CA2289600C - Techniques et compositions destinees au traitement d'une insuffisance cardiaque et du remodelage ventriculaire par apport in vivo de transgenes angiogeniques - Google Patents
Techniques et compositions destinees au traitement d'une insuffisance cardiaque et du remodelage ventriculaire par apport in vivo de transgenes angiogeniques Download PDFInfo
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- CA2289600C CA2289600C CA2289600A CA2289600A CA2289600C CA 2289600 C CA2289600 C CA 2289600C CA 2289600 A CA2289600 A CA 2289600A CA 2289600 A CA2289600 A CA 2289600A CA 2289600 C CA2289600 C CA 2289600C
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- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
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- BNHGKKNINBGEQL-UHFFFAOYSA-M sodium;5-ethyl-5-(3-methylbutyl)pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CC(C)CCC1(CC)C(=O)NC(=O)[N-]C1=O BNHGKKNINBGEQL-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne des procédés destinés au traitement de patients souffrant d'insuffisance cardiaque globale (y compris de myocardiopathie dilatée et d'insuffisance cardiaque globale associée à une coronaropathie grave) ainsi qu'à la prévention ou à la limitation du remodelage ventriculaire nuisible à la santé après un infarctus du myocarde. Les procédés préférés de la présente invention comprennent l'apport in vivo au myocarde de gènes codant des protéines angiogéniques ou peptides, par injection directe d'un vecteur contenant le gène dans un vaisseau sanguin irriguant le coeur.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85277997A | 1997-05-06 | 1997-05-06 | |
| US08/852,779 | 1997-05-06 | ||
| PCT/US1998/008848 WO1998050079A2 (fr) | 1997-05-06 | 1998-04-30 | Techniques et compositions destinees au traitement d'une insuffisance cardiaque et du remodelage ventriculaire par apport in vivo de transgenes angiogeniques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2289600A1 CA2289600A1 (fr) | 1998-11-12 |
| CA2289600C true CA2289600C (fr) | 2010-06-29 |
Family
ID=25314196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2289600A Expired - Fee Related CA2289600C (fr) | 1997-05-06 | 1998-04-30 | Techniques et compositions destinees au traitement d'une insuffisance cardiaque et du remodelage ventriculaire par apport in vivo de transgenes angiogeniques |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0980428A2 (fr) |
| JP (1) | JP2002515065A (fr) |
| KR (2) | KR20070005030A (fr) |
| CN (1) | CN1267331A (fr) |
| AU (1) | AU7173598A (fr) |
| CA (1) | CA2289600C (fr) |
| EA (1) | EA005157B1 (fr) |
| WO (1) | WO1998050079A2 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001034208A1 (fr) * | 1999-11-05 | 2001-05-17 | The Regents Of The University Of California | Techniques et compositions permettant de traiter les maladies cardiovasculaires par l'administration de genes in vivo |
| WO1999062940A2 (fr) * | 1998-05-30 | 1999-12-09 | Collateral Therapeutics, Inc. | Procedes de modification du phenotype de la cellule cardiaque |
| DE19915485A1 (de) * | 1999-04-07 | 2000-10-19 | Hugo A Katus | Therapie der Herzinsuffizienz |
| AU2002216751A1 (en) * | 2000-06-30 | 2002-01-14 | Collateral Therapeutics, Inc. | Dual recombinant gene therapy compositions and methods of use |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| AU2008239681B2 (en) | 2007-04-11 | 2013-10-03 | Henry Ford Health System | Cardiac repair, resizing and reshaping using the venous system of the heart |
| EP2244740A1 (fr) | 2008-02-19 | 2010-11-03 | Celladon Corporation | Compositions pour un captage amélioré de vecteurs viraux dans le myocarde |
| RU2470995C2 (ru) | 2008-04-09 | 2012-12-27 | Вайромед Ко., Лтд. | Лиофилизированные днк-составы для увеличенной экспрессии плазмидной днк |
| WO2009132457A1 (fr) | 2008-05-02 | 2009-11-05 | University Of Western Ontario | Fgf-9 et son utilisation se rapportant aux vaisseaux sanguins |
| IN2014DN06789A (fr) * | 2012-02-14 | 2015-05-22 | Univ California | |
| AU2014337870B2 (en) | 2013-10-22 | 2019-11-28 | Helixmith Co., Ltd. | Composition for preventing or treating amyotrophic lateral sclerosis using two or more isoforms of hepatocyte growth factor |
| EP3823677A4 (fr) | 2018-07-19 | 2022-06-01 | Helixmith Co., Ltd. | Compositions pharmaceutiques lyophilisées destinées à la thérapie génique par adn nu |
| CN109517807A (zh) * | 2018-11-20 | 2019-03-26 | 暨南大学 | 一种心脏血管靶向的噬菌体载体及其用途 |
| EP3942018A4 (fr) * | 2019-03-17 | 2022-12-07 | Baylor College of Medicine | Reprogrammation directe de fibroblastes cardiaques en cardiomyocytes à l'aide d'une stratégie de transdifférenciation de cellules endothéliales |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136920C (zh) * | 1995-02-28 | 2004-02-04 | 加利福尼亚大学董事会 | 基因转移介导的血管形成疗法 |
-
1998
- 1998-04-30 EP EP98918904A patent/EP0980428A2/fr not_active Ceased
- 1998-04-30 CA CA2289600A patent/CA2289600C/fr not_active Expired - Fee Related
- 1998-04-30 EA EA199901002A patent/EA005157B1/ru not_active IP Right Cessation
- 1998-04-30 KR KR1020067026818A patent/KR20070005030A/ko not_active Application Discontinuation
- 1998-04-30 JP JP54824398A patent/JP2002515065A/ja active Pending
- 1998-04-30 WO PCT/US1998/008848 patent/WO1998050079A2/fr active Application Filing
- 1998-04-30 KR KR1019997010265A patent/KR20010012313A/ko not_active Application Discontinuation
- 1998-04-30 CN CN98806526A patent/CN1267331A/zh active Pending
- 1998-04-30 AU AU71735/98A patent/AU7173598A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002515065A (ja) | 2002-05-21 |
| KR20010012313A (ko) | 2001-02-15 |
| EP0980428A2 (fr) | 2000-02-23 |
| CA2289600A1 (fr) | 1998-11-12 |
| WO1998050079A2 (fr) | 1998-11-12 |
| WO1998050079A3 (fr) | 1999-02-04 |
| CN1267331A (zh) | 2000-09-20 |
| EA005157B1 (ru) | 2004-12-30 |
| KR20070005030A (ko) | 2007-01-09 |
| EA199901002A1 (ru) | 2000-08-28 |
| AU7173598A (en) | 1998-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180430 |