CA2389524A1 - Techniques et compositions permettant de traiter les maladies cardiovasculaires par l'administration de genes in vivo - Google Patents
Techniques et compositions permettant de traiter les maladies cardiovasculaires par l'administration de genes in vivo Download PDFInfo
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- CA2389524A1 CA2389524A1 CA002389524A CA2389524A CA2389524A1 CA 2389524 A1 CA2389524 A1 CA 2389524A1 CA 002389524 A CA002389524 A CA 002389524A CA 2389524 A CA2389524 A CA 2389524A CA 2389524 A1 CA2389524 A1 CA 2389524A1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des procédés permettant de traiter des patients souffrant de maladies cardiovasculaires, et plus particulièrement, de maladies cardiaques et de maladies vasculaires périphériques. Les procédés préférés de la présente invention concernent l'administration in vivo de gènes, le codage de peptides ou de protéines angiogéniques dans le myocarde ou les tissus ischémiques périphériques. Ces procédés consistent à introduire un vecteur contenant ce gène dans un vaisseau sanguin alimentant le coeur ou dans un tissu ischémique périphérique.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43515699A | 1999-11-05 | 1999-11-05 | |
| US09/435,156 | 1999-11-05 | ||
| US60908000A | 2000-06-30 | 2000-06-30 | |
| US09/609,080 | 2000-06-30 | ||
| PCT/US2000/030345 WO2001034208A1 (fr) | 1999-11-05 | 2000-11-03 | Techniques et compositions permettant de traiter les maladies cardiovasculaires par l'administration de genes in vivo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2389524A1 true CA2389524A1 (fr) | 2001-05-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002389524A Abandoned CA2389524A1 (fr) | 1999-11-05 | 2000-11-03 | Techniques et compositions permettant de traiter les maladies cardiovasculaires par l'administration de genes in vivo |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1225921A1 (fr) |
| JP (1) | JP2003513942A (fr) |
| KR (1) | KR20020049031A (fr) |
| CN (1) | CN1433325A (fr) |
| AU (1) | AU784392B2 (fr) |
| CA (1) | CA2389524A1 (fr) |
| EA (1) | EA008538B1 (fr) |
| HK (1) | HK1048593A1 (fr) |
| NZ (1) | NZ546670A (fr) |
| WO (1) | WO2001034208A1 (fr) |
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| CN1433325A (zh) * | 1999-11-05 | 2003-07-30 | 加利福尼亚大学董事会 | 通过体内基因递送治疗心血管疾病的技术和组合物 |
| US20030093147A1 (en) * | 2001-11-13 | 2003-05-15 | Ogle Matthew F. | Medical devices that stimulate growth factor production |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| PL195457B1 (pl) * | 2002-08-05 | 2007-09-28 | Zaklady Farm Polpharma Sa | Kaseta ekspresyjna, dwucistronowy wektor plazmidowy, środek farmaceutyczny oraz ich zastosowanie |
| CA2658628A1 (fr) * | 2006-07-25 | 2008-01-31 | Celladon Corporation | Transfusion coronaire epicardique anterograde prolongee de vecteurs viraux associes a l'adenovirus pour therapie genique |
| PL2197900T3 (pl) * | 2007-08-24 | 2012-12-31 | Univ Wuerzburg J Maximilians | Zmutowane podwójnie cyklizowane peptydy receptorowe hamujące przeciwciała przeciwko beta 1-adrenoreceptorowi |
| BRPI0911511B8 (pt) | 2008-04-09 | 2021-05-25 | Helixmith Co Ltd | formulação de dna liofilizadas para aumentar a expressão de dna de plasmídeo |
| WO2010078624A1 (fr) * | 2009-01-07 | 2010-07-15 | Vegenics Limited | Matériaux et méthodes pour le traitement de l’hypertension |
| KR101006106B1 (ko) * | 2009-06-04 | 2011-01-07 | 김현태 | 전·자기장 차단 전열선 |
| US10155099B2 (en) | 2009-09-21 | 2018-12-18 | Cook Regentec Llc | Method for infusing stem cells |
| HUE036640T2 (hu) * | 2012-02-14 | 2018-07-30 | Univ California | Parakrin gének szisztémás bejuttatása és szabályozott expressziója szív és érrendszeri betegségekre és egyéb állapotokra |
| KR20150016970A (ko) | 2012-06-05 | 2015-02-13 | 머핀 인코포레이티드 | 세포 치료요법에 유용한 카테터 시스템 및 방법 |
| BR112016008267A2 (pt) | 2013-10-22 | 2017-10-03 | Viromed Co Ltd | Composição para prevenir ou tratar esclerose lateral amiotrófica usando duas ou mais isoformas de fator de crescimento de hepatócito |
| US20210393805A1 (en) * | 2018-05-16 | 2021-12-23 | University Of Massachusetts | Perfusion-based delivery of recombinant aav vectors for expression of secreted proteins |
| AU2019305221A1 (en) | 2018-07-19 | 2021-02-18 | Helixmith Co., Ltd. | Lyophilized pharmaceutical compositions for naked DNA gene therapy |
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| CN1136920C (zh) * | 1995-02-28 | 2004-02-04 | 加利福尼亚大学董事会 | 基因转移介导的血管形成疗法 |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| AU745409B2 (en) * | 1997-01-29 | 2002-03-21 | Cornell Research Foundation Inc. | Multiple site delivery of adenoviral vector for the induction of angiogenesis |
| KR20070005030A (ko) * | 1997-05-06 | 2007-01-09 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 혈관형성성 트랜스유전자의 생체내 송달에 의한 심장 질환및 심실 리모델링을 치료하기 위한 방법 및 조성물 |
| CN101186928A (zh) * | 1998-02-11 | 2008-05-28 | 加利福尼亚大学董事会 | 核酸和血管活性剂相组合用于加强的基因投递 |
| AU763049B2 (en) * | 1998-12-28 | 2003-07-10 | Arch Development Corporation | Efficient and stable (in vivo) gene transfer to cardiomyocytes using recombinantadeno-associated virus vectors |
| CN1433325A (zh) * | 1999-11-05 | 2003-07-30 | 加利福尼亚大学董事会 | 通过体内基因递送治疗心血管疾病的技术和组合物 |
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2000
- 2000-11-03 CN CN00816481A patent/CN1433325A/zh active Pending
- 2000-11-03 KR KR1020027005855A patent/KR20020049031A/ko not_active Application Discontinuation
- 2000-11-03 AU AU14604/01A patent/AU784392B2/en not_active Ceased
- 2000-11-03 EP EP00976894A patent/EP1225921A1/fr not_active Withdrawn
- 2000-11-03 EA EA200200533A patent/EA008538B1/ru not_active IP Right Cessation
- 2000-11-03 WO PCT/US2000/030345 patent/WO2001034208A1/fr active Application Filing
- 2000-11-03 NZ NZ546670A patent/NZ546670A/en not_active IP Right Cessation
- 2000-11-03 CA CA002389524A patent/CA2389524A1/fr not_active Abandoned
- 2000-11-03 JP JP2001536204A patent/JP2003513942A/ja active Pending
-
2003
- 2003-01-29 HK HK03100751.6A patent/HK1048593A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU784392B2 (en) | 2006-03-23 |
| HK1048593A1 (zh) | 2003-04-11 |
| AU1460401A (en) | 2001-06-06 |
| EP1225921A1 (fr) | 2002-07-31 |
| EA008538B1 (ru) | 2007-06-29 |
| WO2001034208A1 (fr) | 2001-05-17 |
| NZ546670A (en) | 2009-02-28 |
| JP2003513942A (ja) | 2003-04-15 |
| EA200200533A1 (ru) | 2002-12-26 |
| CN1433325A (zh) | 2003-07-30 |
| KR20020049031A (ko) | 2002-06-24 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Dead |