DK85490A - Krystallinsk (5r,6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penemcarboxylsyre og dens farmaceutiske formulering - Google Patents

Krystallinsk (5r,6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penemcarboxylsyre og dens farmaceutiske formulering Download PDF

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Publication number
DK85490A
DK85490A DK085490A DK85490A DK85490A DK 85490 A DK85490 A DK 85490A DK 085490 A DK085490 A DK 085490A DK 85490 A DK85490 A DK 85490A DK 85490 A DK85490 A DK 85490A
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DK
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Prior art keywords
carbamoyloxymethyl
hydroxyethyl
crystallic
pharmaceutical formulation
acid
Prior art date
Application number
DK085490A
Other languages
English (en)
Other versions
DK171235B1 (da
DK85490D0 (da
Inventor
Carlo Battistini
Roberto Bianchini
Stefano Del Nero
Pierluigi Griggi
Sergio Vioglio
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK85490D0 publication Critical patent/DK85490D0/da
Publication of DK85490A publication Critical patent/DK85490A/da
Application granted granted Critical
Publication of DK171235B1 publication Critical patent/DK171235B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK085490A 1988-08-08 1990-04-05 Krystallinsk (5R,6S)-2-carbamoyloxymethyl-6-[(IR)-hydroxyethyl]-2-penemcarboxylsyre, fremgangsmåde til fremstilling heraf, samt farmaceutisk præparat indeholdende syren DK171235B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8818789 1988-08-08
GB888818789A GB8818789D0 (en) 1988-08-08 1988-08-08 Crystalline(5r 6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penem-carboxylic acid & pharmaceutical formulation
EP8900924 1989-08-04
PCT/EP1989/000924 WO1990001484A1 (en) 1988-08-08 1989-08-04 Crystalline (5r,6s)-2-carbamoyloxymethyl-6-[(1r)-hydroxyethyl]-2-penem-carboxylic acid and its pharmaceutical formulation

Publications (3)

Publication Number Publication Date
DK85490D0 DK85490D0 (da) 1990-04-05
DK85490A true DK85490A (da) 1990-06-07
DK171235B1 DK171235B1 (da) 1996-08-05

Family

ID=10641768

Family Applications (1)

Application Number Title Priority Date Filing Date
DK085490A DK171235B1 (da) 1988-08-08 1990-04-05 Krystallinsk (5R,6S)-2-carbamoyloxymethyl-6-[(IR)-hydroxyethyl]-2-penemcarboxylsyre, fremgangsmåde til fremstilling heraf, samt farmaceutisk præparat indeholdende syren

Country Status (21)

Country Link
US (1) US5302588A (da)
EP (1) EP0407478B1 (da)
JP (1) JP2954956B2 (da)
KR (1) KR900701799A (da)
AT (1) ATE112777T1 (da)
AU (1) AU626576B2 (da)
CA (1) CA1339422C (da)
DE (1) DE68918849T2 (da)
DK (1) DK171235B1 (da)
ES (1) ES2015770A6 (da)
FI (1) FI95575C (da)
GB (1) GB8818789D0 (da)
GR (1) GR1002251B (da)
HU (1) HU205934B (da)
IE (1) IE68447B1 (da)
IL (1) IL91216A (da)
NZ (1) NZ230196A (da)
PT (1) PT91383B (da)
RU (1) RU2074858C1 (da)
WO (1) WO1990001484A1 (da)
ZA (1) ZA895966B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492903A (en) * 1990-06-19 1996-02-20 Takeda Chemical Industries Ltd. Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
US20090275746A1 (en) * 2006-07-28 2009-11-05 Hetero Drugs Limited Solid faropenem free acid
KR20160109904A (ko) * 2015-03-13 2016-09-21 주식회사 대웅제약 결정형 도리페넴의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482565A (en) 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
US4508649A (en) * 1981-12-11 1985-04-02 Farmitalia Carlo Erba Process for preparing optically active penems
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
US4634556A (en) * 1985-05-10 1987-01-06 Schering Corporation Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
DD268946A5 (de) * 1986-04-29 1989-06-14 ����`��@���k�� Verfahren zur herstellung des (5r,6s)-2-aminopethyl-6-[(1r)-1-hydroxyaethyl]-2-penem-3-carbonsaeure-minophyrats
GB8915392D0 (en) * 1989-07-05 1989-08-23 Erba Carlo Spa Process for penems

Also Published As

Publication number Publication date
JPH03500781A (ja) 1991-02-21
FI95575C (fi) 1996-02-26
HU205934B (en) 1992-07-28
WO1990001484A1 (en) 1990-02-22
PT91383B (pt) 1995-05-31
DE68918849D1 (de) 1994-11-17
HU894594D0 (en) 1991-07-29
EP0407478B1 (en) 1994-10-12
US5302588A (en) 1994-04-12
GR890100493A (el) 1990-08-22
ATE112777T1 (de) 1994-10-15
IL91216A0 (en) 1990-03-19
AU4049089A (en) 1990-03-05
GB8818789D0 (en) 1988-09-07
DK171235B1 (da) 1996-08-05
AU626576B2 (en) 1992-08-06
JP2954956B2 (ja) 1999-09-27
CA1339422C (en) 1997-09-02
ES2015770A6 (es) 1990-09-01
GR1002251B (en) 1996-04-23
IE68447B1 (en) 1996-06-26
NZ230196A (en) 1990-09-26
ZA895966B (en) 1990-06-27
DK85490D0 (da) 1990-04-05
IE892528L (en) 1990-02-08
DE68918849T2 (de) 1995-02-23
IL91216A (en) 1994-10-21
EP0407478A1 (en) 1991-01-16
RU2074858C1 (ru) 1997-03-10
KR900701799A (ko) 1990-12-04
FI95575B (fi) 1995-11-15
PT91383A (pt) 1990-03-08
FI901710A0 (fi) 1990-04-04
HUT56571A (en) 1991-09-30

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed