DK3438125T3 - Gærstammer og fremgangsmåder til styring af hydroxylering af rekombinant kollagen - Google Patents
Gærstammer og fremgangsmåder til styring af hydroxylering af rekombinant kollagen Download PDFInfo
- Publication number
- DK3438125T3 DK3438125T3 DK18186574.2T DK18186574T DK3438125T3 DK 3438125 T3 DK3438125 T3 DK 3438125T3 DK 18186574 T DK18186574 T DK 18186574T DK 3438125 T3 DK3438125 T3 DK 3438125T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxylation
- controlling
- methods
- yeast strains
- recombinant collagen
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title 1
- 108010035532 Collagen Proteins 0.000 title 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 1
- 229920001436 collagen Polymers 0.000 title 1
- 230000033444 hydroxylation Effects 0.000 title 1
- 238000005805 hydroxylation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762539213P | 2017-07-31 | 2017-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3438125T3 true DK3438125T3 (da) | 2024-01-08 |
Family
ID=63254509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18186574.2T DK3438125T3 (da) | 2017-07-31 | 2018-07-31 | Gærstammer og fremgangsmåder til styring af hydroxylering af rekombinant kollagen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20190040400A1 (da) |
| EP (1) | EP3438125B1 (da) |
| JP (2) | JP7402604B2 (da) |
| KR (1) | KR20190013627A (da) |
| CN (1) | CN109321480B (da) |
| BR (1) | BR102018015599A2 (da) |
| CA (1) | CA3012006A1 (da) |
| DK (1) | DK3438125T3 (da) |
| ES (1) | ES2967088T3 (da) |
| FI (1) | FI3438125T3 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3008850A1 (en) | 2017-06-29 | 2018-12-29 | Modern Meadow, Inc. | Yeast strains and methods for producing collagen |
| JP2023513307A (ja) * | 2020-02-14 | 2023-03-30 | モダン メドウ，インコーポレイテッド | アミノ酸をヒドロキシル化するための単量体タンパク質及び生成物 |
| CN112626074B (zh) * | 2021-01-11 | 2021-11-23 | 肽源（广州）生物科技有限公司 | 一种含羟脯氨酸修饰化的重组人iii型胶原蛋白成熟肽及其制备方法与应用 |
| CA3174981A1 (en) * | 2021-04-30 | 2022-10-30 | Modern Meadow, Inc. | Collagen compositions and methods of use thereof |
| CN114404667A (zh) * | 2021-12-07 | 2022-04-29 | 尚诚怡美(成都)生物科技有限公司 | 一种长效型重组人源胶原蛋白植入物及其应用 |
| CN114480471A (zh) * | 2021-12-27 | 2022-05-13 | 江苏创健医疗科技有限公司 | 酵母重组人源iii型三螺旋胶原蛋白及其制备方法 |
| CN116375847A (zh) * | 2022-10-26 | 2023-07-04 | 江苏创健医疗科技股份有限公司 | 酵母重组xvii型人源化胶原蛋白及其制备方法 |
| CN116240187B (zh) * | 2023-04-06 | 2024-05-07 | 广东普言生物科技有限公司 | 脯氨酰羟化酶α1亚基突变体、编码基因及其在催化脯氨酸羟基化中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020142391A1 (en) * | 1991-06-12 | 2002-10-03 | Kivirikko Kari I. | Synthesis of human procollagens and collagens in recombinant DNA systems |
| US5804407A (en) * | 1993-11-04 | 1998-09-08 | University Technologies International, Inc. | Method of expressing genes in mammalian cells |
| US6150081A (en) | 1997-12-24 | 2000-11-21 | Fuji Photo Film B.V. | Silver halide emulsions with recombinant collagen suitable for photographic application and also the preparation thereof |
| US6428978B1 (en) | 1998-05-08 | 2002-08-06 | Cohesion Technologies, Inc. | Methods for the production of gelatin and full-length triple helical collagen in recombinant cells |
| AU2005246967B2 (en) * | 1999-11-12 | 2008-09-04 | Fibrogen, Inc. | Recombinant gelatins |
| CN1285612C (zh) * | 1999-11-12 | 2006-11-22 | 法布罗根股份有限公司 | 动物胶原和明胶 |
| JP2003513659A (ja) | 1999-11-12 | 2003-04-15 | ファイブローゲン、インコーポレーテッド | 動物コラーゲン及びゼラチン |
| KR20060015296A (ko) * | 2003-05-23 | 2006-02-16 | 제넨테크, 인크. | 신경교 기원의 종양의 진단 및 치료를 위한 조성물 및 방법 |
| US20080081353A1 (en) * | 2006-09-29 | 2008-04-03 | Universite Laval | Production of recombinant human collagen |
| CA2748015C (en) * | 2008-12-22 | 2017-02-28 | National University Corporation Hokkaido University | Protein substance having triple helix structure and manufacturing method therefor |
| JP2011190210A (ja) * | 2010-03-15 | 2011-09-29 | Sumitomo Chemical Co Ltd | グリシン繰り返し配列タンパク質を産生する形質転換体 |
| CN102020712B (zh) * | 2010-11-11 | 2013-05-29 | 北京东方红航天生物技术股份有限公司 | 一种可用于疫苗稳定剂的类人胶原蛋白及其生产方法 |
| WO2014138703A1 (en) * | 2013-03-08 | 2014-09-12 | Keck Graduate Institute Of Applied Life Sciences | Yeast promoters from pichia pastoris |
| CA3008850A1 (en) * | 2017-06-29 | 2018-12-29 | Modern Meadow, Inc. | Yeast strains and methods for producing collagen |
-
2018
- 2018-07-20 CA CA3012006A patent/CA3012006A1/en active Pending
- 2018-07-27 KR KR1020180088161A patent/KR20190013627A/ko not_active Application Discontinuation
- 2018-07-30 JP JP2018141979A patent/JP7402604B2/ja active Active
- 2018-07-30 BR BR102018015599-7A patent/BR102018015599A2/pt unknown
- 2018-07-30 US US16/048,920 patent/US20190040400A1/en not_active Abandoned
- 2018-07-31 CN CN201810855911.0A patent/CN109321480B/zh active Active
- 2018-07-31 DK DK18186574.2T patent/DK3438125T3/da active
- 2018-07-31 EP EP18186574.2A patent/EP3438125B1/en active Active
- 2018-07-31 FI FIEP18186574.2T patent/FI3438125T3/fi active
- 2018-07-31 ES ES18186574T patent/ES2967088T3/es active Active
-
2023
- 2023-09-15 JP JP2023150398A patent/JP2023179488A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN109321480B (zh) | 2024-01-02 |
| FI3438125T3 (fi) | 2024-01-02 |
| JP7402604B2 (ja) | 2023-12-21 |
| JP2023179488A (ja) | 2023-12-19 |
| EP3438125B1 (en) | 2023-10-11 |
| KR20190013627A (ko) | 2019-02-11 |
| JP2019047774A (ja) | 2019-03-28 |
| US20190040400A1 (en) | 2019-02-07 |
| BR102018015599A2 (pt) | 2019-03-26 |
| CN109321480A (zh) | 2019-02-12 |
| CA3012006A1 (en) | 2019-01-31 |
| ES2967088T3 (es) | 2024-04-26 |
| EP3438125A1 (en) | 2019-02-06 |
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