EA009080B1 - Композиции с микрочастицами бупренорфина для инъекций и их применение - Google Patents

Композиции с микрочастицами бупренорфина для инъекций и их применение Download PDF

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Publication number
EA009080B1
EA009080B1 EA200200295A EA200200295A EA009080B1 EA 009080 B1 EA009080 B1 EA 009080B1 EA 200200295 A EA200200295 A EA 200200295A EA 200200295 A EA200200295 A EA 200200295A EA 009080 B1 EA009080 B1 EA 009080B1
Authority
EA
Eurasian Patent Office
Prior art keywords
microparticles
specified
buprenorphine
heroin
microparticle composition
Prior art date
Application number
EA200200295A
Other languages
English (en)
Russian (ru)
Other versions
EA200200295A1 (ru
Inventor
Томас Р. Тайс
Джей К. Стаас
Тереза М. Феррелл
Питер Марклэнд
Original Assignee
Бруквуд Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бруквуд Фармасьютикалз, Инк. filed Critical Бруквуд Фармасьютикалз, Инк.
Publication of EA200200295A1 publication Critical patent/EA200200295A1/ru
Publication of EA009080B1 publication Critical patent/EA009080B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA200200295A 1999-08-27 2000-08-25 Композиции с микрочастицами бупренорфина для инъекций и их применение EA009080B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15111299P 1999-08-27 1999-08-27
PCT/US2000/023390 WO2001015699A1 (en) 1999-08-27 2000-08-25 Injectable buprenorphine microparticle compositions and their use

Publications (2)

Publication Number Publication Date
EA200200295A1 EA200200295A1 (ru) 2002-08-29
EA009080B1 true EA009080B1 (ru) 2007-10-26

Family

ID=22537367

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200295A EA009080B1 (ru) 1999-08-27 2000-08-25 Композиции с микрочастицами бупренорфина для инъекций и их применение

Country Status (24)

Country Link
US (2) US6495155B1 (no)
EP (1) EP1212061B1 (no)
JP (1) JP4913298B2 (no)
KR (1) KR100730440B1 (no)
CN (2) CN1248689C (no)
AT (1) ATE280579T1 (no)
AU (1) AU765496C (no)
BR (1) BR0013650A (no)
CA (1) CA2382577C (no)
CY (1) CY1106043T1 (no)
CZ (1) CZ2002728A3 (no)
DE (1) DE60015370T2 (no)
EA (1) EA009080B1 (no)
ES (1) ES2230154T3 (no)
HK (1) HK1046858B (no)
HU (1) HUP0203613A3 (no)
IL (2) IL148343A0 (no)
MX (1) MXPA02002105A (no)
NO (2) NO322650B1 (no)
NZ (1) NZ517997A (no)
PL (1) PL198334B1 (no)
PT (1) PT1212061E (no)
RO (1) RO121631B1 (no)
WO (1) WO2001015699A1 (no)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2382577C (en) * 1999-08-27 2008-01-22 Southern Research Institute Injectable buprenorphine microparticle compositions and their use
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
EP1418862A4 (en) * 2001-06-29 2010-06-09 Leon J Lewandowski INDIVIDUALIZED SEARCH THERAPY
IL159624A0 (en) * 2001-06-29 2004-06-01 Medgraft Microtech Inc Biodegradable injectable implants and related methods of manufacture and use
CN1551770A (zh) 2001-07-06 2004-12-01 ������ҩ�����޹�˾ 羟吗啡酮控释制剂
BR0205722A (pt) * 2001-07-06 2005-04-05 Penwest Pharmaceuticals Compan Formulação de liberação prolongada e método para o tratamento de um paciente que sofre de dor
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
CA2459976A1 (en) * 2001-09-26 2003-04-03 Penwest Pharmaceuticals Company Opioid formulations having reduced potential for abuse
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7041320B1 (en) * 2002-05-31 2006-05-09 Biotek, Inc. High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence
EP1509182A4 (en) 2002-05-31 2009-12-30 Titan Pharmaceuticals Inc IMPLANTABLE POLYMERS DEVICE FOR THE DELAYED RELEASE OF BUPRENORPHINE
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
WO2004078178A1 (en) * 2003-03-03 2004-09-16 Markus Heilig Buprenorphine compounds for treatment of alcohol dependence and excessive alcohol use
MXPA05010450A (es) 2003-03-31 2005-11-04 Titan Pharmaceuticals Inc Dispositivo polimerico implantable para la liberacion prolongada de agonistas de dopamina.
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7919499B2 (en) * 2004-04-22 2011-04-05 Alkermes, Inc. Naltrexone long acting formulations and methods of use
FR2869801B1 (fr) * 2004-05-05 2008-09-12 Ethypharm Sa Procede de preparation de compositions a liberation prolongee et utilisation de ces compositions pour le traitement des affections chroniques du systeme nerveux central (snc)
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
WO2006012667A1 (en) * 2004-08-04 2006-02-09 Clinuvel Pharmaceuticals Limited Methods of inducing melanogenesis in a subject.
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US20070141160A1 (en) * 2005-12-15 2007-06-21 Brown Laura J Method of treatment for osteoarthritis by local intra-articular injection of microparticles
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20080227805A1 (en) * 2007-02-28 2008-09-18 Abbott Laboratories Sustained release parenteral formulations of buprenorphine
CA2699172C (en) 2007-09-03 2016-05-17 Nanotherapeutics, Inc Compositions and methods for delivery of poorly soluble drugs
US8728528B2 (en) * 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
BRPI0823096B8 (pt) 2008-09-24 2022-07-05 Evonik Roehm Gmbh composição farmacêutica de opióide de liberação controlada, dependente do ph, com resistência contra a influência do etanol, processo para sua preparação, e seu uso
PL2326313T3 (pl) 2008-09-24 2015-08-31 Evonik Roehm Gmbh Kompozycja farmaceutyczna o zależnym od pH kontrolowanym uwalnianiu dla nieopioidów z odpornością przed wpływem etanolu
CN104984343B (zh) * 2008-09-24 2019-04-02 赢创罗姆有限公司 耐受乙醇影响的非阿片类药物的pH依赖性受控释放的药物组合物
US20100268191A1 (en) * 2009-04-21 2010-10-21 Medtronic Vascular, Inc. Drug Delivery Catheter using Frangible Microcapsules and Delivery Method
US9125867B2 (en) 2010-02-24 2015-09-08 Invincible Biotechnology Diversion- and/or abuse-resistant compositions and methods for making the same
US9272044B2 (en) * 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2513060B (en) * 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
WO2013126552A1 (en) 2012-02-21 2013-08-29 Auburn University Buprenorphine nanoparticle composition and methods thereof
CA3120681C (en) 2012-04-17 2024-05-28 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
CN102836131A (zh) * 2012-09-28 2012-12-26 山东大学 丁丙诺啡皮下注射用缓释微球制剂及其制备方法
US9636308B2 (en) 2013-03-15 2017-05-02 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
US9393211B2 (en) 2013-03-15 2016-07-19 Oakwood Laboratories LLC High drug load buprenorphine microspheres and method of producing same
JP6135292B2 (ja) * 2013-05-10 2017-05-31 ニプロ株式会社 マイクロカプセル製剤の製造方法
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
US9849124B2 (en) 2014-10-17 2017-12-26 Purdue Pharma L.P. Systems and methods for treating an opioid-induced adverse pharmacodynamic response
CA2965895C (en) * 2014-11-07 2019-08-06 Indivior Uk Limited The use of sustained-release buprenorphine formulations for the treatment of pain or opioid use disorders
MX2018010194A (es) 2016-02-23 2019-06-12 Biodelivery Sciences Int Inc Microsferas de buprenorfina de liberacion sostenida (srbm) y metodos de uso de las mismas.
LT3512518T (lt) 2016-09-13 2023-02-10 Alar Pharmaceuticals Inc. Sulėtinto atpalaidavimo buprenorfino vaisto formos
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
US20220313686A1 (en) * 2019-08-12 2022-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Pharmaceutical compositions comprising a combination of opioid antagonists

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0144243A1 (en) * 1983-12-06 1985-06-12 Reckitt And Colman Products Limited Analgesic compositions
WO1990003783A1 (en) * 1988-10-12 1990-04-19 E.I. Du Pont De Nemours And Company Polylactide compositions
EP0537559A1 (en) * 1991-10-15 1993-04-21 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
EP0631781A1 (en) * 1993-07-01 1995-01-04 Euroceltique S.A. Opioid formulations having extended controlled release
RU2127587C1 (ru) * 1992-01-27 1999-03-20 Ороселтик, С.А. Устойчивые лекарственные формы с регулируемым выделением, имеющие акриловые полимерные покрытия, (варианты) и способ их получения

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464378A (en) 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4623588A (en) 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
US4568559A (en) 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
GB8430346D0 (en) * 1984-11-30 1985-01-09 Reckitt & Colmann Prod Ltd Analgesic compositions
US5143661A (en) * 1987-05-26 1992-09-01 American Cyanamid Company Silicone-hardened pharmaceutical microcapsules
FR2618674B1 (fr) 1987-07-30 1990-06-15 Ire Celltarg Sa Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation
GB8728294D0 (en) 1987-12-03 1988-01-06 Reckitt & Colmann Prod Ltd Treatment compositions
US5702716A (en) * 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
WO1990013361A1 (en) 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
US5486362A (en) 1991-05-07 1996-01-23 Dynagen, Inc. Controlled, sustained release delivery system for treating drug dependency
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5633000A (en) 1994-06-23 1997-05-27 Axxia Technologies Subcutaneous implant
US5716631A (en) 1995-09-29 1998-02-10 Rdn Therapeutics Inc. Long acting narcotic analgesics and antagonists
US5919473A (en) * 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
CA2382577C (en) * 1999-08-27 2008-01-22 Southern Research Institute Injectable buprenorphine microparticle compositions and their use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0144243A1 (en) * 1983-12-06 1985-06-12 Reckitt And Colman Products Limited Analgesic compositions
WO1990003783A1 (en) * 1988-10-12 1990-04-19 E.I. Du Pont De Nemours And Company Polylactide compositions
EP0537559A1 (en) * 1991-10-15 1993-04-21 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
RU2127587C1 (ru) * 1992-01-27 1999-03-20 Ороселтик, С.А. Устойчивые лекарственные формы с регулируемым выделением, имеющие акриловые полимерные покрытия, (варианты) и способ их получения
EP0631781A1 (en) * 1993-07-01 1995-01-04 Euroceltique S.A. Opioid formulations having extended controlled release

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M.D. MASHKOVSKIY, Lekarstvennye sredstva, M., "Meditsina", 1993, ch. 1, s. 178-181,184-185,188-189 *
Ofitsial'nyy Byulleten' Rossiyskogo Agentstva po patentam i tovarnym znakam, Izobreteniya, FIPS, Moskva, No. 5 (1 ch.), 20.02.1999, RU 97101378 A (Assotsiatsiya sovremennoy psikhoterapii), 20.02.1999, formula *
Ofitsial'nyy Byulleten' Rossiyskogo Agentstva po patentam i tovarnym znakam, Izobreteniya, Poleznye modeli, FIPS, Moskva, No. 3 (1 ch.), 27.01.2000, RU 98102450 A (DEPOTEK KORPOREYSHN), 27.01.2000, formula, pp. 1, 13, 22-33 *

Also Published As

Publication number Publication date
HUP0203613A3 (en) 2005-01-28
US7473431B2 (en) 2009-01-06
NO322650B1 (no) 2006-11-13
PL198334B1 (pl) 2008-06-30
CZ2002728A3 (cs) 2002-08-14
KR20020053057A (ko) 2002-07-04
EP1212061B1 (en) 2004-10-27
ES2230154T3 (es) 2005-05-01
HK1046858B (zh) 2005-03-24
ATE280579T1 (de) 2004-11-15
CN1382051A (zh) 2002-11-27
CY1106043T1 (el) 2011-04-06
DE60015370D1 (de) 2004-12-02
NO20063239L (no) 2002-04-03
WO2001015699A1 (en) 2001-03-08
IL148343A0 (en) 2002-09-12
AU765496C (en) 2005-08-25
MXPA02002105A (es) 2003-12-11
PL354977A1 (en) 2004-03-22
US6495155B1 (en) 2002-12-17
AU765496B2 (en) 2003-09-18
EA200200295A1 (ru) 2002-08-29
RO121631B1 (ro) 2008-01-30
NO20020924D0 (no) 2002-02-26
EP1212061A1 (en) 2002-06-12
US20030152638A1 (en) 2003-08-14
PT1212061E (pt) 2005-01-31
DE60015370T2 (de) 2006-03-09
BR0013650A (pt) 2002-05-07
CN1788721A (zh) 2006-06-21
KR100730440B1 (ko) 2007-06-19
HUP0203613A2 (hu) 2003-02-28
CA2382577C (en) 2008-01-22
JP2003508439A (ja) 2003-03-04
NZ517997A (en) 2002-11-26
HK1046858A1 (en) 2003-01-30
AU7075100A (en) 2001-03-26
CN100387228C (zh) 2008-05-14
CA2382577A1 (en) 2001-03-08
NO20020924L (no) 2002-04-03
IL148343A (en) 2008-03-20
JP4913298B2 (ja) 2012-04-11
CN1248689C (zh) 2006-04-05

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