DK1057814T3 - Tetrahydrobenzindolderivater - Google Patents
TetrahydrobenzindolderivaterInfo
- Publication number
- DK1057814T3 DK1057814T3 DK98961493T DK98961493T DK1057814T3 DK 1057814 T3 DK1057814 T3 DK 1057814T3 DK 98961493 T DK98961493 T DK 98961493T DK 98961493 T DK98961493 T DK 98961493T DK 1057814 T3 DK1057814 T3 DK 1057814T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen atom
- integer
- group
- specified substituent
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- C07D209/92—Naphthostyrils
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35838197A JPH11189585A (ja) | 1997-12-25 | 1997-12-25 | ５−ｈｔ７受容体結合能を有するテトラヒドロベンズインドール誘導体 |
| JP35838097 | 1997-12-25 | ||
| JP8591398 | 1998-03-31 | ||
| JP13687298 | 1998-05-19 | ||
| JP22970998 | 1998-08-14 | ||
| JP31933698 | 1998-11-10 | ||
| PCT/JP1998/005827 WO1999033804A1 (fr) | 1997-12-25 | 1998-12-22 | Derives de tetrahydrobenzindole |
| EP98961493A EP1057814B1 (en) | 1997-12-25 | 1998-12-22 | Tetrahydrobenzindole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1057814T3 true DK1057814T3 (da) | 2005-07-04 |
Family
ID=27551662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98961493T DK1057814T3 (da) | 1997-12-25 | 1998-12-22 | Tetrahydrobenzindolderivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6498251B1 (da) |
| EP (1) | EP1057814B1 (da) |
| JP (1) | JP4459437B2 (da) |
| KR (1) | KR100588249B1 (da) |
| CN (1) | CN1129578C (da) |
| AT (1) | ATE290527T1 (da) |
| CA (1) | CA2316388C (da) |
| DE (1) | DE69829317T2 (da) |
| DK (1) | DK1057814T3 (da) |
| ES (1) | ES2238778T3 (da) |
| NO (1) | NO317293B1 (da) |
| WO (1) | WO1999033804A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407112B1 (en) * | 1998-04-22 | 2002-06-18 | Meiji Seika Kaisha, Ltd. | Optically active tetrahydrobenzindole derivative |
| UA69420C2 (uk) | 1998-10-06 | 2004-09-15 | Янссен Фармацевтика Н.В. | ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ |
| GB9828004D0 (en) * | 1998-12-18 | 1999-02-10 | Smithkline Beecham Plc | Use |
| JP2003512372A (ja) * | 1999-10-18 | 2003-04-02 | スミスクライン ビーチャム パブリック リミテッド カンパニー | テトラヒドロベンゾインドロン誘導体、それらの製造および５−ｈｔ７受容体アンタゴニストとしてのそれらの使用 |
| AR035417A1 (es) * | 2001-01-27 | 2004-05-26 | Hoffmann La Roche | Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos |
| AU2003256793A1 (en) * | 2002-08-20 | 2004-03-11 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| JP4517381B2 (ja) * | 2003-08-04 | 2010-08-04 | 曽田香料株式会社 | チエノピリジン系化合物の香料における使用、および新規チエノピリジン系化合物 |
| EP1751134A1 (en) * | 2004-05-11 | 2007-02-14 | EGIS Gyógyszergyár Nyrt | Pyridine derivatives of alkyl oxindoles as 5-ht7 receptor active agents |
| EP1877405B1 (en) * | 2005-04-26 | 2010-03-03 | Hypnion, Inc. | Benzisoxazole piperidine compounds and methods of use thereof |
| PL2054416T3 (pl) * | 2006-08-04 | 2011-05-31 | Merz Pharma Gmbh & Co Kgaa | Podstawione pirazolopirymidyny, sposób ich wytwarzania oraz ich zastosowanie w medycynie |
| EP1956006A1 (en) * | 2007-02-06 | 2008-08-13 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted-tetrahydro-naphthalen derivatives as 5-HT7 receptor ligands |
| EP1975161A1 (en) * | 2007-03-28 | 2008-10-01 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted- tetrahydro-napthalen-amine derivatives, their preparation and use as medicaments |
| BRPI0906244A2 (pt) * | 2008-03-24 | 2015-06-30 | Medivation Technologies Inc | Composto, composição farmacêutica, método para tratar um distúrbio cognitivo, psicótico, mediado por neurotransmissores ou um distúrbio neuronal em um indivíduo, uso de um composto e kit |
| BR112012006644A2 (pt) * | 2009-09-23 | 2019-09-24 | Medivation Neurology Inc | composto,método de tratamento de um distúrbio cognitivo, distúrbio psicótico, distúrbio mediado por neurotransmissor ou um distúrbio neuronal, composição farmacêutica, uso de um composto e kit |
| CN108623585B (zh) * | 2018-05-22 | 2021-07-09 | 中国人民解放军第二军医大学 | β-四氢咔啉类抗真菌药物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355642B1 (en) | 1996-06-28 | 2002-03-12 | Meiji Seika Kaisha, Ltd. | Tetrahydrobenzindole compounds |
| US6407112B1 (en) | 1998-04-22 | 2002-06-18 | Meiji Seika Kaisha, Ltd. | Optically active tetrahydrobenzindole derivative |
-
1998
- 1998-12-22 AT AT98961493T patent/ATE290527T1/de not_active IP Right Cessation
- 1998-12-22 CA CA002316388A patent/CA2316388C/en not_active Expired - Fee Related
- 1998-12-22 DK DK98961493T patent/DK1057814T3/da active
- 1998-12-22 WO PCT/JP1998/005827 patent/WO1999033804A1/ja active IP Right Grant
- 1998-12-22 US US09/582,416 patent/US6498251B1/en not_active Expired - Fee Related
- 1998-12-22 EP EP98961493A patent/EP1057814B1/en not_active Expired - Lifetime
- 1998-12-22 CN CN98813811A patent/CN1129578C/zh not_active Expired - Fee Related
- 1998-12-22 DE DE69829317T patent/DE69829317T2/de not_active Expired - Lifetime
- 1998-12-22 JP JP2000526488A patent/JP4459437B2/ja not_active Expired - Fee Related
- 1998-12-22 ES ES98961493T patent/ES2238778T3/es not_active Expired - Lifetime
- 1998-12-22 KR KR1020007007122A patent/KR100588249B1/ko not_active IP Right Cessation
-
2000
- 2000-06-22 NO NO20003285A patent/NO317293B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1057814B1 (en) | 2005-03-09 |
| DE69829317T2 (de) | 2006-04-06 |
| CN1129578C (zh) | 2003-12-03 |
| NO20003285D0 (no) | 2000-06-22 |
| KR100588249B1 (ko) | 2006-06-13 |
| ATE290527T1 (de) | 2005-03-15 |
| NO20003285L (no) | 2000-08-23 |
| EP1057814A1 (en) | 2000-12-06 |
| CA2316388C (en) | 2009-09-08 |
| EP1057814A4 (en) | 2001-07-11 |
| KR20010033609A (ko) | 2001-04-25 |
| WO1999033804A1 (fr) | 1999-07-08 |
| CA2316388A1 (en) | 1999-07-08 |
| DE69829317D1 (de) | 2005-04-14 |
| NO317293B1 (no) | 2004-10-04 |
| JP4459437B2 (ja) | 2010-04-28 |
| CN1286683A (zh) | 2001-03-07 |
| ES2238778T3 (es) | 2005-09-01 |
| US6498251B1 (en) | 2002-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1057814T3 (da) | Tetrahydrobenzindolderivater | |
| YU84791A (sh) | Biciklicni 1-aza-cikloalkalni | |
| FI950016A0 (fi) | Heterosykliset yhdisteet lääkeaineena | |
| EA200800285A1 (ru) | Новые производные 2,4-дианилинопиримидинов, их получение, лекарственные средства, фармацевтические композиции, содержащие указанные производные, и их применение, в частности, в качестве ингибиторов ikk | |
| BG105781A (en) | Piperidine, tetrahydropyridine and piperazine derivatives, their preparartion and use | |
| DE3856378D1 (de) | Substituierte Thiazolidindionderivate | |
| ATE503746T1 (de) | Neue imidazolidinderivate | |
| WO2004089366A8 (en) | Bicyclic compounds as nr2b receptor antagonists | |
| ATE88714T1 (de) | 2'-desoxy-5-fluoruridinderivate. | |
| FI940229A (fi) | Trisykliset kondensoituneet heterosykliset yhdisteet, niiden valmistus ja käyttö | |
| DE69202120T2 (de) | Harnstoffderivate, ihre Herstellung und ihre Verwendung bei der Therapie. | |
| FI892637A0 (fi) | Menetelmä valmistaa farmakologisesti arvokasta kefeemiyhdistettä | |
| DE69937045D1 (de) | Cyclische amidderivate | |
| AR005120A1 (es) | Derivados 4-(1h-benzimidazol-2-il) [1,4]diazepanos substituidos utiles para el tratamiento de enfermedades alergicas, composicion farmaceutica y usos en la fabricacion de medicamentos. | |
| ATE246682T1 (de) | Benzothiazinderivate | |
| ES2033523T3 (es) | Un derivado de tioformamida. | |
| DE69830600D1 (de) | Anilidverbindungen und medikamente, die diese enthalten | |
| DE69222143T2 (de) | Indanderivate | |
| DE69626624D1 (de) | Medikamente gegen trhombocytopenie | |
| NO20001541L (no) | Nye substituerte dimeriske forbindelser, fremgangsmÕte for deres fremstilling og farmasøytiske sammensetninger inneholdende dem | |
| HUT76276A (en) | 3-substituted 1-arylindole compounds, pharmaceutical compositions containing them and their use | |
| TH60675A (th) | การใช้อนุพันธ์ไพริโดอินโดโลนสำหรับการเตรียมผลิตภัณฑ์ยา |