DK3882249T3 - Deutererede derivater af ruxolitinib - Google Patents

Deutererede derivater af ruxolitinib

Info

Publication number
DK3882249T3
DK3882249T3 DK21156398.6T DK21156398T DK3882249T3 DK 3882249 T3 DK3882249 T3 DK 3882249T3 DK 21156398 T DK21156398 T DK 21156398T DK 3882249 T3 DK3882249 T3 DK 3882249T3
Authority
DK
Denmark
Prior art keywords
deuterized
ruxolitinib
derivatives
deuterized derivatives
Prior art date
Application number
DK21156398.6T
Other languages
Danish (da)
English (en)
Inventor
I Robert Silverman
Julie F Liu
Adam J Morgan
Bhaumik Pandya
Scott L Harbeson
Original Assignee
Sun Pharmaceutical Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48699982&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3882249(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sun Pharmaceutical Ind Inc filed Critical Sun Pharmaceutical Ind Inc
Application granted granted Critical
Publication of DK3882249T3 publication Critical patent/DK3882249T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK21156398.6T 2012-06-15 2013-06-14 Deutererede derivater af ruxolitinib DK3882249T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261660428P 2012-06-15 2012-06-15
US201261678795P 2012-08-02 2012-08-02
EP18188152.5A EP3450434B1 (en) 2012-06-15 2013-06-14 Deuterated derivatives of ruxolitinib

Publications (1)

Publication Number Publication Date
DK3882249T3 true DK3882249T3 (da) 2025-08-25

Family

ID=48699982

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18188152.5T DK3450434T3 (da) 2012-06-15 2013-06-14 Deutererede derivater af ruxolitinib
DK21156398.6T DK3882249T3 (da) 2012-06-15 2013-06-14 Deutererede derivater af ruxolitinib

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK18188152.5T DK3450434T3 (da) 2012-06-15 2013-06-14 Deutererede derivater af ruxolitinib

Country Status (19)

Country Link
US (7) US20150197525A1 (OSRAM)
EP (4) EP2861600A1 (OSRAM)
AU (3) AU2013274030B2 (OSRAM)
BR (1) BR122023027277A2 (OSRAM)
CA (1) CA2876306C (OSRAM)
DK (2) DK3450434T3 (OSRAM)
EA (1) EA201492287A1 (OSRAM)
ES (2) ES2867048T3 (OSRAM)
FI (1) FI3882249T3 (OSRAM)
HR (1) HRP20250965T1 (OSRAM)
IN (1) IN2014DN10670A (OSRAM)
LT (1) LT3882249T (OSRAM)
MX (2) MX360495B (OSRAM)
PL (2) PL3882249T3 (OSRAM)
PT (1) PT3882249T (OSRAM)
RS (1) RS67061B1 (OSRAM)
SI (1) SI3882249T1 (OSRAM)
SM (1) SMT202500302T1 (OSRAM)
WO (1) WO2013188783A1 (OSRAM)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7598257B2 (en) 2005-12-13 2009-10-06 Incyte Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
HRP20160326T1 (hr) 2010-03-10 2016-05-20 Incyte Holdings Corporation Derivati piperidin-4-il azetidina kao inhibitori jak1
BR112013032720A2 (pt) 2011-06-20 2016-09-13 Incyte Corp "derivados de azetidinil fenil, piridil ou pirazinil carboxamida como inibidores de jak, composição e uso dos referidos derivados"
PL3882249T3 (pl) 2012-06-15 2025-09-08 Sun Pharmaceutical Industries, Inc. Pochodne deuterowane ruksolitynibu
SG10202111768XA (en) 2012-11-15 2021-11-29 Incyte Holdings Corp Sustained-release dosage forms of ruxolitinib
PH12019502074B1 (en) 2013-08-07 2023-10-18 Incyte Holdings Corp Sustained release dosage forms for a jak1 inhibitor
US10363260B2 (en) 2014-05-28 2019-07-30 Oncotracker, Inc. Anti-cancer effects of JAK2 inhibitors in combination with thalidomide derivatives and glucocorticoids
US10865203B2 (en) 2015-06-03 2020-12-15 Uwm Research Foundation, Inc. Ligands selective to alpha 6 subunit-containing GABAA receptors and their methods of use
EA035515B1 (ru) 2016-02-04 2020-06-29 Синдом Фарма, Инк. Композиции на основе дейтерированного домперидона и способы терапии расстройств
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation
WO2017139569A1 (en) * 2016-02-12 2017-08-17 Concert Pharmaceuticals, Inc. Deuterium-modified cftr modulators
SMT202400389T1 (it) 2016-05-04 2024-11-15 Sun Pharmaceutical Industries Inc Trattamento dei disturbi di perdita dei capelli con inibitori delle jak deuterati
EP4190318A1 (en) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a jak inhibitor and devices
US12478612B2 (en) 2017-06-30 2025-11-25 Cindome Pharma, Inc. Deuterated domperidone compositions, methods, and preparation
EP3713545A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Therapeutic compound formulations
EP3713660A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
US11179412B2 (en) * 2017-12-04 2021-11-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating conditions involving elevated inflammatory response
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
EP3762424A1 (en) 2018-03-08 2021-01-13 Novartis AG Use of an anti-p-selectin antibody
WO2019191684A1 (en) 2018-03-30 2019-10-03 Incyte Corporation Treatment of hidradenitis suppurativa using jak inhibitors
MA52655A (fr) 2018-03-30 2021-02-17 Incyte Corp Biomarqueurs pour maladie cutanée inflammatoire
EP3775923A1 (en) 2018-04-13 2021-02-17 Incyte Corporation Biomarkers for graft-versus-host disease
WO2020039401A1 (en) 2018-08-24 2020-02-27 Novartis Ag Treatment comprising il-1βeta binding antibodies and combinations thereof
WO2020163653A1 (en) * 2019-02-06 2020-08-13 Concert Pharmaceuticals, Inc. Process for preparing enantiomerically enriched jak inhibitors
SG11202109563WA (en) 2019-03-05 2021-09-29 Incyte Corp Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
JP2022526301A (ja) 2019-03-19 2022-05-24 インサイト・コーポレイション 尋常性白斑のバイオマーカー
WO2020210125A1 (en) 2019-04-10 2020-10-15 University Of Notre Dame Du Lac Deuterated antimicrobial compounds
US20220255867A1 (en) 2019-05-02 2022-08-11 Intel Corporation Enabling quality of service (qos) in information centric networking (icn)
WO2020236950A1 (en) 2019-05-21 2020-11-26 Dauntless 1, Inc. Therapeutic microsphere formulations containing charged polymers
JP2022548627A (ja) 2019-09-16 2022-11-21 ノバルティス アーゲー 骨髄線維症の治療のための、高親和性のリガンドを遮断するヒト化抗ｔ細胞免疫グロブリンドメイン及びムチンドメイン３（ｔｉｍ－３）ｉｇｇ４抗体の使用
KR20220063215A (ko) 2019-09-16 2022-05-17 노파르티스 아게 골수섬유증의 치료를 위한 mdm2 억제제의 용도
CA3156007A1 (en) 2019-09-27 2021-04-01 Disc Medicine, Inc. METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS
WO2021072098A1 (en) 2019-10-10 2021-04-15 Incyte Corporation Biomarkers for graft-versus-host disease
CA3157499A1 (en) 2019-10-10 2021-04-15 Incyte Corporation Biomarkers for graft-versus-host disease
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
JP7518900B2 (ja) 2019-10-16 2024-07-18 インサイト・コーポレイション 皮膚エリテマトーデス及び扁平苔癬（ｌｐ）の治療のためのｊａｋ１阻害剤の使用
CN116059192B (zh) 2019-11-13 2024-10-29 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途
IL293085A (en) 2019-11-22 2022-07-01 Incyte Corp Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor
JP2023528223A (ja) 2020-05-13 2023-07-04 ディスク・メディシン・インコーポレイテッド 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
WO2021236139A1 (en) 2020-05-21 2021-11-25 Concert Pharmaceuticals, Inc. Novel deuterated jak inhibitor and uses thereof
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CN116348467A (zh) 2020-08-12 2023-06-27 康塞特医药品有限公司 用于制备对映异构体富集的jak抑制剂的方法
US20240000777A1 (en) 2020-10-08 2024-01-04 Novartis Ag Use of an erk inhibitor for the treatment of myelofibrosis
EP4236956A1 (en) 2020-10-28 2023-09-06 Sun Pharmaceutical Industries, Inc. Regimens for the treatment of hair loss disorders with deuterated jak inhibitors
EP4247383A1 (en) * 2020-11-19 2023-09-27 Sol-Gel Technologies Ltd. Ruxolitinib or deuterated ruxolitinib composition and uses thereof
LT4255442T (lt) 2020-12-04 2025-07-25 Incyte Corporation Jak inhibitorius su vitamino d analogu, skirtas odos ligų gydymui
TW202237083A (zh) 2021-01-11 2022-10-01 美商英塞特公司 包含ｊａｋ路徑抑制劑及ｒｏｃｋ抑制劑之組合療法
CN114853760B (zh) * 2021-02-03 2025-12-05 南京正大天晴制药有限公司 一种芦可替尼中间体的制备方法
AU2022328272A1 (en) * 2021-08-11 2024-02-22 Sun Pharmaceutical Industries, Inc. Treatment of hair loss disorders with deuterated jak inhibitors
US20240307401A1 (en) 2021-08-12 2024-09-19 Sun Pharmaceeutical Industries, Inc. Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors
CN113820413B (zh) * 2021-09-17 2023-04-07 重庆华邦胜凯制药有限公司 高效液相色谱法分离测定磷酸芦可替尼及杂质的方法
AU2023265574A1 (en) 2022-05-04 2024-12-12 Sun Pharmaceutical Industries, Inc. Dosage regimens for treatment with deuterated jak inhibitors
CN117384163A (zh) * 2022-07-05 2024-01-12 盛世泰科生物医药技术(苏州)股份有限公司 一种含偕二氟基的化合物及其制备方法和用途
WO2024196761A1 (en) * 2023-03-17 2024-09-26 Mayo Foundation For Medical Education And Research Use of oral jak kinase inhibitors to treat lichen planus
WO2024194352A1 (en) 2023-03-23 2024-09-26 Glaxosmithkline Intellectual Property (No.3) Limited Deuterated p2x3 modulators
US12364699B2 (en) 2023-10-10 2025-07-22 Sun Pharmaceuticals Industries, Inc. Method of treating hair loss disorders
US12247034B1 (en) 2024-04-19 2025-03-11 Sun Pharmaceutical Industries, Inc. Crystalline form of deuruxolitinib phosphate
US20250325664A1 (en) 2024-04-22 2025-10-23 Incyte Corporation Combination therapy with an anti-colony stimulating factor 1 receptor antibody and a jak inhibitor

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
ES2293638T3 (es) 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
GB9925962D0 (en) 1999-11-02 1999-12-29 Novartis Ag Organic compounds
DK1104760T3 (da) * 1999-12-03 2003-06-30 Pfizer Prod Inc Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
IL158306A0 (en) 2001-05-03 2004-05-12 Hoffmann La Roche Pharmaceutical dosage form of amorphous nelfinavir mesylate
EP1392262A1 (en) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
TW200413273A (en) * 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
US20060094744A1 (en) 2004-09-29 2006-05-04 Maryanoff Cynthia A Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
BRPI0617987A2 (pt) * 2005-10-06 2011-08-16 Auspex Pharmaceuticals Inc composição, composição farmacêutica, forma de dosagem efervescente, composição farmacêutica oral de comprimidos unitários múltiplos, forma de dosagem farmacêutica de liberação prolongada, forma de dosagem farmacêutica revestida entérica, forma de dosagem farmacêutica estável para administração oral a sujeitos mamìferos, método para tratamento de doenças relacionadas a ácido gástrico pela inibição de secreção de ácido gástrico, método para tratamento de uma infecção bacteriana provocada ou mediada por helicobacter pylori, processo para preparar um composto da fórmula 3, processo para preparar um composto da fórmula 5, uso de um composto da fórmula 1 para a preparação de um medicamento para tratamento de doenças relacionadas a ácido gástrico, pela inibição de secreção de ácido gástrico, uso de um composto da fórmula 1 para a preparação de um medicamento para tratamento de uma infecção bacteriana provocada ou mediada por helicobacter pylori uso de um composto da fórmula 1 para a preparação de um medicamento para tratamento de doenças relecionadas a ácido gástrico pela inibição de secreção de ácido gástrico
US7598257B2 (en) * 2005-12-13 2009-10-06 Incyte Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
JO2630B1 (en) 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
CA2661404A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
CL2008001709A1 (es) 2007-06-13 2008-11-03 Incyte Corp Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
WO2009094216A1 (en) 2008-01-22 2009-07-30 Concert Pharmaceuticals Inc. Derivatives of gefitinib
JOP20190231A1 (ar) 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
PL3882249T3 (pl) 2012-06-15 2025-09-08 Sun Pharmaceutical Industries, Inc. Pochodne deuterowane ruksolitynibu
SG10202111768XA (en) * 2012-11-15 2021-11-29 Incyte Holdings Corp Sustained-release dosage forms of ruxolitinib

Also Published As

Publication number Publication date
EP3450434A1 (en) 2019-03-06
EP3450434B1 (en) 2021-02-24
AU2016238877A1 (en) 2016-10-27
CA2876306C (en) 2024-02-20
LT3882249T (lt) 2025-08-25
WO2013188783A8 (en) 2014-02-27
EA201492287A1 (ru) 2015-07-30
EP2861600A1 (en) 2015-04-22
EP4606434A3 (en) 2025-12-03
EP4606434A2 (en) 2025-08-27
HRP20250965T1 (hr) 2025-10-10
BR112014031204A2 (pt) 2017-06-27
AU2016238877B2 (en) 2018-08-30
WO2013188783A1 (en) 2013-12-19
AU2018271227A1 (en) 2018-12-13
AU2013274030B2 (en) 2016-07-07
PL3450434T3 (pl) 2021-10-04
EP3882249A1 (en) 2021-09-22
RS67061B1 (sr) 2025-08-29
MX373123B (es) 2020-04-27
US20250025467A1 (en) 2025-01-23
AU2013274030A1 (en) 2015-01-22
IN2014DN10670A (OSRAM) 2015-08-28
US20190308976A1 (en) 2019-10-10
FI3882249T3 (fi) 2025-08-11
EP3882249B1 (en) 2025-05-14
ES3037872T3 (en) 2025-10-07
US20150239896A1 (en) 2015-08-27
US20210330674A1 (en) 2021-10-28
MX2014015185A (es) 2015-02-17
SMT202500302T1 (it) 2025-09-12
US9249149B2 (en) 2016-02-02
ES2867048T3 (es) 2021-10-20
US20150197525A1 (en) 2015-07-16
MX360495B (es) 2018-11-06
PT3882249T (pt) 2025-08-06
AU2018271227B2 (en) 2020-08-27
CA2876306A1 (en) 2013-12-19
PL3882249T3 (pl) 2025-09-08
BR122023027277A2 (pt) 2024-01-23
SI3882249T1 (sl) 2025-10-30
US20230355629A1 (en) 2023-11-09
US20170239254A1 (en) 2017-08-24
DK3450434T3 (da) 2021-05-03

Similar Documents

Publication Publication Date Title
DK3882249T3 (da) Deutererede derivater af ruxolitinib
CY2022027I2 (el) Παραγωγα βενζιμιδαζολο-προλινης
DK3235812T3 (da) Deutererede derivater af ivacaftor
DK3461895T3 (da) Modulation af ube3a-ats-ekspression
DK2906696T4 (da) Fremgangsmåder til modulering af c9orf72-ekspression
SMT201700065B (it) Derivato piridonico
EP2789165A4 (en) Chroma quantization parameter extension
DK3725778T3 (da) Formuleringer af enzalutamid
DK2846809T3 (da) Behandling af myelosuppression
DK3454346T3 (da) Anordning til cylotronfremstilling af technetium-99m
AR092198A1 (es) Derivados de pirazolopirimidinas
DK2717941T3 (da) Behandling af cancer
DK2981255T3 (da) Terapeutiske anvendelser af empagliflozin
DK2785349T4 (da) Kombinationsbehandling af cancer
DK2822568T3 (da) Anvendelser af caseinsammensætninger
IL231950B (en) Aryl-quinoline derivatives
BR112014013850A2 (pt) conjunto de prateleiras
DK3106150T3 (da) Forbedrede farmaceutiske sammensætninger af pimobendan
DK2931313T3 (da) Opløsningsformuleringer af manipulerede anti-il-23p19-antistoffer
DK2965026T3 (da) Generering af slushice
DK2919777T3 (da) Transmukosal afgivelse af tocotrienol
DK2800572T3 (da) Sammensætning af ellagitannin-rige ekstrakter
DK2925338T3 (da) Frysetørret formulering af tat-nr2b9c
DK2894998T3 (da) Rotation af kegle
DK2854831T3 (da) Fremstilling af degarelix