DK460182A - Fremgangsmaade til fremstilling af staphylokinase - Google Patents

Fremgangsmaade til fremstilling af staphylokinase Download PDF

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Publication number
DK460182A
DK460182A DK460182A DK460182A DK460182A DK 460182 A DK460182 A DK 460182A DK 460182 A DK460182 A DK 460182A DK 460182 A DK460182 A DK 460182A DK 460182 A DK460182 A DK 460182A
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DK
Denmark
Prior art keywords
hylocinase
preparing step
preparing
step hylocinase
Prior art date
Application number
DK460182A
Other languages
English (en)
Other versions
DK164001B (da
DK164001C (da
Inventor
Tomoyuki Sako
Saeko Sawaki
Toshizo Sakurai
Masahiko Mutai
Isamu Kondo
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of DK460182A publication Critical patent/DK460182A/da
Publication of DK164001B publication Critical patent/DK164001B/da
Application granted granted Critical
Publication of DK164001C publication Critical patent/DK164001C/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK460182A 1981-10-16 1982-10-15 Rekombinant-dna, der kan udtrykke staphylokinase og er afledt fra en temperat phag af staphylococcus aureus, fremgangsmaade til fremstilling af rekominant-dna samt fremgangsmaade til fremstilling af staphylokinase DK164001C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56164064A JPS5867181A (ja) 1981-10-16 1981-10-16 スタフイロキナーゼ産生遺伝情報を担うｄｎａ断片組み換え体ｄｎａおよびそれを導入した大腸菌
JP16406481 1981-10-16

Publications (3)

Publication Number Publication Date
DK460182A true DK460182A (da) 1983-04-17
DK164001B DK164001B (da) 1992-04-27
DK164001C DK164001C (da) 1992-09-21

Family

ID=15786090

Family Applications (1)

Application Number Title Priority Date Filing Date
DK460182A DK164001C (da) 1981-10-16 1982-10-15 Rekombinant-dna, der kan udtrykke staphylokinase og er afledt fra en temperat phag af staphylococcus aureus, fremgangsmaade til fremstilling af rekominant-dna samt fremgangsmaade til fremstilling af staphylokinase

Country Status (7)

Country Link
US (1) US4532211A (da)
EP (1) EP0077664B1 (da)
JP (1) JPS5867181A (da)
KR (1) KR910001807B1 (da)
CA (1) CA1206109A (da)
DE (1) DE3280175D1 (da)
DK (1) DK164001C (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561372B2 (en) * 1983-10-10 1987-05-07 Board Of Regents Of The University Of Oklahoma, The Streptokinase-coding recombinant vectors
US4764469A (en) * 1984-03-02 1988-08-16 Board Of Regents For The University Of Oklahoma Streptokinase-coding recombinant vectors
US5683909A (en) * 1984-03-02 1997-11-04 Van Den Bergh Foods Company, Division Of Conopco, Inc. Plasmids replicatable in Bacillus subtilis, E. coli and lactic acid streptococcus bacteria
US5066589A (en) * 1984-03-02 1991-11-19 Board Of Regents Of The University Of Okla. Streptokinase-coding recombinant vectors
EP0176320B1 (en) * 1984-09-26 1990-07-25 Eli Lilly And Company A method for expression and secretion in bacillus
IT1176997B (it) * 1984-10-17 1987-08-26 Anic Spa Procedimento per la produzione di proteasi neutra
DE68912383T3 (de) * 1988-04-14 1999-06-02 Yakult Honsha Kk Plasminogenaktivator und thrombolytischer Wirkstoff.
EP0621899B1 (de) * 1991-12-30 1996-06-19 Medac Gesellschaft für klinische Spezialpräparate mbH Expression signalpeptid-freier staphylokinasen
CN1035192C (zh) * 1994-04-04 1997-06-18 上海医科大学 一种重组葡激酶的制备方法
US6383483B1 (en) 1995-01-06 2002-05-07 Désiré José Collen Staphylokinase derivatives with cysteine substitutions
US5951980A (en) * 1995-01-06 1999-09-14 Leuven Research & Development Vzw Identification, production and use of new staphylokinase derivatives with reduced immunogenicity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
JPS54107589A (en) * 1978-02-09 1979-08-23 Ajinomoto Co Inc Separation and purification of staphylokinase

Also Published As

Publication number Publication date
KR840002029A (ko) 1984-06-11
CA1206109A (en) 1986-06-17
US4532211A (en) 1985-07-30
KR910001807B1 (ko) 1991-03-26
EP0077664A3 (en) 1984-05-02
DK164001B (da) 1992-04-27
EP0077664A2 (en) 1983-04-27
DK164001C (da) 1992-09-21
JPH0478276B2 (da) 1992-12-10
DE3280175D1 (de) 1990-06-21
EP0077664B1 (en) 1990-05-16
JPS5867181A (ja) 1983-04-21

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