CN1267331A - 通过在体内运送血管生成转基因来治疗心力衰竭和心室重建的技术和组合物 - Google Patents

通过在体内运送血管生成转基因来治疗心力衰竭和心室重建的技术和组合物 Download PDF

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Publication number
CN1267331A
CN1267331A CN98806526A CN98806526A CN1267331A CN 1267331 A CN1267331 A CN 1267331A CN 98806526 A CN98806526 A CN 98806526A CN 98806526 A CN98806526 A CN 98806526A CN 1267331 A CN1267331 A CN 1267331A
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CN
China
Prior art keywords
fgf
angiogenic proteins
carrier
vegf
heart
Prior art date
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Pending
Application number
CN98806526A
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English (en)
Chinese (zh)
Inventor
H·K·哈蒙德
T·L·凯利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adjuvant Therapy Inc
University of California
Original Assignee
Adjuvant Therapy Inc
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adjuvant Therapy Inc, University of California filed Critical Adjuvant Therapy Inc
Publication of CN1267331A publication Critical patent/CN1267331A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • A61K38/1866Vascular endothelial growth factor [VEGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/30Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN98806526A 1997-05-06 1998-04-30 通过在体内运送血管生成转基因来治疗心力衰竭和心室重建的技术和组合物 Pending CN1267331A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85277997A 1997-05-06 1997-05-06
US08/852,779 1997-05-06

Publications (1)

Publication Number Publication Date
CN1267331A true CN1267331A (zh) 2000-09-20

Family

ID=25314196

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98806526A Pending CN1267331A (zh) 1997-05-06 1998-04-30 通过在体内运送血管生成转基因来治疗心力衰竭和心室重建的技术和组合物

Country Status (8)

Country Link
EP (1) EP0980428A2 (fr)
JP (1) JP2002515065A (fr)
KR (2) KR20070005030A (fr)
CN (1) CN1267331A (fr)
AU (1) AU7173598A (fr)
CA (1) CA2289600C (fr)
EA (1) EA005157B1 (fr)
WO (1) WO1998050079A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108310396A (zh) * 2012-02-14 2018-07-24 加利福尼亚大学董事会 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达
CN109517807A (zh) * 2018-11-20 2019-03-26 暨南大学 一种心脏血管靶向的噬菌体载体及其用途

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2329934A1 (fr) * 1998-05-30 1999-12-09 Collateral Therapeutics, Inc. Procedes de modification du phenotype de la cellule cardiaque
DE19915485A1 (de) 1999-04-07 2000-10-19 Hugo A Katus Therapie der Herzinsuffizienz
NZ546670A (en) * 1999-11-05 2009-02-28 Univ California Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
AU2002216751A1 (en) * 2000-06-30 2002-01-14 Collateral Therapeutics, Inc. Dual recombinant gene therapy compositions and methods of use
KR100562824B1 (ko) 2002-03-20 2006-03-23 주식회사 바이로메드 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자
US7875017B2 (en) 2007-04-11 2011-01-25 Henry Ford Health System Cardiac repair, resizing and reshaping using the venous system of the heart
EP2244740A1 (fr) 2008-02-19 2010-11-03 Celladon Corporation Compositions pour un captage amélioré de vecteurs viraux dans le myocarde
MX2010010993A (es) 2008-04-09 2010-11-05 Viromed Co Ltd Formulaciones liofilizadas de adn para expresion mejorada de adn de plasmido.
CN102076352B (zh) 2008-05-02 2016-06-15 西安大略大学 与血管有关的fgf-9和它的用途
CN105682676B (zh) 2013-10-22 2020-10-23 赫利世弥斯株式会社 利用肝细胞生长因子的两种以上的异构体的肌萎缩性侧索硬化症预防或治疗用组合物
AU2019305221A1 (en) 2018-07-19 2021-02-18 Helixmith Co., Ltd. Lyophilized pharmaceutical compositions for naked DNA gene therapy
EP3942018A4 (fr) * 2019-03-17 2022-12-07 Baylor College of Medicine Reprogrammation directe de fibroblastes cardiaques en cardiomyocytes à l'aide d'une stratégie de transdifférenciation de cellules endothéliales

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0760682A4 (fr) * 1995-02-28 1998-09-09 Univ California Therapie angiogenique par transfert de genes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108310396A (zh) * 2012-02-14 2018-07-24 加利福尼亚大学董事会 用于心血管疾病和其它病况的旁分泌基因的全身性递送和受调节的表达
CN109517807A (zh) * 2018-11-20 2019-03-26 暨南大学 一种心脏血管靶向的噬菌体载体及其用途

Also Published As

Publication number Publication date
KR20070005030A (ko) 2007-01-09
KR20010012313A (ko) 2001-02-15
EA005157B1 (ru) 2004-12-30
CA2289600A1 (fr) 1998-11-12
JP2002515065A (ja) 2002-05-21
AU7173598A (en) 1998-11-27
EP0980428A2 (fr) 2000-02-23
CA2289600C (fr) 2010-06-29
EA199901002A1 (ru) 2000-08-28
WO1998050079A3 (fr) 1999-02-04
WO1998050079A2 (fr) 1998-11-12

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