DOP2012000289A - Proceso para preparar compuestos de pirimidinona - Google Patents
Proceso para preparar compuestos de pirimidinonaInfo
- Publication number
- DOP2012000289A DOP2012000289A DO2012000289A DO2012000289A DOP2012000289A DO P2012000289 A DOP2012000289 A DO P2012000289A DO 2012000289 A DO2012000289 A DO 2012000289A DO 2012000289 A DO2012000289 A DO 2012000289A DO P2012000289 A DOP2012000289 A DO P2012000289A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- pirimidinone
- prepare
- formula
- atherosclerosis
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34522410P | 2010-05-17 | 2010-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2012000289A true DOP2012000289A (es) | 2013-04-15 |
Family
ID=44992024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2012000289A DOP2012000289A (es) | 2010-05-17 | 2012-11-15 | Proceso para preparar compuestos de pirimidinona |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9447052B2 (enExample) |
| EP (1) | EP2571857B1 (enExample) |
| JP (1) | JP6027529B2 (enExample) |
| KR (1) | KR20130089157A (enExample) |
| CN (2) | CN103003249B (enExample) |
| AR (1) | AR081399A1 (enExample) |
| AU (1) | AU2011256270B2 (enExample) |
| BR (1) | BR112012030532A2 (enExample) |
| CA (1) | CA2799520C (enExample) |
| CL (1) | CL2012003206A1 (enExample) |
| CO (1) | CO6630197A2 (enExample) |
| CR (1) | CR20120630A (enExample) |
| DO (1) | DOP2012000289A (enExample) |
| EA (1) | EA026569B1 (enExample) |
| IL (1) | IL223068A0 (enExample) |
| MA (1) | MA34301B1 (enExample) |
| MX (1) | MX2012013387A (enExample) |
| NZ (1) | NZ603672A (enExample) |
| PE (1) | PE20130318A1 (enExample) |
| PH (1) | PH12012502247A1 (enExample) |
| SG (1) | SG185559A1 (enExample) |
| TW (1) | TW201209043A (enExample) |
| UY (1) | UY33388A (enExample) |
| WO (1) | WO2011146494A1 (enExample) |
| ZA (1) | ZA201208631B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY33388A (es) * | 2010-05-17 | 2011-12-01 | Glaxo Group Ltd | Nuevos procesos para la preparacion de compuestos de pirimidinona |
| WO2015087239A1 (en) | 2013-12-11 | 2015-06-18 | Ranbaxy Laboratories Limited | Processes for the preparation of darapladib and its intermediates |
| WO2015092687A2 (en) | 2013-12-17 | 2015-06-25 | Ranbaxy Laboratories Limited | Process for the purification of darapladib |
| US11583596B2 (en) | 2017-09-26 | 2023-02-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Radiolabeled Darapladib and analogs thereof and their use as imaging compounds |
| US10866963B2 (en) * | 2017-12-28 | 2020-12-15 | Dropbox, Inc. | File system authentication |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1143516B (de) * | 1961-04-27 | 1963-02-14 | Bayer Ag | Verfahren zur Herstellung von Peptiden |
| US4277465A (en) | 1978-08-26 | 1981-07-07 | Kyoto Yakuhin Kogyo Kabushiki Kaisha | Adjuvant for promoting absorption of therapeutically active substances through the digestive tract |
| US4235776A (en) * | 1979-03-15 | 1980-11-25 | Eli Lilly And Company | Tetrahydro-2H-benzo[c]pyrroles |
| DE2941597A1 (de) * | 1979-10-13 | 1981-04-23 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate von 4,5-dialkyl-3-hydroxy-pyrrol-2-carbonsaeureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
| US4619941A (en) * | 1984-11-19 | 1986-10-28 | American Cyanamid Company | N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents |
| US6417192B1 (en) | 1997-11-06 | 2002-07-09 | Smithkline Beecham P.L.C. | Pyrimidinone compounds and pharmaceutical compositions containing them |
| US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
| WO2000028328A1 (en) | 1998-11-05 | 2000-05-18 | Biocryst Pharmaceuticals, Inc. | New cyclopentane and cyclopentene compounds and use for detecting influenza virus |
| CN1286822C (zh) * | 1999-05-01 | 2006-11-29 | 史密丝克莱恩比彻姆有限公司 | 嘧啶酮化合物 |
| KR100781425B1 (ko) * | 2000-02-16 | 2007-12-03 | 스미스클라인비이참피이엘시이 | Ｌｄｌ-ｐｌａ2 억제제로서 피리미딘-4-온 유도체 |
| GB0119795D0 (en) * | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
| UY33388A (es) * | 2010-05-17 | 2011-12-01 | Glaxo Group Ltd | Nuevos procesos para la preparacion de compuestos de pirimidinona |
-
2011
- 2011-05-16 UY UY33388A patent/UY33388A/es not_active Application Discontinuation
- 2011-05-16 AR ARP110101679 patent/AR081399A1/es unknown
- 2011-05-16 TW TW100117029A patent/TW201209043A/zh unknown
- 2011-05-17 CA CA2799520A patent/CA2799520C/en not_active Expired - Fee Related
- 2011-05-17 BR BR112012030532A patent/BR112012030532A2/pt not_active IP Right Cessation
- 2011-05-17 NZ NZ60367211A patent/NZ603672A/en not_active IP Right Cessation
- 2011-05-17 SG SG2012083648A patent/SG185559A1/en unknown
- 2011-05-17 JP JP2013511295A patent/JP6027529B2/ja not_active Expired - Fee Related
- 2011-05-17 WO PCT/US2011/036821 patent/WO2011146494A1/en not_active Ceased
- 2011-05-17 AU AU2011256270A patent/AU2011256270B2/en not_active Ceased
- 2011-05-17 CN CN201180035126.7A patent/CN103003249B/zh not_active Expired - Fee Related
- 2011-05-17 EA EA201291235A patent/EA026569B1/ru not_active IP Right Cessation
- 2011-05-17 MA MA35441A patent/MA34301B1/fr unknown
- 2011-05-17 MX MX2012013387A patent/MX2012013387A/es unknown
- 2011-05-17 EP EP11784095.9A patent/EP2571857B1/en active Active
- 2011-05-17 PE PE2012002160A patent/PE20130318A1/es not_active Application Discontinuation
- 2011-05-17 US US13/698,102 patent/US9447052B2/en not_active Expired - Fee Related
- 2011-05-17 KR KR20127032795A patent/KR20130089157A/ko not_active Abandoned
- 2011-05-17 PH PH1/2012/502247A patent/PH12012502247A1/en unknown
- 2011-05-17 CN CN201610182606.0A patent/CN105837520A/zh active Pending
-
2012
- 2012-11-15 DO DO2012000289A patent/DOP2012000289A/es unknown
- 2012-11-15 IL IL223068A patent/IL223068A0/en unknown
- 2012-11-16 CL CL2012003206A patent/CL2012003206A1/es unknown
- 2012-11-16 CO CO12208170A patent/CO6630197A2/es unknown
- 2012-11-16 ZA ZA2012/08631A patent/ZA201208631B/en unknown
- 2012-12-12 CR CR20120630A patent/CR20120630A/es unknown
-
2016
- 2016-08-12 US US15/235,468 patent/US9725420B2/en not_active Expired - Fee Related
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