DK78692D0 - Dimere piperidin- og piperazinderivater - Google Patents

Dimere piperidin- og piperazinderivater

Info

Publication number
DK78692D0
DK78692D0 DK92786A DK78692A DK78692D0 DK 78692 D0 DK78692 D0 DK 78692D0 DK 92786 A DK92786 A DK 92786A DK 78692 A DK78692 A DK 78692A DK 78692 D0 DK78692 D0 DK 78692D0
Authority
DK
Denmark
Prior art keywords
dimeric
phenyl
alkyl
spirocyclic
substituents
Prior art date
Application number
DK92786A
Other languages
Danish (da)
English (en)
Inventor
Jens Kristian Perregaard
John W Stenberg
Ejner K Moltzen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority to DK92786A priority Critical patent/DK78692D0/da
Publication of DK78692D0 publication Critical patent/DK78692D0/da
Priority to IL10585893A priority patent/IL105858A/en
Priority to PH46303A priority patent/PH31472A/en
Priority to ZA934031A priority patent/ZA934031B/xx
Priority to AU43113/93A priority patent/AU671462B2/en
Priority to JP6501043A priority patent/JPH08503690A/ja
Priority to CA002137811A priority patent/CA2137811C/en
Priority to AT93912683T priority patent/ATE169291T1/de
Priority to KR1019940704534A priority patent/KR100297676B1/ko
Priority to RU94046403A priority patent/RU2129552C1/ru
Priority to DE69320196T priority patent/DE69320196T2/de
Priority to DK93912683T priority patent/DK0649407T3/da
Priority to ES93912683T priority patent/ES2118962T3/es
Priority to PCT/DK1993/000198 priority patent/WO1993025527A1/en
Priority to SK1526-94A priority patent/SK279622B6/sk
Priority to EP93912683A priority patent/EP0649407B1/en
Priority to CZ943122A priority patent/CZ282787B6/cs
Priority to SG1996008155A priority patent/SG48235A1/en
Priority to NO944757A priority patent/NO301370B1/no
Priority to FI945808A priority patent/FI108231B/fi
Priority to US08/354,280 priority patent/US5658921A/en
Priority to US08/467,760 priority patent/US5837707A/en
Priority to US08/484,361 priority patent/US5830896A/en
Priority to US08/486,740 priority patent/US5684012A/en
Priority to US09/073,884 priority patent/US6090808A/en
Priority to HK98109876A priority patent/HK1009271A1/xx
Priority to GR980401886T priority patent/GR3027709T3/el
Priority to FI20011806A priority patent/FI20011806A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
DK92786A 1992-06-12 1992-06-12 Dimere piperidin- og piperazinderivater DK78692D0 (da)

Priority Applications (28)

Application Number Priority Date Filing Date Title
DK92786A DK78692D0 (da) 1992-06-12 1992-06-12 Dimere piperidin- og piperazinderivater
IL10585893A IL105858A (en) 1992-06-12 1993-05-31 Dimperic piperidines, tetrahydropyridines, piperazines, spirocyclic piperidines and their pharmaceutical preparations
PH46303A PH31472A (en) 1992-06-12 1993-06-03 Dimeric piperidine, tetrahydropyridine and piperazine derivatives.
ZA934031A ZA934031B (en) 1992-06-12 1993-06-08 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
SG1996008155A SG48235A1 (en) 1992-06-12 1993-06-09 Dimeric piperdidine and piperazine derivatives
ES93912683T ES2118962T3 (es) 1992-06-12 1993-06-09 Derivados dimeros de piperidina, tetrahidropiridina y piperazina.
EP93912683A EP0649407B1 (en) 1992-06-12 1993-06-09 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
CA002137811A CA2137811C (en) 1992-06-12 1993-06-09 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
AT93912683T ATE169291T1 (de) 1992-06-12 1993-06-09 Dimere pyridine, tetrahydropyridine und piperazine
KR1019940704534A KR100297676B1 (ko) 1992-06-12 1993-06-09 이합피페리딘,테트라히드로피리딘및피페라진유도체
RU94046403A RU2129552C1 (ru) 1992-06-12 1993-06-09 Димерные соединения 4-фенилпиперидина, 4-фенил-1,2,3,6-тетрагидропиридина или 4-фенилпиперазина или димерные соединения спироциклических пиперидинов и фармацевтическая композиция
DE69320196T DE69320196T2 (de) 1992-06-12 1993-06-09 Dimere pyridine, tetrahydropyridine und piperazine
DK93912683T DK0649407T3 (da) 1992-06-12 1993-06-09 Dimere piperidin-, tetrahydropyridin-, og piperazinderivater
AU43113/93A AU671462B2 (en) 1992-06-12 1993-06-09 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
PCT/DK1993/000198 WO1993025527A1 (en) 1992-06-12 1993-06-09 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
SK1526-94A SK279622B6 (sk) 1992-06-12 1993-06-09 Dimérne zlúčeniny 4-fenylpiperidínu, 4-fenyl-1,2,3
JP6501043A JPH08503690A (ja) 1992-06-12 1993-06-09 二量体のピペリジン、テトラヒドロピリジンおよびピペラジン誘導体
CZ943122A CZ282787B6 (cs) 1992-06-12 1993-06-09 Dimerní piperidinové, tetrahydropiridinové a piperazinové deriváty, farmaceutické prostředky s jejich obsahem a jejich použití pro výrobu farmaceutických prostředků
NO944757A NO301370B1 (no) 1992-06-12 1994-12-08 Dimere piperidin-, tetrahydropyridin- og piperazinderivater
FI945808A FI108231B (fi) 1992-06-12 1994-12-09 Menetelmä uusien, terapeuttisesti käyttökelpoisten dimeeristen, spirosyklisten piperidiinijohdannaisten ja niiden happoadditiosuolojen valmistamiseksi
US08/354,280 US5658921A (en) 1992-06-12 1994-12-12 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
US08/467,760 US5837707A (en) 1992-06-12 1995-06-06 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
US08/484,361 US5830896A (en) 1992-06-12 1995-06-07 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
US08/486,740 US5684012A (en) 1992-06-12 1995-06-07 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
US09/073,884 US6090808A (en) 1992-06-12 1998-05-06 Dimeric piperidine, tetrahydropyridine and piperazine derivatives
HK98109876A HK1009271A1 (en) 1992-06-12 1998-08-12 Dimeric piperidine tetrahydropyridine and piperazine derivatives
GR980401886T GR3027709T3 (en) 1992-06-12 1998-08-20 Dimeric piperidine, tetrahydropyridine and piperazine derivatives.
FI20011806A FI20011806A (fi) 1992-06-12 2001-09-13 Menetelmä uuden, terapeuttisesti käyttökelpoisen, dimeerisen, piperidiini-, tetrahydropyridiini- tai piperatsiinijohdannaisen valmistamiseksi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK92786A DK78692D0 (da) 1992-06-12 1992-06-12 Dimere piperidin- og piperazinderivater

Publications (1)

Publication Number Publication Date
DK78692D0 true DK78692D0 (da) 1992-06-12

Family

ID=8097545

Family Applications (2)

Application Number Title Priority Date Filing Date
DK92786A DK78692D0 (da) 1992-06-12 1992-06-12 Dimere piperidin- og piperazinderivater
DK93912683T DK0649407T3 (da) 1992-06-12 1993-06-09 Dimere piperidin-, tetrahydropyridin-, og piperazinderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK93912683T DK0649407T3 (da) 1992-06-12 1993-06-09 Dimere piperidin-, tetrahydropyridin-, og piperazinderivater

Country Status (22)

Country Link
US (5) US5658921A (cs)
EP (1) EP0649407B1 (cs)
JP (1) JPH08503690A (cs)
KR (1) KR100297676B1 (cs)
AT (1) ATE169291T1 (cs)
AU (1) AU671462B2 (cs)
CA (1) CA2137811C (cs)
CZ (1) CZ282787B6 (cs)
DE (1) DE69320196T2 (cs)
DK (2) DK78692D0 (cs)
ES (1) ES2118962T3 (cs)
FI (2) FI108231B (cs)
GR (1) GR3027709T3 (cs)
HK (1) HK1009271A1 (cs)
IL (1) IL105858A (cs)
NO (1) NO301370B1 (cs)
PH (1) PH31472A (cs)
RU (1) RU2129552C1 (cs)
SG (1) SG48235A1 (cs)
SK (1) SK279622B6 (cs)
WO (1) WO1993025527A1 (cs)
ZA (1) ZA934031B (cs)

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US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
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US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
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GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
NZ335422A (en) 1996-11-26 2000-10-27 Zeneca Ltd 8-azabicyclo[3.2.1]octane-, 8-azabicyclo [3.2.1] oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives for use in insecticides
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
DE69919707T2 (de) 1998-06-19 2005-09-01 Chiron Corp., Emeryville Glycogen synthase kinase 3 inhibitoren
GB9828435D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
FR2791344B1 (fr) * 1999-03-25 2002-02-15 Adir Nouveaux derives dimeriques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI243173B (en) 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
CA2443938C (en) * 2001-04-18 2010-06-22 R. Richard Goehring Spiroindene and spiroindane compounds as opioid ligands useful for treating pain
AU2005263719A1 (en) * 2004-07-16 2006-01-26 Janssen Pharmaceutica N.V. Dimeric piperidine derivatives
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
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AU2005309365B2 (en) * 2004-11-29 2011-10-06 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
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ATE517106T1 (de) * 2006-02-22 2011-08-15 Vertex Pharma Kondensierte spiropiperidine als modulatoren muskarinartiger rezeptoren
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JP2010501561A (ja) * 2006-08-18 2010-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
ATE469900T1 (de) 2006-12-07 2010-06-15 Hoffmann La Roche Spiropiperidinderivate als antagonisten des via- rezeptors
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US5837707A (en) 1998-11-17
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IL105858A0 (en) 1993-09-22
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