DK8892D0 - Humant proteingen - Google Patents

Humant proteingen

Info

Publication number
DK8892D0
DK8892D0 DK9288A DK8892A DK8892D0 DK 8892 D0 DK8892 D0 DK 8892D0 DK 9288 A DK9288 A DK 9288A DK 8892 A DK8892 A DK 8892A DK 8892 D0 DK8892 D0 DK 8892D0
Authority
DK
Denmark
Prior art keywords
mammal
human
expression system
dna sequence
casein
Prior art date
Application number
DK9288A
Other languages
Danish (da)
English (en)
Inventor
Lennart Hansson
Mats Stroemqvist
Sven Bergstroem
Olle Hernell
Jan Toernell
Original Assignee
Symbicom Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symbicom Ab filed Critical Symbicom Ab
Priority to DK9288A priority Critical patent/DK8892D0/da
Publication of DK8892D0 publication Critical patent/DK8892D0/da
Priority to US08/256,799 priority patent/US6222094B1/en
Priority to AT93902110T priority patent/ATE229071T1/de
Priority to DK93902110T priority patent/DK0625197T3/da
Priority to AU33464/93A priority patent/AU3346493A/en
Priority to EP93902110A priority patent/EP0625197B1/fr
Priority to ES93902110T priority patent/ES2188592T3/es
Priority to JP51286793A priority patent/JP3467272B2/ja
Priority to DE69332537T priority patent/DE69332537T2/de
Priority to PT93902110T priority patent/PT625197E/pt
Priority to CA002128110A priority patent/CA2128110A1/fr
Priority to PCT/DK1993/000024 priority patent/WO1993015196A1/fr
Priority to US08/462,437 priority patent/US6232094B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/20Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4732Casein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/101Bovine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/001Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/44Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dairy Products (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK9288A 1992-01-23 1992-01-23 Humant proteingen DK8892D0 (da)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DK9288A DK8892D0 (da) 1992-01-23 1992-01-23 Humant proteingen
PCT/DK1993/000024 WO1993015196A1 (fr) 1992-01-23 1993-01-25 And codant la kappa-caseine, procede permettant d'obtenir cette proteine et son utilisation
AU33464/93A AU3346493A (en) 1992-01-23 1993-01-25 DNA encoding kappa-casein, process for obtaining the protein and use thereof
AT93902110T ATE229071T1 (de) 1992-01-23 1993-01-25 Für kappa-casein kodierende dna, verfahren zur gewinnung des proteins und seine verwendung
DK93902110T DK0625197T3 (da) 1992-01-23 1993-01-25 DNA, der koder for k-kasein, fremgangsmåde til opnåelse af proteinet og anvendelse af dette
US08/256,799 US6222094B1 (en) 1992-01-23 1993-01-25 Transgenic non-human mammal expressing the DNA sequence encoding kappa casein mammary gland and milk
EP93902110A EP0625197B1 (fr) 1992-01-23 1993-01-25 And codant la kappa-caseine, procede permettant d'obtenir cette proteine et son utilisation
ES93902110T ES2188592T3 (es) 1992-01-23 1993-01-25 Adn que codifica para la kappa-caseina, proceso para la obtencion de la proteina y uso de la misma.
JP51286793A JP3467272B2 (ja) 1992-01-23 1993-01-25 κ−カゼインをコードするDNA,そのタンパク質を得る方法および用途
DE69332537T DE69332537T2 (de) 1992-01-23 1993-01-25 Für kappa-casein kodierende dna, verfahren zur gewinnung des proteins und seine verwendung
PT93902110T PT625197E (pt) 1992-01-23 1993-01-25 Adn que codifica a k-cseina, processo para a obtencao da proteina e sua utilizacao
CA002128110A CA2128110A1 (fr) 1992-01-23 1993-01-25 Adn codant pour la kappa-caseine, methode de production de la proteine et utilisation
US08/462,437 US6232094B1 (en) 1992-01-23 1995-06-05 DNA encoding human κ casein and process for obtaining the protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK9288A DK8892D0 (da) 1992-01-23 1992-01-23 Humant proteingen

Publications (1)

Publication Number Publication Date
DK8892D0 true DK8892D0 (da) 1992-01-23

Family

ID=8089602

Family Applications (2)

Application Number Title Priority Date Filing Date
DK9288A DK8892D0 (da) 1992-01-23 1992-01-23 Humant proteingen
DK93902110T DK0625197T3 (da) 1992-01-23 1993-01-25 DNA, der koder for k-kasein, fremgangsmåde til opnåelse af proteinet og anvendelse af dette

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK93902110T DK0625197T3 (da) 1992-01-23 1993-01-25 DNA, der koder for k-kasein, fremgangsmåde til opnåelse af proteinet og anvendelse af dette

Country Status (11)

Country Link
US (2) US6222094B1 (fr)
EP (1) EP0625197B1 (fr)
JP (1) JP3467272B2 (fr)
AT (1) ATE229071T1 (fr)
AU (1) AU3346493A (fr)
CA (1) CA2128110A1 (fr)
DE (1) DE69332537T2 (fr)
DK (2) DK8892D0 (fr)
ES (1) ES2188592T3 (fr)
PT (1) PT625197E (fr)
WO (1) WO1993015196A1 (fr)

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US6204431B1 (en) 1994-03-09 2001-03-20 Abbott Laboratories Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
US5750176A (en) * 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
NZ279676A (en) * 1994-03-09 1998-04-27 Abbott Lab Humanized milk produced by non-human transgenic mammal transformed with a heterologous gene coding for human enzyme producing human oligosaccharides and glycoconjugates
EP0750671A1 (fr) * 1994-03-09 1997-01-02 Abbott Laboratories Animaux transgeniques produisant des oligosaccharides et des glycoconjugues
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US5576300A (en) * 1994-09-16 1996-11-19 Abbott Laboratories Method for inhibition of human rotavirus infection
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CN102180944A (zh) 2001-10-10 2011-09-14 诺和诺德公司 肽的重构和糖缀合
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ZA200700168B (en) 2001-10-10 2010-02-24 Novo Nordisk As Remodeling and glycoconjugation of peptides
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EA023387B1 (ru) * 2012-10-08 2016-05-31 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pFK3, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО ПЕПТИДА RL3, ЯВЛЯЮЩЕГОСЯ АНАЛОГОМ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, РЕКОМБИНАНТНЫЙ ШТАММ БАКТЕРИЙ ESCHERICHIA COLI XL1-Blue/pFK3 И РЕКОМБИНАНТНЫЙ ПЕПТИД RL3 - АНАЛОГ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, ОБЛАДАЮЩИЙ АПОПТОТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К РАКОВЫМ КЛЕТКАМ
EA023475B1 (ru) * 2012-10-08 2016-06-30 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pFK4, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО ПЕПТИДА RL4, ЯВЛЯЮЩЕГОСЯ АНАЛОГОМ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, РЕКОМБИНАНТНЫЙ ШТАММ БАКТЕРИЙ ESCHERICHIA COLI XL1-BLUE/pFK4 И РЕКОМБИНАНТНЫЙ ПЕПТИД RL4 - АНАЛОГ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, ОБЛАДАЮЩИЙ АПОПТОТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К РАКОВЫМ КЛЕТКАМ
EP3977862A1 (fr) 2014-08-21 2022-04-06 Perfect Day, Inc. Compositions comprenant une caséine et procédés de production de celles-ci
CA3034678A1 (fr) 2016-08-25 2018-03-01 Perfect Day, Inc. Produits alimentaires comprenant des proteines laitieres et des proteines d'origine non animale, et leurs procedes de production
CN114206126A (zh) * 2019-05-02 2022-03-18 新培养公司 奶酪和酸奶样组合物以及相关方法
EP3970501A1 (fr) 2020-09-18 2022-03-23 Baio Procédé de production de substituts de fromage
US20230337692A1 (en) 2020-09-18 2023-10-26 Standing Ovation Method for producing cheese substitutes
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US10947552B1 (en) 2020-09-30 2021-03-16 Alpine Roads, Inc. Recombinant fusion proteins for producing milk proteins in plants
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WO2023197003A2 (fr) * 2022-04-08 2023-10-12 Mozza Foods, Inc. Fabrication de fromage avec des protéines de soja
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WO2024102436A1 (fr) * 2022-11-10 2024-05-16 The Johns Hopkins University Système de modulation de signalisation de récepteur de tyrosine kinase et ses méthodes d'utilisation

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Also Published As

Publication number Publication date
DK0625197T3 (da) 2003-03-24
ES2188592T3 (es) 2003-07-01
PT625197E (pt) 2003-04-30
EP0625197A1 (fr) 1994-11-23
ATE229071T1 (de) 2002-12-15
DE69332537T2 (de) 2003-09-04
US6222094B1 (en) 2001-04-24
WO1993015196A1 (fr) 1993-08-05
JP3467272B2 (ja) 2003-11-17
DE69332537D1 (de) 2003-01-16
JPH07503136A (ja) 1995-04-06
EP0625197B1 (fr) 2002-12-04
AU3346493A (en) 1993-09-01
CA2128110A1 (fr) 1993-08-05
US6232094B1 (en) 2001-05-15

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