

g polyethylene glycol;

g diethylene glycol monobutyl ether;

g isobutanol;

g potassium bicarbonate;

g potassium hydroxide (pH of part Α should be adjusted to a value of approximately 10.4).

953 g of water.

Part B (solid oxidizing agent and whitening activator):

g urea hydrogen peroxide;

g ΤΑΕΏ (preferably in encapsulated form, for example \\ ar \\ 1sk 1n1egpa1yupa1 Β637).

This composition will produce 1 liter of foaming solution. For optimal action, the pH of the final composition can be adjusted to a value in the range of about 9.6-9.8. To mix the composition, the following procedures must be carried out: Part B is mixed with Part частью. Wait at least 1 min before use in order to allow time for the reaction of ΤΑΕΏ with hydrogen peroxide. It is preferable to use it within 8 hours. It is useful to know that ΤΑΕΏ will not immediately dissolve in water, but will remain in the form of solid particles for at least 15-20 minutes. Therefore, filtering or sieving may be necessary so that undissolved particles ΤΑΕΏ do not damage or clog the pumps or other parts of the deployment tool. However, the composition will be ready for use approximately 1 minute after adding ΤΑΕΏ particles to part B instead of part Α.

In this configuration, an encapsulated form ΤΑΕΏ is used. This is beneficial for two reasons. Firstly, during storage, the protective coating (which slowly dissolves in water) will protect ΤΑΕΏ from interaction with urea-hydrogen peroxide. Secondly, the coating will protect ΤΑΕΏ from the high pH in part Α until the urea hydrogen peroxide dissolves and lowers the pH of the composition to below about 9.9. With respect to protecting the activator from exposure to high pH ΤΑΕΏ solutions, it should be used in the same way as propylene glycol diacetate. As a whitening activator, ΤΑΕΏ will lose most of its effectiveness if it is kept with solutions whose pH value is above 9.9. Therefore, the use of the encapsulated form ΤΑΕΏ will minimize its exposure to high pH immediately after part B is mixed with part Α. Action 1) 0-2001 II 'suspension of rapid deployment against chemical poisonous substances-simulators are presented in table. eleven.

Table 11

Reaction rates in the kinetic test for the composition EG-200NG-suspension rapid deployment

Simulator % disinfection 1 minute 15 minutes 60 min Mustard gas 76 97 Νϋ About Agents Νϋ Νϋ Νϋ UX 57 97 Νϋ

After a 30-minute exposure with an EG-200NG quick-release suspension, tests against an anthrax spore simulator (Vaschiz d1oYdp) showed spore elimination of 99.9999% (7-code).

A schematic illustration of an example of a method for mixing an EG-200NG quick deployment suspension in the field is presented in FIG. 3.

Above are just a few examples of quick deployment configurations for the EN-200 compositions. It is clear to the ordinary person skilled in the art that, using the fundamental considerations presented in this invention, other rapid deployment configurations can be obtained.

The present invention is also a method for preparing a foaming component (part Α) of rapid deployment configurations. The following is an example of such a method.

1. A suitable amount of water is placed in a mixing bowl.

2. While stirring the water, bicarbonate salt is added to the mixing bowl and continued to mix until completely dissolved.

3. Polyethylene glycol polymer is slowly added to the mixing bowl, then quickly transferred.

- 17 009242 interfere. They carefully monitor that there are no lumps. Stir for at least about 30 minutes.

4. While stirring the foaming solution, Waps. | AI1 80MS is added to the mixing vessel and stirring is continued until complete dissolution.

5. While stirring the foaming solution, Abodep 477 is added to the mixing vessel and stirring is continued until complete dissolution.

6. In a separate container, diethylene glycol monobutyl ether, isobutanol and 1-dodecanol are mixed and, carefully mixed, this mixture is added to the foaming solution.

7. While stirring the foaming solution, solid KOH is slowly added to the mixing vessel until the pH reaches the desired value.

Alternative ΌΕ-200 compositions.

The invention also includes the following alternative ΌΕ-200 compositions.

1. An alternative composition that contains propylene glycol to reduce the freezing point of the solution.

2. An alternative composition that uses sodium percarbonate as a solid source of hydrogen peroxide.

3. An alternative composition that contains a corrosion inhibitor.

4. An alternative composition that contains glycerin to impart viscosity in procedures such as skin disinfection.

5. An alternative composition that uses O-acetyl whitening activators, including those that are available in solid form.

6. An alternative composition that uses a whitening activator containing a nitrile group.

ΌΕ-200 with propylene glycol.

The following is the first example of the configuration of a 2-part kit for ΌΕ-200ΗΕ, which contains propylene glycol as a freezing point depressant and where all the water is pre-packaged in part A. The kit contains (the quantities are illustrative) the following.

ΌΕ-200ΗΕ rapid deployment with propylene glycol, the first example (a set of 2 parts).

Part A (liquid foaming component):

Mr. Waps. | IA1 80MS;

Mr. Abodep 477;

g polyethylene glycol (M \ U 8000);

g diethylene glycol monobutyl ether;

g isobutanol;

g 1-dodecanol;

g propylene glycol diacetate;

150 g propylene glycol (freezing point depressant);

approximately 6 g of a 10% HC1 solution (sufficient to obtain a final pH of 2.5 in part A);

777 g of water.

Part B (solid additive):

g urea hydrogen peroxide;

g potassium bicarbonate;

g potassium carbonate (buffer to obtain the final pH value).

This composition gives 1 l of a foaming solution. For optimal action, the pH of the final composition can be adjusted to between approximately 9.6 and 9.8. It will be understood by one of ordinary skill in the art that the ratio of potassium carbonate to potassium bicarbonate used in Part B can be adjusted to obtain the desired pH of the final composition (preferably from about 9.6 to about 9.8). Therefore, in this example, potassium carbonate works both as a base and as a source of carbonate / bicarbonate. To obtain this composition, part B is mixed with part A. It is used preferably for 8 hours. The effect of this first example of EE-200HE using propylene glycol against chemical poisonous agents is shown in Table 1. 12.

- 18 009242

Table 12

Reaction rates from a kinetic study for IR-200HP with propylene glycol (first example)

Simulator % 1 minute Mustard Gas (NI) sixteen C agents Νϋ UX 66

Disinfection 15 minutes 60 minutes 80 Νϋ Νϋ Νϋ 90 > 99

After a 30-minute exposure with IR-200HP with propylene glycol (the first example), tests against an anthrax spore imitator (Vaschiz dlOydy) showed spore elimination of 99.9999% (7-od).

When all the water is pre-packaged in part A, mixing the composition for use can be done in a very short time, since the composition consists of only two parts. Therefore, at the scene of an incident with chemical and biological warfare agents, the composition can be deployed very quickly. This kit is ideal for use by civilian first responders (fire department, chemical safety unit, police and others who should be the first to arrive at the site of a chemical or biological attack). However, this kit is harder to carry than other kits to which water is added to the field.

This configuration also includes the inclusion of a whitening activator, propylene glycol diacetate, in the foaming component of Part A (it is best to store it separately as the third component). This is possible because the pH of the foaming component is less than 3. In solutions whose pH is more than 3, propylene glycol diacetate will undergo hydrolysis, but at pH less than 3 it will be hydrolytically stable in water. To increase the viscosity, polyethylene glycol polymer (PEC 8000) is also used in this configuration. This polymer is used in many cosmetics and is particularly soluble and stable in water. In addition, in the solution it mixes more easily than 1adnag 8000 ™ or high molecular weight polyethylene oxide, since it does not tend to form lumps.

In this configuration, propylene glycol is included as a freezing point depressant. Propylene glycol is considered an environmentally friendly antifreeze. In this case, the concentration at which the freezing temperature of part A is reduced to approximately −20 ° C. is approximately 15% by weight. This configuration has also been successfully tested at higher propylene glycol concentrations of 40% by weight.

An alternative to the first example of IR-200HP with propylene glycol, which is discussed above, is the use of sodium percarbonate in part B as a source of bicarbonate and a portion of peroxide, instead of the urea hydrogen peroxide used. This is a useful substitute because sodium percarbonate is cheaper than urea hydrogen peroxide. This second example of IR-200HP with propylene glycol is presented below (quantities are illustrative).

IR-200HR rapid deployment with propylene glycol, the second example (a set of 2 parts). Part A (Liquid Foaming Agent):

Mr. Wapscha! 80MS;

Mr. Abodep 477;

g polyethylene glycol (MA 8000);

g diethylene glycol monobutyl ether;

g isobutanol;

g 1-dodecanol;

g propylene glycol diacetate;

150 g propylene glycol (freezing point depressant); approximately 6 g of a 10% HC1 solution (sufficient to obtain a final pH of 2.5 in part A);

777 g of water.

Part B (Solid Additive):

g sodium percarbonate;

g citric acid (buffer to regulate the final pH).

This composition will produce 1 liter of foaming solution. For optimal action, the pH of the final composition can be adjusted to between about 9.6 and about 9.8. The following mixing procedure can be used: Part B is mixed with Part A. It is used preferably for 8 hours. Alternatively, sodium bisulfate (a single bank of conditioned chemicals) or another acid can be used instead of citric acid to adjust the pH. The effect of this second example of IR-200HP with propylene glycol (using sodium percarbonate) against chemical chemical simulators is shown in Table. thirteen.

- 19 009242

Table 13

Reaction rates from the kinetic test for the second example 0P-200HP with propylene glycol (using sodium percarbonate)

Simulator % Disinfection 1 minute 15 minutes 60 minutes Mustard Gas (BUT) 80 ΝΟ ΝΟ ΥΧ 76 96 > 99

In general, after adding to Part A, sodium percarbonate dissolves much more slowly than urea hydrogen peroxide. However, to increase the dissolution rate in this configuration, sodium percarbonate can be ground to a size of approximately 100 mesh. When using ground sodium percarbonate, its dissolution time is reduced from about 30 to about 2 minutes.

ΌΕ-200 with a corrosion inhibitor.

Corrosion inhibitors can be added to the ΌΕ-200 compositions to reduce corrosion. The best corrosion inhibitor for ΌΕ-200 compositions is Ν, Ν-dimethylethanolamine. However, other corrosion inhibitors can be used, such as triethanolamine, mixtures of ethanolamine salts with C ₉ , C ₁₀ and C ₁₂ dibasic acids, dicyclohexylamine nitrite and Ν, Ν-dibenzylamine. Corrosion inhibitors added to ΌΕ-200 compositions can be useful for many purposes:

1. Corrosion inhibitor.

2. pH buffer.

3. Solvent to retain 1-dodecanol in solution.

4. Co-solvent for dissolving insoluble chemical poisons such as sarin or mustard gas.

An example configuration of a 3-piece kit for ^ Ε-200НΕ with a corrosion inhibitor contains (the quantities are illustrative) the following.

^ Ε-200НΕ quick deployment with corrosion inhibitor (set of 3 parts).

Part A (Liquid Foaming Agent):

g Wa1shchia1 80MS;

Mr. Abodep 477;

g 1-dodecanol;

g polyethylene glycol;

g Ν, Ν-dimethylethanolamine (corrosion inhibitor);

g potassium bicarbonate; approximately 18 g of potassium hydroxide (sufficient to obtain a final pH of 10.2 in part A); 936 g of water.

Part B (Solid Oxidizing Component):

g urea is hydrogen peroxide.

Part C (Liquid Whitening Activator):

g propylene glycol diacetate.

This composition will produce 1 liter of foaming solution. For optimal action, the pH of the final composition can be adjusted to between about 9.6 and about 9.8. The following mixing procedure can be used: part B is mixed with part A. Then, after the urea hydrogen peroxide is dissolved, part C is added. Part C is preferably used for 8 hours. Action ^ Ε-200НΕ with a corrosion inhibitor against chemical poison agents shown in table 14.

Table 14 Reaction rates in the kinetic test for ^ Ε-200НΕ with a corrosion inhibitor

Simulator % Disinfection 1 minute 15 minutes 60 minutes Mustard Gas (BUT) 7 41 79 UX 58 94 99

After a 60-minute exposure to C ^ 200H with a corrosion inhibitor, experiments against an anthrax spore simulator (Vaschiz d1O2dp zrogesis) showed spore elimination of 99.9999% (7-Baud). The addition of a corrosion inhibitor has a negative effect on the action of ΌΕ-200 against chemical poisons, but has an immeasurable effect on the effect of Ε-200HΕ against biological agents. Similar results were obtained using an alternative corrosion inhibitor, 1% triethanolamine.

- 20 009242

ΌΡ-200 with glycerin.

In another embodiment of the ΌΡ-200 composition, glycerol can be used as a viscosity component instead of 1diag 8000 ™, polyethylene oxide or polyethylene glycol. Glycerin is a common ingredient in cosmetics, where it is used as a component of viscosity, as well as a moisturizing and emollient. Thus, the use of glycerol in ΌΡ-200 compositions can be useful for many purposes:

1. The viscosity component.

2. Moisturizer (ie a substance that moisturizes the skin).

3. Solvent to retain 1-dodecanol in solution.

4. Co-solvent for dissolving insoluble chemical poisons such as sarin or mustard gas.

An example configuration of a 3-piece kit for ΌΡ-200ΗΡ with glycerin contains (the quantities are illustrative) the following.

ΌΡ-200ΗΡ quick deployment with glycerin (set of 3 parts).

Part A (Liquid Foaming Agent):

Mr. Wapcia! 80MS;

Mr. Abodep 477;

g 1-dodecanol% g glycerol (viscosity component);

g potassium bicarbonate;

approximately 17 g of potassium hydroxide (sufficient to obtain a final ρΗ 10.2 in part A);

906 g of water.

Part B (Solid Oxidizing Component):

g urea is hydrogen peroxide.

Part C (Liquid Whitening Activator):

g propylene glycol diacetate.

This composition will produce 1 liter of foaming solution. For optimal action, ρΗ of the final composition can be adjusted to values between about 9.6 and about 9.8. The following mixing procedure is used: part B is mixed with part A. Then, after the urea hydrogen peroxide is dissolved, part C is added. Part C is used preferably for 8 hours. The action of ΌΡ-200ΗΡ with glycerin against chemical poisonous substances imitators is shown in Table 1. fifteen.

Table 15

Reaction rates in kinetic testing for ΌΡ-200ΗΡ with glycerin

Simulator % Disinfection 1 minute 15 minutes 60 minutes Mustard Gas (Ηϋ) 63 96 Νϋ 6 agents Νϋ Νϋ Νϋ UX 76 99 Νϋ

After a 30-minute exposure with ΌΡ-200ΗΡ with glycerin, tests against an anthrax spore simulator (Bae111i8 d1o3 dI zrogesis) showed spore elimination of 99.9999% (7-od).

This composition can be used directly for people because glycerin will act as a moisturizer. This composition can also be used, for example, in the form of a spray or shower by removing foaming components (such as 1-dodecanol and Abodep 477) and by reducing the concentration of peroxide. However, an obstacle to the use of glycerol is that it is solid at a fairly high temperature (below about 10 ° C). Therefore, it is preferable that it be used under controlled temperature conditions (i.e., under high temperature conditions).

Propylene glycol diacetate, a bleaching activator used in many of the previously described ΌΡ-200 configurations, is not suitable in this case in the form of a solid form. However, other whitening activators are suitable in solid form.

ΌΡ-200 with acetylcholine chloride.

In ΌΡ-200 compositions, instead of (liquid) propylene glycol diacetate, solid O-acetyl whitening activators (for example, acetylcholine chloride, which is often used in eye drop solutions) can be used. The chemical structure of O-acetyl whitening activators is presented below. As can be seen, the molecule contains an O-acetyl group, which can activate peroxide, and is a quaternary compound that combines well with ΌΡ-200 compositions. Acetylcholine chloride is also soluble in water and very hygroscopic

- 21 009242

An example configuration of a 2-piece kit for ΌΤ-200ΗΤ with acetylcholine chloride contains (the amounts are illustrative) the following.

ΌΤ-200ΗΤ quick deployment with acetylcholine chloride (set of 2 parts).

Part A (Liquid Foaming Agent):

Mr. Wapcia! 80MS;

Mr. Abodei 477;

g of polyethylene glycol (MA 8000);

g diethylene glycol monobutyl ether;

g isobutanol;

g 1-dodecanol;

150 g propylene glycol;

g potassium bicarbonate;

approximately 17 g of potassium hydroxide (sufficient to obtain a final pH of 10.2 in part A);

803 g of water.

Part B (Solid Additive):

g urea hydrogen peroxide;

g acetylcholine chloride (solid whitening activator).

This composition will produce 1 liter of foaming solution. For optimal action, the pH of the final composition can be adjusted to between about 9.6 and about 9.8. The following mixing procedure is used: part B is mixed with part A. It is used preferably for 8 hours. The action of ΌΤ-200ΗΤ using acetylcholine chloride against chemical poisonous agents is shown in table. sixteen.

Table 16

Reaction rates in the kinetic test for ΌΤ-200ΗΤ using acetylcholine chloride as activator

Simulator % Disinfection 1 minute 15 minutes 60 minutes Mustard Gas (Ηϋ) 60 98 Νϋ UX 10 85 > 99

After a 30-minute exposure with ΌΤ-200ΗΤ using acetylcholine chloride, tests against an anthrax spore simulator (Vaschiz §1oYdp) showed spore elimination of 99.9999% (7-bo _§ ).

Two other O-acetyl whitening activators: monoacetin (glycerol monoacetate) and diacetin (glycerol diacetate) were also tested for effectiveness in ΌΤ-200 formulations. Both of these compounds turned out to be particularly active whitening activators. These compounds are water soluble lipids.

The experiments also show that peroxide in ΌΤ-200 compositions is also effectively activated by a nitrile-containing compound, for example 4-cyanobenzoic acid (which is soluble in water), at a concentration of, for example, 2% to neutralize imitators of both chemical and biological poisonous substances.

ΌΤ-200 using peracetic acid.

Tests were carried out using peracetic acid as an oxidizing agent in ΌΤ-200 compositions instead of hydrogen peroxide. The following composition was used:

2% Uaptia! 80MS (cationic surfactant);

2% peracetic acid (oxidizing agent);

5% potassium bicarbonate (buffer and activator);

91% water.

ρΗ was adjusted to 9.8 solid ΚΟΗ and the composition was tested against imitators of mustard gas, UX and anthrax spores. The effect of this composition against simulants of chemical poisons is shown in table. 17.

- 22 009242

Table 17

Reaction rates in the kinetic test for 1) 1-200 with 2% peracetic acid

Simulator % Disinfection 1 minute 15 minutes 60 minutes Mustard Gas (Ηϋ) 27 58 68 UX 68 76 95

After a 30-minute exposure from 1) 0-200 with 2% peracetic acid, experiments against an anthrax spore simulator (Baehiz sulphidae) showed spore elimination of 99.9999% (7-bhd).

Tests were also conducted for ΌΡ-200 using peracetic acid in high concentrations (3.5%) in the following composition:

2% WAPCIP 80MS (cationic surfactant);

3.5% peracetic acid (oxidizing agent);

5% potassium bicarbinate (buffer and activator);

89.5% water.

The pH was adjusted to 9.8 with solid KOH and the composition was tested against imitators of mustard gas, UC and anthrax. The effect of this composition against simulants of chemical poisons is shown in table. eighteen.

Table 18

Kinetic test reaction rates for ΌΡ-200 with 3.5% peracetic acid

The results show that the use of peracetic acid as an alternative oxidizing agent is effective against chemical poison simulators, but not to the same extent as in the ΌΡ-200 composition using activated hydrogen peroxide (i.e., in a combination of hydrogen peroxide, bicarbonate and propylene glycol diacetate) as an oxidizing agent. However, ΌΡ-200 compositions with 2-3.5% peracetic acid are very effective in killing spores. However, the use of this oxidizing agent is not as tempting as the use of hydrogen peroxide, since peracetic acid is really not available in the form of a safe, suitable solid form and the shelf life of the liquid form is quite short.

Studies were also conducted to determine the minimum required for spore elimination of the constituents in the ΌΡ-200 formulations that use peracetic acid as an oxidizing agent. These results show that there are only three components, i.e. peracetic acid, bicarbonate and a cationic surfactant are necessary to achieve high rates of spore destruction.

Tests on living organisms using Γ) Ρ-200Ι ΙΡ.

Tests on living organisms were carried out with three chemical poisonous substances (soman (ΟΌ), UC and mustard gas (HO)) and two biological agents (anthrax spores (aplgach) and Ugz1sha resyz). The results of kinetic tests ^ Ρ-200ΗΡ (using a 3-part configuration) for chemical agents are presented in Table. nineteen.

Table 19

Kinetic test reaction rates for ^ Ρ-200ΗΡ against chemical poisons

After exposure to ΟΌ with ΌΡ-200НН, methylphosphonic acid (MPA) and pinacolylmethylphosphonic acid (ΡΜΡΑ) were identified as by-products. After exposure to UC with ^ Ρ -200ΗΡ, ethyl methylphosphonic acid (EMPA) and MPA were identified as by-products. This indicated that the destruction of UX occurred along a more desirable path to phosphonic acid than to EA2192 (a toxic by-product that can also be produced during the degradation of UX). Finally, after exposure of BUT with ^ Ρ-200ΗΡ initial products

- 23 009242 degradation Ηϋ, which contained a mixture of sulfoxide and sulfone by-products, later, after 60 minutes, almost completely disappeared.

The test results against anthrax spores are presented in table. 20 and 21 and against Ueg81sh res118 (for example, plague bacteria) - in table. 22 (ΝΌ refers to the expression no growth). The detection threshold for these tests was 10 SEI / ml. It is noteworthy that the errors in the% reduction graph are within this threshold.

Table 20

The rate of destruction of spores B. ap1ygas18 LME8-K1Sh in solution ^ Г-200ΗГ

B. ap1b | -ac18 AME8- ΚΙΙϋ average CEI / ml decrease % reduction the control 1.21E + 07 0 0.00 15 min contact ΝΟ 7 1001.00004 30 min contact ΝΟ 7 1001.00004 60 min contact N0 7 1001.00004

Table 21

The rate of destruction of spores B. ap1ygas18 ΆΝΚ-1 in a solution 0E-200NE

B. ap (bgas18 p-1 average sgi / ml Bo§ decrease % reduction the control 6.42E + 07 0 0.00 15 min contact ΝΟ 7 1001.00004 30 min contact ΝΟ 7 1001.00004 60 min contact ΝΟ 7 1001.00004

Table 22

The rate of destruction of spores of Uegzpia re8Y8 in a solution P1'-200111 '

Уег81П1а ре $ Of (ATCC 11953) average sgi / ml Bo§ decrease % reduction the control 1.33E + 07 0 0.00 15 min contact ΝΟ 7 1001.00004 30 min contact ΝΟ 7 1001.00004 60 min contact N6 7 1001.00004

Petri dishes used to cultivate cells in each of these tests were stored for 21 days and then tested to confirm that PE-200HE actually kills spores rather than inhibits their growth. After a 21-day time period, no growth was observed on any of the Petri dishes.

Tests for toxic industrial chemicals using PE-200NE.

^ Ε-200ΗΕ has also been tested against several toxic industrial chemicals (TLC). The results of these tests are presented in table. 23. It is noteworthy that the results for malathion, butyl isocyanate, sodium cyanide and carbon disulfide were obtained by analyzing unreacted chemicals in a foaming solution, while the results for phosgene were obtained by analyzing the chemical in the free space above the foaming solution. These results show a very effective neutralization of these toxic industrial chemicals.

- 24 009242

Table 23

Generalization of tests to neutralize toxic industrial chemicals using PB-200NB

The previous examples can be repeated with similar success by replacing in a general form and specifically described reagents and / or operating modes of this invention those that were used in the previous examples.

Although the invention has been described in detail, with specific reference to preferred implementations, similar results can be obtained using other implementations. Changes and modifications of the present invention are obvious to a qualified specialist and all such modifications and equivalents are provided within the scope of the attached claims. Full descriptions of all posts, applications, and publications cited above are incorporated by reference.

Claims (47)

1. Composition for neutralizing at least one toxic substance, which contains at least two solubilizing compounds, where at least one solubilizing compound is a cationic surfactant and at least one solubilizing compound is a cationic hydrotropic substance; at least one reactive compound, wherein said at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium perborate, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate; at least one whitening activator, which is selected from the group consisting of O-acetyl, Ν-acetyl and whitening activators of the nitrile group; wherein said at least two solubilizing compounds, said at least one reacting compound, and said at least one whitening activator, when mixed with water and applied to at least one toxic substance, neutralize at least one toxic substance. 2. The composition according to claim 1, where the specified surfactant contains a Quaternary ammonium salt. 3. A composition according to claim 2, wherein said quaternary ammonium salt is selected from the group consisting of cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, alkyldimethylbenzylammonium salt, tetrabutylammonium bromide, benzyl chloride and the mixture (C1 -C1 _{2 6)} alkyldimethylammonium. 4. The composition according to claim 1, additionally containing a water-soluble polymer. 5. The composition according to claim 4, where the water-soluble polymer is selected from the group consisting of polyvinyl alcohol, guar gum, (cationic or nonionic) polydiallyldimethylammonium chloride, polyacrylamide, polyethylene oxide, glycerol, polyethylene glycol 8000 (ΡΕΟ 8000) and 1diag 8000 ™ ( Guar gum 2-hydroxypropyl ether) and combinations thereof. 6. The composition according to claim 1, additionally containing fatty alcohol with 8-20 carbon atoms per molecule. 7. The composition according to claim 1, additionally containing a solvent. 8. The composition according to claim 7, where the solvent is selected from the group consisting of dipropylene glycol methyl ether and diethylene glycol monobutyl ether and combinations thereof. 9. The composition according to claim 1, additionally containing a carbonate salt. 10. The composition according to claim 9, where the carbonate salt is selected from the group consisting of potassium bicarbonate, sodium bicarbonate, ammonium bicarbonate, ammonium bicarbonate, lithium bicarbonate, ammonium carbonate and potassium carbonate, and combinations thereof. - 25 009242 11. The composition according to claim 1, where the specified at least one whitening activator is soluble in water. 12. The composition according to claim 11, wherein said at least one water soluble whitening activator is selected from the group consisting of acetylcholine chloride, monoacetin (glycerol monoacetate), diacetin (glycerol diacetate), 4-cyanobenzoic acid, ethylene glycol diacetate, monomethyl acetate propylene glycol ether, methyl acetate, dimethyl glutarate, diethylene glycol monoethyl ether acetate, glycerol triacetate and propylene glycol diacetate, and combinations thereof. 13. The composition according to claim 1, where the specified at least one whitening activator is insoluble in water. 14. The composition according to item 13, wherein said at least one water-insoluble whitening activator is selected from the group consisting of tetraacetyl ethylenediamine (TABO), p-nonanoyloxybenzene sulfonate (N068) and Ν-acetylglucosamine, and combinations thereof. 15. The composition according to claim 1, which when mixed with water has a pH of approximately 9.6 and approximately 9.8. 16. Composition for neutralizing at least one toxic substance, which contains at least one cationic surfactant; at least one reactive compound, wherein said at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium perborate, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate; at least one whitening activator selected from the group consisting of O-acetyl, Ν-acetyl and whitening activators of the nitrile group; at least one carbonate salt of at least non-reactive components; wherein said at least one cationic surfactant, said at least one reactive compound, said at least one whitening activator, and said at least one carbonate salt are neutralized when mixed with water and applied to at least one toxic substance at least one toxic substance. 17. The composition according to clause 16, which when mixed with water has a pH of approximately 9.6 and approximately 9.8. 18. The composition according to clause 16, where the specified cationic surfactant contains a Quaternary ammonium salt. 19. The composition according to p, where the specified Quaternary ammonium salt contains benzalkonium chloride. 20. The composition according to clause 16, wherein said at least one carbonate salt is selected from the group consisting of potassium bicarbonate, sodium bicarbonate, ammonium bicarbonate, ammonium bicarbonate, lithium bicarbonate, ammonium carbonate and potassium carbonate, and combinations thereof. 21. The composition according to clause 16, consisting essentially of the specified at least one cationic surfactant, the specified at least one reactive compound, the specified at least one bleaching activator and the specified at least one carbonate salt. 22. The composition according to clause 16, where the specified at least one whitening activator is soluble in water. 23. The composition according to claim 22, wherein said at least one water soluble whitening activator is selected from the group consisting of acetylcholine chloride, monoacetin (glycerol monoacetate), diacetin (glycerol diacetate), 4-cyanobenzoic acid, ethylene glycol diacetate, monomethyl acetate propylene glycol ether, methyl acetate, dimethyl glutarate, diethylene glycol monoethyl ether acetate, glycerol triacetate and propylene glycol diacetate, and combinations thereof. 24. The composition according to claim 1, packaged in a kit configuration. 25. The composition according to paragraph 24, where the specified kit includes a pre-mixed component containing the specified at least two solubilizing substances; a first component comprising said at least one whitening activator; a second component containing the specified at least one reactive compound. 26. The composition according to claim 25, further comprising water and a base. 27. The composition according A.25, where the specified pre-mixed component further comprises a water-soluble polymer. 28. The composition according to claim 25, wherein said at least one whitening activator is selected from the group consisting of propylene glycol diacetate, glycerol diacetate and ΤΛΕΌ, and combinations thereof. - 26 009242 29. The composition according to p. 25, where the specified pre-mixed component further comprises a fatty alcohol with 8-20 carbon atoms per molecule. 30. The composition according A.25, where the specified at least one reacting compound contains urea-hydrogen peroxide and where the specified second component, including the specified at least one reacting compound, further comprises sodium percarbonate. 31. The composition according to claim 25, wherein said pre-mixed component further comprises a short chain alcohol. 32. The composition according to paragraph 24, where the specified kit includes a first pre-mixed component containing the specified at least two solubilizing substances and water; a second pre-mixed component containing said at least one bleaching activator and said at least one reactive compound, wherein said at least one bleaching activator is in solid form. 33. The composition according to p, where the specified first pre-mixed component further comprises an acid. 34. The composition according to p, where the specified at least one whitening activator contains acetylcholine chloride. 35. The composition according to p, where the specified at least one reacting compound further comprises urea-hydrogen peroxide and where the specified at least one bleaching activator contains TABO. 36. The composition according to p, where the specified at least one whitening activator is encapsulated to prevent premature reaction with the specified at least one reacting compound. 37. The composition according to paragraph 24, where the specified kit includes a pre-mixed component containing the specified at least two solubilizing substances and the specified at least one whitening activator; a component containing the specified at least one reactive compound. 38. The composition according to clause 37, where the specified pre-mixed component further comprises water and acid. 39. The composition according to clause 37, where the specified component, including the specified at least one reactive compound, contains sodium percarbonate and additionally contains acid. 40. The composition according to clause 37, where the specified at least one reacting compound contains urea-hydrogen peroxide and where the specified component, including the specified at least one reacting compound, further comprises a mixture of potassium carbonate and potassium bicarbonate. 41. Composition for neutralizing at least one toxic substance, which contains at least one cationic surfactant; at least one carbonate salt, which is selected from the group consisting of potassium bicarbonate, sodium bicarbonate, ammonium bicarbonate, ammonium bicarbonate, lithium bicarbonate, ammonium carbonate and potassium carbonate, and combinations thereof; at least one reactive compound, wherein said at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate; at least one water-soluble whitening activator, which is selected from the group consisting of whitening activators of the O-acetyl, Ν-acetyl and nitrile groups; wherein said at least one surfactant, said at least one reactive compound, and said at least one water soluble whitening activator, when mixed with water and applied to at least one toxic substance, neutralizes at least one toxic substance and wherein said at least one water soluble whitening activator is selected from the group consisting of acetylcholine chloride, monoacetin (glycerol monoacetate), diacetin (glycerol diacetate), 4-cyanoben oynoy acid, ethylene glycol diacetate, propylene glycol monomethyl ether acetate, methyl acetate, diethylene glycol monoethyl ether acetate, glycerol triacetate and diacetate, propylene glycol and combinations thereof. 42. The composition according to paragraph 41, where the specified cationic surfactant contains a Quaternary ammonium salt. 43. The composition according to paragraph 42, where the specified Quaternary ammonium salt contains benzalkonium chloride. 44. The composition according to paragraph 41, which when mixed with water has a ρΗ value of approximately 9.6 and approximately 9.8. - 27 009242 45. The composition according to paragraph 41, consisting mainly of the specified at least one cationic surfactant, at least one reactive compound and the specified at least one water-soluble whitening activator. 46. The composition according to claim 1, consisting mainly of the following: 1-10% benzalkonium chloride; 1-8% propylene glycol diacetate; 1-16% hydrogen peroxide; 2-8% potassium bicarbonate. 47. A composition for neutralizing at least one toxic substance, which contains at least one solubilizing compound selected from the group consisting of a cationic hydrotropic substance and a fatty alcohol containing 8-20 carbon atoms per molecule; at least one reactive compound, wherein said at least one reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, peracetic acid, sodium perborate, sodium peroxypyrophosphate, sodium peroxysilicate and sodium percarbonate; at least one whitening activator, which is selected from the group consisting of O-acetyl, Ν-acetyl and whitening activators of the nitrile group; wherein said at least one solubilizing compound, said at least one reacting compound, and said at least one whitening activator, when mixed with water and applied to at least one toxic substance, neutralize at least one toxic substance. FIG. one Part a 981 ml of liquid foam component Part B 19 ml liquid whitening component