DK3518960T3 - Doseringsskema for en PTH-forbindelse med kontrolleret frigivelse - Google Patents
Doseringsskema for en PTH-forbindelse med kontrolleret frigivelse Download PDFInfo
- Publication number
- DK3518960T3 DK3518960T3 DK17781425.8T DK17781425T DK3518960T3 DK 3518960 T3 DK3518960 T3 DK 3518960T3 DK 17781425 T DK17781425 T DK 17781425T DK 3518960 T3 DK3518960 T3 DK 3518960T3
- Authority
- DK
- Denmark
- Prior art keywords
- controlled release
- dosage schedule
- pth compound
- release pth
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 238000013270 controlled release Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16191451 | 2016-09-29 | ||
EP17155843 | 2017-02-13 | ||
PCT/EP2017/074592 WO2018060310A1 (en) | 2016-09-29 | 2017-09-28 | Dosage regimen for a controlled-release pth compound |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3518960T3 true DK3518960T3 (da) | 2023-09-04 |
Family
ID=60051488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK17781425.8T DK3518960T3 (da) | 2016-09-29 | 2017-09-28 | Doseringsskema for en PTH-forbindelse med kontrolleret frigivelse |
Country Status (23)
Country | Link |
---|---|
US (4) | US11590207B2 (da) |
EP (2) | EP4275677A3 (da) |
JP (3) | JP7197468B2 (da) |
KR (2) | KR102627405B1 (da) |
CN (2) | CN117838873A (da) |
AU (1) | AU2017336249A1 (da) |
BR (1) | BR112019005533A2 (da) |
CA (1) | CA3037442A1 (da) |
DK (1) | DK3518960T3 (da) |
ES (1) | ES2959995T3 (da) |
FI (1) | FI3518960T3 (da) |
HR (1) | HRP20231079T1 (da) |
HU (1) | HUE063235T2 (da) |
IL (2) | IL304086A (da) |
LT (1) | LT3518960T (da) |
MX (1) | MX2019003181A (da) |
NZ (1) | NZ751969A (da) |
PL (1) | PL3518960T3 (da) |
RS (1) | RS64440B1 (da) |
SG (1) | SG11201901576QA (da) |
SI (1) | SI3518960T1 (da) |
WO (1) | WO2018060310A1 (da) |
ZA (1) | ZA201901811B (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2859412C (en) * | 2011-12-14 | 2021-05-25 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents using bacterial collagen-binding polypeptide segments |
SG11201806092TA (en) * | 2016-03-01 | 2018-08-30 | Ascendis Pharma Bone Diseases As | Pth prodrugs |
US11590207B2 (en) | 2016-09-29 | 2023-02-28 | Ascendis Pharma Bone Diseases A/S | Dosage regimen for a controlled-release PTH compound |
KR102611820B1 (ko) | 2016-09-29 | 2023-12-07 | 아센디스 파마 본 디지즈 에이/에스 | 낮은 피크 대 트로프 비를 가진 pth 화합물 |
US11624060B2 (en) | 2017-02-10 | 2023-04-11 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
MX2020012179A (es) * | 2018-05-18 | 2021-01-29 | Ascendis Pharma Bone Diseases As | Dosis inicial de conjugados de hormona paratiroidea (pth). |
WO2020165087A1 (en) | 2019-02-11 | 2020-08-20 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of pth conjugates |
CN117586372A (zh) * | 2022-08-10 | 2024-02-23 | 成都奥达生物科技有限公司 | 一种长效特立帕肽化合物 |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744444A (en) | 1989-10-27 | 1998-04-28 | Haemopep Pharma Gmbh | HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof |
US5567439A (en) * | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
ZA9811127B (en) | 1997-12-09 | 2000-07-11 | Lilly Co Eli | Stabilized teriparatide solutions. |
US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
WO2003064462A1 (fr) | 2002-02-01 | 2003-08-07 | Chugai Seiyaku Kabushiki Kaisha | Pth a liaison peg ou derive de pth a liaison peg |
US6559293B1 (en) * | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
CA2521784C (en) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
US7690003B2 (en) | 2003-08-29 | 2010-03-30 | Fuller Jeffrey C | System and method for increasing data throughput using thread scheduling |
EP2932981B1 (en) | 2003-09-19 | 2021-06-16 | Novo Nordisk A/S | Albumin-binding derivatives of GLP-1 |
AU2005232371B2 (en) | 2004-03-23 | 2010-10-14 | Complex Biosystems Gmbh | Polymeric prodrug with a self-immolative linker |
EP1750756A2 (en) | 2004-05-10 | 2007-02-14 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of parathyroid hormone |
US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
CN1597697A (zh) | 2004-07-19 | 2005-03-23 | 中国药科大学 | 一种人的甲状旁腺素1-34肽相关肽-Pro-Pro-[Arg11]]hPTH(1-34)-Pro-Pro |
US20060069021A1 (en) | 2004-08-13 | 2006-03-30 | Nastech Pharmaceutical Company Inc. | Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs |
US20060045912A1 (en) * | 2004-08-30 | 2006-03-02 | Peter Truog | 4-phenylbutyric acid controlled-release formulations for therapeutic use |
EP1736059A1 (en) | 2005-06-21 | 2006-12-27 | Fuji Oil Europe | Structuring granular composition |
GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
CN1298386C (zh) | 2005-08-31 | 2007-02-07 | 上海交通大学 | 甲状旁腺激素缓释微球的制备方法 |
US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
AU2007225056A1 (en) | 2006-03-15 | 2007-09-20 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia |
CN101534643A (zh) | 2006-09-15 | 2009-09-16 | 安佐制药股份有限公司 | 用于递送寡核苷酸的基于位阻酯的生物可降解连接体 |
PL2084183T3 (pl) * | 2006-10-13 | 2010-10-29 | Lilly Co Eli | Pegylowane pth jako modulatory receptora pth i ich zastosowania |
US8101729B2 (en) * | 2007-03-19 | 2012-01-24 | Henry Joseph Niemczyk | Pegylated amino acid derivatives and the process to synthesize the same |
CA2930681C (en) | 2007-04-09 | 2019-10-15 | The Board Of Trustees Of The University Of Arkansas | Fusion protein of collagen-binding domain and parathyroid hormone |
ATE502114T1 (de) | 2007-06-21 | 2011-04-15 | Univ Muenchen Tech | Biologisch aktive proteine mit erhöhter in-vivo- und/oder in-vitro-stabilität |
CA2693616A1 (en) | 2007-07-11 | 2009-01-15 | Enzon Pharmaceuticals, Inc. | Polymeric drug delivery system containing a multi-substituted aromatic moiety |
US7633977B2 (en) | 2007-08-08 | 2009-12-15 | Wisconsin Alumni Research Foundation | Multispectral laser with improved time division multiplexing |
EP2052736A1 (en) | 2007-10-26 | 2009-04-29 | Nycomed Danmark ApS | Parathyroid hormone formulations und uses thereof |
MX2010008024A (es) | 2008-02-01 | 2010-12-21 | Ascendis Pharma As | Profarmaco que comprende un enlazador que se puede separar por si mismo. |
ES2875426T3 (es) | 2008-04-29 | 2021-11-10 | Ascendis Pharma Endocrinology Div A/S | Compuestos de hormona de crecimiento humana recombinante pegilada |
JP2011520983A (ja) | 2008-05-23 | 2011-07-21 | エンゾン ファーマシューティカルズ,インコーポレーテッド | オリゴヌクレオチドの送達のための細胞内遊離可能ジスルフィドリンカーを含有するポリマーシステム |
WO2009156481A1 (en) | 2008-06-25 | 2009-12-30 | Ascendis Pharma As | Pegylated bnp |
JP2012500284A (ja) | 2008-08-19 | 2012-01-05 | フェリング ベスローテン フェンノートシャップ | ペプチド性pth受容体アゴニスト |
CN116925238A (zh) | 2009-02-03 | 2023-10-24 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
AU2010273345B2 (en) | 2009-07-16 | 2013-02-21 | Lockheed Martin Corporation | Helical tube bundle arrangements for heat exchangers |
MX2012001399A (es) | 2009-07-31 | 2012-03-21 | Sanofi Aventis Deutschland | Profarmacos que comprenden un conjugado de insulina-conector. |
WO2011012723A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Injectable sustained release compositions comprising a pramipexole prodrug |
WO2011012722A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Prodrugs containing an aromatic amine connected by an amido bond to a linker |
SG178195A1 (en) | 2009-07-31 | 2012-03-29 | Sanofi Aventis Deutschland | Long acting insulin composition |
LT2459220T (lt) | 2009-07-31 | 2020-12-28 | Ascendis Pharma A/S | Biologiškai suyrantys vandenyje netirpūs hidrogeliai polietilenglikolio pagrindu |
WO2011012721A1 (en) * | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Carrier linked pramipexole prodrugs |
AR078458A1 (es) | 2009-09-30 | 2011-11-09 | Sanofi Aventis Deutschland | Conjunto de accionamiento, vastago de piston, dispositivo para la entrega de drogas, y uso de un resorte |
EP2676692A1 (en) | 2009-09-30 | 2013-12-25 | Sanofi-Aventis Deutschland GmbH | A mechanism for a drug delivery device |
WO2011042450A1 (en) * | 2009-10-06 | 2011-04-14 | Ascendis Pharma As | Carrier linked paliperidone prodrugs |
LT2512450T (lt) | 2009-12-15 | 2018-04-25 | Ascendis Pharma Endocrinology Division A/S | Sausa augimo hormono kompozicija, laikinai prijungta prie polimero nešiklio |
CN102724967A (zh) | 2009-12-31 | 2012-10-10 | 安龙制药公司 | 包括可释放的脲连接体的含芳香胺化合物的聚合缀合物 |
WO2011089215A1 (en) * | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aromatic amine-containing drugs |
US9561285B2 (en) | 2010-01-22 | 2017-02-07 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
WO2011089216A1 (en) | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
US20110229580A1 (en) * | 2010-03-22 | 2011-09-22 | Indian Institute of Technology Bombay, School of Biosciences and Bioengineering | Compositions and methods for nano-in-micro particles |
WO2011123813A2 (en) | 2010-04-02 | 2011-10-06 | Amunix Operating Inc. | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same |
CN103025165B (zh) | 2010-05-05 | 2016-06-08 | 普罗林科斯有限责任公司 | 自大分子共轭物的控释 |
CN103025164B (zh) | 2010-05-05 | 2017-03-08 | 普罗林科斯有限责任公司 | 从固体支撑物中药物的控制释放 |
US9492508B2 (en) * | 2010-05-13 | 2016-11-15 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
EA024755B1 (ru) | 2010-05-21 | 2016-10-31 | ИксЭль-ПРОТЕИН ГМБХ | Биосинтетические нерегулярные спиральные полипептиды пролина/аланина и их применения |
US8865220B2 (en) * | 2010-06-14 | 2014-10-21 | Kaohsiung Medical University | Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres |
CN102959585B (zh) | 2010-06-30 | 2016-03-30 | 日本电气方案创新株式会社 | 属性确定方法、属性确定装置及属性确定系统 |
US20120040320A1 (en) * | 2010-08-13 | 2012-02-16 | Nadeau Daniel A | Injection Simulation Device and Methods Thereof |
EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
AU2012296950B2 (en) | 2011-08-12 | 2016-09-22 | Ascendis Pharma A/S | Polymeric hyperbranched carrier-linked prodrugs |
AU2012296951B2 (en) | 2011-08-12 | 2016-09-15 | Ascendis Pharma A/S | Protein carrier-linked prodrugs |
CA2843506C (en) * | 2011-08-12 | 2020-05-12 | Ascendis Pharma A/S | Carrier-linked prodrugs having reversible carboxylic ester linkages |
CA2843883C (en) | 2011-08-12 | 2020-04-28 | Ascendis Pharma A/S | Carrier-linked treprostinil prodrugs |
MX2014001496A (es) | 2011-08-12 | 2014-04-30 | Ascendis Pharma As | Composicion de liberacion sostenida de prostaciclina. |
WO2013036857A1 (en) | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
MY171920A (en) * | 2011-10-12 | 2019-11-07 | Ascendis Pharma Ophthalmology Div A/S | Prevention and treatment of ocular conditions |
DE102011116960B3 (de) | 2011-10-26 | 2012-10-25 | Stahlbrandschutz Gmbh | Dämmschichtbildendes Anstrichmittel |
DE102011117182A1 (de) | 2011-10-28 | 2013-05-02 | Ruhrpumpen Gmbh | Teilstromführung, insbesondere einer Magnetkupplungspumpe |
US8883862B2 (en) | 2012-01-12 | 2014-11-11 | Kaohsiung Medical University | Method for controlled release of parathyroid hormone from cross-linked hyaluronic acid hydrogel |
US20150087688A1 (en) | 2012-04-25 | 2015-03-26 | Ascendis Pharma A/S | Prodrugs of hydroxyl-comprising drugs |
US9457096B2 (en) * | 2012-07-06 | 2016-10-04 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) | Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery |
WO2014033540A2 (en) | 2012-08-28 | 2014-03-06 | The Governors Of The University Of Alberta | Parathyroid hormone, insulin, and related peptides conjugated to bone targeting moieties and methods of making and using thereof |
JP2015533132A (ja) | 2012-10-11 | 2015-11-19 | アセンディス ファーマ オフサルモロジー ディヴィジョン エー/エス | 眼状態を処置するためのvegf中和プロドラッグ |
CA2885169C (en) * | 2012-10-11 | 2021-06-22 | Ascendis Pharma A/S | Diagnosis, prevention and treatment of diseases of the joint |
CA2883833C (en) * | 2012-10-11 | 2020-10-27 | Ascendis Pharma A/S | Hydrogel prodrugs |
CN104955472A (zh) | 2012-10-17 | 2015-09-30 | 诺和诺德保健股份有限公司 | 用于生长激素递送的脂肪酸酰化的氨基酸 |
AU2013353985B2 (en) | 2012-12-07 | 2017-07-13 | Ascendis Pharma A/S | Carrier-linked prostanoid prodrugs |
GB201303771D0 (en) * | 2013-03-04 | 2013-04-17 | Midatech Ltd | Nanoparticles peptide compositions |
EP2988783A1 (en) | 2013-04-22 | 2016-03-02 | Ascendis Pharma A/S | Hydrogel-linked prodrugs releasing modified drugs |
US20150065423A1 (en) * | 2013-08-30 | 2015-03-05 | Perosphere, Inc. | Rapid acting injectable formulations |
CA2925190C (en) * | 2013-10-08 | 2021-10-12 | Ascendis Pharma A/S | Protecting group comprising a purification tag |
EP2868326A1 (en) * | 2013-11-04 | 2015-05-06 | Université Pierre et Marie Curie (Paris 6) | Peptide inhibitors of TEAD/YAP-TAZ interaction |
WO2016020373A1 (en) * | 2014-08-06 | 2016-02-11 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
WO2016065042A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
JP2018502868A (ja) * | 2015-01-09 | 2018-02-01 | アセンディス ファーマ グロース ディスオーダーズ エー/エス | Cnpプロドラッグ |
AR105319A1 (es) * | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
SG11201806092TA (en) | 2016-03-01 | 2018-08-30 | Ascendis Pharma Bone Diseases As | Pth prodrugs |
SG10202111952PA (en) | 2016-09-29 | 2021-12-30 | Ascendis Pharma Growth Disorders As | Combination therapy with controlled-release cnp agonists |
US11590207B2 (en) | 2016-09-29 | 2023-02-28 | Ascendis Pharma Bone Diseases A/S | Dosage regimen for a controlled-release PTH compound |
MA46428A (fr) | 2016-09-29 | 2019-08-07 | Ascendis Pharma Bone Diseases As | Schéma posologique incrémentiel dans des composés de pth à libération contrôlée |
KR102611820B1 (ko) * | 2016-09-29 | 2023-12-07 | 아센디스 파마 본 디지즈 에이/에스 | 낮은 피크 대 트로프 비를 가진 pth 화합물 |
AR110299A1 (es) | 2016-12-02 | 2019-03-13 | Sanofi Sa | Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico |
MX2020012179A (es) | 2018-05-18 | 2021-01-29 | Ascendis Pharma Bone Diseases As | Dosis inicial de conjugados de hormona paratiroidea (pth). |
WO2020165087A1 (en) | 2019-02-11 | 2020-08-20 | Ascendis Pharma Bone Diseases A/S | Liquid pharmaceutical formulations of pth conjugates |
JP2023510790A (ja) | 2020-01-13 | 2023-03-15 | アセンディス ファーマ ボーン ディジージズ エー/エス | 副甲状腺機能低下症の治療 |
-
2017
- 2017-09-28 US US16/337,713 patent/US11590207B2/en active Active
- 2017-09-28 WO PCT/EP2017/074592 patent/WO2018060310A1/en active Application Filing
- 2017-09-28 SI SI201731422T patent/SI3518960T1/sl unknown
- 2017-09-28 RS RS20230661A patent/RS64440B1/sr unknown
- 2017-09-28 DK DK17781425.8T patent/DK3518960T3/da active
- 2017-09-28 BR BR112019005533A patent/BR112019005533A2/pt unknown
- 2017-09-28 EP EP23185728.5A patent/EP4275677A3/en active Pending
- 2017-09-28 ES ES17781425T patent/ES2959995T3/es active Active
- 2017-09-28 PL PL17781425.8T patent/PL3518960T3/pl unknown
- 2017-09-28 NZ NZ751969A patent/NZ751969A/en unknown
- 2017-09-28 LT LTEPPCT/EP2017/074592T patent/LT3518960T/lt unknown
- 2017-09-28 HR HRP20231079TT patent/HRP20231079T1/hr unknown
- 2017-09-28 IL IL304086A patent/IL304086A/en unknown
- 2017-09-28 FI FIEP17781425.8T patent/FI3518960T3/fi active
- 2017-09-28 IL IL265591A patent/IL265591B2/en unknown
- 2017-09-28 CN CN202410041714.0A patent/CN117838873A/zh active Pending
- 2017-09-28 AU AU2017336249A patent/AU2017336249A1/en active Pending
- 2017-09-28 CN CN201780060151.8A patent/CN109789189B/zh active Active
- 2017-09-28 MX MX2019003181A patent/MX2019003181A/es unknown
- 2017-09-28 KR KR1020197012457A patent/KR102627405B1/ko active IP Right Grant
- 2017-09-28 KR KR1020247001729A patent/KR20240013849A/ko active Search and Examination
- 2017-09-28 HU HUE17781425A patent/HUE063235T2/hu unknown
- 2017-09-28 JP JP2019516674A patent/JP7197468B2/ja active Active
- 2017-09-28 CA CA3037442A patent/CA3037442A1/en active Pending
- 2017-09-28 EP EP17781425.8A patent/EP3518960B1/en active Active
- 2017-09-28 SG SG11201901576QA patent/SG11201901576QA/en unknown
-
2019
- 2019-03-25 ZA ZA2019/01811A patent/ZA201901811B/en unknown
-
2022
- 2022-10-21 JP JP2022168807A patent/JP7418527B2/ja active Active
- 2022-12-08 US US18/063,294 patent/US11890326B2/en active Active
-
2023
- 2023-02-28 US US18/176,372 patent/US20230321198A1/en active Pending
- 2023-07-19 US US18/355,223 patent/US11918628B2/en active Active
-
2024
- 2024-01-09 JP JP2024001242A patent/JP2024041859A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1249728B (zh) | 控制釋放的藥物劑型 | |
DK3518960T3 (da) | Doseringsskema for en PTH-forbindelse med kontrolleret frigivelse | |
HRP20201847T1 (hr) | Postupak za pripremu spoja diariltiohidantoina | |
MA45277A (fr) | Promédicaments de pth | |
DK3152176T5 (da) | Fremgangsmåde til fremstillingen af en cementforbindelse | |
IL281292A (en) | Processes for preparing a diarylthiohydantoin compound | |
HK1249199A1 (zh) | 用於鐘錶機芯的構件 | |
GB201720016D0 (en) | Fixing for a balcony | |
HK1249200A1 (zh) | 用於鐘錶機芯的構件 | |
HK1209063A1 (en) | A device for diffusing a compound | |
ITUB20151964A1 (it) | Cabina per la verniciatura a polveri | |
HK1248326A1 (zh) | 用於鐘錶機芯的構件 | |
DK2946774T3 (da) | Coatede kapsler med modificeret frigivelse | |
ES1153687Y (es) | Guía para el posicionamiento de enganches ortodónticos | |
HK1256197A1 (zh) | 用於鐘錶機芯的部件 | |
ZA201607107B (en) | Salts and polymorphs of a substituted imidazopyridinyl-aminopyridine compound | |
GB201604756D0 (en) | An attachment means for a building component | |
EP3149633C0 (en) | INTELLIGENT RESTRICTION SELECTION FOR POSITIONING TASKS | |
MA46343A (fr) | Schéma posologique pour un composé de pth à libération contrôlée | |
GB201503860D0 (en) | A spacing means for a building component | |
ES1140769Y (es) | Dispositivo de anclaje para piezas de revestimiento | |
GB201410537D0 (en) | An attachment means for a building component | |
ITGO20140002U1 (it) | Dispositivo di regolazione idraulica di un freno idraulico |