DK577989A - Bakteriecelle og fremgangsmaade til fremstilling af et heterologt polypeptid i en saadan celle - Google Patents

Bakteriecelle og fremgangsmaade til fremstilling af et heterologt polypeptid i en saadan celle

Info

Publication number
DK577989A
DK577989A DK577989A DK577989A DK577989A DK 577989 A DK577989 A DK 577989A DK 577989 A DK577989 A DK 577989A DK 577989 A DK577989 A DK 577989A DK 577989 A DK577989 A DK 577989A
Authority
DK
Denmark
Prior art keywords
cell
heterological
polypeptide
procedures
preparing
Prior art date
Application number
DK577989A
Other languages
Danish (da)
English (en)
Other versions
DK577989D0 (da
Inventor
Alan Sloma
Jr Gerald A Rufo
Cathy Faye Rudolph
Barbara J Sullivan
Janice Pero
Original Assignee
Bioteknika International
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27402569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK577989(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioteknika International filed Critical Bioteknika International
Publication of DK577989D0 publication Critical patent/DK577989D0/da
Publication of DK577989A publication Critical patent/DK577989A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Materials For Medical Uses (AREA)
DK577989A 1988-11-18 1989-11-17 Bakteriecelle og fremgangsmaade til fremstilling af et heterologt polypeptid i en saadan celle DK577989A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27342388A 1988-11-18 1988-11-18
US34742889A 1989-05-04 1989-05-04
US39652189A 1989-08-21 1989-08-21

Publications (2)

Publication Number Publication Date
DK577989D0 DK577989D0 (da) 1989-11-17
DK577989A true DK577989A (da) 1990-05-19

Family

ID=27402569

Family Applications (1)

Application Number Title Priority Date Filing Date
DK577989A DK577989A (da) 1988-11-18 1989-11-17 Bakteriecelle og fremgangsmaade til fremstilling af et heterologt polypeptid i en saadan celle

Country Status (8)

Country Link
US (3) US5620880A (de)
EP (1) EP0369817B1 (de)
JP (1) JP3210315B2 (de)
AT (1) ATE137265T1 (de)
AU (1) AU4476689A (de)
CA (1) CA2003078A1 (de)
DE (1) DE68926333T2 (de)
DK (1) DK577989A (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143846A (en) * 1988-03-17 1992-09-01 The General Hospital Corporation Protease deficient bacterial hosts
US5294542A (en) * 1991-03-19 1994-03-15 Omnigene, Inc. Residual protease-III
US5429950A (en) * 1992-03-30 1995-07-04 Genencor International, Inc. Heterologous gene expression in bacillus subtilis: fusion approach
AT397390B (de) * 1992-04-06 1994-03-25 Immuno Ag Verfahren zur spaltung von proteinen
US5792623A (en) * 1992-04-06 1998-08-11 Immuno Aktiengesellschaft Method for producing activated blood factors with a protease and a detergent
WO1997003185A1 (en) * 1995-07-07 1997-01-30 Novo Nordisk A/S Production of proteins using bacillus incapable of sporulation
GB9708452D0 (en) * 1997-04-26 1997-06-18 Univ Newcastle Improved prokaryotic expression of protein
EP0991754A2 (de) * 1997-07-15 2000-04-12 Genencor International, Inc. Proteasen von gram-positieve organismen
US6723550B1 (en) 1997-07-15 2004-04-20 Genencor International, Inc. Proteases from gram-positive organisms
CA2296708A1 (en) * 1997-07-15 1999-01-28 Genencor International, Inc. Proteases from gram-positive organisms
GB9719637D0 (en) * 1997-09-15 1997-11-19 Genencor Int Bv Proteases from gram-positive organisms
GB9719636D0 (en) * 1997-09-15 1997-11-19 Genencor Int Bv Proteases from gram-positive organisms
US6521440B1 (en) 1997-09-15 2003-02-18 Genencor International, Inc. Proteases from gram-positive organisms
US6300117B1 (en) 1997-09-15 2001-10-09 Genencor International, Inc. Proteases from gram-positive organisms
GB9724629D0 (en) * 1997-11-20 1998-01-21 Genencor Int Bv Alpha/beta hydrolase-fold enzymes
US6528255B1 (en) 1997-12-30 2003-03-04 Genencor International, Inc. Proteases from gram positive organisms
US6489108B1 (en) * 1997-12-30 2002-12-03 Genencor International, Inc. Proteases from gram positive organisms
GB9727470D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
US6599731B1 (en) 1997-12-30 2003-07-29 Genencor International, Inc. Proteases from gram positive organisms
US6465186B1 (en) 1997-12-30 2002-10-15 Genecor International, Inc. Proteases from gram positive organisms
GB9727471D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
GB9727468D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
GB9727466D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
GB9727464D0 (en) * 1997-12-30 1998-02-25 Genencor Int Bv Proteases from gram positive organisms
US6558939B1 (en) 1999-08-31 2003-05-06 Novozymes, A/S Proteases and variants thereof
EP2206786A1 (de) 1999-08-31 2010-07-14 Novozymes A/S Neue Proteasen und Varianten davon
US7217554B2 (en) 1999-08-31 2007-05-15 Novozymes A/S Proteases and variants thereof
GB0116798D0 (en) * 2001-07-10 2001-08-29 Secr Defence Expression system
FI112666B (fi) * 2001-11-06 2003-12-31 Ipsat Therapies Oy Itiöimätön Bacillus subtilis, sen valmistus ja käyttö
DK1495128T3 (da) * 2002-03-29 2014-08-11 Genencor Int Forstærket proteinekspression i Bacillus
ATE399869T1 (de) 2002-04-10 2008-07-15 Novozymes As Verbesserte bacillus-wirtszelle
US20050176097A1 (en) * 2002-04-10 2005-08-11 Andersen Jens T. Bacillus host cell
TW200521103A (en) * 2003-11-21 2005-07-01 Toshiba Kk High thermally conductive aluminum nitride sintered product
US20070281332A1 (en) 2004-02-13 2007-12-06 Allan Svendsen Protease Variants
WO2005123914A1 (en) * 2004-06-21 2005-12-29 Novozymes A/S Improved methods of producing heterologous proteases
JP4485341B2 (ja) 2004-12-20 2010-06-23 花王株式会社 組換え微生物
CN101321866B (zh) 2005-10-13 2012-11-14 花王株式会社 新型枯草杆菌突变株
US7932520B2 (en) * 2006-04-07 2011-04-26 Chimei Innolux Corporation Organic light emitting device and method of fabricating the same
TWI303535B (en) * 2006-04-07 2008-11-21 Chi Mei El Corp Organic light emitting device and method of fabricating the same
JP2008231063A (ja) * 2007-03-22 2008-10-02 Takano Foods Kk 納豆菌ワクチン
RU2011132127A (ru) 2008-12-31 2013-02-10 СОЛАЕ, ЭлЭлСи Композиции белкового гидролизата
EP2856885A3 (de) 2008-12-31 2015-05-27 Solae, Llc Proteinhydrolysatzusammensetzungen mit verbesserter Fähigkeit zur Freigabe von CCK
US9267182B2 (en) 2010-06-22 2016-02-23 Novozymes A/S Dehairing of skins and hides
JP2014518542A (ja) 2011-02-23 2014-07-31 ソレイ リミテッド ライアビリティ カンパニー 改善されたｃｃｋおよびｇｌｐ−１放出活性を有するタンパク質加水分解組成物
US20170335360A1 (en) * 2014-10-30 2017-11-23 Merck Sharp & Dohme Corp. Bacillus megaterium recombinant protein expression system
CN113249287B (zh) * 2021-07-07 2021-09-24 中国科学院天津工业生物技术研究所 一株表达d-阿洛酮糖3-差向异构酶的枯草芽孢杆菌工程菌株及其应用
EP4387638A4 (de) * 2021-09-22 2025-05-14 BiomEdit, Inc. Genetisch modifizierter bacillus subtilis-stamm und verwendung als system zur live-abgabe und -produktion
CN118434872A (zh) * 2021-12-20 2024-08-02 巴斯夫欧洲公司 用于提高芽孢杆菌中胞内蛋白质产量的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2926808A1 (de) * 1978-07-04 1980-01-17 Novo Industri As Proteaseprodukt mit verringerter allergener wirkung, herstellungsverfahren und waschmittel
US4828994A (en) * 1984-09-21 1989-05-09 Genex Corporation Bacillus strains with reduced extracellular protease levels
US5585253A (en) * 1989-11-27 1996-12-17 The Regents Of The University Of California Extracellular serine protease and a Bacillus subtilis alkaline neutral an serine protease mutant strain

Also Published As

Publication number Publication date
DE68926333T2 (de) 1996-11-28
CA2003078A1 (en) 1990-05-18
EP0369817A2 (de) 1990-05-23
JPH0367582A (ja) 1991-03-22
JP3210315B2 (ja) 2001-09-17
EP0369817B1 (de) 1996-04-24
DK577989D0 (da) 1989-11-17
US5589383A (en) 1996-12-31
US5874278A (en) 1999-02-23
AU4476689A (en) 1990-05-24
ATE137265T1 (de) 1996-05-15
DE68926333D1 (de) 1996-05-30
US5620880A (en) 1997-04-15
EP0369817A3 (de) 1991-07-31

Similar Documents

Publication Publication Date Title
DK577989A (da) Bakteriecelle og fremgangsmaade til fremstilling af et heterologt polypeptid i en saadan celle
DK234088A (da) Fremgangsmaade til fremstilling af kimere plantegener og genetisk transformerede mikroorganismer eller cellelinier
EP0320500A3 (de) Nichtonkogenisches Ti-Plasmidvektorsystem und für das Einschleusen expressionsfähiger Gene in Pflanzengenomen verwendbare rekombinante DNA-Moleküle
NO884423L (no) Molekylaer kloning og ekspresjon av gener som koder for proteolytiske enzymer.
DE69535352D1 (de) Expression der bazillus thuringiensis cry-proteine in pflanzen-plastiden
IL68366A (en) Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
DK82293A (da) Normalt sporulerende bacillus uden evne til at udskille subtilisin eller neutral protease, kulturer deraf og fremgangsmaade til fremstilling af heterologe proteiner dermed
DK0691405T3 (da) Materialer og fremgangsmåde til hypersecernering af aminosyrer
CA2153068A1 (en) Enhancer sequence for modulating expression in epithelial cells
EP0305275A3 (de) Pflanzen, die mit einer DNS-Sequenz aus Bacillus thuringiensis transformiert werden
NO853012L (no) Nye genetiske sekvenser, interfenonpeptider av type i uttrykt av disse og organismer som produserer dem.
EP0362283A4 (en) Bovine interleukin-1_g(a)
DE3688282D1 (de) Erhoehung der expression von genen in mikroorganismen.
FI915149A0 (fi) Foerfarande och material foer expression av humant plasminogen i ett eukaryotiskt cellsystem som saknar en laegesspecifik plasminogenaktivator.
GR3021040T3 (en) Process for production of stranger protein in streptomycetes
NZ296562A (en) Recombinant peptides and secretory mehods for their preparation
ES2100953T3 (es) Expresion en lineas linfoblastoides humanas no tumorales con un vector integrante.
DK0430635T3 (da) Bakterialt collagenasegen
DK0544250T3 (da) Gen, der koder for esterase, og ny mikroorganisme indeholdende dette gen
ATE78870T1 (de) Verfahren zur herstellung von neutraler protease.
DK251385D0 (da) Kultur af bacillus subtilis mutant og fremgangsmaade til fremstillingderaf samt fremgangsmaade til anvendelse deraf
IT1186750B (it) Vettore di clonaggio,molecole di dna ricombinante,ceppi di bacillus subtilis trasformati con dette molecole e metodi per l'espressione di geni eterologhi e produzione e secrezione di proteine codificate da detti geni

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment