DK589985D0 - Bicycliske heteroarylpiperazinderivater og fremgangsmaade til deres fremstilling - Google Patents
Bicycliske heteroarylpiperazinderivater og fremgangsmaade til deres fremstillingInfo
- Publication number
- DK589985D0 DK589985D0 DK589985A DK589985A DK589985D0 DK 589985 D0 DK589985 D0 DK 589985D0 DK 589985 A DK589985 A DK 589985A DK 589985 A DK589985 A DK 589985A DK 589985 D0 DK589985 D0 DK 589985D0
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- bicyclic
- compounds
- procedures
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Furan Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL8403918 | 1984-12-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK589985D0 true DK589985D0 (da) | 1985-12-18 |
DK589985A DK589985A (da) | 1986-06-22 |
Family
ID=19844955
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK589985A DK589985A (da) | 1984-12-21 | 1985-12-18 | Bicycliske heteroarylpiperazinderivater og fremgangsmaade til deres fremstilling |
DK590085A DK590085A (da) | 1984-12-21 | 1985-12-18 | Bicycliske heteroarylpiperazinderivater og fremgangsmaade til deres fremstilling |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK590085A DK590085A (da) | 1984-12-21 | 1985-12-18 | Bicycliske heteroarylpiperazinderivater og fremgangsmaade til deres fremstilling |
Country Status (14)
Country | Link |
---|---|
US (1) | US4782061A (da) |
EP (2) | EP0185429A1 (da) |
JP (2) | JPS61152666A (da) |
AT (1) | ATE44528T1 (da) |
AU (2) | AU589387B2 (da) |
DE (1) | DE3571436D1 (da) |
DK (2) | DK589985A (da) |
ES (2) | ES8704348A1 (da) |
GR (2) | GR853063B (da) |
IE (1) | IE58916B1 (da) |
IL (1) | IL77396A (da) |
NZ (2) | NZ214612A (da) |
PH (2) | PH22040A (da) |
ZA (2) | ZA859664B (da) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE44528T1 (de) * | 1984-12-21 | 1989-07-15 | Duphar Int Res | Arzneimittel mit antipsychotischer wirkung. |
ATE81975T1 (de) * | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
US5328905A (en) * | 1987-07-20 | 1994-07-12 | Duphar International Research B.V. | 8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives |
ATE136032T1 (de) * | 1987-07-20 | 1996-04-15 | Duphar Int Res | 8,9-anellierte 1,2,3,4-tetrahydro-beta-carbolin- derivate |
US4889852A (en) * | 1987-09-11 | 1989-12-26 | Duphar International Research B.V. | Anxiolytically active piperazine derivatives |
US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
DK611489A (da) * | 1988-12-08 | 1990-06-09 | Duphar Int Res | Anxiolytisk aktive piperazinderivater og farmaceutiske praeparater med indhold af saadanne forbindelser |
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
EP0380155A1 (en) * | 1989-01-19 | 1990-08-01 | Duphar International Research B.V | 8,9-Annelated-1,2,3,4-tetrahydro-beta-carboline derivatives |
EP0398413A1 (en) * | 1989-05-16 | 1990-11-22 | Duphar International Research B.V | "3,4-dehydropiperidine derivatives having psychotropic activity |
US5296497A (en) * | 1989-05-16 | 1994-03-22 | Duphar International Research B.V. | 3,4-dehydropiperidine derivatives having psychotropic activity |
FR2670491B1 (fr) * | 1990-12-14 | 1993-02-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
US5569659A (en) * | 1991-09-11 | 1996-10-29 | Mcneilab, Inc. | 4-arylpiperazines and 4-arylpiperidines |
NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
GB9200293D0 (en) * | 1992-01-08 | 1992-02-26 | Wyeth John & Brother Ltd | Piperazine derivatives |
FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
DE4219973A1 (de) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung |
US5314885A (en) * | 1992-09-11 | 1994-05-24 | Mcneilab, Inc. | Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents |
US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
EP0939135A1 (en) * | 1992-12-21 | 1999-09-01 | Duphar International Research B.V | Substantially pure hetero-bicyclic alcohol enantiomers |
HU213569B (en) * | 1992-12-21 | 1997-08-28 | Duphar Int Res | Enzymatic process for the stereoselective preparation of a heterobicyclic alcohol enantiomer |
US5395936A (en) * | 1993-06-04 | 1995-03-07 | Manzo; Ruben H. | 7-(4-[4-aminophenyl)sulphonyl]-1-piperazinyl fluorquinolonic derivatives and synthesis |
RU2118322C1 (ru) * | 1993-07-05 | 1998-08-27 | Дюфар Интернэшнл Рисерч Б.В. | 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли |
DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
GB9408872D0 (en) * | 1994-05-03 | 1994-06-22 | Zeneca Ltd | Heterocyclic compounds |
JP3155008B2 (ja) * | 1994-07-26 | 2001-04-09 | ファイザー・インコーポレーテッド | セロトニンアゴニストおよびアンタゴニストとしての4−インドール誘導体 |
US5998444A (en) * | 1995-10-24 | 1999-12-07 | Zeneca Ltd. | Piperidinyl compounds as NK1 or NK2 antagonists |
DE69534213T2 (de) * | 1994-10-25 | 2006-01-12 | Astrazeneca Ab | Therapeutisch wirksame Heterocyclen |
US6008223A (en) * | 1994-10-27 | 1999-12-28 | Zeneca Limited | Therapeutic compounds |
GB9508786D0 (en) | 1995-04-29 | 1995-06-21 | Zeneca Ltd | Substituted heterocycles |
GB9523526D0 (en) * | 1995-11-17 | 1996-01-17 | Zeneca Ltd | Therapeutic compounds |
BRPI9708389B8 (pt) * | 1996-03-29 | 2015-12-08 | Duphar Int Res | compostos de piperazina e piperidina, composições farmacêuticas. |
TW530054B (en) * | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
FR2769312B1 (fr) * | 1997-10-03 | 1999-12-03 | Adir | Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
NZ522116A (en) | 2000-05-12 | 2004-04-30 | Solvay Pharmaceuticals B | Piperazine and piperidine compounds that have partial agonism towards dopamine D2-receptor subfamily and affinity for relevant serotonin and/or noradrenergic receptors |
CA2405758A1 (en) * | 2000-05-12 | 2001-11-15 | Solvay Pharmaceuticals B.V. | Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders |
AR034206A1 (es) * | 2001-02-16 | 2004-02-04 | Solvay Pharm Bv | Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos |
DE60231507D1 (de) | 2001-07-20 | 2010-07-01 | Psychogenics Inc | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
JP2008075402A (ja) * | 2006-09-25 | 2008-04-03 | Jfe Metal Products & Engineering Inc | 防護柵用ブラケット及び防護柵 |
PL392436A1 (pl) | 2010-09-17 | 2012-03-26 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Pochodne arylosulfonamidów do leczenia chorób odśrodkowego układu nerwowego |
RU2013131161A (ru) | 2010-12-20 | 2015-01-27 | Астразенека Аб | Производное 2-карбоксамид-4-пиперазинил-бензофурана |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2037852C3 (de) * | 1970-07-30 | 1980-06-26 | Boehringer Sohn Ingelheim | Neue Piperazinderivate und Verfahren zu ihrer Herstellung |
US4100173A (en) * | 1974-01-04 | 1978-07-11 | Hoffmann-La Roche Inc. | Dibenz[b,f]oxepin derivatives |
US4062870A (en) * | 1974-05-31 | 1977-12-13 | Beecham Group Limited | Chroman derivatives |
US4091101A (en) * | 1977-06-15 | 1978-05-23 | Merck & Co., Inc. | 6-(1-Piperazinyl)quinoxaline |
US4404383A (en) * | 1979-07-31 | 1983-09-13 | The Quaker Oats Company | N,N'-Bis[5-hydroxymethylfurfuryl]piperazine |
NL8005133A (nl) * | 1980-09-12 | 1982-04-01 | Duphar Int Res | Fenylpiperazinederivaten met antiagressieve werking. |
JPS5777676A (en) * | 1980-10-31 | 1982-05-15 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
KR880001634B1 (ko) * | 1980-12-18 | 1988-09-03 | 오쯔까 세이야꾸 가부시끼가이샤 | 벤조 헤테로사이클릭 화합물의 제조방법 |
CH653021A5 (fr) * | 1981-04-24 | 1985-12-13 | Delalande Sa | Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant. |
US4355031A (en) * | 1981-05-11 | 1982-10-19 | American Home Products Corp. | 2,3-Dihydro-3-[4-(substituted)-1-piperazinyl]-1H-isoindol-1-ones |
US4426380A (en) * | 1981-10-28 | 1984-01-17 | Ciba-Geigy Corporation | Benzofuran-2-ones and pharmaceutical compositions |
JPS5883677A (ja) * | 1981-11-11 | 1983-05-19 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体 |
JPS5888314A (ja) * | 1981-11-20 | 1983-05-26 | Otsuka Pharmaceut Co Ltd | 強心剤 |
JPS5955878A (ja) * | 1982-09-24 | 1984-03-31 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
IL69898A0 (en) * | 1982-10-08 | 1984-01-31 | Ciba Geigy Ag | Furans |
ZA848005B (en) * | 1983-10-17 | 1985-05-29 | Duphar Int Res | Blood-pressure lowering piperazine derivatives |
ATE81975T1 (de) * | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
ATE44528T1 (de) * | 1984-12-21 | 1989-07-15 | Duphar Int Res | Arzneimittel mit antipsychotischer wirkung. |
-
1985
- 1985-12-16 AT AT85202086T patent/ATE44528T1/de not_active IP Right Cessation
- 1985-12-16 DE DE8585202086T patent/DE3571436D1/de not_active Expired
- 1985-12-16 EP EP85202081A patent/EP0185429A1/en not_active Withdrawn
- 1985-12-16 EP EP85202086A patent/EP0190472B1/en not_active Expired
- 1985-12-18 AU AU51390/85A patent/AU589387B2/en not_active Ceased
- 1985-12-18 US US06/810,207 patent/US4782061A/en not_active Expired - Fee Related
- 1985-12-18 ZA ZA859664A patent/ZA859664B/xx unknown
- 1985-12-18 IE IE321885A patent/IE58916B1/en not_active IP Right Cessation
- 1985-12-18 GR GR853063A patent/GR853063B/el unknown
- 1985-12-18 ZA ZA859662A patent/ZA859662B/xx unknown
- 1985-12-18 AU AU51392/85A patent/AU5139285A/en not_active Abandoned
- 1985-12-18 ES ES550106A patent/ES8704348A1/es not_active Expired
- 1985-12-18 DK DK589985A patent/DK589985A/da not_active Application Discontinuation
- 1985-12-18 NZ NZ214612A patent/NZ214612A/xx unknown
- 1985-12-18 NZ NZ214611A patent/NZ214611A/xx unknown
- 1985-12-18 GR GR853065A patent/GR853065B/el unknown
- 1985-12-18 DK DK590085A patent/DK590085A/da not_active Application Discontinuation
- 1985-12-19 PH PH33218A patent/PH22040A/en unknown
- 1985-12-19 PH PH33217A patent/PH23958A/en unknown
- 1985-12-19 IL IL77396A patent/IL77396A/xx not_active IP Right Cessation
- 1985-12-20 JP JP60285843A patent/JPS61152666A/ja active Pending
- 1985-12-20 JP JP60285842A patent/JPS61152662A/ja active Pending
-
1987
- 1987-01-29 ES ES557359A patent/ES8802516A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ATE44528T1 (de) | 1989-07-15 |
ES550106A0 (es) | 1987-04-01 |
JPS61152666A (ja) | 1986-07-11 |
IE853218L (en) | 1986-06-21 |
IL77396A (en) | 1990-02-09 |
AU5139085A (en) | 1986-07-17 |
ES8704348A1 (es) | 1987-04-01 |
ZA859664B (en) | 1986-08-27 |
EP0190472B1 (en) | 1989-07-12 |
US4782061A (en) | 1988-11-01 |
GR853065B (da) | 1986-04-09 |
NZ214612A (en) | 1988-06-30 |
ES557359A0 (es) | 1988-07-16 |
GR853063B (da) | 1986-04-09 |
EP0190472A1 (en) | 1986-08-13 |
PH23958A (en) | 1990-01-23 |
ES8802516A1 (es) | 1988-07-16 |
DK590085D0 (da) | 1985-12-18 |
PH22040A (en) | 1988-05-13 |
ZA859662B (en) | 1986-08-27 |
DK589985A (da) | 1986-06-22 |
DE3571436D1 (en) | 1989-08-17 |
EP0185429A1 (en) | 1986-06-25 |
IE58916B1 (en) | 1993-12-01 |
JPS61152662A (ja) | 1986-07-11 |
AU589387B2 (en) | 1989-10-12 |
NZ214611A (en) | 1988-06-30 |
AU5139285A (en) | 1986-06-26 |
DK590085A (da) | 1986-06-22 |
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