DK3642343T3 - Improved protein expression strains - Google Patents
Improved protein expression strains Download PDFInfo
- Publication number
- DK3642343T3 DK3642343T3 DK18730809.3T DK18730809T DK3642343T3 DK 3642343 T3 DK3642343 T3 DK 3642343T3 DK 18730809 T DK18730809 T DK 18730809T DK 3642343 T3 DK3642343 T3 DK 3642343T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein expression
- improved protein
- expression strains
- strains
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
- C12Y603/02002—Glutamate-cysteine ligase (6.3.2.2)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17176932 | 2017-06-20 | ||
| PCT/EP2018/066344 WO2018234349A1 (en) | 2017-06-20 | 2018-06-20 | IMPROVED STRAINS FOR THE EXPRESSION OF PROTEINS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3642343T3 true DK3642343T3 (en) | 2022-03-14 |
Family
ID=59257979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18730809.3T DK3642343T3 (en) | 2017-06-20 | 2018-06-20 | Improved protein expression strains |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11130979B2 (da) |
| EP (2) | EP4026908A1 (da) |
| JP (1) | JP7282693B2 (da) |
| KR (1) | KR102638505B1 (da) |
| CN (1) | CN111032871A (da) |
| AU (1) | AU2018286919B2 (da) |
| BR (1) | BR112019027397A2 (da) |
| CA (1) | CA3064037A1 (da) |
| DK (1) | DK3642343T3 (da) |
| ES (1) | ES2906997T3 (da) |
| IL (1) | IL271404A (da) |
| WO (1) | WO2018234349A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102638505B1 (ko) * | 2017-06-20 | 2024-02-20 | 알부메딕스 리미티드 | 개선된 단백질 발현 스트레인 |
| KR102546738B1 (ko) | 2021-01-04 | 2023-06-22 | 씨제이제일제당 주식회사 | 글루타메이트-시스테인 리가아제 변이체 및 이를 이용한 글루타치온 생산방법 |
| GB202301984D0 (en) | 2023-02-13 | 2023-03-29 | Phenotypeca Ltd | Engineered eukaryotic cell |
| GB202301988D0 (en) | 2023-02-13 | 2023-03-29 | Phenotypeca Ltd | Breeding process |
| GB202301983D0 (en) | 2023-02-13 | 2023-03-29 | Phenotypeca Ltd | Engineered eukaryotic cell |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9019919D0 (en) | 1990-09-12 | 1990-10-24 | Delta Biotechnology Ltd | Purification of proteins |
| US4302386A (en) | 1978-08-25 | 1981-11-24 | The Ohio State University | Antigenic modification of polypeptides |
| IL88326A (en) | 1987-11-18 | 1993-03-15 | Gist Brocades Nv | Purification of serum albumin |
| EP0387319B1 (en) | 1988-07-23 | 1996-03-06 | Delta Biotechnology Limited | Secretory leader sequences |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| CA2017176A1 (en) | 1989-05-22 | 1990-11-22 | Yoshitomi Pharmaceutical Industries Ltd. | Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin |
| JPH03155791A (ja) | 1989-11-14 | 1991-07-03 | Green Cross Corp:The | 雑種プロモーター |
| JP3230091B2 (ja) | 1990-06-25 | 2001-11-19 | ウェルファイド株式会社 | ヒト血清アルブミンの着色抑制方法 |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| WO1992013951A1 (en) | 1991-02-04 | 1992-08-20 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of human serum albumin in methylotrophic yeast cells |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| CN101659926A (zh) | 1994-06-30 | 2010-03-03 | 诺沃奇梅兹有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| PT889949E (pt) | 1996-03-13 | 2003-10-31 | Delta Biotechnology Ltd | Controlo de fermentacao |
| US6159705A (en) | 1996-09-24 | 2000-12-12 | Cadus Pharmaceutical Corporation | Recombinant yeast cells for identifying receptor effectors |
| EP1124949B1 (en) | 1998-10-26 | 2006-07-12 | Novozymes A/S | Constructing and screening a dna library of interest in filamentous fungal cells |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| CN100482801C (zh) | 1999-03-22 | 2009-04-29 | 诺沃奇梅兹有限公司 | 用于在真菌细胞中表达基因的启动子 |
| US7314712B2 (en) | 2001-07-27 | 2008-01-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Systems for in vivo site-directed mutagenesis using oligonucleotides |
| CN1646154B (zh) | 2002-02-07 | 2010-12-01 | 诺维信生物制药英国有限公司 | 与白蛋白融合的抗-血管生成肽 |
| GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
| EP2169067A1 (en) | 2004-12-22 | 2010-03-31 | Novozymes A/S | Recombinant production of serum albumin |
| EP1831375B1 (en) | 2004-12-23 | 2014-07-16 | Novozymes Biopharma DK A/S | Gene expression technique |
| GB0512707D0 (en) | 2005-06-22 | 2005-07-27 | Delta Biotechnology Ltd | Gene expression technique |
| KR20110008086A (ko) | 2008-04-11 | 2011-01-25 | 메리맥 파마슈티컬즈, 인크. | 인간 혈청 알부민 링커 및 그 콘쥬게이트 |
| JP5410703B2 (ja) | 2008-07-30 | 2014-02-05 | アサヒグループホールディングス株式会社 | 酵母変異株の作製方法および酵母変異株 |
| CN102282168A (zh) | 2008-11-18 | 2011-12-14 | 梅里麦克制药股份有限公司 | 人血清白蛋白接头以及其结合物 |
| CN102317315A (zh) | 2009-02-11 | 2012-01-11 | 诺维信生物制药丹麦公司 | 白蛋白变体和缀合物 |
| WO2010128142A1 (en) | 2009-05-07 | 2010-11-11 | Novozymes Biopharma Dk A/S | Method for purifying albumin |
| EP2493921B1 (en) | 2009-10-30 | 2018-09-26 | Albumedix Ltd | Albumin variants |
| JP5634051B2 (ja) | 2009-11-13 | 2014-12-03 | Ｍｃフードスペシャリティーズ株式会社 | グルタチオン高生産酵母及びその利用 |
| KR20130020765A (ko) | 2010-02-16 | 2013-02-28 | 메디뮨 엘엘씨 | Ｈｓａ-관련 조성물 및 사용방법 |
| US10233228B2 (en) | 2010-04-09 | 2019-03-19 | Albumedix Ltd | Albumin derivatives and variants |
| CN103347893A (zh) | 2010-11-01 | 2013-10-09 | 诺维信生物制药丹麦公司 | 白蛋白变体 |
| JP2014510518A (ja) | 2011-02-15 | 2014-05-01 | メディミューン，エルエルシー | Ｈｓａ関連組成物および使用方法 |
| CN102296033B (zh) | 2011-04-26 | 2013-08-28 | 武汉大学 | 一种酿酒酵母gshl缺失突变株的构建方法及应用 |
| US8822417B2 (en) | 2011-05-05 | 2014-09-02 | Novozymes Biopharma DIC A/S | Albumin variants |
| FR2980483B1 (fr) | 2011-09-23 | 2015-07-17 | Lesaffre & Cie | Souches de levure pour la production de glutathion |
| CN109602489A (zh) | 2011-11-16 | 2019-04-12 | 通用医疗公司 | 用于低温处理皮肤组织的方法和装置 |
| US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
| KR20140136934A (ko) | 2012-03-16 | 2014-12-01 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 변이체 |
| CA2881407A1 (en) | 2012-08-22 | 2014-02-27 | Butamax Advanced Biofuels Llc | Production of fermentation products |
| AU2013343503B2 (en) | 2012-11-08 | 2017-12-14 | Albumedix Ltd. | Albumin variants |
| ES2843679T3 (es) | 2013-03-06 | 2021-07-20 | Glaxosmithkline Llc | Células hospedadoras y métodos de uso |
| WO2014179657A1 (en) | 2013-05-03 | 2014-11-06 | Eleven Biotherapeutics, Inc. | Albumin variants binding to fcrn |
| CN114657079A (zh) * | 2013-07-12 | 2022-06-24 | 味之素株式会社 | 具有高含量的Abu、γ-Glu-Abu和/或γ-Glu-Abu-Gly的酵母 |
| US20160222087A1 (en) | 2013-09-13 | 2016-08-04 | Novozymes Biopharma Dk A/S | Albumin variants |
| WO2015063611A2 (en) | 2013-11-01 | 2015-05-07 | University Of Oslo | Albumin variants and uses thereof |
| CN104059936B (zh) * | 2014-04-30 | 2017-01-25 | 唐星 | 一种用于合成谷胱甘肽的基因工程菌的制备方法及其产品 |
| AU2016308504A1 (en) | 2015-08-20 | 2018-01-18 | Albumedix Ltd. | Albumin variants and conjugates |
| BR112018012851A2 (pt) | 2015-12-22 | 2018-12-26 | Albumedix Ltd | cepas de expressão de proteína melhoradas |
| KR102638505B1 (ko) * | 2017-06-20 | 2024-02-20 | 알부메딕스 리미티드 | 개선된 단백질 발현 스트레인 |
-
2018
- 2018-06-20 KR KR1020207001925A patent/KR102638505B1/ko active IP Right Grant
- 2018-06-20 US US16/624,616 patent/US11130979B2/en active Active
- 2018-06-20 CA CA3064037A patent/CA3064037A1/en active Pending
- 2018-06-20 JP JP2019570064A patent/JP7282693B2/ja active Active
- 2018-06-20 EP EP21205401.9A patent/EP4026908A1/en active Pending
- 2018-06-20 EP EP18730809.3A patent/EP3642343B1/en active Active
- 2018-06-20 DK DK18730809.3T patent/DK3642343T3/da active
- 2018-06-20 WO PCT/EP2018/066344 patent/WO2018234349A1/en unknown
- 2018-06-20 BR BR112019027397-2A patent/BR112019027397A2/pt unknown
- 2018-06-20 AU AU2018286919A patent/AU2018286919B2/en active Active
- 2018-06-20 ES ES18730809T patent/ES2906997T3/es active Active
- 2018-06-20 CN CN201880054025.6A patent/CN111032871A/zh active Pending
-
2019
- 2019-12-12 IL IL271404A patent/IL271404A/en unknown
-
2021
- 2021-09-02 US US17/464,991 patent/US11396670B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020530260A (ja) | 2020-10-22 |
| US11396670B2 (en) | 2022-07-26 |
| IL271404A (en) | 2020-01-30 |
| EP3642343A1 (en) | 2020-04-29 |
| BR112019027397A2 (pt) | 2020-07-14 |
| AU2018286919A1 (en) | 2019-12-05 |
| CA3064037A1 (en) | 2018-12-27 |
| CN111032871A (zh) | 2020-04-17 |
| AU2018286919B2 (en) | 2022-10-06 |
| KR102638505B1 (ko) | 2024-02-20 |
| US11130979B2 (en) | 2021-09-28 |
| EP4026908A1 (en) | 2022-07-13 |
| EP3642343B1 (en) | 2021-12-08 |
| US20200123584A1 (en) | 2020-04-23 |
| KR20200019731A (ko) | 2020-02-24 |
| JP7282693B2 (ja) | 2023-05-29 |
| US20220090159A1 (en) | 2022-03-24 |
| ES2906997T3 (es) | 2022-04-21 |
| WO2018234349A1 (en) | 2018-12-27 |
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