ES2015770A6 - Procedimiento de preparacion de acido (5r,6s)-2-carbamoiloximetil-6- (1r-hidroxietil)-2-penem carboxilico y sus formulaciones farmaceuticas - Google Patents

Procedimiento de preparacion de acido (5r,6s)-2-carbamoiloximetil-6- (1r-hidroxietil)-2-penem carboxilico y sus formulaciones farmaceuticas

Info

Publication number
ES2015770A6
ES2015770A6 ES898902797A ES8902797A ES2015770A6 ES 2015770 A6 ES2015770 A6 ES 2015770A6 ES 898902797 A ES898902797 A ES 898902797A ES 8902797 A ES8902797 A ES 8902797A ES 2015770 A6 ES2015770 A6 ES 2015770A6
Authority
ES
Spain
Prior art keywords
carbamoyloxymethyl
penem
hydroxyethyl
carboxylic acid
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES898902797A
Other languages
English (en)
Inventor
Carlo Battistini
Roberto Bianchini
Nero Stefano Del
Pierluigi Griggi
Sergio Vioglio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of ES2015770A6 publication Critical patent/ES2015770A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE ACIDO (5R,6S)-2-CARBAMOILOXIMETIL-6-[(1R)-HIDROXIETIL]-2-PENEM CARBOXILICO Y SUS FORMULACIONES FARMACEUTICAS. UN PROCEDIMIENTO PARA PREPARAR UNA FORMA CRISTALINA DE ACIDO (5R,6S)-2-CARBAMOILOXIMETIL-6-[(1R)-HIDROXIETIL]-2-PENEM CARBOXILICO CON DOS MOLECULAS DE AGUA POR MOLECULA DE ACIDO, UTIL COMO AGENTE ANTIBACTERIANO.
ES898902797A 1988-08-08 1989-08-04 Procedimiento de preparacion de acido (5r,6s)-2-carbamoiloximetil-6- (1r-hidroxietil)-2-penem carboxilico y sus formulaciones farmaceuticas Expired - Lifetime ES2015770A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888818789A GB8818789D0 (en) 1988-08-08 1988-08-08 Crystalline(5r 6s)-2-carbamoyloxymethyl-6-((1r)-hydroxyethyl)-2-penem-carboxylic acid & pharmaceutical formulation

Publications (1)

Publication Number Publication Date
ES2015770A6 true ES2015770A6 (es) 1990-09-01

Family

ID=10641768

Family Applications (1)

Application Number Title Priority Date Filing Date
ES898902797A Expired - Lifetime ES2015770A6 (es) 1988-08-08 1989-08-04 Procedimiento de preparacion de acido (5r,6s)-2-carbamoiloximetil-6- (1r-hidroxietil)-2-penem carboxilico y sus formulaciones farmaceuticas

Country Status (21)

Country Link
US (1) US5302588A (es)
EP (1) EP0407478B1 (es)
JP (1) JP2954956B2 (es)
KR (1) KR900701799A (es)
AT (1) ATE112777T1 (es)
AU (1) AU626576B2 (es)
CA (1) CA1339422C (es)
DE (1) DE68918849T2 (es)
DK (1) DK171235B1 (es)
ES (1) ES2015770A6 (es)
FI (1) FI95575C (es)
GB (1) GB8818789D0 (es)
GR (1) GR1002251B (es)
HU (1) HU205934B (es)
IE (1) IE68447B1 (es)
IL (1) IL91216A (es)
NZ (1) NZ230196A (es)
PT (1) PT91383B (es)
RU (1) RU2074858C1 (es)
WO (1) WO1990001484A1 (es)
ZA (1) ZA895966B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5492903A (en) * 1990-06-19 1996-02-20 Takeda Chemical Industries Ltd. Crystalline esters of (+)-(5R, 6S)-6-[(R)-1-hydroxyethyl]-3-(3-pyridyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]he
US20090275746A1 (en) * 2006-07-28 2009-11-05 Hetero Drugs Limited Solid faropenem free acid
KR20160109904A (ko) * 2015-03-13 2016-09-21 주식회사 대웅제약 결정형 도리페넴의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
AT379399B (de) * 1981-12-11 1985-12-27 Erba Farmitalia Verfahren zur herstellung von optisch aktiven penemen
US4761408A (en) * 1984-11-02 1988-08-02 Ciba-Geigy Corporation Crystalline aminomethyl compound
US4634556A (en) * 1985-05-10 1987-01-06 Schering Corporation Crystalline sodium (5R, 6S, 8R)-6-(1-hydroxyethyl)-2-(2-carbamoyloxyethylthio)-penem-3-carboxylate and process for making same
FI871835A (fi) * 1986-04-29 1987-10-30 Ciba Geigy Ag Kristallint hydrat.
GB8915392D0 (en) * 1989-07-05 1989-08-23 Erba Carlo Spa Process for penems

Also Published As

Publication number Publication date
HUT56571A (en) 1991-09-30
DK85490A (da) 1990-06-07
IL91216A0 (en) 1990-03-19
KR900701799A (ko) 1990-12-04
IL91216A (en) 1994-10-21
EP0407478A1 (en) 1991-01-16
HU205934B (en) 1992-07-28
US5302588A (en) 1994-04-12
NZ230196A (en) 1990-09-26
JP2954956B2 (ja) 1999-09-27
HU894594D0 (en) 1991-07-29
RU2074858C1 (ru) 1997-03-10
IE68447B1 (en) 1996-06-26
IE892528L (en) 1990-02-08
DE68918849T2 (de) 1995-02-23
GB8818789D0 (en) 1988-09-07
FI901710A0 (fi) 1990-04-04
DK171235B1 (da) 1996-08-05
AU626576B2 (en) 1992-08-06
FI95575C (fi) 1996-02-26
DE68918849D1 (de) 1994-11-17
JPH03500781A (ja) 1991-02-21
PT91383B (pt) 1995-05-31
GR1002251B (en) 1996-04-23
AU4049089A (en) 1990-03-05
DK85490D0 (da) 1990-04-05
WO1990001484A1 (en) 1990-02-22
EP0407478B1 (en) 1994-10-12
ZA895966B (en) 1990-06-27
GR890100493A (el) 1990-08-22
FI95575B (fi) 1995-11-15
CA1339422C (en) 1997-09-02
ATE112777T1 (de) 1994-10-15
PT91383A (pt) 1990-03-08

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-08-04

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