DK3793995T3 - Matrix metalloproteinase (MMP)-inhibitorer og fremgangsmåder til anvendelse deraf - Google Patents

Matrix metalloproteinase (MMP)-inhibitorer og fremgangsmåder til anvendelse deraf Download PDF

Info

Publication number
DK3793995T3
DK3793995T3 DK19728197.5T DK19728197T DK3793995T3 DK 3793995 T3 DK3793995 T3 DK 3793995T3 DK 19728197 T DK19728197 T DK 19728197T DK 3793995 T3 DK3793995 T3 DK 3793995T3
Authority
DK
Denmark
Prior art keywords
mmp
inhibitors
methods
matrix metalloproteinase
metalloproteinase
Prior art date
Application number
DK19728197.5T
Other languages
Danish (da)
English (en)
Inventor
Wenjin Yang
Kai-Wei Chang
Suying Liu
Cheng-Han Tsai
Original Assignee
Foresee Pharmaceuticals Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Foresee Pharmaceuticals Usa Inc filed Critical Foresee Pharmaceuticals Usa Inc
Application granted granted Critical
Publication of DK3793995T3 publication Critical patent/DK3793995T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/74Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK19728197.5T 2018-05-15 2019-05-14 Matrix metalloproteinase (MMP)-inhibitorer og fremgangsmåder til anvendelse deraf DK3793995T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862671753P 2018-05-15 2018-05-15
PCT/US2019/032131 WO2019222157A1 (en) 2018-05-15 2019-05-14 Matrix metalloproteinase (mmp) inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
DK3793995T3 true DK3793995T3 (da) 2024-04-08

Family

ID=66690981

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19728197.5T DK3793995T3 (da) 2018-05-15 2019-05-14 Matrix metalloproteinase (MMP)-inhibitorer og fremgangsmåder til anvendelse deraf
DK19731374.5T DK3793992T3 (da) 2018-05-15 2019-05-14 Matrix metalloproteinase (MMP)-inhibitorer og fremgangsmåder til anvendelse deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK19731374.5T DK3793992T3 (da) 2018-05-15 2019-05-14 Matrix metalloproteinase (MMP)-inhibitorer og fremgangsmåder til anvendelse deraf

Country Status (20)

Country Link
US (6) US20190352288A1 (https=)
EP (4) EP4335499A3 (https=)
JP (4) JP7343571B2 (https=)
KR (3) KR102861502B1 (https=)
CN (3) CN112424186A (https=)
AU (3) AU2019269409B2 (https=)
BR (1) BR112020023269A2 (https=)
CA (2) CA3100320A1 (https=)
DK (2) DK3793995T3 (https=)
ES (2) ES2978192T3 (https=)
FI (2) FI3793992T3 (https=)
HU (2) HUE066619T2 (https=)
LT (1) LT3793995T (https=)
MY (1) MY199200A (https=)
PL (1) PL3793995T3 (https=)
PT (2) PT3793992T (https=)
SG (2) SG11202011316RA (https=)
SI (1) SI3793995T1 (https=)
TW (3) TWI827601B (https=)
WO (2) WO2019222157A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10532102B2 (en) * 2016-08-19 2020-01-14 Foresee Pharmaceuticals Co., Ltd. Pharmaceutical composition and methods of uses
SI3793995T1 (sl) 2018-05-15 2024-05-31 Foresee Pharmaceuticals Usa, Inc. Zaviralci matrične metaloproteinaze (mmp)in načini njihove uporabe
CA3158234A1 (en) * 2019-11-14 2021-05-20 Foresee Pharmaceuticals Co., Ltd. Matrix metalloproteinase (mmp) inhibitors and methods of use thereof
EP4351566A4 (en) * 2021-06-08 2025-04-23 Foresee Pharmaceuticals USA, Inc. SAFE ADMINISTRATION OF MMP-12 INHIBITOR
TW202313011A (zh) * 2021-06-08 2023-04-01 逸達生物科技股份有限公司 Mmp抑制劑於治療急性呼吸窘迫綜合症之用途
EP4198033A1 (en) 2021-12-14 2023-06-21 Basf Se Heterocyclic compounds for the control of invertebrate pests
WO2023110473A1 (en) 2021-12-14 2023-06-22 Basf Se Heterocyclic compounds for the control of invertebrate pests

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482618A1 (fr) 1980-05-16 1981-11-20 Inst Corps Gras Iterg Procede de conjugaison catalytique de corps gras polyinsatures, produits obtenus et application
US6352976B1 (en) 1998-12-31 2002-03-05 Aventis Pharmaceuticals Inc. Selective inhibitors of MMP-12
EP1150975A1 (en) 1998-12-31 2001-11-07 Aventis Pharmaceuticals Inc. 1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12
EP1288199A4 (en) 2000-04-28 2005-10-12 Shionogi & Co INHIBITORS OF MMP-12
JP2004527511A (ja) 2001-03-15 2004-09-09 アストラゼネカ・アクチエボラーグ メタロプロテイナーゼ阻害剤
SE0100903D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
US6890915B2 (en) 2001-05-25 2005-05-10 Bristol-Myers Squibb Pharma Company Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
EP1394159A1 (fr) 2002-08-13 2004-03-03 Warner-Lambert Company LLC Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
SE0202539D0 (sv) 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
AU2003282920A1 (en) 2002-10-04 2004-05-04 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace)
US7132432B2 (en) * 2003-06-05 2006-11-07 Bristol-Myers Squibb Company Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
JP5042833B2 (ja) 2004-08-19 2012-10-03 クエスト ファーマシューティカル サーヴィシーズ マクロファージエラスターゼの阻害剤としての5−[3−(4−ベンジルオキシフェニルチオ)−フラ−2−イル]−イミダゾリジン−2,4−ジオン及び類似体
EP2797002A4 (en) 2011-12-21 2015-05-20 Panasonic Corp DATA PROCESSING DEVICE, DATA TRANSMISSION DEVICE, DATA PROCESSING SYSTEM, DATA PROCESSING METHOD AND DATA TRANSMISSION METHOD
SI3793995T1 (sl) * 2018-05-15 2024-05-31 Foresee Pharmaceuticals Usa, Inc. Zaviralci matrične metaloproteinaze (mmp)in načini njihove uporabe

Also Published As

Publication number Publication date
CN112424192A (zh) 2021-02-26
AU2019269409B2 (en) 2023-11-23
EP3793995A1 (en) 2021-03-24
FI3793992T3 (fi) 2024-04-17
TW202003493A (zh) 2020-01-16
EP3793992A1 (en) 2021-03-24
EP4335499A3 (en) 2024-05-15
KR20210020011A (ko) 2021-02-23
TW202002975A (zh) 2020-01-16
HUE066619T2 (hu) 2024-08-28
AU2019269409A1 (en) 2021-01-07
SG11202011318QA (en) 2020-12-30
EP4335499A2 (en) 2024-03-13
PT3793992T (pt) 2024-05-13
TW202400584A (zh) 2024-01-01
CA3100320A1 (en) 2019-11-21
US20240018131A1 (en) 2024-01-18
KR20250021604A (ko) 2025-02-13
BR112020023269A2 (pt) 2021-02-23
JP2023164905A (ja) 2023-11-14
KR20210020897A (ko) 2021-02-24
SI3793995T1 (sl) 2024-05-31
ES2984594T3 (es) 2024-10-30
WO2019222154A1 (en) 2019-11-21
TWI895726B (zh) 2025-09-01
JP7344959B2 (ja) 2023-09-14
US12258335B1 (en) 2025-03-25
CN112424186A (zh) 2021-02-26
HUE066627T2 (hu) 2024-08-28
PT3793995T (pt) 2024-05-02
PL3793995T3 (pl) 2024-05-06
AU2019270975B2 (en) 2023-12-14
AU2024200323B2 (en) 2025-06-05
EP4349332A2 (en) 2024-04-10
US20210214340A1 (en) 2021-07-15
US20190352288A1 (en) 2019-11-21
US11739080B2 (en) 2023-08-29
AU2019270975A1 (en) 2021-01-07
MY199200A (en) 2023-10-19
US12215096B2 (en) 2025-02-04
JP7656669B2 (ja) 2025-04-03
EP4349332A3 (en) 2024-05-15
AU2024200323A1 (en) 2024-02-01
SG11202011316RA (en) 2020-12-30
CN119462623A (zh) 2025-02-18
JP2021523241A (ja) 2021-09-02
TWI798435B (zh) 2023-04-11
US10851089B2 (en) 2020-12-01
US20250115590A1 (en) 2025-04-10
JP7343571B2 (ja) 2023-09-12
TWI827601B (zh) 2024-01-01
ES2978192T3 (es) 2024-09-06
JP2023164924A (ja) 2023-11-14
CN112424192B (zh) 2024-11-26
CA3100319A1 (en) 2019-11-21
US20190352287A1 (en) 2019-11-21
LT3793995T (lt) 2024-04-25
KR102761591B1 (ko) 2025-01-31
EP3793995B1 (en) 2024-01-10
WO2019222157A1 (en) 2019-11-21
KR102861502B1 (ko) 2025-09-18
EP3793992B1 (en) 2024-01-10
JP2021523240A (ja) 2021-09-02
DK3793992T3 (da) 2024-04-08
FI3793995T3 (fi) 2024-04-17

Similar Documents

Publication Publication Date Title
DK3793992T3 (da) Matrix metalloproteinase (MMP)-inhibitorer og fremgangsmåder til anvendelse deraf
DK3966207T3 (da) Phenylaminopyrimidinamid-autophagi-hæmmere og fremgangsmåder til anvendelse deraf
DK3966206T3 (da) Heteroarylaminopyrimidinamid-autophagihæmmere og fremgangsmåder til anvendelse deraf
DK3870579T3 (da) Tyk2-inhibitorer og anvendelser deraf
DK3761980T3 (da) Aminosyreforbindelser og fremgangsmåder til anvendelse
DK3774789T3 (da) BRM-målrettede forbindelser og tilhørende fremgangsmåder til anvendelse
IL284640A (en) Pcsk9 inhibitors and methods of use thereof
DK4175951T3 (da) Hpk1-hæmmere og anvendelser
DK3710430T3 (da) Acss2-inhibitorer og fremgangsmåder til anvendelse deraf
DK3752251T3 (da) Arginasehæmmere og fremgangsmåder til anvendelse deraf
IL287751A (en) Kcnt1 inhibitors and methods of use
IL283592A (en) Inhibitors of apol1 and methods of using same
IL287768A (en) Kcnt1 inhibitors and methods of use
DK3788044T3 (da) RIP1-hæmmende forbindelser og fremgangsmåder til fremstilling og anvendelse heraf
DK3753937T3 (da) Atr-hæmmer og anvendelse deraf
DK3677278T3 (da) Isoformselektive tgfbeta1-inhibitorer og anvendelse deraf
DK3565520T3 (da) Vandfrie sammensætninger af mtor-hæmmere og fremgangsmåder til anvendelse
DK3618928T3 (da) Anti-Sortilin-antistoffer og fremgangsmåder til anvendelse deraf
DK3840837T3 (da) Arginasehæmmere og fremgangsmåder til anvendelse deraf
DK3621694T3 (da) Lrrc33-inhibitorer og anvendelse heraf
DK3595665T3 (da) Dobbelthæmmere af magl og faah
IL286485A (en) Pi4-kinase inhibitors and methods of using the same
DK3337791T3 (da) Inhibitorer af peptidylarginindeiminase (pad)-enzymer og anvendelser deraf
DK3796979T3 (da) Mir-181-hæmmere og anvendelser deraf
DK4218753T3 (da) Ny lipasehæmmer og anvendelser deraf