EA007530B1 - Противоопухолевые комбинации - Google Patents
Противоопухолевые комбинации Download PDFInfo
- Publication number
- EA007530B1 EA007530B1 EA200301319A EA200301319A EA007530B1 EA 007530 B1 EA007530 B1 EA 007530B1 EA 200301319 A EA200301319 A EA 200301319A EA 200301319 A EA200301319 A EA 200301319A EA 007530 B1 EA007530 B1 EA 007530B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- rapamycin
- alkylating agent
- derivative
- esters
- neoplasm
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
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| US29523601P | 2001-06-01 | 2001-06-01 | |
| US29519001P | 2001-06-01 | 2001-06-01 | |
| PCT/US2002/016737 WO2002098416A2 (en) | 2001-06-01 | 2002-05-29 | Antineoplastic combinations |
Publications (2)
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|---|---|
| EA200301319A1 EA200301319A1 (ru) | 2004-04-29 |
| EA007530B1 true EA007530B1 (ru) | 2006-10-27 |
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| EA200301319A EA007530B1 (ru) | 2001-06-01 | 2002-05-29 | Противоопухолевые комбинации |
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| MX (1) | MXPA03010907A (cg-RX-API-DMAC7.html) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2678448C2 (ru) * | 2007-03-07 | 2019-01-29 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи. | Наночастица, содержащая рапамицин и альбумин, в качестве противоракового агента |
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|---|---|---|---|---|
| PL231418B1 (pl) | 2001-02-19 | 2019-02-28 | Novartis Ag | 40-O-( 2-hydroksyetylo)- rapamycyna do zastosowania w leczeniu guzów litych płuc, innych niż nowotwór tkanki limfatycznej |
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| AR046194A1 (es) | 2003-11-04 | 2005-11-30 | Mayo Foundation | Metodo de tratamiento del linfoma de celulas del manto |
| MX2007009317A (es) | 2005-02-03 | 2008-01-30 | Gen Hospital Corp | Metodo para tratar cancer resistente a gefitinib. |
| CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
| GB0523658D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
| JP2009516671A (ja) * | 2005-11-21 | 2009-04-23 | ノバルティス アクチエンゲゼルシャフト | ｍＴＯＲ阻害剤を使用する神経内分泌腫瘍処置 |
| US20090023768A1 (en) * | 2006-02-24 | 2009-01-22 | Novartis Ag | Rapamycin derivatives for treating neuroblastoma |
| KR20140019032A (ko) * | 2006-04-05 | 2014-02-13 | 노파르티스 아게 | 암을 치료하기 위한 치료제의 조합물 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| WO2010008744A2 (en) | 2008-06-17 | 2010-01-21 | Wyeth | Antineoplastic combinations containing hki-272 and vinorelbine |
| RU2498804C2 (ru) | 2008-08-04 | 2013-11-20 | ВАЙЕТ ЭлЭлСи | Противоопухолевые комбинации из 4-анилино-3-цианохинолинов и капецитабина |
| JP5992325B2 (ja) | 2009-04-06 | 2016-09-14 | ワイス・エルエルシー | 乳癌のための、ネラチニブを活用する治療計画 |
| CN103721189A (zh) * | 2013-12-27 | 2014-04-16 | 刘玉含 | 一种脑膜瘤护理药物及其制备方法 |
| CN105168204A (zh) * | 2015-09-06 | 2015-12-23 | 江志鑫 | 一种含有丝裂霉素的抗结肠癌药物组合物 |
| CN119732959A (zh) * | 2024-12-31 | 2025-04-01 | 吉林大学 | 具有mTOR抑制能力的制剂在制备抗肿瘤联合用药物组合物中的应用 |
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|---|---|---|---|---|
| US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
| US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
| EP0525960A1 (en) * | 1991-06-18 | 1993-02-03 | American Home Products Corporation | Use of rapamycin for the treatment of adult T-cell leukemia/lymphoma |
| WO2002040000A2 (en) * | 2000-11-15 | 2002-05-23 | Wyeth | Use of cci-779 as an antineoplastic agent |
| WO2002066019A2 (en) * | 2001-02-19 | 2002-08-29 | Novartis Ag | Cancer treatment |
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2008
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|---|---|---|---|---|
| US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
| US4401653A (en) * | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
| EP0525960A1 (en) * | 1991-06-18 | 1993-02-03 | American Home Products Corporation | Use of rapamycin for the treatment of adult T-cell leukemia/lymphoma |
| WO2002040000A2 (en) * | 2000-11-15 | 2002-05-23 | Wyeth | Use of cci-779 as an antineoplastic agent |
| WO2002066019A2 (en) * | 2001-02-19 | 2002-08-29 | Novartis Ag | Cancer treatment |
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| BONI J. ET AL.: "PHARMACOKINETICS OF ESCALATING DOSES OF CCI-779 IN COMBINATION WITH 5-FLUOROURACIL AND LEUCOVORIN IN PATIENTS WITH ADVANCED SOLID TUMORS", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, VOL. 37, NR. SUPPL 6, PAGE(S) S68, XP001084492, ISSN: 0959-8049, abstract * |
| GEOERGER B. ET AL.: "ANTITUMOR ACTIVITY OF THE RAPAMYCIN ANALOG CCI-779 IN HUMAN PRIMITIVE NEUROECTODERMAL TUMOR/MEDULLOBLASTOMA MODELS AS SINGLE AGENT AND IN COMBINATION CHEMOTHERAPY" CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 4, no. 61, 15 February 2001 (2001-02-15), pages 1527-1532, XP001079526, ISSN: 0008-5472, page 1528, right-hand column, line 30-45, discussion, page 1529, right-hand column, line 15-22; figures 1,6; table 1 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2678448C2 (ru) * | 2007-03-07 | 2019-01-29 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи. | Наночастица, содержащая рапамицин и альбумин, в качестве противоракового агента |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1392286A2 (en) | 2004-03-03 |
| HUP0400006A2 (hu) | 2004-04-28 |
| CO5540294A2 (es) | 2005-07-29 |
| PL367267A1 (en) | 2005-02-21 |
| AU2002259309B2 (en) | 2008-05-01 |
| AU2008202690A1 (en) | 2008-07-10 |
| EA200301319A1 (ru) | 2004-04-29 |
| NO20035317L (no) | 2003-12-22 |
| KR20040025923A (ko) | 2004-03-26 |
| MXPA03010907A (es) | 2004-02-17 |
| CN1646120A (zh) | 2005-07-27 |
| NZ529877A (en) | 2006-08-31 |
| CA2447732A1 (en) | 2002-12-12 |
| WO2002098416A3 (en) | 2003-03-13 |
| JP2004532883A (ja) | 2004-10-28 |
| CN100496485C (zh) | 2009-06-10 |
| WO2002098416A2 (en) | 2002-12-12 |
| KR100875611B1 (ko) | 2008-12-24 |
| IL158800A0 (en) | 2004-05-12 |
| SG153647A1 (en) | 2009-07-29 |
| BR0210101A (pt) | 2004-06-08 |
| NO20035317D0 (no) | 2003-11-28 |
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