EA008538B1 - Способы и композиции для лечения сердечно-сосудистого заболевания доставкой генов in vivo - Google Patents
Способы и композиции для лечения сердечно-сосудистого заболевания доставкой генов in vivo Download PDFInfo
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- EA008538B1 EA008538B1 EA200200533A EA200200533A EA008538B1 EA 008538 B1 EA008538 B1 EA 008538B1 EA 200200533 A EA200200533 A EA 200200533A EA 200200533 A EA200200533 A EA 200200533A EA 008538 B1 EA008538 B1 EA 008538B1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
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- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43515699A | 1999-11-05 | 1999-11-05 | |
| US60908000A | 2000-06-30 | 2000-06-30 | |
| PCT/US2000/030345 WO2001034208A1 (fr) | 1999-11-05 | 2000-11-03 | Techniques et compositions permettant de traiter les maladies cardiovasculaires par l'administration de genes in vivo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200533A1 EA200200533A1 (ru) | 2002-12-26 |
| EA008538B1 true EA008538B1 (ru) | 2007-06-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200533A EA008538B1 (ru) | 1999-11-05 | 2000-11-03 | Способы и композиции для лечения сердечно-сосудистого заболевания доставкой генов in vivo |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1225921A1 (fr) |
| JP (1) | JP2003513942A (fr) |
| KR (1) | KR20020049031A (fr) |
| CN (1) | CN1433325A (fr) |
| AU (1) | AU784392B2 (fr) |
| CA (1) | CA2389524A1 (fr) |
| EA (1) | EA008538B1 (fr) |
| HK (1) | HK1048593A1 (fr) |
| NZ (1) | NZ546670A (fr) |
| WO (1) | WO2001034208A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020049031A (ko) * | 1999-11-05 | 2002-06-24 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 생체내 유전자 송달에 의하여 심혈관 질환을 치료하기위한 기술 및 조성물 |
| US20030093147A1 (en) * | 2001-11-13 | 2003-05-15 | Ogle Matthew F. | Medical devices that stimulate growth factor production |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| PL195457B1 (pl) * | 2002-08-05 | 2007-09-28 | Zaklady Farm Polpharma Sa | Kaseta ekspresyjna, dwucistronowy wektor plazmidowy, środek farmaceutyczny oraz ich zastosowanie |
| GB2437893A (en) * | 2006-07-25 | 2007-11-07 | Celladon Corp | Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy |
| CN103992406A (zh) * | 2007-08-24 | 2014-08-20 | 乌利班-马克西姆利安大学 | 抑制β1-肾上腺素受体抗体的突变双环化受体肽 |
| ES2556711T3 (es) | 2008-04-09 | 2016-01-19 | Viromed Co., Ltd. | Formulaciones liofilizadas de ADN para el aumento de la expresión del ADN plasmídico |
| WO2010078624A1 (fr) * | 2009-01-07 | 2010-07-15 | Vegenics Limited | Matériaux et méthodes pour le traitement de l’hypertension |
| KR101006106B1 (ko) * | 2009-06-04 | 2011-01-07 | 김현태 | 전·자기장 차단 전열선 |
| US10155099B2 (en) | 2009-09-21 | 2018-12-18 | Cook Regentec Llc | Method for infusing stem cells |
| CN104220098B (zh) * | 2012-02-14 | 2018-04-10 | 加利福尼亚大学董事会 | 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达 |
| JP6499578B2 (ja) | 2012-06-05 | 2019-04-10 | マフィン・インコーポレイテッドＭｕｆｆｉｎ Ｉｎｃｏｒｐｏｒａｔｅｄ | 細胞療法に有用なカテーテルシステム及び方法 |
| ES2773305T3 (es) | 2013-10-22 | 2020-07-10 | Helixmith Co Ltd | Composición para la prevención o tratamiento de la esclerosis lateral amiotrófica que utiliza dos o más isoformas del factor de crecimiento de hepatocitos |
| WO2019222455A1 (fr) * | 2018-05-16 | 2019-11-21 | University Of Massachusetts | Administration à base de perfusion de vecteurs de vaa recombinés pour l'expression de protéines sécrétées |
| JP7212230B2 (ja) | 2018-07-19 | 2023-01-25 | ヘリックスミス カンパニー， リミテッド | ネイキッドｄｎａ遺伝子療法のための凍結乾燥した薬剤学的組成物 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996026742A1 (fr) * | 1995-02-28 | 1996-09-06 | The Regents Of The University Of California | Therapie angiogenique par transfert de genes |
| WO1998032859A1 (fr) * | 1997-01-29 | 1998-07-30 | Cornell Research Foundation, Inc. | Administration a des sites multiples d'un vecteur d'adenovirus en vue de provoquer une angiogenese |
| WO1998050079A2 (fr) * | 1997-05-06 | 1998-11-12 | The Regents Of The University Of California | Techniques et compositions destinees au traitement d'une insuffisance cardiaque et du remodelage ventriculaire par apport in vivo de transgenes angiogeniques |
| WO1999040945A2 (fr) * | 1998-02-11 | 1999-08-19 | The Regents Of The University Of California | Traitement de l'angiogenese par transfert de genes et techniques d'apport intravasculaire de genes |
| WO2000038518A1 (fr) * | 1998-12-28 | 2000-07-06 | Arch Development Corporation | Transfert efficace et stable in vivo de genes dans des cardiomyocytes a l'aide de vecteurs viraux adeno-associes de recombinaison |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| KR20020049031A (ko) * | 1999-11-05 | 2002-06-24 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 생체내 유전자 송달에 의하여 심혈관 질환을 치료하기위한 기술 및 조성물 |
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2000
- 2000-11-03 KR KR1020027005855A patent/KR20020049031A/ko not_active Application Discontinuation
- 2000-11-03 EP EP00976894A patent/EP1225921A1/fr not_active Withdrawn
- 2000-11-03 CN CN00816481A patent/CN1433325A/zh active Pending
- 2000-11-03 WO PCT/US2000/030345 patent/WO2001034208A1/fr active Application Filing
- 2000-11-03 NZ NZ546670A patent/NZ546670A/en not_active IP Right Cessation
- 2000-11-03 JP JP2001536204A patent/JP2003513942A/ja active Pending
- 2000-11-03 AU AU14604/01A patent/AU784392B2/en not_active Ceased
- 2000-11-03 EA EA200200533A patent/EA008538B1/ru not_active IP Right Cessation
- 2000-11-03 CA CA002389524A patent/CA2389524A1/fr not_active Abandoned
-
2003
- 2003-01-29 HK HK03100751.6A patent/HK1048593A1/zh unknown
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| WO1996026742A1 (fr) * | 1995-02-28 | 1996-09-06 | The Regents Of The University Of California | Therapie angiogenique par transfert de genes |
| WO1998032859A1 (fr) * | 1997-01-29 | 1998-07-30 | Cornell Research Foundation, Inc. | Administration a des sites multiples d'un vecteur d'adenovirus en vue de provoquer une angiogenese |
| WO1998050079A2 (fr) * | 1997-05-06 | 1998-11-12 | The Regents Of The University Of California | Techniques et compositions destinees au traitement d'une insuffisance cardiaque et du remodelage ventriculaire par apport in vivo de transgenes angiogeniques |
| WO1999040945A2 (fr) * | 1998-02-11 | 1999-08-19 | The Regents Of The University Of California | Traitement de l'angiogenese par transfert de genes et techniques d'apport intravasculaire de genes |
| WO2000038518A1 (fr) * | 1998-12-28 | 2000-07-06 | Arch Development Corporation | Transfert efficace et stable in vivo de genes dans des cardiomyocytes a l'aide de vecteurs viraux adeno-associes de recombinaison |
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| GIORDANO F.J. ET AL.: "INTRACORONARY GENE TRANSFER OF FIBROBLAST GROWTH FACTOR-5 INCREASES BLOOD FLOW AND CONTRACTILE FUNCTION IN AN ISCHEMIC REGION OF THE HEART", NATURE MEDICINE, US, NATURE PUBLISHING, CO, vol. 2, no. 5, 1 May 1996 (1996-05-01), pages 534-539, XP000619527, ISSN: 1078-8956, the whole document * |
| ISNER J.M. ET AL.: "CLINICAL EVIDENCE OF ANGLOGENESIS AFTER ARTERIAL GENE TRANSFER OF PHVEGF165 IN PATIENT WITH ISCHAEMIC LIMB", LANCET THE,GB, LANCET LIMITED. LONDON, vol. 348, 10 August 1996 (1996-08-10), pages 370-374, XP002059360, ISSN: 0140-6736, the whole document * |
| LEWIS B.S. ET AL.: "ANGIOGENESIS BY GENE THERAPY: A NEW HORIZON FOR MYOCARDIAL REVASCULARIZATION?", CARDIOVASCULAR RESEARCH, XX, XX, vol. 35, no. 3, 1997, pages 490-497, XP000916748, ISSN: 0008-6363, the whole document * |
| MACK C.A. ET AL.: "SALVAGE ANGIOGENESIS INDUCED BY ADENOVIRUS-MEDIATED GENE TRANSFER OF VASCULAR ENDOTHELIAL GROWTH FACTOR PROTECTS AGAINST ISCHEMIC VASCULAR OCCLUSION," JOURNAL OF VASCULAR SURGERY, C. V. MOSBY CO., ST. LOUIS, MO, US, vol. 27, no. 4, April 1998 (1998-04), pages 699-709, XP000949375, ISSN: 0741-5214, the whole document * |
| RAJANAYAGAM S. ET AL.: "DELIVERY OF VEGF TO ISCHEMIC TISSUE USING ADENOVIRAL-MODIFIED AUTOLOGOUS ENDOTHELIAL CELLS", CIRCULATION, US, AMERICAN HEART ASSOCIATION, DALLAS, TX, vol. 94, no. 8, 15 October 1996 (1996-10-15), page 646, XP002064912, ISSN: 0009-7322, the whole document * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1433325A (zh) | 2003-07-30 |
| AU1460401A (en) | 2001-06-06 |
| EP1225921A1 (fr) | 2002-07-31 |
| HK1048593A1 (zh) | 2003-04-11 |
| CA2389524A1 (fr) | 2001-05-17 |
| AU784392B2 (en) | 2006-03-23 |
| NZ546670A (en) | 2009-02-28 |
| JP2003513942A (ja) | 2003-04-15 |
| EA200200533A1 (ru) | 2002-12-26 |
| WO2001034208A1 (fr) | 2001-05-17 |
| KR20020049031A (ko) | 2002-06-24 |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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