DZ3197A1 - Acides aminés bicycliques utilises comme agents pharmaceutiques. - Google Patents

Acides aminés bicycliques utilises comme agents pharmaceutiques.

Info

Publication number
DZ3197A1
DZ3197A1 DZ003197A DZ003197A DZ3197A1 DZ 3197 A1 DZ3197 A1 DZ 3197A1 DZ 003197 A DZ003197 A DZ 003197A DZ 003197 A DZ003197 A DZ 003197A DZ 3197 A1 DZ3197 A1 DZ 3197A1
Authority
DZ
Algeria
Prior art keywords
amino acids
pharmaceutical agents
acids used
bicyclic amino
bicyclic
Prior art date
Application number
DZ003197A
Other languages
English (en)
French (fr)
Inventor
Justin Stephen Bryans
David Clive Blakemore
Simon Osborne
Jean-Marie Receveur
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DZ3197A1 publication Critical patent/DZ3197A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/18All rings being cycloaliphatic the ring system containing six carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/20All rings being cycloaliphatic the ring system containing seven carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/22All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/26All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28Hydrogenated naphthalenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
DZ003197A 1999-10-20 2000-10-17 Acides aminés bicycliques utilises comme agents pharmaceutiques. DZ3197A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16072599P 1999-10-20 1999-10-20
PCT/US2000/028687 WO2001028978A1 (en) 1999-10-20 2000-10-17 Bicyclic amino acids as pharmaceutical agents

Publications (1)

Publication Number Publication Date
DZ3197A1 true DZ3197A1 (fr) 2001-04-26

Family

ID=22578159

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ003197A DZ3197A1 (fr) 1999-10-20 2000-10-17 Acides aminés bicycliques utilises comme agents pharmaceutiques.

Country Status (50)

Country Link
US (2) US6689906B1 (ru)
EP (2) EP1506955B1 (ru)
JP (2) JP3632191B2 (ru)
KR (2) KR100566462B1 (ru)
CN (1) CN1165518C (ru)
AP (2) AP2004003186A0 (ru)
AR (2) AR026087A1 (ru)
AT (2) ATE293590T1 (ru)
AU (2) AU778871B2 (ru)
BG (2) BG106719A (ru)
BR (1) BR0014972B1 (ru)
CA (1) CA2386297C (ru)
CO (1) CO5280060A1 (ru)
CR (1) CR6620A (ru)
CU (1) CU23112A3 (ru)
CZ (1) CZ295960B6 (ru)
DE (2) DE60034157T2 (ru)
DO (1) DOP2000000083A (ru)
DZ (1) DZ3197A1 (ru)
EA (1) EA005206B1 (ru)
EC (1) ECSP045393A (ru)
EE (1) EE200200211A (ru)
ES (2) ES2237464T3 (ru)
GE (1) GEP20043297B (ru)
GT (2) GT200000183A (ru)
HK (1) HK1049826B (ru)
HN (1) HN2000000224A (ru)
HR (2) HRP20020428B1 (ru)
HU (1) HUP0203325A3 (ru)
IL (3) IL149143A0 (ru)
IS (2) IS6348A (ru)
MA (1) MA26842A1 (ru)
MX (1) MXPA02003229A (ru)
MY (1) MY127678A (ru)
NO (2) NO20021780L (ru)
NZ (1) NZ517961A (ru)
OA (1) OA12070A (ru)
PA (1) PA8505201A1 (ru)
PE (1) PE20010740A1 (ru)
PL (1) PL354607A1 (ru)
PT (1) PT1226110E (ru)
SI (1) SI1226110T1 (ru)
SK (1) SK5232002A3 (ru)
SV (1) SV2001000188A (ru)
TR (2) TR200201094T2 (ru)
TW (2) TW200505824A (ru)
UA (1) UA72931C2 (ru)
WO (1) WO2001028978A1 (ru)
YU (2) YU73004A (ru)
ZA (1) ZA200202543B (ru)

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CN1279900C (zh) * 2000-06-26 2006-10-18 沃尼尔·朗伯公司 用于睡眠障碍的加巴喷丁类似物
US6620829B2 (en) 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
EP1226820A1 (en) 2001-01-26 2002-07-31 Warner-Lambert Company Use of bicyclic amino acids for preventing and treating visceral pain and gastrointestinal disorders
DE60235619D1 (de) 2001-04-19 2010-04-22 Warner Lambert Co Kondensierte bizyklische oder trizyklische aminosäuren
GB2375109A (en) * 2001-05-04 2002-11-06 Warner Lambert Co Process for preparing bicyclic amino acid
GB2375108A (en) * 2001-05-04 2002-11-06 Warner Lambert Co Production of a bicycloheptanone
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
ATE380029T1 (de) * 2001-06-11 2007-12-15 Xenoport Inc Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
NZ532624A (en) 2002-01-31 2007-05-31 Warner Lambert Co Alpha2delta ligands to treat tinnitus
CA2476438A1 (en) * 2002-02-22 2003-08-28 Warner-Lambert Company Llc Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
JP2005534678A (ja) * 2002-06-27 2005-11-17 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 注意欠陥多動性障害の治療方法
BR0313432A (pt) * 2002-08-15 2005-07-12 Pfizer Uso terapêutico de aminoácidos bicìclicos ou tricìclicos fundidos
GB0219024D0 (en) * 2002-08-15 2002-09-25 Pfizer Ltd Synergistic combinations
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US7018818B2 (en) 2002-10-04 2006-03-28 Pfizer Inc. Intermediates in the preparation of therapeutic fused bicyclic amino acids
GB0223072D0 (en) 2002-10-04 2002-11-13 Pfizer Ltd Cyclic nitromethyl acetic acid derivatives
AU2003297927A1 (en) 2002-12-11 2004-06-30 Xenoport, Inc. Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof
CA2505788A1 (en) 2002-12-13 2004-07-01 Warner-Lambert Company Llc Pregabalin derivatives for the treatment of fibromyalgia and other disorders
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
KR20070091049A (ko) 2002-12-13 2007-09-06 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드
RU2320369C2 (ru) 2003-09-12 2008-03-27 Пфайзер Инк. Комбинации, содержащие альфа-2-дельта лиганды и ингибиторы обратного захвата серотонина/норадреналина
WO2006092692A1 (en) * 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
AR061728A1 (es) * 2006-06-30 2008-09-17 Pfizer Prod Inc Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
UA94979C2 (uk) 2006-12-22 2011-06-25 Рекордати Айеленд Лимитед КОМБІНОВАНА ТЕРАПІЯ ПОРУШЕНЬ НИЖНІХ СЕЧОВИВІДНИХ ШЛЯХІВ ЛІГАНДАМИ α2δ І НПЗП
CA2701110C (en) 2007-09-28 2013-01-08 Daiichi Sankyo Company, Limited Bicyclic .gamma.-amino acid derivative
TWI462893B (zh) * 2009-03-26 2014-12-01 Daiichi Sankyo Co Ltd 二環性γ-胺基酸衍生物之製造方法
ES2659162T3 (es) 2011-06-08 2018-03-14 Daiichi Sankyo Company, Limited Procedimiento de producción de compuesto bicíclico a través de una sal de iminio
EP2719677B1 (en) 2011-06-08 2017-09-06 Daiichi Sankyo Company, Limited Method for producing bicyclic compound via claisen rearrangement
WO2013089188A1 (ja) 2011-12-15 2013-06-20 第一三共株式会社 不斉触媒を用いる二環性化合物の光学分割方法
CA2869994C (en) 2012-04-10 2017-05-30 Daiichi Sankyo Company, Limited Optical resolution method for bicyclic compound using enzyme
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DE2460891C2 (de) 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JP3756761B2 (ja) 1997-10-27 2006-03-15 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 医薬として有用な環状アミノ酸およびその誘導体

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DE60034157D1 (de) 2007-05-10
PE20010740A1 (es) 2001-07-27
JP3632191B2 (ja) 2005-03-23
GT200000183AA (es) 2005-06-17
IL164060A0 (en) 2005-12-18
MY127678A (en) 2006-12-29
PA8505201A1 (es) 2002-08-29
KR100593349B1 (ko) 2006-06-26
HK1049826B (zh) 2005-02-25
NO20021780D0 (no) 2002-04-16
SK5232002A3 (en) 2003-07-01
CO5280060A1 (es) 2003-05-30
YU29302A (sh) 2005-06-10
CZ20021310A3 (cs) 2003-05-14
EP1226110A1 (en) 2002-07-31
BR0014972A (pt) 2002-07-16
AU1092001A (en) 2001-04-30
JP3744928B2 (ja) 2006-02-15
BG108860A (en) 2006-03-31
OA12070A (en) 2003-11-10
AR026087A1 (es) 2002-12-26
AU2005201268A1 (en) 2005-04-21
DOP2000000083A (es) 2002-03-30
GEP20043297B (en) 2004-01-12
GT200000183A (es) 2000-10-19
HUP0203325A3 (en) 2003-12-29
YU73004A (sh) 2005-11-28
US20040152779A1 (en) 2004-08-05
TR200500221T2 (tr) 2005-03-21
PL354607A1 (en) 2004-01-26
AR045456A2 (es) 2005-10-26
KR20020040900A (ko) 2002-05-30
IL149143A0 (en) 2002-11-10
CN1382118A (zh) 2002-11-27
US6835751B2 (en) 2004-12-28
BR0014972B1 (pt) 2011-09-06
IS7497A (is) 2004-10-08
HRP20020428A2 (en) 2005-02-28
US6689906B1 (en) 2004-02-10
EA005206B1 (ru) 2004-12-30
ES2237464T3 (es) 2005-08-01
CN1165518C (zh) 2004-09-08
IS6348A (is) 2002-04-17
ES2282785T3 (es) 2007-10-16
WO2001028978A1 (en) 2001-04-26
KR20060013701A (ko) 2006-02-13
IL149143A (en) 2007-02-11
SV2001000188A (es) 2001-09-07
AP2002002517A0 (en) 2002-06-30
DE60019628T2 (de) 2006-01-19
JP2003512348A (ja) 2003-04-02
DE60019628D1 (de) 2005-05-25
TR200201094T2 (tr) 2002-09-23
TWI225855B (en) 2005-01-01
EP1506955B1 (en) 2007-03-28
DE60034157T2 (de) 2007-12-13
KR100566462B1 (ko) 2006-03-31
EP1226110B1 (en) 2005-04-20
AU778871B2 (en) 2004-12-23
CR6620A (es) 2004-02-02
CZ295960B6 (cs) 2005-12-14
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HK1049826A1 (en) 2003-05-30
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ZA200202543B (en) 2003-09-23
EE200200211A (et) 2003-06-16
CA2386297C (en) 2010-02-09
UA72931C2 (ru) 2005-05-16
CA2386297A1 (en) 2001-04-26
BG106719A (bg) 2003-02-28
ECSP045393A (es) 2004-10-23
PT1226110E (pt) 2005-07-29
CU23112A3 (es) 2006-02-27
SI1226110T1 (en) 2005-08-31
EP1506955A1 (en) 2005-02-16
ATE293590T1 (de) 2005-05-15
MA26842A1 (fr) 2004-12-20
NO20021780L (no) 2002-04-16
ATE358116T1 (de) 2007-04-15
HUP0203325A2 (hu) 2003-02-28
HN2000000224A (es) 2001-04-11
HRP20040709A2 (en) 2004-12-31
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MXPA02003229A (es) 2002-09-30
TW200505824A (en) 2005-02-16
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EA200200293A1 (ru) 2002-10-31
NO20043663L (no) 2002-04-16

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