DK2542685T3 - Fremgangsmåde til enzymatisk syntese af fedtsyre-alkylestere - Google Patents

Fremgangsmåde til enzymatisk syntese af fedtsyre-alkylestere

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Publication number
DK2542685T3
DK2542685T3 DK11706030.1T DK11706030T DK2542685T3 DK 2542685 T3 DK2542685 T3 DK 2542685T3 DK 11706030 T DK11706030 T DK 11706030T DK 2542685 T3 DK2542685 T3 DK 2542685T3
Authority
DK
Denmark
Prior art keywords
procedure
alkyl esters
acid alkyl
enzymatic synthesis
fatic acid
Prior art date
Application number
DK11706030.1T
Other languages
English (en)
Inventor
Sobhi Basheer
Maisa Haj
Doaa Shehadeh
Ahmad Hindawi
Emad Masoud
Usama Mohsen
Original Assignee
Trans Bio Diesel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trans Bio Diesel Ltd filed Critical Trans Bio Diesel Ltd
Application granted granted Critical
Publication of DK2542685T3 publication Critical patent/DK2542685T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/091—Phenol resins; Amino resins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/649—Biodiesel, i.e. fatty acid alkyl esters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK11706030.1T 2010-03-01 2011-02-02 Fremgangsmåde til enzymatisk syntese af fedtsyre-alkylestere DK2542685T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30912210P 2010-03-01 2010-03-01
PCT/IL2011/000121 WO2011107977A1 (en) 2010-03-01 2011-02-02 A process for the enzymatic synthesis of fatty acid alkyl esters

Publications (1)

Publication Number Publication Date
DK2542685T3 true DK2542685T3 (da) 2014-06-23

Family

ID=44150462

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11706030.1T DK2542685T3 (da) 2010-03-01 2011-02-02 Fremgangsmåde til enzymatisk syntese af fedtsyre-alkylestere

Country Status (14)

Country Link
EP (1) EP2542685B1 (da)
JP (1) JP5554848B2 (da)
KR (2) KR101858915B1 (da)
CN (1) CN102812128B (da)
AR (1) AR080117A1 (da)
AU (1) AU2011222439B2 (da)
BR (1) BR112012022006B1 (da)
CA (1) CA2791836C (da)
DK (1) DK2542685T3 (da)
ES (1) ES2462548T3 (da)
MX (1) MX2012010056A (da)
RU (1) RU2600879C2 (da)
WO (1) WO2011107977A1 (da)
ZA (1) ZA201206168B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10000731B2 (en) 2010-03-01 2018-06-19 Trans Bio-Diesel Ltd. Enzymatic transesterification/esterification processes employing lipases immobilized on hydrophobic resins in the presence of water solutions
US8313648B2 (en) 2010-04-06 2012-11-20 Heliae Development, Llc Methods of and systems for producing biofuels from algal oil
US8115022B2 (en) 2010-04-06 2012-02-14 Heliae Development, Llc Methods of producing biofuels, chlorophylls and carotenoids
US8475660B2 (en) 2010-04-06 2013-07-02 Heliae Development, Llc Extraction of polar lipids by a two solvent method
KR20130041802A (ko) 2010-04-06 2013-04-25 헬리아에 디벨롭먼트, 엘엘씨 감소하는 극성의 용매를 사용하는, 유지성 물질로부터 오일 및 단백질성 물질의 연속 용매 추출법
US8273248B1 (en) 2010-04-06 2012-09-25 Heliae Development, Llc Extraction of neutral lipids by a two solvent method
US8308951B1 (en) 2010-04-06 2012-11-13 Heliae Development, Llc Extraction of proteins by a two solvent method
AU2011376066B2 (en) * 2011-08-31 2015-11-26 Trans Bio-Diesel Ltd. Enzymatic transesterification with lipases immobilized on hydrophobic resins in water solutions
WO2013075116A2 (en) 2011-11-17 2013-05-23 Heliae Development, Llc Omega 7 rich compositions and methods of isolating omega 7 fatty acids
WO2013081446A1 (en) * 2011-12-02 2013-06-06 Universiti Malaya A process for producing biodiesel from natural oil and a system thereof
US20150353970A1 (en) * 2012-12-31 2015-12-10 Trans Bio-Diesel Ltd. Enzymatic transesterification/esterification processing systems and processes employing lipases immobilzed on hydrophobic resins
CN103044260A (zh) * 2013-01-18 2013-04-17 武汉大学 一种制备碳酸甲基烷基酯的方法
KR101355141B1 (ko) * 2013-03-20 2014-01-29 주식회사 엠알아이 바이오디젤의 제조방법
KR101684455B1 (ko) * 2013-07-30 2016-12-08 한국생명공학연구원 고정화 효소를 이용한 연속식 바이오디젤 생산 반응기 및 바이오디젤 생산 방법
KR101511744B1 (ko) * 2014-04-28 2015-04-22 티케이엘 주식회사 효소순환공정을 이용한 세틸화된 지방산 복합물의 생산장치
EP3149179A1 (en) * 2014-05-28 2017-04-05 Novozymes A/S Production of fatty acid alkyl esters with caustic treatment
KR101590268B1 (ko) * 2014-09-16 2016-02-01 광운대학교 산학협력단 효소를 이용한 글리세롤 아세테이트의 제조 방법
US11248245B2 (en) 2014-12-19 2022-02-15 International Flora Technologies, Ltd. Processes and systems for catalytic manufacture of wax ester derivatives
US10435726B2 (en) 2014-12-19 2019-10-08 International Flora Technologies, Ltd. Processes and systems for catalytic manufacture of wax ester derivatives
JP7261011B2 (ja) * 2015-08-31 2023-04-19 インターナショナル フローラ テクノロジーズ，リミテッド ワックスエステル誘導体の触媒的製造の方法および系
CN106906256A (zh) * 2017-03-20 2017-06-30 威莱(广州)日用品有限公司 一种脂肪酸甲酯乙氧基化物的合成方法
KR102312069B1 (ko) * 2019-12-31 2021-10-13 주식회사 제이엘비 식물성 에스테르 오일이 함유된 천연화장품 조성물
KR102332935B1 (ko) * 2020-04-06 2021-11-30 한국조선해양 주식회사 바이오 연료 시스템 및 이를 포함하는 해양구조물
IL286349A (en) * 2021-09-13 2023-04-01 Univice M E Ltd Processes for the production of biodiesel from fatty waste
FR3126994A1 (fr) * 2021-09-14 2023-03-17 Gecco Procédé et installation pour la synthèse enzymatique d’un biodiésel à partir de lipides usagés

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US5204251A (en) * 1987-05-11 1993-04-20 Kanegafuchi Kagaku Kogyo & Kabushiki Kaisha Process of enzymatic interesterification maintaining a water content of 30-300 ppm using Rhizopus
KR0164050B1 (ko) * 1996-03-29 1998-11-16 남창우 비용매상에서 효소를 이용한 에스테르 화합물의 제조방법
JP4012117B2 (ja) * 2002-07-02 2007-11-21 花王株式会社 固定化酵素の製造方法
DE102004015781A1 (de) * 2004-03-31 2005-10-20 Cognis Ip Man Gmbh Verfahren zur enzymatischen Synthese von Triglyceriden ungesättigter Fettsäuren
US7473539B2 (en) 2004-09-20 2009-01-06 Sunho Biodiesel Corporation Methods for producing alkyl esters
DE102005002700A1 (de) 2005-01-19 2006-07-27 Cognis Deutschland Gmbh & Co. Kg Zusammensetzungen verwendbar als Biotreibstoff
ES2836774T3 (es) 2005-05-23 2021-06-28 Epax Norway As Concentración de ésteres de alquilo de ácido graso mediante reacciones enzimáticas con glicerol
KR101294635B1 (ko) * 2005-09-12 2013-08-16 노보자임스 에이/에스 효소학적 오일 에스테르 교환반응
ES2289943B1 (es) * 2006-07-21 2008-12-16 Universidad De Cordoba Procedimiento de produccion de biodiesel mediante el uso de lipasa pancreatica de cerdo como biocatalizador enzimatico.
JP5080797B2 (ja) * 2006-12-15 2012-11-21 花王株式会社 固定化酵素を用いた有用物質の製造方法
IL180598A0 (en) 2007-01-08 2007-07-04 Basheer Sobhi Immobilized interfacial enzymes of improved and stabilized activity
IL183084A0 (en) 2007-05-09 2007-09-20 Trans Biodisel Ltd Modified-immobilized enzymes of high tolerance to hydrophilic substrates in organic media
US7790429B2 (en) * 2007-11-28 2010-09-07 Transbiodiesel Ltd. Robust multi-enzyme preparation for the synthesis of fatty acid alkyl esters

Also Published As

Publication number Publication date
MX2012010056A (es) 2012-09-28
ES2462548T3 (es) 2014-05-23
BR112012022006A2 (pt) 2019-09-24
EP2542685B1 (en) 2014-03-26
JP2013520985A (ja) 2013-06-10
ZA201206168B (en) 2014-01-29
EP2542685A1 (en) 2013-01-09
KR20170104002A (ko) 2017-09-13
RU2012141298A (ru) 2014-04-27
CA2791836A1 (en) 2011-09-09
AU2011222439A1 (en) 2012-09-06
AR080117A1 (es) 2012-03-14
CN102812128B (zh) 2017-09-12
JP5554848B2 (ja) 2014-07-23
BR112012022006B1 (pt) 2021-02-23
KR101858915B1 (ko) 2018-05-16
CN102812128A (zh) 2012-12-05
WO2011107977A1 (en) 2011-09-09
CA2791836C (en) 2014-10-28
KR20130004286A (ko) 2013-01-09
RU2600879C2 (ru) 2016-10-27
AU2011222439B2 (en) 2013-07-18

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