DK475186D0 - Fremgangsmaade til fremstilling af amikacin - Google Patents

Fremgangsmaade til fremstilling af amikacin

Info

Publication number
DK475186D0
DK475186D0 DK475186A DK475186A DK475186D0 DK 475186 D0 DK475186 D0 DK 475186D0 DK 475186 A DK475186 A DK 475186A DK 475186 A DK475186 A DK 475186A DK 475186 D0 DK475186 D0 DK 475186D0
Authority
DK
Denmark
Prior art keywords
amikacin
metal cation
solvent
reaction
manufacturing
Prior art date
Application number
DK475186A
Other languages
English (en)
Other versions
DK166829B1 (da
DK475186A (da
Inventor
Alberto Mangia
Vincenzo Giobbio
Giorgio Ornato
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of DK475186D0 publication Critical patent/DK475186D0/da
Publication of DK475186A publication Critical patent/DK475186A/da
Application granted granted Critical
Publication of DK166829B1 publication Critical patent/DK166829B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Quinoline Compounds (AREA)
  • Removal Of Specific Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Floor Finish (AREA)
DK475186A 1985-10-10 1986-10-03 Fremgangsmaade til fremstilling af amikacin DK166829B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22425/85A IT1200774B (it) 1985-10-10 1985-10-10 Procedimento di sentisi dell'amikacina
IT2242585 1985-10-10

Publications (3)

Publication Number Publication Date
DK475186D0 true DK475186D0 (da) 1986-10-03
DK475186A DK475186A (da) 1987-04-11
DK166829B1 DK166829B1 (da) 1993-07-19

Family

ID=11196139

Family Applications (1)

Application Number Title Priority Date Filing Date
DK475186A DK166829B1 (da) 1985-10-10 1986-10-03 Fremgangsmaade til fremstilling af amikacin

Country Status (21)

Country Link
US (1) US4902790A (da)
EP (1) EP0218292B1 (da)
JP (1) JPS6293297A (da)
KR (1) KR910005897B1 (da)
AT (1) ATE55391T1 (da)
AU (1) AU603998B2 (da)
BG (1) BG50164A3 (da)
CA (1) CA1296331C (da)
CS (1) CS257292B2 (da)
DD (1) DD258991A1 (da)
DE (1) DE3673305D1 (da)
DK (1) DK166829B1 (da)
HU (1) HU196421B (da)
IT (1) IT1200774B (da)
NO (1) NO165297C (da)
NZ (1) NZ217862A (da)
PH (1) PH22748A (da)
PL (1) PL147396B1 (da)
RU (1) RU1771477C (da)
YU (1) YU44579B (da)
ZA (1) ZA867440B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
IT1237490B (it) * 1989-09-22 1993-06-07 Chementecno S R L Monza Milano Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
YU45590A (sh) * 1990-03-07 1992-07-20 PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
ATE111917T1 (de) * 1990-03-08 1994-10-15 Opos Biochimica Srl Verfahren zur herstellung von amikacin- vorläufern.
US6653456B2 (en) * 2001-07-31 2003-11-25 Roche Diagnostics Corporation Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
WO2003072735A2 (en) * 2002-02-22 2003-09-04 New River Pharmaceuticals Inc. Use of peptide-drug conjugation to reduce inter-subject variability of drug serum levels
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US8791245B2 (en) * 2008-10-03 2014-07-29 Glycan Bioscience LLC Anionic conjugates of glycosylated bacterial metabolite
CN103113429B (zh) * 2013-03-05 2015-02-18 齐鲁天和惠世制药有限公司 一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) * 2014-08-27 2018-03-09 北大医药重庆大新药业股份有限公司 一种阿米卡星的合成方法
CN111138505B (zh) * 2020-02-17 2021-10-08 山东安信制药有限公司 一种阿米卡星的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
US4230847A (en) * 1976-06-17 1980-10-28 Schering Corporation Aminoglycoside antibiotic compounds
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
US4468513A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
US4424344A (en) * 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
JPS5782399A (en) * 1980-09-22 1982-05-22 Lilly Co Eli 2-deoxystreptamine aminoglycoside derivative and manufacture

Also Published As

Publication number Publication date
PH22748A (en) 1988-11-28
YU44579B (en) 1990-10-31
NO864011L (no) 1987-04-13
US4902790A (en) 1990-02-20
IT1200774B (it) 1989-01-27
NO864011D0 (no) 1986-10-08
EP0218292A1 (en) 1987-04-15
CA1296331C (en) 1992-02-25
AU6363386A (en) 1987-04-16
RU1771477C (ru) 1992-10-23
NO165297C (no) 1991-01-23
EP0218292B1 (en) 1990-08-08
AU603998B2 (en) 1990-12-06
DK166829B1 (da) 1993-07-19
DE3673305D1 (de) 1990-09-13
DD258991A1 (de) 1988-08-10
ATE55391T1 (de) 1990-08-15
DK475186A (da) 1987-04-11
KR910005897B1 (ko) 1991-08-06
IT8522425A0 (it) 1985-10-10
JPH0212958B2 (da) 1990-03-30
HUT43084A (en) 1987-09-28
NZ217862A (en) 1990-06-26
YU108686A (en) 1987-12-31
BG50164A3 (en) 1992-05-15
PL260615A1 (en) 1987-06-15
HU196421B (en) 1988-11-28
ZA867440B (en) 1987-06-24
KR870004050A (ko) 1987-05-07
NO165297B (no) 1990-10-15
CS257292B2 (en) 1988-04-15
PL147396B1 (en) 1989-05-31
JPS6293297A (ja) 1987-04-28

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed