DK511887D0 - Hidtil ukendte thrombolytiske proteiner - Google Patents

Hidtil ukendte thrombolytiske proteiner

Info

Publication number
DK511887D0
DK511887D0 DK511887A DK511887A DK511887D0 DK 511887 D0 DK511887 D0 DK 511887D0 DK 511887 A DK511887 A DK 511887A DK 511887 A DK511887 A DK 511887A DK 511887 D0 DK511887 D0 DK 511887D0
Authority
DK
Denmark
Prior art keywords
hitherto unknown
thrombolytic proteins
thrombolytic
proteins
hitherto
Prior art date
Application number
DK511887A
Other languages
English (en)
Other versions
DK511887A (da
DK175784B1 (da
Inventor
Glenn R Larsen
Tim J Ahern
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27505870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK511887(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/882,051 external-priority patent/US5002887A/en
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of DK511887A publication Critical patent/DK511887A/da
Publication of DK511887D0 publication Critical patent/DK511887D0/da
Application granted granted Critical
Publication of DK175784B1 publication Critical patent/DK175784B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
DK198705118A 1986-01-31 1987-09-29 Hidtil ukendte thrombolytiske proteiner DK175784B1 (da)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US82510486A 1986-01-31 1986-01-31
US82510486 1986-01-31
US85378186A 1986-04-18 1986-04-18
US85378186 1986-04-18
US86169986A 1986-05-09 1986-05-09
US86169986 1986-05-09
US88205186 1986-07-03
US06/882,051 US5002887A (en) 1986-01-31 1986-07-03 Truncated thrombolytic proteins
PCT/US1987/000257 WO1987004722A1 (en) 1986-01-31 1987-01-30 Novel thrombolytic proteins
US8700257 1987-01-30

Publications (3)

Publication Number Publication Date
DK511887A DK511887A (da) 1987-09-29
DK511887D0 true DK511887D0 (da) 1987-09-29
DK175784B1 DK175784B1 (da) 2005-02-21

Family

ID=27505870

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198705118A DK175784B1 (da) 1986-01-31 1987-09-29 Hidtil ukendte thrombolytiske proteiner

Country Status (6)

Country Link
EP (1) EP0293394B2 (da)
JP (4) JP2527454B2 (da)
AU (1) AU612974B2 (da)
DE (1) DE3789664T3 (da)
DK (1) DK175784B1 (da)
WO (1) WO1987004722A1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
FR2581652B1 (fr) * 1985-04-22 1989-12-22 Genentech Inc Nouveaux mutants de l'activateur tissulaire du plasminogene humain
US5073494A (en) * 1985-04-22 1991-12-17 Genentech, Inc. Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
US5589361A (en) * 1986-03-18 1996-12-31 Genentech, Inc. Human tissue-type plasminogen activator variant
US5550036A (en) * 1986-04-09 1996-08-27 Eli Lilly And Company Method for co-amplification of human protein C genes in human cells
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
GB8701811D0 (en) * 1987-01-28 1987-03-04 Beecham Group Plc Compounds
NO882226L (no) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiske proteiner.
ES2069536T3 (es) * 1987-06-04 1995-05-16 Zymogenetics Inc Analogos del activador del plasminogeno tisular que tienen dominios modificados del factor de crecimiento.
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
AU613942B2 (en) * 1987-06-30 1991-08-15 Genentech Inc. Improved processes for the treatment of vascular disease
DE3886755T3 (de) * 1987-06-30 2005-12-08 Genentech, Inc., South San Francisco Verfahren zur behandlung von gefässkrankheiten.
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
AU2081788A (en) * 1987-07-06 1989-01-30 Genetics Institute Inc. Novel thrombolytic proteins
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
US5037646A (en) * 1988-04-29 1991-08-06 Genentech, Inc. Processes for the treatment of vascular disease
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
US5258180A (en) * 1988-09-02 1993-11-02 Genetech, Inc. Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3831714A1 (de) * 1988-09-17 1990-03-22 Basf Ag Tpa-aehnliche polypeptide, ihre herstellung und verwendung
SE462829B (sv) * 1989-01-10 1990-09-10 Kabigen Ab Trombolytiskt aktiva kompositioner innehaallande en modifierad plasminogenaktivator av vaevnadstyp samt en normal human t-pa, streptokinas eller humant urokinas
CA2025743A1 (en) * 1989-09-20 1991-03-21 Hitoshi Yahara Plasminogen activator derivative and a method for its manufacture
IL97311A0 (en) * 1990-02-23 1992-05-25 Lilly Co Eli Vectors and compounds for expression of glycosylation mutants of human protein c
EP0445464A3 (en) * 1990-03-01 1992-03-04 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha A new plasminogen activator derivative and a method for its manufacture
DE10199044I2 (de) * 1992-06-03 2006-02-09 Genentech Inc Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkung
US6139838A (en) * 1996-09-06 2000-10-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue plasminogen activator medicinal composition
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
EP0125254A1 (en) * 1982-10-28 1984-11-21 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
DE3588149T2 (de) * 1984-10-01 1997-10-09 Genzyme Corp Rekombinante DNS-Verfahren und dadurch hergestellte Produkte
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPS61247384A (ja) * 1984-10-18 1986-11-04 チモ−ジエネテイツクス　インコ−ポレ−テツド 酵母中でプラスミノ−ゲン活性化因子を発現する方法
FR2581652B1 (fr) * 1985-04-22 1989-12-22 Genentech Inc Nouveaux mutants de l'activateur tissulaire du plasminogene humain
EP0227462B1 (en) * 1985-12-23 1992-04-01 Chiron Corporation Novel peptide plasminogen activators
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
JPH0644175B2 (ja) * 1986-04-18 1994-06-08 キヤノン株式会社 画像形成装置

Also Published As

Publication number Publication date
DK511887A (da) 1987-09-29
JP2527454B2 (ja) 1996-08-21
AU612974B2 (en) 1991-07-25
DE3789664T2 (de) 1994-09-15
JPH05268959A (ja) 1993-10-19
JP2568382B2 (ja) 1997-01-08
DK175784B1 (da) 2005-02-21
EP0293394A1 (en) 1988-12-07
JP2679915B2 (ja) 1997-11-19
DE3789664T3 (de) 2004-09-16
EP0293394B1 (en) 1994-04-20
JPH104960A (ja) 1998-01-13
JPS63501335A (ja) 1988-05-26
AU7239587A (en) 1987-08-25
EP0293394B2 (en) 2003-10-29
DE3789664D1 (en) 1994-05-26
EP0293394A4 (en) 1989-11-14
JPH0746989A (ja) 1995-02-21
WO1987004722A1 (en) 1987-08-13

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