DK93584A - Haemophilus-b-influenza polysaccharid exotoxoid-konjugatvaccine - Google Patents

Haemophilus-b-influenza polysaccharid exotoxoid-konjugatvaccine Download PDF

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Publication number
DK93584A
DK93584A DK93584A DK93584A DK93584A DK 93584 A DK93584 A DK 93584A DK 93584 A DK93584 A DK 93584A DK 93584 A DK93584 A DK 93584A DK 93584 A DK93584 A DK 93584A
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DK
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Prior art keywords
influenza
polysaccharide
polysaccharid
haemophilus
conjugate vaccine
Prior art date
Application number
DK93584A
Other languages
English (en)
Other versions
DK161013B (da
DK93584D0 (da
DK161013C (da
Inventor
Gordon K Lance
Original Assignee
Connaught Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Connaught Lab filed Critical Connaught Lab
Publication of DK93584D0 publication Critical patent/DK93584D0/da
Publication of DK93584A publication Critical patent/DK93584A/da
Publication of DK161013B publication Critical patent/DK161013B/da
Application granted granted Critical
Publication of DK161013C publication Critical patent/DK161013C/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK093584A 1982-07-06 1984-02-23 Fremgangsmaade til fremstilling af et vandoploeseligt covalent polysaccharid-diphtheria-toxoid-konjugat samt hapten, i det vaesentlige frit for protein og nucleinsyre, til anvendelse ved fremgangsmaaden DK161013C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/395,743 US4496538A (en) 1982-07-06 1982-07-06 Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
US39574382 1982-07-06
US8301007 1983-07-01
PCT/US1983/001007 WO1984000300A1 (en) 1982-07-06 1983-07-01 Haemophilus influenzae b polysaccharide exotoxoid conjugate vaccine

Publications (4)

Publication Number Publication Date
DK93584D0 DK93584D0 (da) 1984-02-23
DK93584A true DK93584A (da) 1984-02-23
DK161013B DK161013B (da) 1991-05-21
DK161013C DK161013C (da) 1991-10-28

Family

ID=23564316

Family Applications (1)

Application Number Title Priority Date Filing Date
DK093584A DK161013C (da) 1982-07-06 1984-02-23 Fremgangsmaade til fremstilling af et vandoploeseligt covalent polysaccharid-diphtheria-toxoid-konjugat samt hapten, i det vaesentlige frit for protein og nucleinsyre, til anvendelse ved fremgangsmaaden

Country Status (16)

Country Link
US (1) US4496538A (da)
EP (1) EP0098581B1 (da)
JP (2) JPS59501360A (da)
KR (1) KR880001098B1 (da)
AT (1) ATE19734T1 (da)
AU (1) AU561978B2 (da)
CA (1) CA1210695A (da)
DE (1) DE3363505D1 (da)
DK (1) DK161013C (da)
ES (1) ES523905A0 (da)
FI (1) FI79024C (da)
IE (1) IE55268B1 (da)
IL (1) IL69165A (da)
NZ (1) NZ204771A (da)
WO (1) WO1984000300A1 (da)
ZA (1) ZA834939B (da)

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US5360897A (en) * 1981-08-31 1994-11-01 The University Of Rochester Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
US4902506A (en) * 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US5097020A (en) * 1983-07-05 1992-03-17 The University Of Rochester Immunogenic conjugates
US4761283A (en) * 1983-07-05 1988-08-02 The University Of Rochester Immunogenic conjugates
US4762713A (en) * 1983-07-05 1988-08-09 The University Of Rochester Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers
US4695624A (en) * 1984-05-10 1987-09-22 Merck & Co., Inc. Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
GB8421282D0 (en) * 1984-08-22 1984-09-26 Connaught Lab Multispecific antigenic proteins
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US5173294A (en) * 1986-11-18 1992-12-22 Research Foundation Of State University Of New York Dna probe for the identification of haemophilus influenzae
NZ223009A (en) * 1986-12-31 1990-06-26 Nl Rivm Of Thoven Oligosaccharides containing d-ribose d-ribitol and phosphate units mimicing haemophilus influenzae type b antigens
US5785973A (en) * 1988-02-01 1998-07-28 Praxis Biologics, Inc. Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines
EP0378929A3 (en) * 1988-12-23 1990-08-01 Connaught Laboratories Limited Membrane proteins and peptides of haemophilus influenzae type b
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GR1001220B (el) * 1990-08-06 1993-06-21 Praxis Biolog Inc Φορεις κυτοκινης και ορμονης για συζευγμενα εμβολια.
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
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US5980909A (en) * 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A
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US5686078A (en) * 1992-09-14 1997-11-11 Connaught Laboratories, Inc. Primary and secondary immunization with different physio-chemical forms of antigen
US5604108A (en) * 1992-09-14 1997-02-18 Connaught Laboratories, Inc. Test for determining the dose response of a conjugated vaccine
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US5955089A (en) * 1993-04-20 1999-09-21 Uab Research Foundation Strain selection of pneumococcal surface proteins
DE69434839T2 (de) * 1993-11-08 2007-10-25 Sanofi Pasteur Ltd., Toronto Transferrin-rezeptor-gene von haemophilus
US6361779B1 (en) 1993-11-08 2002-03-26 Aventis Pasteur Limited Transferrin receptor genes
AU699913B2 (en) * 1993-11-10 1998-12-17 Henry M. Jackson Foundation For The Advancement Of Military Medicine Compositions and method for stimulating antibody release by B lymphocytes
WO1996020012A2 (en) * 1994-12-23 1996-07-04 Middlesex Sciences, Inc. Methods for preparing and purifying macromolecular conjugates
ES2200059T3 (es) * 1995-03-22 2004-03-01 Henry M. Jackson Foundation For The Advancement Of Military Medicine Produccion de construcciones inmunogenicas usando carbohidratos solubles activados mediante reactivos cianilados organicos.
KR100417183B1 (ko) * 1995-03-22 2004-05-31 헨리 엠. 잭슨 파운데이션 포 더 어드벤스먼트 오브 밀리터리 메디신 유기시아닐화제로활성화된가용성탄수화물을이용한면역원성구조체제조
US5811102A (en) * 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
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WO2017117539A1 (en) 2015-12-30 2017-07-06 Northwestern University Cell-free glycoprotein synthesis (cfgps) in prokaryotic cell lysates enriched with components for glycosylation
US10829795B2 (en) 2016-07-14 2020-11-10 Northwestern University Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates
EP3323424A1 (en) 2016-11-17 2018-05-23 Cyanimal IP Cyaa polypeptides as immune enhancer
CA3052621A1 (en) 2017-02-03 2018-08-09 Schadeck, Eva Barbara Haemophilus influenzae saccharide-carrier conjugate compositions and uses thereof
WO2019070994A1 (en) 2017-10-04 2019-04-11 Liffey Biotech Limited SACCHARIDE-POLYPEPTIDE CONJUGATE COMPOSITIONS AND METHODS OF USE
US11530432B2 (en) 2018-03-19 2022-12-20 Northwestern University Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
JP7644454B2 (ja) 2019-01-11 2025-03-12 ノースウェスタン ユニバーシティ 原核細胞溶解物におけるバイオコンジュゲートワクチンの合成
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Also Published As

Publication number Publication date
FI79024B (fi) 1989-07-31
JPS59501360A (ja) 1984-08-02
JPH05262668A (ja) 1993-10-12
US4496538A (en) 1985-01-29
JPH0347253B2 (da) 1991-07-18
ATE19734T1 (de) 1986-05-15
IE55268B1 (en) 1990-07-18
WO1984000300A1 (en) 1984-02-02
EP0098581B1 (en) 1986-05-14
DK161013B (da) 1991-05-21
EP0098581A3 (en) 1984-02-15
DK93584D0 (da) 1984-02-23
IE831574L (en) 1984-01-06
FI840874A7 (fi) 1984-03-05
ES8500745A1 (es) 1984-11-01
IL69165A0 (en) 1983-11-30
EP0098581A2 (en) 1984-01-18
FI79024C (fi) 1989-11-10
DK161013C (da) 1991-10-28
NZ204771A (en) 1987-03-06
FI840874A0 (fi) 1984-03-05
ES523905A0 (es) 1984-11-01
DE3363505D1 (de) 1986-06-19
AU1822783A (en) 1984-02-08
KR880001098B1 (ko) 1988-06-29
AU561978B2 (en) 1987-05-21
CA1210695A (en) 1986-09-02
ZA834939B (en) 1984-08-29
JPH07121872B2 (ja) 1995-12-25
IL69165A (en) 1987-11-30
KR840005488A (ko) 1984-11-14

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